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1. 发明授权

US10016277B2 Heart correction net 有权
公开(公告)号：US10016277B2
公开(公告)日：2018-07-10
申请号：US14383923
申请日：2013-03-08
申请人： KANAZAWA MEDICAL UNIVERSITY , Kanazawa Institute of Technology
发明人： Toshiaki Akita , Masashi Yamabe , Masahiro Seto
IPC分类号： A61F2/24 , D04B37/02 , D04B1/18 , A61B17/00 , A61B34/10
CPC分类号： A61F2/2481 , A61B2017/00526 , A61B2034/108 , A61F2210/0004 , A61F2240/002 , A61F2240/004 , A61F2250/0031 , A61F2250/0041 , D04B1/18 , D04B37/02 , D10B2509/08
摘要： A heart correction net according to the present invention is attached to an exterior of a heart. The heart correction net includes a first area that is a partial area included in a right ventricle side area of an entire area surrounding exteriors of ventricles; and a second area that is an area surrounding the first area in the right ventricle side area and a left ventricle side area. The first area in the heart correction net is configured to provide a lower contact pressure against a heart during a cardiac diastole than the second area.

2. 发明公开

US20230301617A1 STETHOSCOPE 审中-公开
公开(公告)号：US20230301617A1
公开(公告)日：2023-09-28
申请号：US18125760
申请日：2023-03-24
申请人： ONKYO CORPORATION , KANAZAWA MEDICAL UNIVERSITY
发明人： Makoto YOSHIDA , Kunimasa YAGI , Mikifumi SHIKIDA
IPC分类号： A61B7/04 , A61B7/00
CPC分类号： A61B7/04 , A61B7/003
摘要： A stethoscope system comprising: a plurality of sensors for collecting auscultatory sounds; and a controller which detects a first heart sound and a second heart sound of heart sounds based on a volume of the auscultatory sounds which are collected by the plurality of sensors.

3. 发明申请

US20220008419A1 PHARMACEUTICAL COMPOSITION FOR TREATING DIFFUSE-TYPE GASTRIC CANCER 有权
公开(公告)号：US20220008419A1
公开(公告)日：2022-01-13
申请号：US17293114
申请日：2019-11-14
申请人： KANAZAWA MEDICAL UNIVERSITY
发明人： Kazuo YASUMOTO
IPC分类号： A61K31/506 , C07K16/22 , A61K31/4985 , A61P35/04
摘要： An object of the present invention is to provide a molecular targeted drug effective for diffuse gastric cancer. According to the present invention, there is provided a pharmaceutical composition for treating diffuse gastric cancer in a patient, which comprises an EGF receptor inhibitor having an ErbB1 inhibitory activity and an ErbB4 inhibitory activity. According to the present invention, there is provided the aforementioned pharmaceutical composition for use in a combination therapy with an anti-VEGF receptor 2 antibody and/or a cMET inhibitor. According to the present invention, there is provided a method for treating diffuse gastric cancer in a patient, which comprises the step of administering an EGF receptor inhibitor having an ErbB1 inhibitory activity and an ErbB4 inhibitory activity to the patient.

4. 发明申请

US20150285718A1 KIT FOR PRODUCING CLEARED BIOLOGICAL SPECIMENS AND METHOD FOR PRODUCING CLEARED BIOLOGICAL SPECIMENS 审中-公开
标题翻译：用于生产清除生物样本的试剂盒和生产清除生物样本的方法
公开(公告)号：US20150285718A1
公开(公告)日：2015-10-08
申请号：US14439447
申请日：2013-10-30
申请人： Kanazawa Medical University
发明人： Toshihisa Hatta , Maimi Uchishiba , Nobuaki Higashi , Hiroki Shimada , Eriko Shimamura
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , A01N1/0231 , G01N2001/305
摘要： A method and a kit are provided to produce a biological clear specimen within a short time and with a wide variety of biological specimens. The method includes the following steps: (1) treating a material to be cleared with an aqueous fixing solution containing paraformaldehyde or the like, a nonionic surfactant, an alkali, and optionally a buffering agent; (2) treating the material from step (1) or a conventionally fixed material with an aqueous clearing accelerator solution containing a nonionic surfactant and an alkali; and (3) treating the material produced in step (1) or (2) with an aqueous preservation solution containing a nonionic surfactant and a polyhydric alcohol. In each of the steps, the nonionic surfactant is present at a concentration of 1% or more. The kit includes solutions used in each of the steps of the method.
摘要翻译：提供了一种方法和试剂盒，用于在短时间内生成一种生物学清晰的样品，并具有多种生物样本。该方法包括以下步骤：（1）用含有多聚甲醛等的固定液处理待清洗的物质，非离子表面活性剂，碱和任选的缓冲剂; （2）用含有非离子表面活性剂和碱的含水净化促进剂溶液处理来自步骤（1）的材料或常规固定的材料; 和（3）用含有非离子表面活性剂和多元醇的水性保存溶液处理步骤（1）或（2）中产生的材料。在每个步骤中，非离子表面活性剂以1％或更高的浓度存在。该套件包括在该方法的每个步骤中使用的解决方案。

5. 外观设计

USD717952S1 Cardiac support net 有权
标题翻译：心脏支撑网
公开(公告)号：USD717952S1
公开(公告)日：2014-11-18
申请号：US29464824
申请日：2013-08-21
申请人： Kanazawa Medical University , Kanazawa Institute of Technology
设计人： Toshiaki Akita , Masahiro Seto , Masashi Yamabe

6. 发明申请

US20140296945A1 LIGHT IRRADIATION DEVICE FOR IMPROVING COGNITIVE SYMPTOM AND DEPRESSION SYMPTOM, ROOM HAVING THE LIGHT IRRADIATION DEVICE, AND LIGHTING DEVICE FOR IMPROVING COGNITIVE SYMPTOM AND DEPRESSION SYMPTOM 审中-公开
标题翻译：用于改善认知症状和抑郁症状的灯光照射装置，具有光照射装置的房间，以及用于改善认知症状和抑郁症状的照明装置
公开(公告)号：US20140296945A1
公开(公告)日：2014-10-02
申请号：US14353772
申请日：2012-10-25
申请人： KANAZAWA MEDICAL UNIVERSITY
发明人： Nobuo Kato
IPC分类号： A61N5/06
CPC分类号： A61N5/0618 , A61M21/00 , A61M2021/0044 , A61N2005/0629 , A61N2005/0632 , A61N2005/0642 , F04C2270/0421 , H05B41/34
摘要： In a light irradiation device 20 for improving cognitive symptom and depression symptom according to the present invention, photostimulation is given to a retina by continuous flashing of a light source 21 of frequency of 1 to 10 Hz, Homer 1a is made to continuously express by the photostimulation, and BK-type potassium channel in pyramidal cell of cerebral cortex is activated. It is possible to exert an effect equivalent to a depression symptom improving effect obtained by an electroconvusion stimulation device, an effect equivalent to a depression symptom improving effect and an effect equivalent to a cognitive symptom improving effect obtained by a transcranial magnetic stimulation device. It is possible to utilize these devices also in home environment as compared with an electroconvusion stimulation device and a transcranial magnetic stimulation device which are limited to treatment in clinical institutions as opposed to home environment.
摘要翻译：在根据本发明的用于改善认知症状和抑郁症状的光照射装置20中，通过连续闪烁频率为1至10Hz的光源21对视网膜进行光刺激，使荷马1a由大脑皮质锥体细胞中的光刺激和BK型钾通道被激活。可以发挥与电加压刺激装置获得的抑郁症状改善效果相当的效果，与抑制症状改善效果相当的效果和与通过经颅磁刺激装置获得的认知症状改善效果相当的效果。与在家庭环境中相比，限于在临床机构中的治疗的电加压刺激装置和经颅磁刺激装置相比，在家庭环境中也可以利用这些装置。

7. 发明授权

US11035763B2 Kit for producing cleared biological specimens and method for producing cleared biological specimens 有权
公开(公告)号：US11035763B2
公开(公告)日：2021-06-15
申请号：US14439447
申请日：2013-10-30
申请人： Kanazawa Medical University
发明人： Toshihisa Hatta , Maimi Uchishiba , Nobuaki Higashi , Hiroki Shimada , Eriko Shimamura
IPC分类号： G01N1/30 , A01N1/02
摘要： A method and a kit are provided to produce a biological clear specimen within a short time and with a wide variety of biological specimens. The method includes the following steps: (1) treating a material to be cleared with an aqueous fixing solution containing paraformaldehyde or the like, a nonionic surfactant, an alkali, and optionally a buffering agent; (2) treating the material from step (1) or a conventionally fixed material with an aqueous clearing accelerator solution containing a nonionic surfactant and an alkali; and (3) treating the material produced in step (1) or (2) with an aqueous preservation solution containing a nonionic surfactant and a polyhydric alcohol. In each of the steps, the nonionic surfactant is present at a concentration of 1% or more. The kit includes solutions used in each of the steps of the method.

8. 发明授权

US10253291B2 Culture vessel 有权
公开(公告)号：US10253291B2
公开(公告)日：2019-04-09
申请号：US14901775
申请日：2014-07-31
申请人： KANAZAWA MEDICAL UNIVERSITY , SHINKO CHEMICAL CO., LTD.
发明人： Takeo Shimasaki , Yumiko Kitano , Hideki Yamada
IPC分类号： C12M1/00 , C12M1/12 , C12M1/34 , C12M3/00
摘要： The present invention relates to a culture vessel which can be broadly applied to culture, regeneration, manufacture, observation and the like of targets such as cells, organs, and microorganisms. In the culture vessel of the present invention, a first vessel 10 and a second vessel 20 each being a close-bottom, open-top vessel are provided. In the first vessel 10 and the second vessel 20, a sideways-facing opening 12 and a sideways-facing opening 22 are formed. The opening 12 and the opening 22 communicate in a watertight manner when the openings 12, 22 are connected face to face.

9. 发明授权

US09702067B2 Manufacturing method for heart correction net 有权
公开(公告)号：US09702067B2
公开(公告)日：2017-07-11
申请号：US14383919
申请日：2013-03-08
申请人： KANAZAWA MEDICAL UNIVERSITY , Kanazawa Institute of Technology , Tokai Medical Products, Inc.
发明人： Toshiaki Akita , Masashi Yamabe , Masahiro Seto , Toru Suzuki , Naoyuki Takesue
IPC分类号： G06K9/00 , D04B15/66 , A61F2/24 , A61B17/00 , G06F19/00 , A61B34/10
CPC分类号： D04B15/66 , A61B17/00 , A61B2017/00526 , A61B2034/108 , A61F2/2481 , A61F2240/002 , G16H50/50
摘要： A manufacturing method of a heart correction net is provided. The method includes: a first step of taking cross-sectional images of a heart in a layer direction, in which an apex and a base of the heart are connected; a second step of extracting outlines of the heart from the cross-sectional images; a third step of defining dividing points with respect to a three-dimensional shape reconstructed based on the outlines, the dividing points being defined on the outlines in a circumferential direction of the heart; a fourth step of dividing a contour of the heart in three-dimensions into divided regions based on the plurality of the dividing points, and creating development data, in which the each of the divided regions is developed on a two-dimensional plane, while an approximate shape of each of the divided regions is maintained; a fifth step of creating paper-pattern data based on the development data; and a sixth step of knitting the heart correction net with a knitting machine based on the paper-pattern data.

10. 发明授权

US10695467B2 Antibacterial member 有权
公开(公告)号：US10695467B2
公开(公告)日：2020-06-30
申请号：US16348607
申请日：2017-11-09
申请人： Kanazawa Medical University , Kanazawa Institute of Technology , Onward Ceramic Coating Co., Ltd.
发明人： Masahito Kawaguchi , Norio Kawahara , Yoshitsugu Iinuma , Kazuhiro Shintani , Shinobu Oda , Makoto Taki
IPC分类号： A61L27/54 , A61L27/30 , A61L31/08 , A61L31/16
摘要： An antibacterial member that maintains a high antibacterial property and a high osteoconductive property for a long duration is provided. The antibacterial member includes a DLC film (F-DLC film) 40 containing fluorine at least partially or entirely on an outermost surface of a base material 10. The F-DLC film has an element ratio (F/(F+C)) of 17% to 72% and a nanoindentation hardness of 2,000 MPa to 16,000 MPa. This maintains wear resistance and close contact, and obtains an antibacterial member that maintains a high antibacterial property and a high osteoconductive property for a long duration. The F-DLC film does not necessarily need to cover the entire outermost surface of the base material but may be disposed in a mottled pattern.

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