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1. 发明授权

US07244573B2 Polynucleotides and polypeptides associated with the development of rheumatoid arthritis 有权
标题翻译：与类风湿性关节炎发展相关的多核苷酸和多肽
公开(公告)号：US07244573B2
公开(公告)日：2007-07-17
申请号：US10308279
申请日：2002-12-03
申请人： Julie Carman , Steven G. Nadler , Michael Bowen , Michael G. Neubauer , Pin Lu
发明人： Julie Carman , Steven G. Nadler , Michael Bowen , Michael G. Neubauer , Pin Lu
IPC分类号： G01N33/53 , G01N33/564 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
摘要翻译：本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

2. 发明授权

US07670785B2 Polynucleotides and polypeptides associated with the development of rheumatoid arthritis 有权
标题翻译：与类风湿性关节炎发展相关的多核苷酸和多肽
公开(公告)号：US07670785B2
公开(公告)日：2010-03-02
申请号：US11811442
申请日：2007-06-07
申请人： Julie Carman , Steven G. Nadler , Michael A. Bowen , Michael G. Neubauer , Pin Lu
发明人： Julie Carman , Steven G. Nadler , Michael A. Bowen , Michael G. Neubauer , Pin Lu
IPC分类号： G01N33/53 , G01N33/52 , G01N33/554 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
摘要翻译：本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

3. 发明授权

US07226791B2 Polynucleotides encoding novel guanylate binding proteins (GBP's) 失效
标题翻译：编码新型鸟苷酸结合蛋白的多核苷酸（GBP）
公开(公告)号：US07226791B2
公开(公告)日：2007-06-05
申请号：US10858367
申请日：2004-06-01
申请人： Julie Carman , Stephen J. Warner , Rolf-Peter Ryseck
发明人： Julie Carman , Stephen J. Warner , Rolf-Peter Ryseck
IPC分类号： C12N1/20 , C12N15/00 , C12N5/00 , C12Q1/68 , C12P21/06
CPC分类号： C07K14/47
摘要： The present invention provides polynucleotides encoding human and murine guanylate binding protein polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The present invention further relates to diagnostic and therapeutic methods for applying the guanylate binding protein polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as rheumatoid arthritis and/or conditions related to aberrant NF-κB activity, guanylate binding activity and GTPase activity. The present invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码人和鼠鸟苷酸结合蛋白多肽的多核苷酸，其片段和同系物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及用于将鸟苷酸结合蛋白多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法，所述疾病和/或病症例如类风湿性关节炎和/或与异常相关的病症 NF-κB活性，鸟苷酸结合活性和GTPase活性。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

4. 发明申请

US20100119509A1 POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：与发病风湿性关节炎相关的多核苷酸和多肽
公开(公告)号：US20100119509A1
公开(公告)日：2010-05-13
申请号：US12686415
申请日：2010-01-13
申请人： Julie Carman , Steven G. Nadler , Michael Bowen , Michael G. Neubauer , Pin Lu
发明人： Julie Carman , Steven G. Nadler , Michael Bowen , Michael G. Neubauer , Pin Lu
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , A61P19/02 , C07K16/00
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
摘要翻译：本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

5. 发明申请

US20090004184A1 Polynucleotides and polypeptides associated with the development of rheumatoid arthritis 有权
标题翻译：与类风湿性关节炎发展相关的多核苷酸和多肽
公开(公告)号：US20090004184A1
公开(公告)日：2009-01-01
申请号：US11811442
申请日：2007-06-07
申请人： Julie Carman , Steven G. Nadler , Michael Bowen , Michael G. Neubauer , Pin Lu
发明人： Julie Carman , Steven G. Nadler , Michael Bowen , Michael G. Neubauer , Pin Lu
IPC分类号： C12Q1/68 , G01N33/53 , A61K39/395 , A61P19/02
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
摘要翻译：本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

6. 发明申请

US20050026191A1 Polynucleotides encoding novel guanylate binding proteins (GBP's) 失效
标题翻译：编码新型鸟苷酸结合蛋白的多核苷酸（GBP）
公开(公告)号：US20050026191A1
公开(公告)日：2005-02-03
申请号：US10858367
申请日：2004-06-01
申请人： Julie Carman , Stephen Warner
发明人： Julie Carman , Stephen Warner
IPC分类号： C07H21/04 , C07K14/47 , C07K14/705 , C12N20060101 , C12P21/04 , C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention provides polynucleotides encoding human and murine guanylate binding protein polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The present invention further relates to diagnostic and therapeutic methods for applying the guanylate binding protein polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as rheumatoid arthritis and/or conditions related to aberrant NF-κB activity, guanylate binding activity and GTPase activity. The present invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码人和鼠鸟苷酸结合蛋白多肽的多核苷酸，其片段和同系物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及用于将鸟苷酸结合蛋白多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法，所述疾病和/或病症例如类风湿性关节炎和/或与异常相关的病症 NF-κB活性，鸟苷酸结合活性和GTPase活性。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

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