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1. 发明授权

US08751011B2 Defining therapy parameter values for posture states 有权
标题翻译：定义姿势状态的治疗参数值
公开(公告)号：US08751011B2
公开(公告)日：2014-06-10
申请号：US12433854
申请日：2009-04-30
申请人： Dennis M. Skelton , Jon P. Davis , Joseph J. Nolan , Rajeev Sahasrabudhe , Shyam Gokaldas
发明人： Dennis M. Skelton , Jon P. Davis , Joseph J. Nolan , Rajeev Sahasrabudhe , Shyam Gokaldas
IPC分类号： A61N1/00
CPC分类号： A61N1/36135 , A61B5/1116 , A61B5/686 , A61B5/7435 , A61B2560/0219 , A61B2562/0219 , A61N1/36535 , A61N1/36542 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63 , G16H40/67 , G16H50/20
摘要： The disclosure is directed towards posture-responsive therapy. To avoid interruptions in effective therapy, an implantable medical device may include a posture state module that detects the posture state of the patient and automatically adjusts therapy parameter values according to the detected posture state. A system may include an external programmer comprising a user interface that receives user input defining therapy parameter values for delivery of therapy to a patient, and user input associating one or more of the therapy parameter values with a plurality of posture states based on user input, a processor that automatically defines therapy parameter values for delivery of therapy to a patient when the patient occupies the posture states based on the association, and an implantable medical device that delivers the therapy to the patient in response to detection of the posture states.
摘要翻译：本公开涉及姿势响应疗法。为了避免有效治疗中断，可植入医疗装置可以包括检测患者的姿势状态的姿势状态模块，并且根据检测到的姿势状态自动调整治疗参数值。系统可以包括外部编程器，其包括用户接口，用户接口定义用于向患者传递治疗的治疗参数值的用户输入，以及基于用户输入将治疗参数值中的一个或多个与多个姿势状态相关联的用户输入，处理器，当处于基于关联的患者占据姿势状态时，自动地定义用于将治疗递送到患者的治疗参数值;以及可植入医疗装置，其响应于姿势状态的检测将治疗递送给患者。

2. 发明申请

US20120262108A1 RECHARGE TUNING TECHNIQUES FOR AN IMPLANTABLE DEVICE 有权
标题翻译：用于可移植设备的充电调谐技术
公开(公告)号：US20120262108A1
公开(公告)日：2012-10-18
申请号：US13439591
申请日：2012-04-04
申请人： David P. Olson , Nicholas A. Delisi , Jay T. Eisch , Philip R. LaBrosse , Joseph J. Nolan
发明人： David P. Olson , Nicholas A. Delisi , Jay T. Eisch , Philip R. LaBrosse , Joseph J. Nolan
IPC分类号： H02J7/00 , H02J17/00
CPC分类号： A61N1/3787 , H02J7/025
摘要： Techniques are disclosed for tuning a frequency at which an external device transcutaneously transfers energy. The transferred energy may be used to charge a rechargeable power source of an implantable medical device (IMD) and/or to power the IMD directly. One embodiment relates to a charging system that may comprise a circuit to drive a primary coil of an external device at a drive frequency and a control circuit to tune the drive frequency based on a characteristic of a monitored signal that is associated with the primary coil. The characteristic is not present when the primary coil is being driven at a resonant frequency of the system. In a specific example, the characteristic comprises a stub pulse and the control circuit is configured to tune the drive frequency based on at least one of a relative timing and a width of the stub pulse.
摘要翻译：公开了用于调谐外部设备经由能量传递的频率的技术。转移的能量可以用于对可植入医疗装置（IMD）的可再充电电源进行充电和/或直接为IMD供电。一个实施例涉及一种充电系统，其可以包括用于以驱动频率驱动外部设备的初级线圈的电路和用于基于与初级线圈相关联的监控信号的特性来调节驱动频率的控制电路。当初级线圈以系统的谐振频率驱动时，该特性不存在。在具体示例中，特征包括短截线脉冲，并且控制电路被配置为基于短截线脉冲的相对定时和宽度中的至少一个来调节驱动频率。

3. 发明授权

US07974703B2 Shifting between electrode combinations in electrical stimulation device 有权
标题翻译：在电刺激装置中的电极组合之间移动
公开(公告)号：US07974703B2
公开(公告)日：2011-07-05
申请号：US12406607
申请日：2009-03-18
申请人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
发明人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
IPC分类号： A61N1/18
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36185 , A61N1/37252
摘要： Techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.
摘要翻译：用于在两个电极组合之间切换的技术。第一电极组合的振幅逐渐减小，而第二或随后的电极组合的振幅同时递增地增加。或者，第一电极组合的振幅保持在目标振幅水平，而第二电极组合的振幅逐渐增加。电极组合的刺激脉冲在时间上交付给患者。以这种方式，本发明提供从第一电极组合到第二电极组合的平滑，逐渐的移动，允许患者保持连续的刺激感知。本文描述的移位技术可以在编程期间用于在不同电极组合之间移动以找到有效的电极组合。另外，这些技术可用于在与不同刺激程序或程序集相关联的不同电极组合之间进行移位。

4. 发明申请

US20100010576A1 PATIENT INTERACTION WITH POSTURE-RESPONSIVE THERAPY 有权
标题翻译：患者与感冒治疗相互作用
公开(公告)号：US20100010576A1
公开(公告)日：2010-01-14
申请号：US12433530
申请日：2009-04-30
申请人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan
发明人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36132 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/743 , A61B2560/0219 , A61B2562/0219 , A61M5/14276 , A61M5/1723 , A61M37/00 , A61M2205/054 , A61M2230/62 , A61N1/36071 , A61N1/36135 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H40/63
摘要： In general, the disclosure relates to the delivery of therapy according to a detected posture state of a patient. The disclosure contemplates a variety of techniques for managing therapy delivered to a patent, including patient and clinician interaction with a medical device configured to deliver therapy according to posture state. In one example, the disclosure relates to a technique including obtaining an operational status of a therapy group from a medical device, wherein the medical device is configured to deliver therapy to a patient according to a detected posture state of the patient; and presenting the operational status of the therapy group via an external device, wherein presenting the operational status of the therapy group comprises presenting whether the therapy group is active for delivery of therapy.
摘要翻译：通常，本公开涉及根据检测到的患者的姿势状态的治疗的递送。本公开考虑了用于管理递送到专利的治疗的各种技术，包括患者和临床医生与被配置为根据姿势状态递送治疗的医疗装置的相互作用。在一个示例中，本公开涉及一种技术，包括从医疗设备获得治疗组的操作状态，其中所述医疗设备被配置为根据患者的检测到的姿势状态向患者递送治疗; 以及通过外部设备呈现治疗组的操作状态，其中呈现治疗组的操作状态包括呈现治疗组是否有效用于治疗的递送。

5. 发明申请

US20100010575A1 PATIENT INTERACTION WITH POSTURE-RESPONSIVE THERAPY 有权
标题翻译：患者与感冒治疗相互作用
公开(公告)号：US20100010575A1
公开(公告)日：2010-01-14
申请号：US12433325
申请日：2009-04-30
申请人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan
发明人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36132 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/743 , A61B2560/0219 , A61B2562/0219 , A61M5/14276 , A61M5/1723 , A61M37/00 , A61M2205/054 , A61M2230/62 , A61N1/36071 , A61N1/36135 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H40/63
摘要： In general, the disclosure relates to the delivery of therapy according to a detected posture state of a patient. The disclosure contemplates a variety of techniques for managing therapy delivered to a patent, including patient and clinician interaction with a medical device configured to deliver therapy according to posture state. In one example, the disclosure relates to a technique including receiving an indication from an external device to resume delivery of therapy to a patient that was previously turned off, wherein the therapy that was previously turned off comprises therapy delivered to the patient according to a detected posture state of the patient; obtaining therapy information defining the therapy; and resuming the delivery of therapy to the patient in response to the receipt of the indication, wherein the delivery of therapy is resumed according to the obtained therapy information.
摘要翻译：通常，本公开涉及根据检测到的患者的姿势状态的治疗的递送。本公开考虑了用于管理递送到专利的治疗的各种技术，包括患者和临床医生与被配置为根据姿势状态递送治疗的医疗装置的相互作用。在一个示例中，本公开涉及一种技术，包括从外部设备接收指示以恢复对先前关闭的患者的治疗的传递，其中先前关闭的治疗包括根据检测到的递送给患者的治疗患者的姿势状态; 获得定义治疗的治疗信息; 以及响应于所述指示的接收而恢复对所述患者的治疗，其中根据获得的治疗信息恢复治疗的递送。

6. 发明申请

US20100010392A1 MODIFICATION PROFILES FOR POSTURE-RESPONSIVE THERAPY 有权
标题翻译：用于治疗有效治疗的修改资料
公开(公告)号：US20100010392A1
公开(公告)日：2010-01-14
申请号：US12433856
申请日：2009-04-30
申请人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan , Dennis Bourget , Duane Bourget , Keith A. Miesel , James Zimmerman
发明人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan , Dennis Bourget , Duane Bourget , Keith A. Miesel , James Zimmerman
IPC分类号： A61N1/08 , A61N1/36 , A61B5/103
CPC分类号： A61N1/37247 , A61B5/1116 , A61B5/1118 , A61B2562/0219 , A61N1/36071 , A61N1/36132 , A61N1/36135 , A61N1/36542 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H20/10 , G16H40/63 , G16H50/20 , G16H80/00
摘要： In general, the disclosure describes techniques for modifying therapy provided to a patient by a medical device. The techniques may be applicable to electrical stimulation therapy or other therapies. Modification of therapy may include adjustment of one or more therapy parameter values that define one or more characteristics of stimulation therapy delivered to a patient. The therapy modification may be based on activity of a patient that is detected by an IMD, such as a change in a detected posture state occupied by the patient. Different therapy modifications may be applied for different changes in detected posture state. An IMD may modify therapy based on a transition from one posture state to another posture state, and apply different modifications for different transitions. In some aspects, the modification may include a profile, such as a ramp up or ramp down in a parameter value over a period of time. The profile may be different for different posture transitions. A ramp slope may be steeper for one transition than for another transition. When a patient transitions from an upright to a lying posture state, for example, the profile may be especially abrupt. In some examples, a modification profile may define a dwell time.
摘要翻译：通常，本公开描述了用于修改由医疗装置提供给患者的治疗的技术。这些技术可能适用于电刺激治疗或其他疗法。治疗的修改可以包括调整一个或多个治疗参数值，其定义递送给患者的刺激疗法的一个或多个特征。治疗修改可以基于由IMD检测到的患者的活动，例如患者所占据的检测到的姿势状态的变化。可以对检测到的姿势状态的不同变化应用不同的治疗修改。 IMD可以基于从一个姿势状态到另一个姿势状态的转变来修改治疗，并对不同的转变应用不同的修改。在一些方面，修改可以包括轮廓，例如在一段时间内在参数值中的斜坡上升或下降。对于不同的姿势转换，轮廓可能不同。坡度斜坡对于一个过渡而言可能比另一个过渡更陡峭。当患者从直立状态转变到躺卧状态时，例如，轮廓可能特别突然。在一些示例中，修改简档可以定义驻留时间。

7. 发明申请

US20090299438A1 INDICATION OF COUPLING BETWEEN MEDICAL DEVICES 有权
标题翻译：医疗器械联接指示
公开(公告)号：US20090299438A1
公开(公告)日：2009-12-03
申请号：US12127404
申请日：2008-05-27
申请人： Joseph J. Nolan , Andrew H. Houchins
发明人： Joseph J. Nolan , Andrew H. Houchins
IPC分类号： A61N1/08
CPC分类号： A61N1/37211 , A61N1/08
摘要： Techniques for providing an indication of coupling between medical devices are disclosed. For example, when a programming device and a telemetry module are coupled, the telemetry module provides a first indication, and the programming device provides a second indication substantially similar to the first indication. The indications may be, for example, colors, and different indications may signify communication with different implantable medical devices, programming different therapies, or use of different applications of the programming device.
摘要翻译：公开了用于提供医疗装置之间的耦合指示的技术。例如，当编程设备和遥测模块耦合时，遥测模块提供第一指示，并且编程设备提供基本上类似于第一指示的第二指示。指示可以是例如颜色，并且不同的指示可以表示与不同的可植入医疗设备的通信，编程不同的治疗方法或使用编程设备的不同应用。

8. 发明授权

US09937342B2 Shifting of electrical stimulation electrode combinations among differently sized electrode arrays 有权
公开(公告)号：US09937342B2
公开(公告)日：2018-04-10
申请号：US12110906
申请日：2008-04-28
申请人： Dennis M. Skelton , Joseph J. Nolan , Nathan A. Torgerson , Wende L. Dewing , Todd V. Smith , Shyam Gokaldas , Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher
发明人： Dennis M. Skelton , Joseph J. Nolan , Nathan A. Torgerson , Wende L. Dewing , Todd V. Smith , Shyam Gokaldas , Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher
IPC分类号： A61N1/05 , A61N1/372
CPC分类号： A61N1/0553 , A61N1/0531 , A61N1/0534 , A61N1/37247
摘要： The disclosure provides techniques for parameter-directed shifting of electrical stimulation electrode combinations. An external programmer permits a user to shift electrode combinations, e.g., along the length of a lead or leads. The external programmer accepts shift input and causes an electrical stimulator to shift electrode combinations as indicated by the input. Different sets of electrodes may have different electrode counts. For example, an array of electrodes carried by one lead may have a greater number of electrodes than an array of electrodes carried on another lead. The disclosure provides techniques for shifting electrode combinations among leads with different electrode counts. For example, an external programmer may execute shifts in a series of shift operations, where the number of shift operations along the length of a lead having a greater electrode count is greater than the number of shift steps along the length of a lead having a lesser electrode count.

9. 发明授权

US09259587B2 Shifting between electrode combinations in electrical stimulation device 有权
公开(公告)号：US09259587B2
公开(公告)日：2016-02-16
申请号：US13152870
申请日：2011-06-03
申请人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
发明人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
IPC分类号： A61N1/18 , A61N1/372 , A61N1/36
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36185 , A61N1/37252
摘要： The disclosure is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.

10. 发明授权

US09050471B2 Posture state display on medical device user interface 有权
标题翻译：姿态显示在医疗器械用户界面上
公开(公告)号：US09050471B2
公开(公告)日：2015-06-09
申请号：US12433103
申请日：2009-04-30
申请人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan
发明人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan
IPC分类号： A61N1/37 , A61N1/36 , A61B5/00 , A61N1/372 , G06F19/00 , A61B5/11 , A61N1/365
CPC分类号： A61M5/1723 , A61B5/11 , A61B5/6846 , A61B5/7445 , A61B5/7475 , A61B2562/0219 , A61M2205/502 , A61M2230/005 , A61M2230/62 , A61N1/36071 , A61N1/36132 , A61N1/36135 , A61N1/36139 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/3418 , G16H40/63 , G16H50/20
摘要： The disclosure provides a system that displays a posture state indication to a user. A posture state indication represents the current posture state of the patient, which may be a combination of patient posture and activity. As a patient changes posture and activity throughout a daily routine, a posture state detector may generate a posture state value that may be used to categorize the patient's posture or posture and activity level as one of multiple posture states used to adjust therapy. The posture state may be associated with one of multiple posture state indications that may be presented to the patient. The posture state indication shows the patient the posture state currently detected by the posture state detector. The posture state indication may help the patient to effectively monitor therapy changes due to automatic, semi-automatic or patient-directed therapy adjustments made as a function of posture state.
摘要翻译：本公开提供了向用户显示姿势状态指示的系统。姿势状态指示表示患者的当前姿势状态，其可以是患者姿势和活动的组合。作为患者在整个日常程序中改变姿势和活动，姿势状态检测器可以生成姿势状态值，其可以将患者的姿势或姿势和活动水平分类为用于调整治疗的多个姿势状态之一。姿势状态可以与可以呈现给患者的多个姿势状态指示中的一个相关联。姿势状态指示显示患者姿势状态检测器当前检测到的姿势状态。姿势状态指示可以帮助患者有效地监测由于作为姿势状态的函数而进行的自动，半自动或患者导向的治疗调节的治疗变化。

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