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1. 发明授权

US09295655B2 Fentanyl transdermal patch 有权
标题翻译：芬太尼透皮贴剂
公开(公告)号：US09295655B2
公开(公告)日：2016-03-29
申请号：US14004889
申请日：2012-03-13
申请人： Young Kwen Choi , Jung Ju Kim , Jung Sik Lee , Sung Soo Kim
发明人： Young Kwen Choi , Jung Ju Kim , Jung Sik Lee , Sung Soo Kim
IPC分类号： A61K9/70 , A61K31/4468 , A61M35/00 , A61F13/02 , A61L15/44 , A61L15/58 , A61K31/454
CPC分类号： A61K9/7076 , A61F13/02 , A61F13/0206 , A61F13/0246 , A61F13/0253 , A61F13/0256 , A61K9/7053 , A61K31/4468 , A61K31/454 , A61L15/44 , A61L15/58 , A61L2300/402 , A61M35/00 , F04C2270/0421 , C08L33/08
摘要： Provided is a fentanyl transdermal patch comprising an acrylic-rubber hybrid as a drug-adhesive layer. The fentanyl transdermal patch can maintain constant fentanyl skin permeability for three days by maintaining close contact with the skin such that desorption, release by moisture and sweat, and skin stimulation are all improved.
摘要翻译：本发明提供一种芬太尼透皮贴剂，其包含作为药物 - 粘合剂层的丙烯酸 - 橡胶杂化物。通过与皮肤保持紧密接触，芬太尼透皮贴剂可以保持芬太尼皮肤的不断渗透，持续三天，从而改善了解吸，水分和汗水释放以及皮肤刺激。

2. 发明申请

US20140005617A1 FENTANYL TRANSDERMAL PATCH 有权
公开(公告)号：US20140005617A1
公开(公告)日：2014-01-02
申请号：US14004889
申请日：2012-03-13
申请人： Young Kwen Choi , Jung Ju Kim , Jung Sik Lee , Sung Soo Kim
发明人： Young Kwen Choi , Jung Ju Kim , Jung Sik Lee , Sung Soo Kim
IPC分类号： A61K9/70 , A61K31/4468 , A61M35/00
CPC分类号： A61K9/7076 , A61F13/02 , A61F13/0206 , A61F13/0246 , A61F13/0253 , A61F13/0256 , A61K9/7053 , A61K31/4468 , A61K31/454 , A61L15/44 , A61L15/58 , A61L2300/402 , A61M35/00 , F04C2270/0421 , C08L33/08
摘要： Provided is a fentanyl transdermal patch comprising an acrylic-rubber hybrid as a drug-adhesive layer. The fentanyl transdermal patch can maintain constant fentanyl skin permeability for three days by maintaining close contact with the skin such that desorption, release by moisture and sweat, and skin stimulation are all improved.
摘要翻译：本发明提供一种芬太尼透皮贴剂，其包含作为药物 - 粘合剂层的丙烯酸 - 橡胶杂化物。通过与皮肤保持紧密接触，芬太尼透皮贴剂可以保持芬太尼皮肤的不断渗透，持续三天，从而改善了解吸，水分和汗水释放以及皮肤刺激。

3. 发明申请

US20130165875A1 TRANSDERMAL ABSORPTION PREPARATION 审中-公开
标题翻译：超吸收制剂
公开(公告)号：US20130165875A1
公开(公告)日：2013-06-27
申请号：US13642960
申请日：2011-04-21
申请人： Young Kweon Choi , Jung Ju Kim , Seong Su Kim , Jung Sik Lee , Seong Min Park
发明人： Young Kweon Choi , Jung Ju Kim , Seong Su Kim , Jung Sik Lee , Seong Min Park
IPC分类号： A61M35/00
CPC分类号： A61K9/7061 , A61K9/7053 , A61K9/7076 , A61K31/4045
摘要： The present, invention relates to a transdermal absorption preparation. The transdermal absorption preparation of the present invention comprises a drug-containing adhesive layer, a drug-protective layer and a release layer, wherein the drug-containing adhesive layer contains ropinirole or a salt thereof, rubber, an adhesion-imparting resin, an antioxidant, and a transdermal absorption promoter. Also, the present invention provides a transdermal absorption preparation comprising a drug-containing adhesive layer, a drug-protective layer, and a release layer, wherein the drug-containing adhesive layer contains ropinirole or a salt thereof, acrylic rubber, an anti-crystallisation agent, and a transdermal absorption promoter. When the transdermal absorption preparation of the present invention is used for the treatment of Parkinson's disease or restless leg syndrome, no side effect due to an increase in the initial drug concentration in blood occurs and the skin penetration effect of the drug is excellent.
摘要翻译：本发明涉及一种透皮吸收制剂。本发明的透皮吸收制剂包含含药物的粘合剂层，药物保护层和剥离层，其中含药物的粘合剂层含有罗哌尼罗或其盐，橡胶，赋形树脂，抗氧化剂，和透皮吸收促进剂。另外，本发明提供了含有药物的粘合剂层，药物保护层和剥离层的透皮吸收制剂，其中含药物的粘合剂层含有罗哌尼罗或其盐，丙烯酸橡胶，抗结晶试剂和透皮吸收促进剂。当本发明的经皮吸收制剂用于治疗帕金森病或不宁腿综合征时，由于血液中初始药物浓度的增加而引起副作用，药物的皮肤渗透作用优异。

4. 发明授权

US08728514B2 Transdermal preparations containing hydrophoic non-steroidal anti-inflammatory drugs 有权
标题翻译：含有疏水性非甾体抗炎药的透皮制剂
公开(公告)号：US08728514B2
公开(公告)日：2014-05-20
申请号：US12084014
申请日：2006-10-23
申请人： Yang Gyu Choi , Young Chang Ah , Woo Jeong Choi , Jung Ju Kim
发明人： Yang Gyu Choi , Young Chang Ah , Woo Jeong Choi , Jung Ju Kim
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K31/00 , A61K31/19 , A61K31/192 , A61K31/196
摘要： Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.
摘要翻译：公开了含有疏水性药物的透皮制剂。作为持续高药物渗透的方法，使用独特的亲水性聚合物体系，其中药物可以在无水环境下以高浓度包含，疏水性药物的溶解度随着水被引入贴剂而降低即使在药物渗入皮肤时药物含量降低，药物也保持在饱和浓度。在将透皮制剂施用于皮肤期间，由于亲水性聚合物从皮肤吸收水分，因此可以连续渗透大量的药物，以保持使用期间的足够的粘附性和最小化皮肤的副作用。亲水性聚合物体系可以通过能够防止皮肤快速吸收的水蒸发到贴剂外部的疏水性粘合剂层来发挥功能。

5. 发明申请

US20090137684A1 SUSTAINED-RELEASE PREPARATIONS AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：可持续发行的制备方法及其生产方法
公开(公告)号：US20090137684A1
公开(公告)日：2009-05-28
申请号：US12358426
申请日：2009-01-23
申请人： Jin Woo PARK , Joon Ho Bae , Jung Ju Kim
发明人： Jin Woo PARK , Joon Ho Bae , Jung Ju Kim
IPC分类号： A61K31/135
CPC分类号： A61K9/2077 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2095 , A61K9/2846 , A61K9/2866 , A61K31/00 , A61K31/485
摘要： The present invention relates to sustained-release preparations prepared by double granulation and methods for producing the same. The sustained-release preparations according to the present invention enables maintenance of effective blood concentration of drug for many hours via sustained release of the drug over 12 hours or more, and further its production is easy owing to convenience of process.
摘要翻译：本发明涉及通过双重造粒制备的缓释制剂及其制备方法。根据本发明的持续释放制剂能够通过药物持续释放12小时或更长时间维持药物的有效血药浓度许多小时，并且由于方法的便利，其进一步的生产容易。

6. 发明申请

US20080286375A1 Method for Preparing Sustained-Release Microparticles Comprising Sucrose Acetate Isobutyrate 审中-公开
标题翻译：制备包含醋酸蔗糖异丁酸盐的缓释微粒的方法
公开(公告)号：US20080286375A1
公开(公告)日：2008-11-20
申请号：US12093872
申请日：2002-11-15
申请人： Eun Seong Lee , Hyeok Lee , Jung Ju Kim
发明人： Eun Seong Lee , Hyeok Lee , Jung Ju Kim
IPC分类号： A61K9/14 , A61K38/16 , A61K38/47 , A61K38/28 , A61K38/14 , A61K38/21 , A61K39/395 , A61K38/20 , A61K38/48 , A61K38/44 , A61K39/12 , A61K38/30 , A61K38/27 , A61K38/18 , A61P43/00
CPC分类号： A61K9/1647 , A61K9/19 , A61K47/14
摘要： A sustained release microparticles which is capable of releasing a protein drug continuously over a long period of time without initial burst release of the drug can be simply prepared by a method including the steps of a) dissolving a protein drug in an aqueous solution to obtain a water phase; b) dissolving sucrose acetate isobutyrate (SAIB) and a biodegradable polymer in an organic solvent to obtain an oil phase; c) adding the water phase obtained in step a) to the oil phase obtained in step b) to form a primary emulsion; and d) adding the primary emulsion to an external aqueous continuous phase to form a secondary emulsion and recovering the solid product formed in the secondary emulsion.
摘要翻译：可以简单地通过包括以下步骤的方法制备能够长时间连续释放蛋白质药物而没有药物初始爆发释放的持续释放微粒：a）将蛋白质药物溶解在水溶液中以获得水相; b）将蔗糖乙酸异丁酸酯（SAIB）和可生物降解的聚合物溶于有机溶剂中以获得油相; c）将步骤a）中获得的水相加入到步骤b）中获得的油相中以形成初级乳液; 和d）将初级乳液加入到外部水性连续相中以形成二次乳液并回收在二次乳液中形成的固体产物。

7. 发明授权

US06750291B2 Film-forming agent for drug delivery and preparation for percutaneous administration containing the same 失效
标题翻译：用于药物递送的成膜剂和含有该成膜剂的经皮给药制剂
公开(公告)号：US06750291B2
公开(公告)日：2004-06-15
申请号：US10121288
申请日：2002-04-12
申请人： Young So Kim , Yang Gyu Choi , Jung Ju Kim
发明人： Young So Kim , Yang Gyu Choi , Jung Ju Kim
IPC分类号： C08G1848
CPC分类号： C08G18/4808 , C08G18/4018 , C08L29/10 , C08L33/06 , C08L75/08 , C08L2666/04
摘要： The present invention relates to a film-forming agent which forms a film on the skin, and also to a preparation for percutaneous administration containing the film-forming agent and active ingredient. The transdermal preparation including the film-forming agent of the present invention and active ingredient exhibits excellent elasticity and flexibility, shows superior adhesion power when formed on the skin, and forms non-sticky film.
摘要翻译：本发明涉及在皮肤上形成膜的成膜剂，还涉及含有成膜剂和活性成分的经皮给药制剂。包含本发明的成膜剂和活性成分的透皮制剂表现出优异的弹性和柔韧性，当在皮肤上形成时显示出优异的附着力，并形成不粘膜。

8. 发明申请

US20090252782A1 Transdermal Preparations Containing Hydrophoic Non-Steroidal Anti-Inflammatory Drugs 有权
标题翻译：含有疏水性非甾体抗炎药的透皮制剂
公开(公告)号：US20090252782A1
公开(公告)日：2009-10-08
申请号：US12084014
申请日：2006-10-23
申请人： Yang Gyu Choi , Young Chang Ah , Woo Jeong Choi , Jung Ju Kim
发明人： Yang Gyu Choi , Young Chang Ah , Woo Jeong Choi , Jung Ju Kim
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K31/00 , A61K31/19 , A61K31/192 , A61K31/196
摘要： Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.
摘要翻译：公开了含有疏水性药物的透皮制剂。作为持续高药物渗透的方法，使用独特的亲水性聚合物体系，其中药物可以在无水环境下以高浓度包含，疏水性药物的溶解度随着水被引入贴剂而降低即使在药物渗入皮肤时药物含量降低，药物也保持在饱和浓度。在将透皮制剂施用于皮肤期间，由于亲水性聚合物从皮肤吸收水分，因此可以连续渗透大量的药物，以保持使用期间的足够的粘附性和最小化皮肤的副作用。亲水性聚合物体系可以通过能够防止皮肤快速吸收的水蒸发到贴剂外部的疏水性粘合剂层来发挥功能。

9. 发明申请

US20080226738A1 Sustained-Released Pellet Formulation of Alpha1-Receptor Antagonist and Process For the Preparation Thereof 审中-公开
标题翻译： α1受体拮抗剂的持续释放丸剂制剂及其制备方法
公开(公告)号：US20080226738A1
公开(公告)日：2008-09-18
申请号：US12064174
申请日：2006-08-11
申请人： Kwang Hyun Shin , Young Hee Shin , Sung Ah Bin , Jung Ju Kim
发明人： Kwang Hyun Shin , Young Hee Shin , Sung Ah Bin , Jung Ju Kim
IPC分类号： A61K9/52 , A61P35/00 , A61P43/00 , A61P13/08
CPC分类号： A61K9/5026 , A61K9/1652 , A61K31/18 , A61K31/505
摘要： A sustained-release pellet formulation comprising: a pellet core comprising an α1-receptor antagonist, a pellet-forming substance and a pharmaceutically acceptable excipient and a coating layer comprising an enteric coating substance and a water-insoluble polymer, which is coated on said pellet core maintains a therapeutically effective drug level in the blood for a sufficient time without an initial burst and sustains the release of the drug even in the small intestine due to the water-insoluble polymer in the coating layer
摘要翻译：一种持续释放丸剂制剂，其包括：包含α1-受体拮抗剂，颗粒形成物质和药学上可接受的赋形剂的丸粒核心和包含肠溶衣物质和水不溶性聚合物的涂层，其涂覆在所述丸粒核心在血液中维持治疗有效的药物水平足够的时间而没有初始爆发，并且由于涂层中的水不溶性聚合物，甚至在小肠中也能维持药物的释放

10. 发明授权

US5866493A Method of manufacturing a sintered body of indium tin oxide 失效
标题翻译：制造氧化铟锡烧结体的方法
公开(公告)号：US5866493A
公开(公告)日：1999-02-02
申请号：US903655
申请日：1997-07-31
申请人： In Gyu Lee , Chong Kwang Yoon , Seung Moo Heo , Se Hong Chang , Jung Ju Kim
发明人： In Gyu Lee , Chong Kwang Yoon , Seung Moo Heo , Se Hong Chang , Jung Ju Kim
IPC分类号： C04B35/457
CPC分类号： C04B35/457
摘要： According to the method, an aqueous salt solution containing either tin, indium or both, are mixed with an alkali to produce a slurry containing precipitated particles. Then, the slurry is maintained at a predetermined temperature range for a time sufficient to convert the precipitated particles to larger size particles by coagulation or agglomeration. The resulting slurry is then dried and calcined to produce a mixed power. The mixed power is ball milled, press molded and/or cold isostatic press (CIP) molded. The molded body is then sintered to form an ITO sintered body. The ITO sintered body obtained by this process offers superior sinterability whose theoretical density can reach more than 95%.
摘要翻译：根据该方法，将含有锡，铟或两者的盐水溶液与碱混合以产生含有沉淀颗粒的浆料。然后，将浆料保持在预定温度范围足以通过凝结或凝聚将沉淀的颗粒转化成更大尺寸的颗粒。然后将所得浆液干燥并煅烧以产生混合动力。混合动力是球磨，压模和/或冷等静压（CIP）成型。然后将成型体烧结以形成ITO烧结体。通过该方法获得的ITO烧结体提供了优异的烧结性，其理论密度可以达到95％以上。

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