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1. 发明授权

US09327049B2 Anti-adhesion polymer composition capable of supporting growth factor 有权
标题翻译：抗粘连聚合物组合物能够支持生长因子
公开(公告)号：US09327049B2
公开(公告)日：2016-05-03
申请号：US14374988
申请日：2012-03-08
申请人： Jung Ju Kim , Jung Won So , Hyun Seung Ryu , Jun Hyuk Seo
发明人： Jung Ju Kim , Jung Won So , Hyun Seung Ryu , Jun Hyuk Seo
IPC分类号： A61K31/74 , A61L24/04 , A61L31/16 , A61L31/04 , A61L24/00 , C08L71/02 , A61K47/30 , A61K47/10 , A61K47/34
CPC分类号： A61L24/046 , A61B2090/0816 , A61K47/10 , A61K47/30 , A61K47/34 , A61L24/0015 , A61L24/043 , A61L31/041 , A61L31/16 , A61L2300/252 , A61L2300/414 , A61L2400/04 , A61L2400/06 , C08L71/02 , C08L2203/02 , C08L89/06 , C08L5/08
摘要： The present invention relates to an anti-adhesion polymer composition capable of supporting growth factor, which effectively exhibits anti-adhesion function and, at the same time, has an excellent adhesive property so as to be able to easily and continuously adhere to a wound site, has antibacterial and hemostatic properties, and is composed of an injectable formulation suitable for use in minimally invasive surgery, laparoscopic surgery or the like. The anti-adhesion polymer composition capable of supporting growth factor comprises: 24-50 wt % of a polyethyleneglycol-polypropyleneglycol-polyethyleneglycol (PEG-PPG-PEG) block copolymer having a polyethyleneglycol (PEG) content of 65-85 wt % and a molecular weight of 6,000-20,000 Da; 0.03-5 wt % of gelatin; 0.03-5 wt % of chitosan; and distilled water.
摘要翻译：本发明涉及一种能够有效显示抗粘连功能的支持生长因子的抗粘连聚合物组合物，同时具有优异的粘合性能，从而能够容易地并且连续地附着于伤口部位具有抗菌和止血特性，并且由适用于微创手术，腹腔镜手术等的可注射制剂组成。能够支持生长因子的抗粘连聚合物组合物包括：具有聚乙二醇（PEG）含量为65-85重量％的聚乙二醇 - 聚丙二醇 - 聚乙二醇（PEG-PPG-PEG）嵌段共聚物的24-50重量％和分子量重量6,000-20,000 Da; 0.03-5重量％的明胶; 0.03-5重量％的壳聚糖; 和蒸馏水。

2. 发明申请

US20150182666A1 HYALURONIC ACID-CALCIUM PHOSPHATE COMPOSITE FOR GROWTH FACTOR SUPPORT AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：用于生长因子支持的羟基磷酸钙复合物及其生产方法
公开(公告)号：US20150182666A1
公开(公告)日：2015-07-02
申请号：US14388013
申请日：2012-03-30
申请人： Jung Ju Kim , Su Hyun Jung , Hyun Seung Ryu , Jun Hyuk Seo
发明人： Jung Ju Kim , Su Hyun Jung , Hyun Seung Ryu , Jun Hyuk Seo
IPC分类号： A61L27/46 , A61L27/12 , A61L27/58 , A61L27/56 , A61L27/54 , A61L27/20 , A61L27/52
CPC分类号： A61L27/46 , A61L27/12 , A61L27/20 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/414 , A61L2430/02 , C01B25/327 , C01P2004/32 , C01P2004/61 , C08K3/32 , C08K7/18 , C08K2003/325 , C08K2201/005 , C08L5/08
摘要： The present invention relates to a carrier for growth factor related to regeneration of bone tissues that is capable of arbitrarily controlling the delivery rate of growth factors related to bone regeneration and thus especially applicable to a bone void filler in the fields of the dental or orthopedic applications.The carrier for controlling the delivery rate of the growth factor in the present invention is composed of a hyaluronic acid hydrogel having a distribution of interconnected pores and a calcium phosphate microsphere being distributed in the pores of the hyaluronic acid hydrogel. The calcium phosphate microsphere having a porosity suitable for delivery of the growth factor is positioned into the pores of the cross-linked hyaluronic acid hydrogel to complete the carrier.
摘要翻译：本发明涉及与骨组织再生相关的生长因子的载体，其能够任意地控制与骨再生相关的生长因子的递送率，并且因此特别适用于牙科或矫形应用领域中的骨空隙填充物。用于控制本发明中生长因子的递送速度的载体由具有互连孔分布的透明质酸水凝胶和分布在透明质酸水凝胶的孔中的磷酸钙微球组成。具有适于递送生长因子的孔隙率的磷酸钙微球定位于交联透明质酸水凝胶的孔中以完成载体。

3. 发明授权

US08246985B2 Pharmaceutical composition comprising lipase inhibitor and lipophilic oil absorbent and oral formulation prepared therefrom 有权
标题翻译：包含由其制备的脂肪酶抑制剂和亲油性油吸收剂和口服制剂的药物组合物
公开(公告)号：US08246985B2
公开(公告)日：2012-08-21
申请号：US12297763
申请日：2007-04-20
申请人： Jin Woo Park , Sung Ah Bin , Jeong A Lee , Jung Ju Kim
发明人： Jin Woo Park , Sung Ah Bin , Jeong A Lee , Jung Ju Kim
IPC分类号： A61K9/48 , A61K9/52 , A61K9/20
CPC分类号： A61K31/365 , A61K9/1652 , A61K9/2077 , A61K9/2081 , A61K9/5026 , A61K9/5084 , A61K45/06 , A61K2300/00
摘要： This invention provides a pharmaceutical composition comprising a lipase inhibitor; a lipophilic oil absorbent selected from the group consisting of hydrogenated castor oil, hydrogenated vegetable oil, glyceryl behenate, glyceryl palmitostearate and a mixture thereof; and a pharmaceutically acceptable additive, an oral formulation of a lipase inhibitor prepared there from and a method for preparing said formulation. The formulation of the present invention can minimize side effects such as oily spotting, fatty/oily stool, abdominal distension and flatus, and thus it can be advantageously used for preventing or treating obesity and hyperlipaemia.
摘要翻译：本发明提供包含脂肪酶抑制剂的药物组合物; 选自氢化蓖麻油，氢化植物油，山嵛酸甘油酯，棕榈酸硬脂酸甘油酯及其混合物的亲油性油吸收剂; 和药学上可接受的添加剂，其上制备的脂肪酶抑制剂的口服制剂和制备所述制剂的方法。本发明的制剂可以使诸如油性斑点，脂肪/油性粪便，腹胀和腹胀等副作用最小化，因此可有利地用于预防或治疗肥胖症和高脂血症。

4. 发明申请

US20070224281A1 Sustained-Release Preparations Containing Topiramate and the Producing Method Thereof 审中-公开
标题翻译：含有托吡酯的缓释制剂及其制备方法
公开(公告)号：US20070224281A1
公开(公告)日：2007-09-27
申请号：US11572326
申请日：2005-07-21
申请人： Jin Woo Park , Young Hee Shin , Kwang Hyun Shin , Jung Ju Kim
发明人： Jin Woo Park , Young Hee Shin , Kwang Hyun Shin , Jung Ju Kim
IPC分类号： A61K9/16
CPC分类号： A61K9/2027 , A61K9/2077
摘要： Disclosed herein is a sustained-release topiramate preparation and a method for producing the topiramate preparation. The sustained-release topiramate preparation is produced using double granules obtained by granulating topiramate or a pharmaceutically acceptable salt thereof using a solid dispersant by a solid dispersion method (first granulation), and further by granulating the granules using a release sustaining material by dry or wet granulation (second granulation).
摘要翻译：本文公开了缓释托吡酯制剂和制备托吡酯制剂的方法。缓释托吡酯制剂是使用通过固体分散方法（第一制粒）将固体分散剂造粒托吡酯或其药学上可接受的盐制备的双重颗粒制备的，并且还使用干燥或湿润的释放维持材料造粒（第二次造粒）。

5. 发明申请

US20060153915A1 Sustained-release preparations and method for producing the same 审中-公开
标题翻译：持续释放制剂及其制备方法
公开(公告)号：US20060153915A1
公开(公告)日：2006-07-13
申请号：US10538695
申请日：2004-01-19
申请人： Jin Park , Joon Bae , Jung Ju Kim
发明人： Jin Park , Joon Bae , Jung Ju Kim
IPC分类号： A61K31/485 , A61K9/26
CPC分类号： A61K9/2077 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2095 , A61K9/2846 , A61K9/2866 , A61K31/00 , A61K31/485
摘要： The present invention relates to sustained-release preparations prepared by double granulation and methods for producing the same. The sustained-release preparation according to the present invention enables maintenance of effective blood concentration of drug for many hours via sustained release of the drug over 12 hours or more, and further its production is easy owing to convenience of process.
摘要翻译：本发明涉及通过双重造粒制备的缓释制剂及其制备方法。根据本发明的缓释制剂能够通过持续释放12小时或更长时间维持药物的有效血药浓度许多小时，并且由于方法的便利，其进一步的生产容易。

6. 发明申请

US20060057221A1 Polymeric microparticulates for sustained release of drug and their preparation methods 审中-公开
标题翻译：用于药物持续释放的聚合物微粒及其制备方法
公开(公告)号：US20060057221A1
公开(公告)日：2006-03-16
申请号：US10534991
申请日：2003-11-12
申请人： Hyeok Lee , Ham Yong Park , Jeong Hwa Yang , Jung Ju Kim
发明人： Hyeok Lee , Ham Yong Park , Jeong Hwa Yang , Jung Ju Kim
IPC分类号： A61K9/50 , A61K9/16 , B01J13/04 , B01J13/02
CPC分类号： A61K9/5031
摘要： The present invention relates to polymeric microparticulates for sustained release of drug and to the process for the preparation thereof. The process of the present invention for preparing polymeric microparticulates based on microcoagulation phenomenon of water-soluble polymer not only improves loading amount of drug but also minimizes initial burst of drug, thereby providing polymeric microparticulates enabling sustained and prolonged release of drug
摘要翻译：本发明涉及用于药物持续释放的聚合物微粒及其制备方法。基于水溶性聚合物的微凝聚现象制备聚合物微粒的本发明的方法不仅改善了药物的加载量，而且使药物的初始爆发最小化，从而提供可持续和延长药物释放的聚合物微粒

7. 发明授权

US08728514B2 Transdermal preparations containing hydrophoic non-steroidal anti-inflammatory drugs 有权
标题翻译：含有疏水性非甾体抗炎药的透皮制剂
公开(公告)号：US08728514B2
公开(公告)日：2014-05-20
申请号：US12084014
申请日：2006-10-23
申请人： Yang Gyu Choi , Young Chang Ah , Woo Jeong Choi , Jung Ju Kim
发明人： Yang Gyu Choi , Young Chang Ah , Woo Jeong Choi , Jung Ju Kim
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K31/00 , A61K31/19 , A61K31/192 , A61K31/196
摘要： Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.
摘要翻译：公开了含有疏水性药物的透皮制剂。作为持续高药物渗透的方法，使用独特的亲水性聚合物体系，其中药物可以在无水环境下以高浓度包含，疏水性药物的溶解度随着水被引入贴剂而降低即使在药物渗入皮肤时药物含量降低，药物也保持在饱和浓度。在将透皮制剂施用于皮肤期间，由于亲水性聚合物从皮肤吸收水分，因此可以连续渗透大量的药物，以保持使用期间的足够的粘附性和最小化皮肤的副作用。亲水性聚合物体系可以通过能够防止皮肤快速吸收的水蒸发到贴剂外部的疏水性粘合剂层来发挥功能。

8. 发明申请

US20090137684A1 SUSTAINED-RELEASE PREPARATIONS AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：可持续发行的制备方法及其生产方法
公开(公告)号：US20090137684A1
公开(公告)日：2009-05-28
申请号：US12358426
申请日：2009-01-23
申请人： Jin Woo PARK , Joon Ho Bae , Jung Ju Kim
发明人： Jin Woo PARK , Joon Ho Bae , Jung Ju Kim
IPC分类号： A61K31/135
CPC分类号： A61K9/2077 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2095 , A61K9/2846 , A61K9/2866 , A61K31/00 , A61K31/485
摘要： The present invention relates to sustained-release preparations prepared by double granulation and methods for producing the same. The sustained-release preparations according to the present invention enables maintenance of effective blood concentration of drug for many hours via sustained release of the drug over 12 hours or more, and further its production is easy owing to convenience of process.
摘要翻译：本发明涉及通过双重造粒制备的缓释制剂及其制备方法。根据本发明的持续释放制剂能够通过药物持续释放12小时或更长时间维持药物的有效血药浓度许多小时，并且由于方法的便利，其进一步的生产容易。

9. 发明授权

US09295655B2 Fentanyl transdermal patch 有权
标题翻译：芬太尼透皮贴剂
公开(公告)号：US09295655B2
公开(公告)日：2016-03-29
申请号：US14004889
申请日：2012-03-13
申请人： Young Kwen Choi , Jung Ju Kim , Jung Sik Lee , Sung Soo Kim
发明人： Young Kwen Choi , Jung Ju Kim , Jung Sik Lee , Sung Soo Kim
IPC分类号： A61K9/70 , A61K31/4468 , A61M35/00 , A61F13/02 , A61L15/44 , A61L15/58 , A61K31/454
CPC分类号： A61K9/7076 , A61F13/02 , A61F13/0206 , A61F13/0246 , A61F13/0253 , A61F13/0256 , A61K9/7053 , A61K31/4468 , A61K31/454 , A61L15/44 , A61L15/58 , A61L2300/402 , A61M35/00 , F04C2270/0421 , C08L33/08
摘要： Provided is a fentanyl transdermal patch comprising an acrylic-rubber hybrid as a drug-adhesive layer. The fentanyl transdermal patch can maintain constant fentanyl skin permeability for three days by maintaining close contact with the skin such that desorption, release by moisture and sweat, and skin stimulation are all improved.
摘要翻译：本发明提供一种芬太尼透皮贴剂，其包含作为药物 - 粘合剂层的丙烯酸 - 橡胶杂化物。通过与皮肤保持紧密接触，芬太尼透皮贴剂可以保持芬太尼皮肤的不断渗透，持续三天，从而改善了解吸，水分和汗水释放以及皮肤刺激。

10. 发明申请

US20150010490A1 ANTI-ADHESION POLYMER COMPOSITION CAPABLE OF SUPPORTING GROWTH FACTOR 有权
标题翻译：抗粘合聚合物组合物可支持生长因子
公开(公告)号：US20150010490A1
公开(公告)日：2015-01-08
申请号：US14374988
申请日：2012-03-08
申请人： Jung Ju Kim , Jung Won So , Hyun Seung Ryu , Jun Hyuk Seo
发明人： Jung Ju Kim , Jung Won So , Hyun Seung Ryu , Jun Hyuk Seo
IPC分类号： A61L24/04 , A61L24/00 , C08L71/02
CPC分类号： A61L24/046 , A61B2090/0816 , A61K47/10 , A61K47/30 , A61K47/34 , A61L24/0015 , A61L24/043 , A61L31/041 , A61L31/16 , A61L2300/252 , A61L2300/414 , A61L2400/04 , A61L2400/06 , C08L71/02 , C08L2203/02 , C08L89/06 , C08L5/08
摘要： The present invention relates to an anti-adhesion polymer composition capable of supporting growth factor, which effectively exhibits anti-adhesion function and, at the same time, has an excellent adhesive property so as to be able to easily and continuously adhere to a wound site, has antibacterial and hemostatic properties, and is composed of an injectable formulation suitable for use in minimally invasive surgery, laparoscopic surgery or the like. The anti-adhesion polymer composition capable of supporting growth factor comprises: 24-50 wt % of a polyethyleneglycol-polypropyleneglycol-polyethyleneglycol (PEG-PPG-PEG) block copolymer having a polyethyleneglycol (PEG) content of 65-85 wt % and a molecular weight of 6,000-20,000 Da; 0.03-5 wt % of gelatin; 0.03-5 wt % of chitosan; and distilled water.
摘要翻译：本发明涉及一种能够有效显示抗粘连功能的支持生长因子的抗粘连聚合物组合物，同时具有优异的粘合性能，从而能够容易地并且连续地附着于伤口部位具有抗菌和止血特性，并且由适用于微创手术，腹腔镜手术等的可注射制剂组成。能够支持生长因子的抗粘连聚合物组合物包括：具有聚乙二醇（PEG）含量为65-85重量％的聚乙二醇 - 聚丙二醇 - 聚乙二醇（PEG-PPG-PEG）嵌段共聚物的24-50重量％和分子量重量6,000-20,000 Da; 0.03-5重量％的明胶; 0.03-5重量％的壳聚糖; 和蒸馏水。

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