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1. 发明授权

US08591954B2 Phospholipid-based inhalation system 有权
标题翻译：基于磷脂的吸入系统
公开(公告)号：US08591954B2
公开(公告)日：2013-11-26
申请号：US13532473
申请日：2012-06-25
申请人： Shailaja Somaraju , Julie Suman , Sudipta Ganguly , Richard Dalby
发明人： Shailaja Somaraju , Julie Suman , Sudipta Ganguly , Richard Dalby
IPC分类号： A61K9/00 , A61K9/12 , A61K9/14 , A61M11/00 , A61M11/02 , A61M11/04
CPC分类号： A61K9/008 , A61K9/0082 , A61M15/009 , A61M2202/0488 , A61M2209/02
摘要： The present invention includes a method for delivering medications deeper into the lungs and to the medications' pulmonary targets, which include bronchioles and alveoli. A first particularly preferred embodiment of the invention describes the use of two steps for delivery of a medication. In a first step, an aerosolized therapeutic composition or medication is administered into a patient's respiratory tract, wherein the patient may be any animal or human subject. Following the first step, an aerosolized surfactant is administered into the patient's respiratory tract that facilitates delivery of the aerosolized medication of the first step to the medication's pulmonary target. Another embodiment of the present invention contemplates an apparatus for the delivery of an aerosolized surfactant used that facilitates delivery of previously inhaled aerosolized medication.
摘要翻译：本发明包括用于将药物更深地输送到肺部和药物的肺部靶（包括细支气管和肺泡）的方法。本发明的第一个特别优选的实施方案描述了用于递送药物的两个步骤的用途。在第一步骤中，将雾化的治疗组合物或药物施用于患者的呼吸道，其中所述患者可以是任何动物或人类受试者。在第一步之后，将雾化的表面活性剂施用到患者的呼吸道中，其有助于将第一步的雾化药物递送到药物的肺靶。本发明的另一个实施方案考虑了用于递送雾化表面活性剂的装置，其便于先前吸入的雾化药物的递送。

2. 发明申请

US20080127968A1 Phospholipid-based inhalation system 有权
标题翻译：基于磷脂的吸入系统
公开(公告)号：US20080127968A1
公开(公告)日：2008-06-05
申请号：US11977932
申请日：2007-10-26
申请人： SHAILAJA SOMARAJU , JULIE SUMAN
发明人： SHAILAJA SOMARAJU , JULIE SUMAN
IPC分类号： A61M11/04
CPC分类号： A61K9/008 , A61K9/0082 , A61M15/009 , A61M2202/0488 , A61M2209/02
摘要： The present invention includes a method for delivering medications deeper into the lungs and to the medications' pulmonary targets, which include bronchioles and alveoli. A first particularly preferred embodiment of the invention describes the use of two steps for delivery of a medication. In a first step, an aerosolized therapeutic composition or medication is administered into a patient's respiratory tract, wherein the patient may be any animal or human subject. Following the first step, an aerosolized surfactant is administered into the patient's respiratory tract that facilitates delivery of the aerosolized medication of the first step to the medication's pulmonary target. Another embodiment of the present invention contemplates an apparatus for the delivery of an aerosolized surfactant used that facilitates delivery of previously inhaled aerosolized medication.
摘要翻译：本发明包括用于将药物更深地输送到肺部和药物的肺部靶（包括细支气管和肺泡）的方法。本发明的第一个特别优选的实施方案描述了用于递送药物的两个步骤的用途。在第一步骤中，将雾化的治疗组合物或药物施用于患者的呼吸道，其中所述患者可以是任何动物或人类受试者。在第一步之后，将雾化的表面活性剂施用到患者的呼吸道中，其有助于将第一步的雾化药物递送到药物的肺靶。本发明的另一个实施方案考虑了用于递送雾化表面活性剂的装置，其便于先前吸入的雾化药物的递送。

3. 发明申请

US20050072421A1 Apparatus, system and method for positive confirmation of inhaled drug delivery by attenuation at point-of-use 审中-公开
标题翻译：通过使用点衰减来正确确认吸入药物输送的装置，系统和方法
公开(公告)号：US20050072421A1
公开(公告)日：2005-04-07
申请号：US10677485
申请日：2003-10-03
申请人： Julie Suman , Shailaja Somaraju
发明人： Julie Suman , Shailaja Somaraju
IPC分类号： A61M15/00 , A61M11/00
CPC分类号： A61M15/00 , A61M15/0065 , A61M15/009 , A61M2205/3306
摘要： A system, method and apparatus for providing positive confirmation of inhaled drug delivery by light or radiation attenuation at point-of-use is disclosed, including a tube adapted to be coupled at an outlet to an inhaler; a light or radiation source coupled to the tube; and a light or radiation detector coupled to the tube, where the source transmits light or radiation along a path intersecting a path of an emission such as a drug dose emitted from the inhaler, and where the detector receives the light or radiation from the source.
摘要翻译：公开了一种用于在使用点处通过光或辐射衰减来提供吸入药物递送的积极确认的系统，方法和装置，包括适于在出口处耦合到吸入器的管; 耦合到所述管的光或辐射源; 以及耦合到管的光或辐射检测器，其中源沿着与诸如从吸入器发射的药物剂量的发射路径交叉的路径透射光或辐射，并且其中检测器接收来自源的光或辐射。

4. 发明申请

US20120308617A1 PHOSPHOLIPID-BASED INHALATION SYSTEM 有权
标题翻译：基于磷脂的吸入系统
公开(公告)号：US20120308617A1
公开(公告)日：2012-12-06
申请号：US13532473
申请日：2012-06-25
申请人： Shailaja Somaraju , Julie Suman , Sudipta Ganguly , Richard Balby
发明人： Shailaja Somaraju , Julie Suman , Sudipta Ganguly , Richard Balby
IPC分类号： A61K47/24 , A61K31/137 , A61P11/00 , A61K9/12
CPC分类号： A61K9/008 , A61K9/0082 , A61M15/009 , A61M2202/0488 , A61M2209/02
摘要： The present invention includes a method for delivering medications deeper into the lungs and to the medications' pulmonary targets, which include bronchioles and alveoli. A first particularly preferred embodiment of the invention describes the use of two steps for delivery of a medication. In a first step, an aerosolized therapeutic composition or medication is administered into a patient's respiratory tract, wherein the patient may be any animal or human subject. Following the first step, an aerosolized surfactant is administered into the patient's respiratory tract that facilitates delivery of the aerosolized medication of the first step to the medication's pulmonary target. Another embodiment of the present invention contemplates an apparatus for the delivery of an aerosolized surfactant used that facilitates delivery of previously inhaled aerosolized medication.
摘要翻译：本发明包括用于将药物更深地输送到肺部和药物的肺部靶（包括细支气管和肺泡）的方法。本发明的第一个特别优选的实施方案描述了用于递送药物的两个步骤的用途。在第一步骤中，将雾化的治疗组合物或药物施用于患者的呼吸道，其中所述患者可以是任何动物或人类受试者。在第一步之后，将雾化的表面活性剂施用到患者的呼吸道中，其有助于将第一步的雾化药物递送到药物的肺靶。本发明的另一个实施方案考虑了用于递送雾化表面活性剂的装置，其便于先前吸入的雾化药物的递送。

5. 发明授权

US08206687B2 Phospholipid-based inhalation system 有权
标题翻译：基于磷脂的吸入系统
公开(公告)号：US08206687B2
公开(公告)日：2012-06-26
申请号：US11977932
申请日：2007-10-26
申请人： Shailaja Somaraju , Julie Suman , Richard Dalby , Sudipta Ganguly
发明人： Shailaja Somaraju , Julie Suman , Richard Dalby , Sudipta Ganguly
IPC分类号： A61K9/00 , A61K9/12 , A61K9/14 , A61M11/00 , A61M11/02 , A61M11/04
CPC分类号： A61K9/008 , A61K9/0082 , A61M15/009 , A61M2202/0488 , A61M2209/02
摘要： The present invention includes a method for delivering medications deeper into the lungs and to the medications' pulmonary targets, which include bronchioles and alveoli. A first particularly preferred embodiment of the invention describes the use of two steps for delivery of a medication. In a first step, an aerosolized therapeutic composition or medication is administered into a patient's respiratory tract, wherein the patient may be any animal or human subject. Following the first step, an aerosolized surfactant is administered into the patient's respiratory tract that facilitates delivery of the aerosolized medication of the first step to the medication's pulmonary target. Another embodiment of the present invention contemplates an apparatus for the delivery of an aerosolized surfactant used that facilitates delivery of previously inhaled aerosolized medication.
摘要翻译：本发明包括用于将药物更深地输送到肺部和药物的肺部靶（包括细支气管和肺泡）的方法。本发明的第一个特别优选的实施方案描述了用于递送药物的两个步骤的用途。在第一步骤中，将雾化的治疗组合物或药物施用于患者的呼吸道，其中所述患者可以是任何动物或人类受试者。在第一步之后，将雾化的表面活性剂施用到患者的呼吸道中，其有助于将第一步的雾化药物递送到药物的肺靶。本发明的另一个实施方案考虑了用于递送雾化表面活性剂的装置，其便于先前吸入的雾化药物的递送。

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