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1. 发明授权

US07696203B2 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US07696203B2
公开(公告)日：2010-04-13
申请号：US11403606
申请日：2006-04-13
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger John Griffin , Bernard Thomas Golding , Ian Robert Hardcastle , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Kappusamy Saravanan , Marine Desage-El Murr
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger John Griffin , Bernard Thomas Golding , Ian Robert Hardcastle , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Kappusamy Saravanan , Marine Desage-El Murr
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D413/00 , C07D401/14 , C07D405/04 , C07D407/04 , C07D407/14 , C07D409/04 , C07D471/04
摘要： Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(═O), CH2 and NH are disclosed for use in inhibiting DNA-PK.
摘要翻译：式I化合物：其中A，B和D分别选自：（i）CH，NH，C; （ii）CH，N，N; 和（iii）CH，O，C; 虚线表示适当位置的两个双键; 并且其中Z选自S，O，C（= O），CH 2和NH用于抑制DNA-PK。

2. 发明申请

US20060106025A1 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US20060106025A1
公开(公告)日：2006-05-18
申请号：US11231041
申请日：2005-09-20
申请人： Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Laurent Rigoreau , Roger Griffin , Bernard Golding , David Newell , Hilary Calvert , Nicola Curtin , Ian Hardcastle , Kappusamy Saravanan
发明人： Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Laurent Rigoreau , Roger Griffin , Bernard Golding , David Newell , Hilary Calvert , Nicola Curtin , Ian Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/496 , C07D409/14
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选地取代的C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或者可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（-O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中R 3，R 3，R 3， 4和R 5独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基，或 C 3-20杂环基或R 4和R 5可以一起与它们所连接的氮原子一起形成一个具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（-O）-NR 6 R 7，其中R 6和R 独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基或C 3-20 或者R 6和R 7可以与它们所连接的氮原子一起形成任选取代的杂环，其具有4个至8个环原子; 并且如果Q是-NH-C（-O） - ，-Y-X可另外选自C 1-7烷基。

3. 发明授权

US07402607B2 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US07402607B2
公开(公告)日：2008-07-22
申请号：US11231041
申请日：2005-09-20
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/381 , C07D333/76
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选地取代的C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或者可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（-O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中R 3，R 3，R 3， 4和R 5独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基，或 C 3-20杂环基或R 4和R 5可以一起与它们所连接的氮原子一起形成一个具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（-O）-NR 6 R 7，其中R 6和R 独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基或C 3-20 或者R 6和R 7可以与它们所连接的氮原子一起形成任选取代的杂环，其具有4个至8个环原子; 并且如果Q是-NH-C（-O） - ，-Y-X可另外选自C 1-7烷基。

4. 发明申请

US20060264427A1 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US20060264427A1
公开(公告)日：2006-11-23
申请号：US11403606
申请日：2006-04-13
申请人： Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , HiIary Calvert , Nicola Curtin , Kappusamy Saravanan , Marine Desage-El Murr
发明人： Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , HiIary Calvert , Nicola Curtin , Kappusamy Saravanan , Marine Desage-El Murr
IPC分类号： A61K31/541 , A61K31/5377 , C07D487/02
CPC分类号： C07D413/00 , C07D401/14 , C07D405/04 , C07D407/04 , C07D407/14 , C07D409/04 , C07D471/04
摘要： Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(═O), CH2 and NH are disclosed for use in inhibiting DNA-PK.
摘要翻译：式I化合物：其中A，B和D分别选自：（i）CH，NH，C; （ii）CH，N，N;和（iii）CH，O，C; 虚线表示适当位置的两个双键; 并且其中Z选自S，O，C（-O），CH 2和NH，用于抑制DNA-PK。

5. 发明授权

US07732483B2 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US07732483B2
公开(公告)日：2010-06-08
申请号：US12133837
申请日：2008-06-05
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/381 , C07D333/74 , C07D409/04
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5- 20芳基，或者可以与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（= O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中，R 3或R 4和R 5独立地选自氢，任选取代的C 1-7烷基，C 5-20芳基或C 3-20杂环基，或者R 4和R 5可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（= O）-NR 6 R 7，其中R 6和R 7独立地选自氢，任选取代的C 1-7烷基，C 5-20芳基或C 3-20杂环基，或R6和R7可以与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; 并且如果Q是-NH-C（= O） - ，-Y-X可另外选自C 1-7烷基。

6. 发明申请

US20080242664A1 DNA-PK INHIBITORS 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US20080242664A1
公开(公告)日：2008-10-02
申请号：US12133837
申请日：2008-06-05
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/5377 , C07D409/10 , A61K31/381 , C07D409/14 , A61P35/04 , A61K31/496 , C07D413/14
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选地取代的C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或者可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（-O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中R 3，R 3，R 3， 4和R 5独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基，或 C 3-20杂环基或R 4和R 5可以一起与它们所连接的氮原子一起形成一个具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（-O）-NR 6 R 7，其中R 6和R 独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基或C 3-20 或者R 6和R 7可以与它们所连接的氮原子一起形成任选取代的杂环，其具有4个至8个环原子; 并且如果Q是-NH-C（-O） - ，-Y-X可另外选自C 1-7烷基。

7. 发明申请

US20070238731A1 Dna-Pk Inhibitors 审中-公开
标题翻译： Dna-Pk抑制剂
公开(公告)号：US20070238731A1
公开(公告)日：2007-10-11
申请号：US11575606
申请日：2005-09-20
申请人： Graeme Smith , Niall Martin , Roger Griffin , Bernard Golding , Ian Hardcastle , Kappusamy Saravanan , David Newell , Hilary Calvert , Nicola Curtin , Keith Menear , Marc Hummersone
发明人： Graeme Smith , Niall Martin , Roger Griffin , Bernard Golding , Ian Hardcastle , Kappusamy Saravanan , David Newell , Hilary Calvert , Nicola Curtin , Keith Menear , Marc Hummersone
IPC分类号： A61K31/5355 , C07D413/14
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3 or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选地取代的C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或者可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（-O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中，R 3或R 4 R 5和R 5独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20芳基或C 3-20个杂环基或R 4和R 5可以一起与它们所连接的氮原子一起形成任选地具有4至8个环原子的取代杂环; 如果Q是-O-，X另外选自-C（-O）-NR 6 R 7，其中R 6和R 独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基或C 3-20 或者R 6和R 7可以与它们所连接的氮原子一起形成任选取代的杂环，其具有4个至8个环原子; 并且如果Q是-NH-C（-O） - ，-Y-X可另外选自C 1-7烷基。

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