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1. 发明授权

US06808709B1 Immunoglobulins containing protection proteins and their use 失效
标题翻译：含有保护蛋白的免疫球蛋白及其用途
公开(公告)号：US06808709B1
公开(公告)日：2004-10-26
申请号：US09717888
申请日：2000-11-20
申请人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
发明人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
IPC分类号： A61K39395
CPC分类号： C07K16/1278 , C07K14/705 , C07K16/00 , C07K2317/13 , C07K2318/10 , C12N15/8242 , C12N15/8258
摘要： The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates he production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins a therapeutic antibodies against mucosal and other pathogens is also contemplated.
摘要翻译：本发明的免疫球蛋白是针对粘膜病原体如变形链球菌的有用的治疗性免疫球蛋白。免疫球蛋白含有保护蛋白质，其保护粘膜环境中的免疫球蛋白。本发明还包括通过在与免疫球蛋白的其它组分相同的细胞中产生保护性蛋白质来大大改进在植物中产生免疫球蛋白的方法。以非常改进的效率组装免疫球蛋白的组分。本发明的方法允许这种复合分子的组装和高效生产。本发明还考虑在多种细胞（包括植物细胞）中产生含有保护性蛋白质的免疫球蛋白，其可以选择用于有用的附加性质。还考虑使用含有保护性蛋白的免疫球蛋白针对粘膜和其它病原体的治疗性抗体。

2. 发明授权

US6046037A Method for producing immunoglobulins containing protection proteins in plants and their use 失效
标题翻译：在植物中产生含有保护性蛋白质的免疫球蛋白的方法及其用途
公开(公告)号：US6046037A
公开(公告)日：2000-04-04
申请号：US434000
申请日：1995-05-04
申请人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
发明人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
IPC分类号： C07K14/705 , C07K16/00 , C12N15/82 , C12N15/00 , A01H4/00 , C12N15/29
CPC分类号： C12N15/8258 , C07K14/705 , C07K16/00
摘要： The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment.The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules.The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
摘要翻译：本发明的免疫球蛋白是针对粘膜病原体如变形链球菌的有用的治疗性免疫球蛋白。免疫球蛋白含有保护蛋白质，其保护粘膜环境中的免疫球蛋白。本发明还包括通过在与免疫球蛋白的其它组分相同的细胞中产生保护性蛋白质来大大改进在植物中产生免疫球蛋白的方法。以非常改进的效率组装免疫球蛋白的组分。本发明的方法允许这种复合分子的组装和高效生产。本发明还考虑在多种细胞（包括植物细胞）中产生含有保护性蛋白质的免疫球蛋白，其可以选择用于有用的附加性质。还考虑使用含有保护性蛋白质的免疫球蛋白作为针对粘膜和其它病原体的治疗性抗体。

3. 发明授权

US06303341B1 Method for producing immunoglobulins containing protection proteins in plants and their use 失效
标题翻译：在植物中产生含有保护性蛋白质的免疫球蛋白的方法及其用途
公开(公告)号：US06303341B1
公开(公告)日：2001-10-16
申请号：US09312157
申请日：1999-05-14
申请人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
发明人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
IPC分类号： C12M1500
CPC分类号： C12N15/8258 , C07K14/705 , C07K16/00 , C12N15/8242
摘要： The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
摘要翻译：本发明的免疫球蛋白是针对粘膜病原体如变形链球菌的有用的治疗性免疫球蛋白。免疫球蛋白含有保护粘膜环境中的免疫球蛋白的保护蛋白。本发明还包括通过在与免疫球蛋白的其它成分相同的细胞中产生保护性蛋白质而在植物中产生免疫球蛋白的极大改进的方法。以非常改进的效率组装免疫球蛋白的组分。本发明的方法允许组装和高效生产这样的复合分子。本发明还考虑在多种细胞（包括植物细胞）中产生含有保护性蛋白质的免疫球蛋白，其可以选择用于有用的附加性质。还考虑使用含有保护性蛋白质的免疫球蛋白作为针对粘膜和其它病原体的治疗性抗体。

4. 发明授权

US07211389B2 Method for producing immunoglobulins containing protection proteins and their use 失效
标题翻译：用于生产含有保护性蛋白质的免疫球蛋白的方法及其用途
公开(公告)号：US07211389B2
公开(公告)日：2007-05-01
申请号：US10781989
申请日：2004-02-18
申请人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
发明人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
IPC分类号： C12Q1/68
CPC分类号： C07K16/1278 , C07K14/705 , C07K16/00 , C07K2317/13 , C07K2318/10 , C12N15/8242 , C12N15/8258
摘要： The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
摘要翻译：本发明的免疫球蛋白是针对粘膜病原体如变形链球菌的有用的治疗性免疫球蛋白。免疫球蛋白含有保护蛋白质，其保护粘膜环境中的免疫球蛋白。本发明还包括通过在与免疫球蛋白的其它组分相同的细胞中产生保护性蛋白质来大大改进在植物中产生免疫球蛋白的方法。以非常改进的效率组装免疫球蛋白的组分。本发明的方法允许这种复合分子的组装和高效生产。本发明还考虑在多种细胞（包括植物细胞）中产生含有保护性蛋白质的免疫球蛋白，其可以选择用于有用的附加性质。还考虑使用含有保护性蛋白质的免疫球蛋白作为针对粘膜和其它病原体的治疗性抗体。

5. 发明授权

US06995014B1 Transgenic plants expressing assembled secretory antibodies 失效
公开(公告)号：US06995014B1
公开(公告)日：2006-02-07
申请号：US09512736
申请日：2000-02-24
申请人： Mich B. Hein , Andrew Hiatt , Julian K-C Ma
发明人： Mich B. Hein , Andrew Hiatt , Julian K-C Ma
IPC分类号： C12N15/82 , C12N15/13 , A01H5/00 , A01H13/00
CPC分类号： C07K16/00 , C07K2317/13 , C12N15/8258
摘要： The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.

6. 发明申请

US20080115244A1 Method for producing immunoglobulins containing protection proteins and their use 审中-公开
标题翻译：用于生产含有保护性蛋白质的免疫球蛋白的方法及其用途
公开(公告)号：US20080115244A1
公开(公告)日：2008-05-15
申请号：US11605720
申请日：2006-11-28
申请人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner
发明人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner
IPC分类号： C12N15/82 , C07K16/18 , C12N9/14 , C12P21/04
CPC分类号： C07K16/1278 , C07K14/705 , C07K16/00 , C07K2317/13 , C07K2318/10 , C12N15/8242 , C12N15/8258
摘要： The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment.The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules.The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
摘要翻译：本发明的免疫球蛋白是针对粘膜病原体如变形链球菌的有用的治疗性免疫球蛋白。免疫球蛋白含有保护蛋白质，其保护粘膜环境中的免疫球蛋白。本发明还包括通过在与免疫球蛋白的其它组分相同的细胞中产生保护性蛋白质来大大改进在植物中产生免疫球蛋白的方法。以非常改进的效率组装免疫球蛋白的组分。本发明的方法允许这种复合分子的组装和高效生产。本发明还考虑在多种细胞（包括植物细胞）中产生含有保护性蛋白质的免疫球蛋白，其可以选择用于有用的附加性质。还考虑使用含有保护性蛋白质的免疫球蛋白作为针对粘膜和其它病原体的治疗性抗体。

7. 发明授权

US06852319B2 Method of use of transgenic plant expressed antibodies 失效
标题翻译：转基因植物表达抗体的使用方法
公开(公告)号：US06852319B2
公开(公告)日：2005-02-08
申请号：US09491322
申请日：2000-01-25
申请人： Mich B. Hein , Andrew Hiatt , Julian K-C Ma
发明人： Mich B. Hein , Andrew Hiatt , Julian K-C Ma
IPC分类号： A61K38/00 , C07K16/00 , C07K16/12 , C07K16/44 , C12N9/00 , C12N9/18 , C12N15/82 , A61K39/395
CPC分类号： C07K16/00 , A61K38/00 , C07K16/12 , C07K16/1228 , C07K16/1275 , C07K16/44 , C07K2317/13 , C07K2319/00 , C07K2319/02 , C12N9/0002 , C12N9/18 , C12N15/8242 , C12N15/8258 , Y02A50/471
摘要： The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.
摘要翻译：本发明涉及外源多聚体蛋白质的表达和装配，例如植物中的抗体以及表达这种蛋白质的转基因植物。在几个优选实施方案中的一个中，公开了植物中功能分泌抗体的产生和组装。本发明还公开了由本发明的转基因植物产生的组合物及其使用方法。

8. 发明授权

US5959177A Transgenic plants expressing assembled secretory antibodies 失效
公开(公告)号：US5959177A
公开(公告)日：1999-09-28
申请号：US642406
申请日：1996-05-03
申请人： Mich B. Hein , Andrew Hiatt , Julian K-C Ma
发明人： Mich B. Hein , Andrew Hiatt , Julian K-C Ma
IPC分类号： C12N15/09 , A01H5/00 , A61K38/00 , C07K16/00 , C07K16/12 , C07K16/44 , C12N5/10 , C12N9/00 , C12N9/18 , C12N15/82 , C12N15/00 , C12N15/29
CPC分类号： C07K16/12 , C07K16/00 , C07K16/1228 , C07K16/1275 , C07K16/44 , C12N15/8242 , C12N15/8258 , C12N9/0002 , C12N9/18 , A61K38/00 , C07K2317/13 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to expression and assembly of foreign multimeric proteins--e.g., antibodies--in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.

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