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1. 发明授权

US5709943A Biological adsorption supports 失效
标题翻译：生物吸附支架
公开(公告)号：US5709943A
公开(公告)日：1998-01-20
申请号：US434930
申请日：1995-05-04
申请人： Patrick L. Coleman , Mark K. Debe , Julie B. Stahl
发明人： Patrick L. Coleman , Mark K. Debe , Julie B. Stahl
IPC分类号： G01N33/553 , B01D15/00 , B01J20/02 , B01J20/32 , B01J35/10 , B82B1/00 , G01N33/53 , D02B3/00
CPC分类号： G01N33/53 , B01D15/00 , B01J20/3204 , B01J20/3212 , B01J20/3236 , B01J20/3289 , B01J20/3293 , Y10T428/2938 , Y10T428/294 , Y10T428/2942
摘要： The present invention provides biological assay and adsorption supports comprising an inert substrate supporting a nanostructured surface comprising metal coated, oriented, discrete submicron-size whiskers. Optionally, conformally metal coated whiskers may be partially encapsulated or conformally coated with a second material. The nanostructured surface adsorbs biomolecules rapidly at high levels of tight binding without vortexing or agitation. Advantageously, the bound biomolecules retain their biological activity.
摘要翻译：本发明提供了生物测定和吸附支持物，其包括支持纳米结构化表面的惰性底物，其包含金属涂覆的取向的离散的亚微米尺寸的晶须。任选地，保形金属涂覆的晶须可以部分包封或用第二材料共形涂覆。纳米结构化表面以高水平的紧密结合快速吸附生物分子，而不涡旋或搅动。有利地，结合的生物分子保持其生物活性。

2. 发明授权

US5344701A Porous supports having azlactone-functional surfaces 失效
标题翻译：具有吖内酯功能性表面的多孔载体
公开(公告)号：US5344701A
公开(公告)日：1994-09-06
申请号：US896107
申请日：1992-06-09
申请人： David R. Gagnon , Patrick L. Coleman , Gary J. Ortina , Christopher S. Lyons , Dean S. Milbrath , Jerald K. Rasmussen , Julie B. Stahl
发明人： David R. Gagnon , Patrick L. Coleman , Gary J. Ortina , Christopher S. Lyons , Dean S. Milbrath , Jerald K. Rasmussen , Julie B. Stahl
IPC分类号： C08F2/52 , A61L33/00 , B01J20/32 , C07K17/08 , C08F2/00 , C08F8/30 , C08F26/06 , C08F226/06 , C12N11/08 , G01N33/543 , B32B3/26 , B32B5/14 , B32B27/00
CPC分类号： C08F226/06 , A61L33/0011 , B01J20/28023 , B01J20/28033 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J20/3276 , B01J20/3278 , B01J20/328 , C07K17/08 , C08F8/30 , C12N11/08 , G01N33/54353 , B01J2220/54 , Y10T428/249953 , Y10T428/249954 , Y10T428/249958 , Y10T428/249959 , Y10T428/249978 , Y10T428/249991
摘要： Supports having azlactone-functional surfaces, adduct supports prepared from such azlactone-functional supports, and methods of preparing both are disclosed. Azlactone functionality is introduced to surfaces of a pre-existing support in a manner which retains useful physical and chemical characteristics of the pre-existing support. One method involves exposing surfaces with high energy radiation to generate free radical reaction sites on the surfaces and causing azlactone-functional moieties to react with the free radical reaction sites. Another method involves coating surfaces with azlactone monomers, crosslinking monomers, and optionally co-monomers and polymerizing the monomers to form a polymerized coating of azlactone-functionality on the surfaces. Another method involves dispersion polymerization of azlactone-functional moieties to produce azlactone-functional particles within pores and interstices of a pre-existing support. Adduct supports are formed by coupling nucleophilic reagents, such as biologically active materials, to azlactone-functional moieties of the support.
摘要翻译：公开了具有吖内酯功能性表面的载体，由这种吖内酯官能载体制备的加合物载体，以及制备两者的方法。将Azlactone功能以保留现有支持物的有用物理和化学特性的方式引入预先存在的载体的表面。一种方法包括用高能量辐射暴露表面以在表面上产生自由基反应位点并使吖内酯官能部分与自由基反应位点反应。另一种方法包括用吖内酯单体，交联单体和任选的共聚单体涂覆表面，并聚合单体以在表面上形成吖内酯官能团的聚合涂层。另一种方法涉及吖内酯功能部分的分散聚合以在预先存在的载体的孔和间隙内产生吖内酯官能团的颗粒。加成载体通过将亲核试剂（例如生物活性物质）偶联到载体的吖内酯官能部分而形成。

3. 发明授权

US5486358A Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both 失效
标题翻译：吖内酯官能聚合物共混物，由其制备的制品及其制备方法
公开(公告)号：US5486358A
公开(公告)日：1996-01-23
申请号：US415730
申请日：1995-04-03
申请人： Patrick L. Coleman , Steven M. Heilmann , Steven L. Kangas , Jerald K. Rasmussen , Richard J. Rolando , Julie B. Stahl
发明人： Patrick L. Coleman , Steven M. Heilmann , Steven L. Kangas , Jerald K. Rasmussen , Richard J. Rolando , Julie B. Stahl
IPC分类号： G01N33/545 , C07D263/32 , C08F2/02 , C08K5/357 , C08L23/02 , C08L33/04 , C08L33/12 , C08L45/00 , C08L77/00 , C08L101/00 , C08L39/04 , A61K47/32 , B32B27/30
CPC分类号： C08L23/02 , C08L101/00 , C08L23/06 , C08L23/0815 , C08L23/10 , C08L77/00 , C08L2203/02 , C08L2203/16 , Y10T428/31754 , Y10T428/31935
摘要： An azlactone-functional thermoplastic composition is disclosed, The composition is a blend of an azlactone-functional composition and a thermoplastic polymer. A method of making azlactone-functional homopolymers by bulk homopolymerization is disclosed, optionally also concurrent or sequential blending of a thermoplastic polymer. A method of blending azlactone-functional compositions and thermoplastic polymers is disclosed. Molded articles coupled with biologically active substances are claimed.
摘要翻译：公开了吖内酯官能的热塑性组合物。该组合物是吖内酯官能组合物和热塑性聚合物的共混物。公开了通过本体均聚制备吖内酯官能的均聚物的方法，任选地还可以并行或顺序共混热塑性聚合物。公开了混合吖内酯官能组合物和热塑性聚合物的方法。要求具有与生物活性物质偶联的成型制品。

4. 发明授权

US5451453A Supports having azlactone-functional surfaces, adduct supports, and methods of preparing both 失效
标题翻译：支持具有吖内酯功能性表面，加合物载体和制备两者的方法
公开(公告)号：US5451453A
公开(公告)日：1995-09-19
申请号：US262738
申请日：1994-06-20
申请人： David R. Gagnon , Patrick L. Coleman , Gary J. Drtina , Oh-Seung Kwon , Christopher S. Lyons , Dean S. Milbrath , Jerald K. Rasmussen , Julie B. Stahl
发明人： David R. Gagnon , Patrick L. Coleman , Gary J. Drtina , Oh-Seung Kwon , Christopher S. Lyons , Dean S. Milbrath , Jerald K. Rasmussen , Julie B. Stahl
IPC分类号： C08F2/52 , A61L33/00 , B01J20/32 , C07K17/08 , C08F2/00 , C08F8/30 , C08F26/06 , C08F226/06 , C12N11/08 , G01N33/543 , C08F20/58 , B01J20/28 , B32B3/26
CPC分类号： C08F226/06 , A61L33/0011 , B01J20/28023 , B01J20/28033 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J20/3276 , B01J20/3278 , B01J20/328 , C07K17/08 , C08F8/30 , C12N11/08 , G01N33/54353 , B01J2220/54 , Y10T428/249953 , Y10T428/249954 , Y10T428/249958 , Y10T428/249959 , Y10T428/249978 , Y10T428/249991
摘要： Supports having azlactone-functional surfaces, adduct supports prepared from such azlactone-functional supports, and methods of preparing both are disclosed. Azlactone functionality is introduced to surfaces of a pre-existing support in a manner which retains useful physical and chemical characteristics of the pre-existing support. One method involves exposing surfaces with high energy radiation to generate free radical reaction sites on the surfaces and causing azlactone-functional moieties to react with the free radical reaction sites. Another method involves coating surfaces with azlactone monomers, crosslinking monomers, and optionally co-monomers and polymerizing the monomers to form a polymerized coating of azlactone-functionality on the surfaces. Another method involves dispersion polymerization of azlactone-functional moieties to produce azlactone-functional particles within pores and interstices of a pre-existing support. Adduct supports are formed by coupling nucleophilic reagents, such as biologically active materials, to azlactone-functional moieties of the support.
摘要翻译：公开了具有吖内酯功能性表面的载体，由这种吖内酯官能载体制备的加合物载体，以及制备两者的方法。将Azlactone功能以保留现有支持物的有用物理和化学特性的方式引入预先存在的载体的表面。一种方法包括用高能量辐射暴露表面以在表面上产生自由基反应位点并使吖内酯官能部分与自由基反应位点反应。另一种方法包括用吖内酯单体，交联单体和任选的共聚单体涂覆表面并聚合单体以在表面上形成吖内酯官能团的聚合涂层。另一种方法涉及吖内酯功能部分的分散聚合以在预先存在的载体的孔和间隙内产生吖内酯官能团的颗粒。加成载体通过将亲核试剂（例如生物活性物质）偶联到载体的吖内酯官能部分而形成。

5. 发明授权

US4806478A Dry enzyme formulations containing D-amino acid oxidase 失效
标题翻译：含有D-氨基酸氧化酶的干酶制剂
公开(公告)号：US4806478A
公开(公告)日：1989-02-21
申请号：US661662
申请日：1984-10-17
申请人： Julie B. Stahl
发明人： Julie B. Stahl
IPC分类号： C12Q1/26 , C12Q1/37 , G01N33/52 , C12N11/08 , C12N9/96
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/521 , G01N2333/906
摘要： A stable formulation of a non-cellulosic fabric having D-amino acid oxidase coated and dried thereon is shown. The fabric may be woven, nonwoven, or knit and may be made from polyolefin, nylon, polyester, or polyurethane fabrics. Polyolefin fabrics may be pretreated with a surfactant. Also shown are formulations containing some or all of the reagents used to detect beta lactam antibiotics. Kits having webs coated with analytically effective amounts of D-amino acid oxidase, peroxidase, flavin adenine, dinucleotide, a peroxide sensitive dye and a D,D-carboxypeptidase substrate containing a carboxyterminal D-alanine are shown. D,D-carboxypeptidase R39 enzyme may be provided separately in either aqueous form or dried on a separate piece of fabric. Under appropriate conditions the D,D-carboxypeptidase may also be dried on the fabric.
摘要翻译：显示了在其上涂覆并干燥了D-氨基酸氧化酶的非纤维素织物的稳定配方。织物可以是编织物，无纺布或编织物，并且可以由聚烯烃，尼龙，聚酯或聚氨酯织物制成。聚烯烃织物可用表面活性剂预处理。还显示了含有用于检测β-内酰胺抗生素的一些或全部试剂的制剂。显示了具有分析有效量的D-氨基酸氧化酶，过氧化物酶，黄素腺嘌呤，二核苷酸，过氧化物敏感染料和含有羧基末端D-丙氨酸的D，D-羧肽酶底物的网的试剂盒。 D，D-羧肽酶R39酶可以以水溶液形式分开提供，也可以在单独的织物上干燥。在合适的条件下，D，D-羧肽酶也可以在织物上干燥。

6. 发明授权

US5408002A Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both 失效
标题翻译：吖内酯官能聚合物共混物，由其制备的制品及其制备方法
公开(公告)号：US5408002A
公开(公告)日：1995-04-18
申请号：US119036
申请日：1993-09-09
申请人： Patrick L. Coleman , Steven M. Heilmann , Steven L. Kangas , Robert H. Menzies , Jerald K. Rasmussen , Richard J. Rolando , Jennifer J. Sahlin , Julie B. Stahl
发明人： Patrick L. Coleman , Steven M. Heilmann , Steven L. Kangas , Robert H. Menzies , Jerald K. Rasmussen , Richard J. Rolando , Jennifer J. Sahlin , Julie B. Stahl
IPC分类号： G01N33/545 , C07D263/32 , C08F2/02 , C08K5/357 , C08L23/02 , C08L33/04 , C08L33/12 , C08L45/00 , C08L77/00 , C08L101/00 , C08L39/04
CPC分类号： C08L23/02 , C08L101/00 , C08L23/06 , C08L23/0815 , C08L23/10 , C08L77/00 , C08L2203/02 , C08L2203/16 , Y10T428/31754 , Y10T428/31935
摘要： An azlactone-functional thermoplastic composition is disclosed. The composition is a blend of an azlactone-functional composition and a thermoplastic polymer. A method of making azlactone-functional homopolymers by bulk homopolymerization is disclosed, optionally also concurrent or sequential blending of a thermoplastic polymer. A method of blending azlactone-functional compositions and thermoplastic polymers is disclosed. Molded articles and adduct molded articles formed from the thermoplastic composition are disclosed.
摘要翻译：公开了一种吖内酯官能的热塑性组合物。组合物是吖内酯官能组合物和热塑性聚合物的共混物。公开了通过本体均聚制备吖内酯官能的均聚物的方法，任选地还可以并行或顺序共混热塑性聚合物。公开了混合吖内酯官能组合物和热塑性聚合物的方法。公开了由热塑性组合物形成的模制品和加合成型品。

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