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1. 发明申请

US20090163573A1 COMPOSITIONS AND METHODS FOR ENHANCING PROTEIN ACCRETION IN SKELETAL MUSCLE 审中-公开
标题翻译：用于增强骨骼肌肉蛋白质摄取的组合物和方法
公开(公告)号：US20090163573A1
公开(公告)日：2009-06-25
申请号：US11962948
申请日：2007-12-21
申请人： Marvin A. Heuer , Ken Clement , Michele Molino , Joseph MacDougall
发明人： Marvin A. Heuer , Ken Clement , Michele Molino , Joseph MacDougall
IPC分类号： A61P21/00 , A61K31/385 , A61K31/195
CPC分类号： A61K31/198 , A61K31/195 , A61K31/385 , A61K2300/00
摘要： A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and an effective amount of glutamine or derivative of glutamine, wherein the ingredients act substantially simultaneously to increase protein synthesis and inhibit protein degradation in skeletal muscle, via enhanced expression of heat shock proteins in cells, particularly heat shock protein 72. A method of same is also provided.
摘要翻译：一种营养组合物，其包含至少有效量的香叶基香叶基丙酮或前列腺素基丙酮衍生物和有效量的谷氨酰胺或谷氨酰胺衍生物，其中所述成分基本上同时作用，通过增强的热休克表达来增加蛋白质合成和抑制骨骼肌中的蛋白质降解细胞中的蛋白质，特别是热休克蛋白72.还提供了其方法。

2. 发明申请

US20090156676A1 Organic salts of beta-alanine 有权
标题翻译： β-丙氨酸的有机盐
公开(公告)号：US20090156676A1
公开(公告)日：2009-06-18
申请号：US11954644
申请日：2007-12-12
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
IPC分类号： A61K31/195 , C07C229/04
CPC分类号： C07C229/08
摘要： The present invention relates to stable salts of β-alanine and an organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral administration. A method of preparation is also provided.
摘要翻译：本发明涉及β-丙氨酸的稳定盐和赋予其对各自作用的增强的营养和/或治疗功效的有机酸，以及含有特别适合于口服给药的盐的固体组合物。还提供了一种制备方法。

3. 发明申请

US20090156647A1 Method for maintaining physiological pH levels during intensive physical exercise 审中-公开
标题翻译：在强力运动时保持生理pH值的方法
公开(公告)号：US20090156647A1
公开(公告)日：2009-06-18
申请号：US11954635
申请日：2007-12-12
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
IPC分类号： A61K31/44 , A61P3/00
CPC分类号： A61K31/44
摘要： A nutritional supplement comprising at least a therapeutically effective amount of pyridoxine α-hydroxyisocaproate is provided by the present invention. The ingredients of the present nutritional supplement act substantially simultaneously to maintain physiological blood and muscular pH and increase the time to muscular fatigue in a mammal during periods of repetitive forceful muscular exercise. A method of use is provided by the present disclosure.
摘要翻译：包含至少治疗有效量的吡哆醇α-羟基异己酸的营养补充剂由本发明提供。本发明的营养补充剂的成分基本上同时起作用以维持生理性血液和肌肉酸碱度，并且在重复强力肌肉运动期间增加哺乳动物肌肉疲劳的时间。本公开提供了一种使用方法。

4. 发明申请

US20090156634A1 Tropane alkaloids and trigonelline combinations and methods for administering the same 审中-公开
标题翻译：托烷生物碱和葫芦巴酮组合及其施用方法
公开(公告)号：US20090156634A1
公开(公告)日：2009-06-18
申请号：US11954662
申请日：2007-12-12
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
IPC分类号： A61K31/44 , A61K31/439 , A61P21/00
CPC分类号： A61K31/439 , A23L33/105 , A23V2002/00 , A61K31/44 , A61K2300/00 , A23V2200/316 , A23V2250/21
摘要： A nutritional composition comprising at least an effective amount of trigonelline or derivative of trigonelline and an effective amount of tropane alkaloids, wherein the ingredients act substantially simultaneously improve the consistency of muscular contractions with respect to applied force and relaxation cycles over time and reduce the onset of central fatigue. A method of same is also provided.
摘要翻译：营养组合物，其包含至少有效量的葫芦巴碱或葫芦巴衍生物和有效量的托烷生物碱，其中所述成分基本上同时改善随着时间推移施加的力和松弛循环的肌肉收缩的一致性，并减少中枢疲劳还提供了其方法。

5. 发明授权

US07511163B2 Creatine-fatty acids 有权
标题翻译：肌酸 - 脂肪酸
公开(公告)号：US07511163B2
公开(公告)日：2009-03-31
申请号：US11856358
申请日：2007-09-17
申请人： Shan Chaudhuri , Joseph MacDougall , Jason Peters , James Ramsbottom
发明人： Shan Chaudhuri , Joseph MacDougall , Jason Peters , James Ramsbottom
IPC分类号： C07C51/00
CPC分类号： C07C279/22
摘要： The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译：本发明描述了由肌酸分子和脂肪酸分子产生的化合物。化合物是由酰胺键结合的肌酸 - 脂肪族化合物的形式，或其混合物，其通过使肌酸或其衍生物与适当的脂肪酸在二氯甲烷和吡啶催化剂存在下反应而生成，预先与亚硫酰卤反应。这种分子的施用提供补充肌酸，具有增强的生物利用度和特定脂肪酸赋予的额外益处。

6. 发明申请

US20080200725A1 PREPARATION OF AMINO ACID-FATTY ACID ANHYDRIDES 有权
标题翻译：氨基酸脂肪酸的制备
公开(公告)号：US20080200725A1
公开(公告)日：2008-08-21
申请号：US11747203
申请日：2007-05-10
申请人： Joseph MacDougall
发明人： Joseph MacDougall
IPC分类号： C07C257/00
CPC分类号： C07C229/08 , C07C229/26 , C07C237/06 , C07C277/08 , C07C279/10 , C07C279/14
摘要： The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译：本发明描述了由氨基酸分子和脂肪酸分子产生的化合物。化合物为氨基酸或其衍生物与预先与亚硫酰卤反应的适当脂肪酸所形成的氨基 - 脂肪酸化合物形式的酸酐键或其混合物。这种分子的施用提供补充氨基酸，其具有增强的生物利用度和特定脂肪酸赋予的额外益处。

7. 发明申请

US20080200705A1 CREATINE-FATTY ACIDS 有权
公开(公告)号：US20080200705A1
公开(公告)日：2008-08-21
申请号：US11856358
申请日：2007-09-17
申请人： Shan Chaudhuri , Joseph MacDougall , Jason Peters , James Ramsbottom
发明人： Shan Chaudhuri , Joseph MacDougall , Jason Peters , James Ramsbottom
IPC分类号： C07C229/26
CPC分类号： C07C279/22
摘要： The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译：本发明描述了由肌酸分子和脂肪酸分子产生的化合物。化合物是由酰胺键结合的肌酸 - 脂肪族化合物的形式，或其混合物，其通过使肌酸或其衍生物与适当的脂肪酸在二氯甲烷和吡啶催化剂存在下反应而生成，预先与亚硫酰卤反应。这种分子的施用提供补充肌酸，具有增强的生物利用度和特定脂肪酸赋予的额外益处。

8. 发明申请

US20090069422A1 COMPOSITION AND METHOD FOR INCREASING THE ANABOLIC STATE OF MUSCLE CELLS 有权
标题翻译：用于增加肌肉细胞的不稳定状态的组合物和方法
公开(公告)号：US20090069422A1
公开(公告)日：2009-03-12
申请号：US11853277
申请日：2007-09-11
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
IPC分类号： A61K31/22 , A61P21/06
CPC分类号： A61K31/22 , A61K2300/00
摘要： A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one α-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.
摘要翻译：本发明提供了至少包含治疗有效量的丙酮酸乙酯和治疗有效量的至少一种α-羟基支链氨基酸代谢物的营养补充剂。本发明的营养补充剂的成分通过基本上同时维持血液和肌肉生理pH水平以及增加支链氨基酸的细胞浓度而基本上同时作用于诱导肌肉的合成代谢状态。本公开提供了组合物和方法。

9. 发明授权

US08236952B2 Preparations containing amino acids and orotic acid 有权
标题翻译：含氨基酸和乳清酸的制剂
公开(公告)号：US08236952B2
公开(公告)日：2012-08-07
申请号：US11958747
申请日：2007-12-18
申请人： Joseph MacDougall , Shan Chaudhuri
发明人： Joseph MacDougall , Shan Chaudhuri
IPC分类号： C07D239/557
CPC分类号： C07D239/54 , Y02P20/55
摘要： The present invention describes compounds produced from an orotic acid molecule and an amino acid molecule. The compounds being in the form of amino acid orotate compounds bound by an amide linkage and produced by one of two disclosed methods; 1) reacting orotic acid or derivatives thereof with a thionyl halide, and then combining the acyl halide with an amino acid in the presence of dichloromethane and a DMAP catalyst; or 2) protecting the carboxylic acid of an amino acid and then combining the amino acid with a DCC activated orotic acid, followed by removal of the carboxylic acid protecting group. The resulting amino acid orotate amide has an enhanced stability in solution as compared to a related ester. In addition, specific benefits are conferred by the particular amino acid used to form the compounds in addition to, and separate from, the orotate substituent.
摘要翻译：本发明描述了由乳清酸分子和氨基酸分子产生的化合物。化合物是由酰胺键结合的氨基酸乳清酸酯化合物的形式，并通过两种公开的方法之一产生; 1）将乳清酸或其衍生物与亚硫酰卤反应，然后在二氯甲烷和DMAP催化剂的存在下将酰基卤与氨基酸组合; 或2）保护氨基酸的羧酸，然后将氨基酸与DCC活化的乳清酸结合，然后除去羧酸保护基。所得到的氨基酸乳清酸酰胺与相关酯相比在溶液中具有增强的稳定性。此外，特别的益处是由用于形成化合物的具体氨基酸，除了和与乳清酸酯取代基分开外，还有其独特之处。

10. 发明授权

US07645794B2 Composition and method for increasing the anabolic state of muscle cells 有权
标题翻译：增加肌肉细胞合成代谢状态的组合物和方法
公开(公告)号：US07645794B2
公开(公告)日：2010-01-12
申请号：US11853277
申请日：2007-09-11
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
IPC分类号： A61K31/225 , A61K31/20
CPC分类号： A61K31/22 , A61K2300/00
摘要： A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one α-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.
摘要翻译：本发明提供了至少包含治疗有效量的丙酮酸乙酯和治疗有效量的至少一种α-羟基支链氨基酸代谢物的营养补充剂。本发明的营养补充剂的成分通过基本上同时维持血液和肌肉生理pH水平以及增加支链氨基酸的细胞浓度而基本上同时作用于诱导肌肉的合成代谢状态。本公开提供了组合物和方法。

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