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1. 发明授权

US06723560B2 Using polyamide nucleic acid oligomers to engender a biological response 失效
公开(公告)号：US06723560B2
公开(公告)日：2004-04-20
申请号：US09168791
申请日：1998-10-08
申请人： Elliott Richelson , Beth Marie Tyler , Bernadette Marie Cusack , Christopher Lee Douglas , Karen Jansen
发明人： Elliott Richelson , Beth Marie Tyler , Bernadette Marie Cusack , Christopher Lee Douglas , Karen Jansen
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , A61K2123/00 , C07K14/003 , C12N2310/3181
摘要： The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal. Further, the invention provides methods and materials for screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, the invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.

2. 发明授权

US06989270B1 Using polyamide nucleic acid oligomers to engender a biological response 失效
标题翻译：使用聚酰胺核酸低聚物产生生物反应
公开(公告)号：US06989270B1
公开(公告)日：2006-01-24
申请号：US09168714
申请日：1998-10-08
申请人： Elliott Richelson , Beth Marie Tyler , Bernadette Marie Cusack , Christopher Lee Douglas , Karen Jansen
发明人： Elliott Richelson , Beth Marie Tyler , Bernadette Marie Cusack , Christopher Lee Douglas , Karen Jansen
IPC分类号： C07H21/04 , C12N15/00 , A61K48/00
CPC分类号： C07K14/003 , A61K38/00 , A61K2123/00 , C12N15/1138 , C12N2310/3181
摘要： The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal. Further, the invention provides methods and materials for screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, the invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.
摘要翻译：本发明涉及用于细胞外活细胞的PNA寡聚体的方法和材料。具体地，本发明提供了用PNA寡聚体处理活细胞的方法和材料，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。此外，本发明提供了用于向动物口服PNA寡聚体的方法和材料，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。本发明还提供分别调节转录和翻译的有义和反义PNA寡聚体。本发明还提供了调节产生的生物反应程度的错配PNA寡聚体。此外，本发明提供了用于检测从动物收集的生物样品中的PNA寡聚体的方法和材料。此外，本发明提供了用于筛选潜在的PNA寡聚体以产生序列特异性生物反应的能力的方法和材料。此外，本发明提供鉴定多肽的功能和确定功能性多肽的相对周转率的方法。

3. 发明授权

US06743627B1 Using polyamide nucleic acid oligomers to engender a biological response 失效
标题翻译：使用聚酰胺核酸低聚物产生生物反应
公开(公告)号：US06743627B1
公开(公告)日：2004-06-01
申请号：US09016685
申请日：1998-01-30
申请人： Elliott Richelson , Beth Marie Tyler , Daniel J. McCormick , Bernadette Marie Cusack , Clark V. Hoshall , Christopher Lee Douglas , Karen Jansen
发明人： Elliott Richelson , Beth Marie Tyler , Daniel J. McCormick , Bernadette Marie Cusack , Clark V. Hoshall , Christopher Lee Douglas , Karen Jansen
IPC分类号： C07K2104
CPC分类号： C12N15/1138 , A61K38/00 , A61K2123/00 , C07K14/003 , C12N2310/3181
摘要： The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.
摘要翻译：本发明涉及用于细胞外活细胞的PNA寡聚体的方法和材料。具体地，本发明提供了用PNA寡聚体处理活细胞的方法，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。此外，本发明提供了用于向动物口服PNA寡聚体的方法和材料，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。本发明还提供了筛选潜在的PNA寡聚体以产生序列特异性生物反应的能力的方法。此外，本发明提供鉴定多肽的功能和确定功能性多肽的相对周转率的方法。

4. 发明授权

US06472209B1 Using polyamide nucleic acid oligomers to engender a biological response 失效
标题翻译：使用聚酰胺核酸低聚物产生生物反应
公开(公告)号：US06472209B1
公开(公告)日：2002-10-29
申请号：US08953269
申请日：1997-10-17
申请人： Elliott Richelson , Beth Marie Tyler , Daniel J. McCormick , Bernadette Marie Cusack , Clark V. Hoshall , Christopher Lee Douglas , Karen Jansen
发明人： Elliott Richelson , Beth Marie Tyler , Daniel J. McCormick , Bernadette Marie Cusack , Clark V. Hoshall , Christopher Lee Douglas , Karen Jansen
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , A61K2123/00 , C07K14/003 , C12N2310/3181
摘要： The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.
摘要翻译：本发明涉及用于细胞外活细胞的PNA寡聚体的方法和材料。具体地，本发明提供了用PNA寡聚体处理活细胞的方法，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。本发明还提供了筛选潜在的PNA寡聚体以产生序列特异性生物反应的能力的方法。此外，本发明提供鉴定多肽的功能和确定功能性多肽的相对周转率的方法。

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