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1. 发明申请

US20120321583A1 Protein-Polymer-Drug Conjugates 有权
标题翻译：蛋白质 - 聚合物 - 药物结合物
公开(公告)号：US20120321583A1
公开(公告)日：2012-12-20
申请号：US13493899
申请日：2012-06-11
申请人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Joshua D. Thomas , Charles E. Hammond , Cheri A. Stevenson , Natalya D. Bodyak , Patrick R. Conlon , Dmitry R. Gumerov
发明人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Joshua D. Thomas , Charles E. Hammond , Cheri A. Stevenson , Natalya D. Bodyak , Patrick R. Conlon , Dmitry R. Gumerov
IPC分类号： C08G65/333 , C08G65/332 , A61P35/00 , A61P35/02 , A61K47/48 , C07K5/103
CPC分类号： A61K47/59 , A61K31/4745 , A61K47/64 , A61K47/6803 , A61K47/6849 , A61K47/6883 , C07K7/02 , C07K16/32 , C08G65/33396 , C08G65/334
摘要： A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
摘要翻译：本文提供药物缀合物。缀合物包含基于蛋白质的识别分子（PBRM）和被一个或多个-LD-D取代的聚合物载体，基于蛋白质的识别分子通过LP连接到聚合物载体上。每次出现的D独立地是具有分子量＆nlE; 5kDa的治疗剂。 LD和LP分别是将治疗剂和PBRM分别连接到聚合物载体的接头。还公开了可用于与PBRM缀合以形成本文所述的聚合物 - 药物-PBRM缀合物的聚合物支架，包含缀合物的组合物，其制备方法，以及用缀合物或其组合物治疗各种病症的方法。

2. 发明授权

US08685383B2 Protein-polymer-drug conjugates 有权
公开(公告)号：US08685383B2
公开(公告)日：2014-04-01
申请号：US13493899
申请日：2012-06-11
申请人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Joshua D. Thomas , Charles E. Hammond , Cheri A. Stevenson , Natalya D. Bodyak , Patrick R. Conlon , Dmitry R. Gumerov
发明人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Joshua D. Thomas , Charles E. Hammond , Cheri A. Stevenson , Natalya D. Bodyak , Patrick R. Conlon , Dmitry R. Gumerov
IPC分类号： A61K31/74 , A61K47/48 , A61K38/04 , C08G63/48 , C08G63/91 , C08G65/32 , C08L67/00 , C08G65/333 , C08G65/334
CPC分类号： A61K47/59 , A61K31/4745 , A61K47/64 , A61K47/6803 , A61K47/6849 , A61K47/6883 , C07K7/02 , C07K16/32 , C08G65/33396 , C08G65/334
摘要： A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

3. 发明申请

US20080111035A1 CLAMP STAND 审中-公开
标题翻译：夹具架
公开(公告)号：US20080111035A1
公开(公告)日：2008-05-15
申请号：US11559670
申请日：2006-11-14
申请人： Joshua D. Thomas , Richard Allen Smith
发明人： Joshua D. Thomas , Richard Allen Smith
IPC分类号： A47F5/06
CPC分类号： B23Q3/103 , B25B5/006
摘要： A clamp stand for supporting a clamp in an elevated position above a fixture base comprises an extruded support column having upper and lower ends and an interior that is at least in substantial part open. The clamp stand includes longitudinally extending fastener attachment openings, which are attachable by threaded fasteners to a base at the lower end and to a clamp base an upper end. Flat and angled adapter plates are used to attach clamps having bases with different hole patterns. The support column can be mounted to a fixture base by a base bracket. Clamps can be mounted for vertical movement in key slots in the sides of the support column.
摘要翻译：用于将夹具支撑在夹具基座上方的升高位置的夹持支架包括具有上端和下端以及至少基本上部分敞开的内部的挤压支撑柱。夹持支架包括纵向延伸的紧固件连接开口，其可通过螺纹紧固件附接到下端的底座和上端的夹具底座。扁平和角度适配器板用于连接具有不同孔图案的基座的夹具。支撑柱可以通过底座支架安装到固定座上。夹具可以安装在支撑柱侧面的关键槽中垂直运动。

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