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1. 发明申请

US20110056863A1 ADHESIVE PREPARATION CONTAINING DONEPEZIL, AND PACKAGE OF THE SAME 审中-公开
标题翻译：含有二苯乙烯的胶粘剂及其包装
公开(公告)号：US20110056863A1
公开(公告)日：2011-03-10
申请号：US12990818
申请日：2009-05-26
申请人： Junichi Sekiya , Akinori Hanatani , Sachiko Sakamoto , Sumiyo Maruyama , Hitoshi Akemi
发明人： Junichi Sekiya , Akinori Hanatani , Sachiko Sakamoto , Sumiyo Maruyama , Hitoshi Akemi
IPC分类号： B65D85/00 , A61K9/70 , A61K31/445 , A61P25/28
CPC分类号： A61K9/7061 , A61K31/4465 , B65D81/24
摘要： [Object] An adhesive preparation containing donepezil is provided in which adhesive layer discoloration over time is inhibited.[Solution] The adhesive preparation containing donepezil has an adhesive layer containing donepezil and an acrylic adhesive on at least one side of a support, and a water content of the adhesive layer is 1000 ppm or more. The water content of the adhesive layer is preferably 8000 ppm or less and more preferably 7000 ppm or less.
摘要翻译：提供了含有多奈哌齐的粘合剂，其中粘合剂层随着时间的变色被抑制。 [解决方案]含有多奈哌齐的粘合剂在载体的至少一侧上具有含有多奈哌齐和丙烯酸类粘合剂的粘合剂层，粘合剂层的含水量为1000ppm以上。粘合剂层的含水量优选为8000ppm以下，更优选为7000ppm以下。

2. 发明授权

US08361493B2 Transdermal patch having a pressure-sensitive adhesive comprising (meth)acrylic acid alkyl ester, N-hydroxyalkyl(meth)acrylamide, and vinyl monomers 有权
标题翻译：具有包含（甲基）丙烯酸烷基酯，N-羟烷基（甲基）丙烯酰胺和乙烯基单体的压敏粘合剂的透皮贴剂
公开(公告)号：US08361493B2
公开(公告)日：2013-01-29
申请号：US12945198
申请日：2010-11-12
申请人： Jun Ishikura , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Ryo Hashino , Satoshi Ameyama , Hidetoshi Kuroda
发明人： Jun Ishikura , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Ryo Hashino , Satoshi Ameyama , Hidetoshi Kuroda
IPC分类号： A61F13/02 , A61F13/00
CPC分类号： A61L15/585 , C09J133/26 , Y10T428/2887 , Y10T428/2891
摘要： The patch according to an embodiment of the present invention includes: a support; and a pressure-sensitive adhesive layer on at least one surface of the support, wherein: the pressure-sensitive adhesive layer contains an acrylic copolymer obtained by copolymerizing monomer components containing (a) at least one kind of a monomer of a (meth)acrylic acid alkyl ester and (b) at least one kind of a monomer of an N-hydroxyalkyl(meth)acrylamide; a content of the (meth)acrylic acid alkyl ester monomer (a) with respect to a total amount of the monomer components is 50 wt % to 90 wt % and a content of the N-hydroxyalkyl(meth)acrylamide monomer (b) with respect to the total amount is 1 wt % to 20 wt %; and the monomer components are substantially free of a monomer having a carboxyl group.
摘要翻译：根据本发明的实施例的贴片包括：支撑件; 和压敏粘合剂层，其中：所述压敏粘合剂层含有丙烯酸共聚物，所述丙烯酸共聚物通过共聚含有（a）至少一种（甲基）丙烯酸单体的单体成分而得到的丙烯酸共聚物酸性烷基酯和（b）至少一种N-羟烷基（甲基）丙烯酰胺的单体; 相对于单体成分的总量，（甲基）丙烯酸烷基酯单体（a）的含量为50重量％〜90重量％，N-羟烷基（甲基）丙烯酰胺单体（b）的含量与相对于总量为1重量％〜20重量％并且单体组分基本上不含具有羧基的单体。

3. 发明申请

US20100062045A1 METHOD FOR SUPPRESSING COLORING OF ADHESIVE PREPARTION CONTAINING DONEPEZIL AND METHOD FOR REDUCING AMOUNTS OF DONEPEZIL-RELATED SUBSTANCES FORMED 审中-公开
标题翻译：用于抑制含有二苯醚的粘合制剂的着色方法和减少形成的与二苯醚相关的物质的量的方法
公开(公告)号：US20100062045A1
公开(公告)日：2010-03-11
申请号：US12516998
申请日：2007-11-30
申请人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
发明人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
IPC分类号： A61K31/445 , A61K9/70 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： [Object] By suppressing coloring of an adhesive preparation containing donepezil, a naturally colored appearance is realized.[Solution] In a method for suppressing coloring of an adhesive preparation having a support and a pressure-sensitive adhesive layer, which comprises a pressure-sensitive adhesive and donepezil in the pressure-sensitive adhesive layer, ascorbic acid, a metal salt or an ester thereof and metal metabisulfite salt are contained in the pressure-sensitive adhesive layer. This method preferably has: a step of preparing a mixture comprising the pressure-sensitive adhesive, the donepezil, the ascorbic acid, a metal salt or an ester thereof, and the metal metabisulfite salt; and a step of film-forming the pressure-sensitive adhesive layer by applying the mixture to the surface of the support.
摘要翻译：通过抑制含有多奈哌齐的粘合剂的着色，实现了自然着色的外观。 [解决方案]在压敏粘合剂层中包含压敏粘合剂和多奈哌齐的粘合剂的制备方法中，具有支持体和粘合剂层的粘合剂的制备方法，抗坏血酸，金属盐或酯并且在压敏粘合剂层中含有偏亚硫酸氢盐。该方法优选具有：制备包含压敏粘合剂，多奈哌齐，抗坏血酸，金属盐或其酯和偏亚硫酸氢盐的混合物的步骤; 以及通过将所述混合物施加到所述载体的表面来成膜所述压敏粘合剂层的步骤。

4. 发明申请

US20100048628A1 METHOD FOR SUPPRESSING DISCOLORATION OVER TIME OF ADHESIVE PREPARATION CONTAINING DONEPEZIL 审中-公开
标题翻译：用于抑制含有二苯醚的胶粘剂制备时间的消除方法
公开(公告)号：US20100048628A1
公开(公告)日：2010-02-25
申请号：US12517004
申请日：2007-11-30
申请人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
发明人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
IPC分类号： A61K31/445 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： [Object] Discoloration, over time, of a donepezil-containing adhesive preparation is suppressed.[Solution] At least one species of stabilizer selected from the group consisting of ascorbic acid, a metal salt or an ester thereof, isoascorbic acid or a metal salt thereof, ethylenediamine tetraacetic acid or a metal salt thereof, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, (±)-α-tocopherol, (±)-α-tocopherol acetate, rutin, hypophosphorous acid, a metal metabisulfite salt and a metal salt of hydroxymethanesulfinic acid, is blended in a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and donepezil.
摘要翻译： [目的]抑制多奈哌齐胶粘剂的变色，随着时间的推移。 [溶液]选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇，（±）-α-生育酚，（±）-α-生育酚乙酸酯，芦丁，次磷酸，偏亚硫酸氢盐金属盐和羟基甲烷亚磺酸的金属盐混合在含有压敏粘合剂和多奈哌齐。

5. 发明授权

US07585907B2 Inorganic powder-containing resin composition, a film-forming material layer, a transfer sheet, method of producing a substrate having a dielectric layer formed thereon, and a substrate having a dielectric layer formed thereon 失效
标题翻译：无机粉末的树脂组合物，成膜材料层，转印片，其上形成有电介质层的基材的制造方法以及在其上形成有电介质层的基材
公开(公告)号：US07585907B2
公开(公告)日：2009-09-08
申请号：US10565565
申请日：2004-07-23
申请人： Tomohide Banba , Katsuya Kume , Makoto Kai , Natsuki Kobayashi , Mami Ikeya , Yasushi Buzoujima , Junichi Sekiya , Mitsuhiro Kanada
发明人： Tomohide Banba , Katsuya Kume , Makoto Kai , Natsuki Kobayashi , Mami Ikeya , Yasushi Buzoujima , Junichi Sekiya , Mitsuhiro Kanada
IPC分类号： C08K5/521
CPC分类号： C08K5/521 , C08K3/01 , H01J2211/38
摘要： The invention provides an inorganic powder-containing resin composition capable of forming a dielectric layer having high light transmittance and excellent in surface smoothness. The invention also provides a film-forming material layer, a transfer sheet and a dielectric layer, which comprise the composition, a method of producing a substrate having a dielectric layer formed thereon, and a substrate having a dielectric layer formed thereon. The inorganic powder-containing resin composition comprises inorganic powder, a binder resin, and a phosphorus compound represented by formula (1): wherein R1, R2 and R3 independently represent H, an alkyl group, an alkylaryl group, NH4+ (ammonium) or —(CH2CH2O)n—R4, wherein n is 1 to 15, and R4 represents H, an alkyl group, an alkylaryl group or a (meth)acryloyl group.
摘要翻译：本发明提供一种无机粉末的树脂组合物，其能够形成具有高透光率和优异的表面光滑度的电介质层。本发明还提供了包含该组合物的成膜材料层，转印片和电介质层，其上形成有电介质层的基板的制造方法和在其上形成有电介质层的基板。无机粉末的树脂组合物包含无机粉末，粘合剂树脂和由式（1）表示的磷化合物：其中R1，R2和R3独立地表示H，烷基，烷基芳基，NH4 +（铵）或 - （CH 2 CH 2 O）n -R 4，其中n为1至15，R 4表示H，烷基，烷基芳基或（甲基）丙烯酰基。

6. 发明申请

US20090166229A1 Patch package structure 有权
标题翻译：贴片包装结构
公开(公告)号：US20090166229A1
公开(公告)日：2009-07-02
申请号：US12314564
申请日：2008-12-12
申请人： Yoshihiro Iwao , Akinori Hanatani , Junichi Sekiya , Hitoshi Akemi
发明人： Yoshihiro Iwao , Akinori Hanatani , Junichi Sekiya , Hitoshi Akemi
IPC分类号： A61B19/02 , B65D81/26
CPC分类号： A61L15/24 , C08L33/20
摘要： The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 having an adhesive layer containing an organic liquid component, and a packaging member 51 housing the patch, wherein the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译：本发明的主要目的是提供一种贴片包装结构，其包括含有生理活性成分的贴剂和容纳该贴剂的包装，其能够在保存期间稳定地保留贴剂中的生理活性成分。该目的可以通过采用以下结构来实现。具体而言，本发明是一种贴片包装结构，其包括具有含有有机液体成分的粘合剂层的贴片1和容纳该贴片的包装部件51，其中，包装部件51包括第一包装体11，第一包装体11 包括丙烯腈树脂层12，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14和丙烯腈树脂层12设置在补丁1。

7. 发明申请

US20080131490A1 Stabilized donepezil-containing patch preparation 审中-公开
标题翻译：稳定的多奈哌齐贴片制剂
公开(公告)号：US20080131490A1
公开(公告)日：2008-06-05
申请号：US11987480
申请日：2007-11-30
申请人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Satoko Washiro , Hitoshi Akemi
发明人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Satoko Washiro , Hitoshi Akemi
IPC分类号： A61K9/70 , A61K31/445 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： A donepezil-containing patch preparation is provided whereby production of donepezil-related substances in the pressure-sensitive adhesive layer is suppressed. A stabilizer comprising at least one or more species selected from the group consisting of ascorbic acid, metal salts or esters thereof, isoascorbic acid or metal salts thereof, ethylenediamine tetraacetic acid or metal salts thereof, cysteine, acetylcysteine, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, 3-mercapto-1,2-propanediol, tocopherol acetate, rutin, quercetin, hydroquinone, metal salts of hydroxymethanesulfinic acid, metal metabisulfite salts, metal sulfite salts and metal thiosulfate salts is blended in a donepezil-containing pressure-sensitive adhesive layer provided on at least one side of a support.
摘要翻译：提供了含多奈哌齐的贴剂，抑制了压敏粘合剂层中多奈哌齐相关物质的产生。包含至少一种或多种选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，半胱氨酸，乙酰半胱氨酸，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇，3-巯基-1,2-丙二醇，生育酚乙酸酯，芦丁，槲皮素，氢醌，羟基甲烷亚磺酸的金属盐，偏亚硫酸氢盐，金属亚硫酸盐和金属硫代硫酸盐，配制在含有多奈哌齐的压敏粘合剂层中在支架的至少一侧。

8. 发明申请

US20110123598A1 PATCH AND PATCH PREPARATION 有权
标题翻译：配对和配对准备
公开(公告)号：US20110123598A1
公开(公告)日：2011-05-26
申请号：US12945198
申请日：2010-11-12
申请人： Jun ISHIKURA , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Ryo Hashino , Satoshi Ameyama , Hidetoshi Kuroda
发明人： Jun ISHIKURA , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Ryo Hashino , Satoshi Ameyama , Hidetoshi Kuroda
IPC分类号： A61F13/02 , B32B27/30
CPC分类号： A61L15/585 , C09J133/26 , Y10T428/2887 , Y10T428/2891
摘要： The patch according to an embodiment of the present invention includes: a support; and a pressure-sensitive adhesive layer on at least one surface of the support, wherein: the pressure-sensitive adhesive layer contains an acrylic copolymer obtained by copolymerizing monomer components containing (a) at least one kind of a monomer of a (meth)acrylic acid alkyl ester and (b) at least one kind of a monomer of an N-hydroxyalkyl(meth)acrylamide; a content of the (meth)acrylic acid alkyl ester monomer (a) with respect to a total amount of the monomer components is 50 wt % to 90 wt % and a content of the N-hydroxyalkyl(meth)acrylamide monomer (b) with respect to the total amount is 1 wt % to 20 wt %; and the monomer components are substantially free of a monomer having a carboxyl group.
摘要翻译：根据本发明的实施例的贴片包括：支撑件; 和压敏粘合剂层，其中：所述压敏粘合剂层含有丙烯酸共聚物，所述丙烯酸共聚物通过共聚含有（a）至少一种（甲基）丙烯酸单体的单体成分而得到的丙烯酸共聚物酸性烷基酯和（b）至少一种N-羟烷基（甲基）丙烯酰胺的单体; 相对于单体成分的总量，（甲基）丙烯酸烷基酯单体（a）的含量为50重量％〜90重量％，N-羟烷基（甲基）丙烯酰胺单体（b）的含量与相对于总量为1重量％〜20重量％并且单体组分基本上不含具有羧基的单体。

9. 发明申请

US20100010043A1 PERCUTANEOUSLY ABSORBABLE PREPARATION 审中-公开
标题翻译： PERCUTANEOUSYOUSLY可吸收制剂
公开(公告)号：US20100010043A1
公开(公告)日：2010-01-14
申请号：US12475249
申请日：2009-05-29
申请人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Hitoshi Akemi
发明人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Hitoshi Akemi
IPC分类号： A61K31/445 , C07D211/08
CPC分类号： A61K31/4465 , A61K9/7053 , A61K9/7061
摘要： The present invention provides a percutaneously absorbable preparation comprising 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one and/or a hydrochloride thereof wherein the percuneously absorbable preoaration is able to administer to a patient such that Cmax per unit surface area of the percutaneously absorbable preparation is 0.025 to 0.5 ng/ml·cm2 in a plasma concentration profile.
摘要翻译：本发明提供了包含2 - [（1-苄基哌啶-4-基）甲基] -5,6-二甲氧基茚满-1-酮和/或其盐酸盐的经皮吸收制剂，其中可以吸收的预制剂能够施用于使得经皮吸收制剂的每单位表面积的C max在血浆浓度分布中为0.025至0.5ng / ml.cm 2。

10. 发明授权

US08033395B2 Patch package structure 有权
标题翻译：贴片包装结构
公开(公告)号：US08033395B2
公开(公告)日：2011-10-11
申请号：US12314564
申请日：2008-12-12
申请人： Yoshihiro Iwao , Akinori Hanatani , Junichi Sekiya , Hitoshi Akemi
发明人： Yoshihiro Iwao , Akinori Hanatani , Junichi Sekiya , Hitoshi Akemi
IPC分类号： A61B19/02 , B65D73/00 , B65D65/26
CPC分类号： A61L15/24 , C08L33/20
摘要： The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 having an adhesive layer containing an organic liquid component, and a packaging member 51 housing the patch, wherein the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译：本发明的主要目的是提供一种贴片包装结构，其包括含有生理活性成分的贴剂和容纳该贴剂的包装，其能够在保存期间稳定地保留贴剂中的生理活性成分。该目的可以通过采用以下结构来实现。具体而言，本发明是一种贴片包装结构，其包括具有含有有机液体成分的粘合剂层的贴片1和容纳该贴片的包装部件51，其中，包装部件51包括第一包装体11，第一包装体11 包括丙烯腈树脂层12，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14和丙烯腈树脂层12设置在补丁1。

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