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1. 发明申请

US20070275061A1 PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS OF METFORMIN EXTENDED RELEASE TABLETS 审中-公开
标题翻译：金属蛋白酶扩展片剂的药物组合物和配方
公开(公告)号：US20070275061A1
公开(公告)日：2007-11-29
申请号：US11534359
申请日：2006-09-22
申请人： Young Gwan Jo , Ja-Seong Koo , Ju-Bin Yim , Yoon-Sik Jun
发明人： Young Gwan Jo , Ja-Seong Koo , Ju-Bin Yim , Yoon-Sik Jun
IPC分类号： A61K9/22 , A61K31/155
CPC分类号： A61K31/155 , A61K9/2027 , A61K9/2054
摘要： The present invention relates to a metformin extended release tablet, particularly to a metformin extended release tablet comprising metformin, which is effective in treating non-insulin dependent diabetes mellitus, as active ingredient, and a matrix in which hydrophilic polymers and hydrophobic materials are mixed at a specific proportion. The hydrophilic polymers enable controlling of the pore size of the gel layer formed by water swelling, thereby enabling primary control of drug release rate. And, the hydrophobic materials block the pores of the gel layer, thereby enabling secondary control of drug release rate. Therefore, the metformin extended release tablet of the present invention has better dissolution properties than conventional extended release tablets and, thus, enables extended drug release at constant rate even with less matrix. A constant blood level can be maintained with one administration a day and the tablet can be made smaller, which makes the administration easier and the production simpler.
摘要翻译：本发明涉及二甲双胍延长释放片剂，特别涉及二甲双胍延长释放片剂，其包含二甲双胍，其有效治疗作为活性成分的非胰岛素依赖性糖尿病，和将亲水性聚合物和疏水性材料混合在其中的基质具体比例。亲水性聚合物能够控制由水溶胀形成的凝胶层的孔径，从而能够初步控制药物释放速率。并且，疏水材料阻挡凝胶层的孔，从而能够二次控制药物释放速率。因此，本发明的二甲双胍延长释放片剂比常规延长释放片剂具有更好的溶解性能，因此即使使用较少的基质也能以恒定的速率延长药物释放。可以每天一次给药维持恒定的血液水平，并且可以使片剂更小，这使得给药更容易并且生产更简单。

2. 发明申请

US20080241240A1 COMBINED PHARMACEUTICAL FORMULATION WITH CONTROLLED-RELEASE COMPRISING DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS AND HMG-COA REDUCTASE INHIBITORS 审中-公开
标题翻译：具有包含二氢吡啶类钙通道阻断剂和HMG-COA还原酶抑制剂的受控释放的组合药物制剂
公开(公告)号：US20080241240A1
公开(公告)日：2008-10-02
申请号：US12038663
申请日：2008-02-27
申请人： Sung Wuk Kim , Sung Soo Jun , Young Gwan Jo , Ja-Seong Koo , Jin Wook Kim , Ju Bin Yim , Jun Young Lee
发明人： Sung Wuk Kim , Sung Soo Jun , Young Gwan Jo , Ja-Seong Koo , Jin Wook Kim , Ju Bin Yim , Jun Young Lee
IPC分类号： A61K31/44 , A61K31/454 , A61K9/14 , A61K9/22 , A61P9/00
CPC分类号： A61K31/44 , A61K9/1652 , A61K9/209 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K31/454
摘要： The present invention relates to a chronotherapeutic combination pharmaceutical formulation, which is designed to control the release of each ingredient of the combined drug in a predetermined rate based on the principle of the so-called chronotherapy and xenobiotics, where drugs are administered to exhibit pharmacological activities at predetermined time intervals. The formulations of the present invention comprise a dihydropyridine, and a statin, as active ingredients. The formulations are structured and arranged such that the respective release rates of the above ingredients can be controlled, thereby reducing or preventing antagonistic effects and side effects resulting from the interaction of the above ingredients, while maintaining the synergistic effect, and providing easy medication.
摘要翻译：本发明涉及一种按时间控制组合药物制剂，其被设计成基于所谓的治疗和异种生物的原理以预定的速率控制组合药物的每种成分的释放，其中施用药物以显示药理活性以预定的时间间隔。本发明的制剂包含二氢吡啶和他汀类作为活性成分。制剂的结构和布置使得可以控制上述成分的各自的释放速率，从而降低或防止由上述成分的相互作用引起的拮抗作用和副作用，同时保持协同效应，并提供容易的药物。

3. 发明申请

US20080050432A1 Combined Pharmaceutical Formulation with Controlled-Release Comprising Dihydropyridine Calcium Channel Blockers and HMG-COA Reductase Inhibitors 审中-公开
标题翻译：含有二氢吡啶钙通道阻断剂和HMG-COA还原酶抑制剂的控制释放的联合药物制剂
公开(公告)号：US20080050432A1
公开(公告)日：2008-02-28
申请号：US11696942
申请日：2007-04-05
申请人： Sung Soo Jun , Young Gwan Jo , Ja-Seong Koo , Jin Wook Kim , Ju-Bin Yim
发明人： Sung Soo Jun , Young Gwan Jo , Ja-Seong Koo , Jin Wook Kim , Ju-Bin Yim
IPC分类号： A61K9/56 , A61K9/36 , A61P9/10 , A61K31/44 , A61P9/12 , A61K9/24 , A61K9/30
CPC分类号： A61K45/06 , A61K9/1635 , A61K9/1652 , A61K9/2077 , A61K9/2081 , A61K9/209 , A61K9/2866 , A61K9/4808 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K31/20 , A61K31/40 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a combined pharmaceutical formulation, which is such designed that the release of each ingredient may be controlled to a predetermined release rate by applying the principle of the so-called chronotherapy, where drugs are administered in such a way that the activities of the drugs are expressed at intervals. The formulation of the present invention comprises statin-based lipid-lowering agent and dihydropyridine-based calcium channel blocker that affects cytochrome P450 enzyme as active ingredients, and is such constituted that the release rates of the aforementioned ingredients are different, thus preventing antagonism and side effects, while maintaining the synergistic effect, which leads to the convenience in medication.
摘要翻译：本发明涉及组合的药物制剂，其被设计成通过应用所谓的定时治疗的原理将每种成分的释放控制到预定的释放速率，其中药物以这样的方式施用，的药物间隔表达。本发明的制剂包含作为活性成分影响细胞色素P450酶的基于他汀类的降脂剂和二氢吡啶类钙通道阻断剂，其构成为上述成分的释放速度不同，从而防止拮抗作用效果，同时保持协同效应，这导致药物的方便。

4. 发明申请

US20070042042A1 Metformin Tablet with Sustained Release and Method for Preparing the Same 审中-公开
标题翻译：具有持续释放的二甲双胍片剂及其制备方法
公开(公告)号：US20070042042A1
公开(公告)日：2007-02-22
申请号：US11428619
申请日：2006-07-05
申请人： Young Jo , Ja-Seong Koo , Ju-Bin Yim , Yoon-Sik Jun
发明人： Young Jo , Ja-Seong Koo , Ju-Bin Yim , Yoon-Sik Jun
IPC分类号： A61K9/22 , A61K31/155
CPC分类号： A61K9/0065 , A61K9/2054 , A61K9/2866 , A61K31/155
摘要： The present invention relates to a metformin tablet with sustained release and a method for preparing the same, more particularly to an improved metformin tablet with sustained release prepared by manufacturing a composition comprising metformin, which is an active ingredient for treatment of insulin-independent diabetes, and a matrix capable of controlling release rate of metformin into a slug at a given pressure condition, forming a tablet core by dry granulation and then forming a coated film on it, which is slowly released into the body at a constant rate for 24 hours, thereby maintaining a constant blood concentration for 24 hours when administered once a day while offering bioequivalence comparable to that of conventional products, and a method for preparing the same.
摘要翻译：本发明涉及具有持续释放的二甲双胍片剂及其制备方法，更具体地涉及通过制备包含作为治疗胰岛素不依赖性糖尿病的活性成分的二甲双胍的组合物而制备的具有持续释放的改进的二甲双胍片剂，以及能够在给定的压力条件下控制二甲双胍释放速率的基质，通过干法造粒形成片芯，然后在其上形成涂膜，以恒定速率缓慢释放24小时，从而维持恒定的血液浓度24小时，每天一次给药，同时提供与常规产品相当的生物等效性及其制备方法。

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