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1. 发明申请

US20050009742A1 Compounds and methods for increasing neurogenesis 有权
公开(公告)号：US20050009742A1
公开(公告)日：2005-01-13
申请号：US10850055
申请日：2004-05-19
申请人： Goran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellstrom , Johan Haggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Ronnholm , Lilian Wikstrom , Olof Zachrisson
发明人： Goran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellstrom , Johan Haggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Ronnholm , Lilian Wikstrom , Olof Zachrisson
IPC分类号： A61K31/675 , A61K38/22 , A61K38/23 , A61K38/26 , A61K38/17 , A61K38/12
CPC分类号： A61K35/30 , A61K31/675 , A61K38/2278 , A61K38/23 , C12N5/0619 , C12N2501/01 , C12N2501/60
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis modulating agents. Novel methods for treating neurological disorders using neurogenesis modulating agents are disclosed.

2. 发明授权

US06969702B2 Compounds and methods for increasing neurogenesis 有权
标题翻译：用于增加神经发生的化合物和方法
公开(公告)号：US06969702B2
公开(公告)日：2005-11-29
申请号：US10850055
申请日：2004-05-19
申请人： Göran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellström , Johan Häggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Rönnholm , Lilian Wikström , Olof Zachrisson
发明人： Göran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellström , Johan Häggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Rönnholm , Lilian Wikström , Olof Zachrisson
IPC分类号： A61K31/675 , A61K38/22 , A61K38/23 , A61K38/26 , A61N37/18 , A61K38/00
CPC分类号： A61K35/30 , A61K31/675 , A61K38/2278 , A61K38/23 , C12N5/0619 , C12N2501/01 , C12N2501/60
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis increasing agents. Novel methods for treating neurological disorders using neurogenesis increasing agents are disclosed.
摘要翻译：本发明涉及通过使神经元组织与神经发生增加剂接触来促进神经发生的方法。公开了使用神经发生增加剂治疗神经障碍的新方法。

3. 发明申请

US20140066318A1 METHOD AND PRODUCT FOR LOCALIZED OR SPATIAL DETECTION OF NUCLEIC ACID IN A TISSUE SAMPLE 有权
标题翻译：在组织样品中局部或空间检测核酸的方法和产品
公开(公告)号：US20140066318A1
公开(公告)日：2014-03-06
申请号：US14111482
申请日：2012-03-13
申请人： Jonas Frisen , Patrik Ståhl , Joakim Lundeberg
发明人： Jonas Frisen , Patrik Ståhl , Joakim Lundeberg
IPC分类号： C12Q1/68
摘要： The present invention relates to methods and products for the localized or spatial detection of nucleic acid in a tissue sample and in particular to a method for localized detection of nucleic acid in a tissue sample comprising: (a) providing an array comprising a substrate on which multiple species of capture probes are directly or indirectly immobilized such that each species occupies a distinct position on the array and is oriented to have a free 3′ end to enable said probe to function as a primer for a primer extension or ligation reaction, wherein each species of said capture probe comprises a nucleic acid molecule with 5′ to 3′: (i) a positional domain that corresponds to the position of the capture probe on the array, and (ii) a capture domain; (b) contacting said array with a tissue sample such that the position of a capture probe on the array may be correlated with a position in the tissue sample and allowing nucleic acid of the tissue sample to hybridize to the capture domain in said capture probes; (c) generating DNA molecules from the captured nucleic acid molecules using said capture probes as extension or ligation primers, wherein said extended or ligated DNA molecules are tagged by virtue of the positional domain; (d) optionally generating a complementary strand of said tagged DNA and/or optionally amplifying said tagged DNA; (e) releasing at least part of the tagged DNA molecules and/or their complements or amplicons from the surface of the array, wherein said part includes the positional domain or a complement thereof; and (f) directly or indirectly analyzing the sequence of the released DNA molecules.
摘要翻译：本发明涉及用于组织样本中核酸的局部或空间检测的方法和产品，特别涉及组织样品中核酸的局部检测方法，包括：（a）提供包含基质的阵列，直接或间接固定多种捕获探针，使得每个物种在阵列上占据不同的位置并且被定向为具有游离的3'末端以使得所述探针能够用作引物延伸或连接反应的引物，其中每个所述捕获探针的种类包括具有5'至3'的核酸分子：（i）对应于阵列上的捕获探针的位置的位置结构域，和（ii）捕获结构域; （b）使所述阵列与组织样品接触，使得阵列上的捕获探针的位置可与组织样品中的位置相关，并允许组织样品的核酸与所述捕获探针中的捕获结构域杂交; （c）使用所述捕获探针作为延伸或连接引物从捕获的核酸分子产生DNA分子，其中所述延伸或连接的DNA分子由于位置结构域而被标记; （d）任选地产生所述标记的DNA的互补链和/或任选地扩增所述标记的DNA; （e）从阵列的表面释放标记的DNA分子和/或其补体或扩增子的至少一部分，其中所述部分包括位置结构域或其互补体; 和（f）直接或间接分析释放的DNA分子的序列。

4. 发明申请

US20050049194A1 Use of ephrins and related molecules to regulate cellular proliferation 审中-公开
标题翻译： ephrins和相关分子的使用调节细胞增殖
公开(公告)号：US20050049194A1
公开(公告)日：2005-03-03
申请号：US10698907
申请日：2003-10-31
申请人： Jonas Frisen , Johan Holmberg
发明人： Jonas Frisen , Johan Holmberg
IPC分类号： A61K38/17 , A61K38/19 , A61K39/395 , C07K14/715 , C12N15/85
CPC分类号： C07K14/715 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0331 , A01K2267/0381 , A61K38/00 , C12N15/8509
摘要： Disclosed are nucleic acids, peptides, proteins, fusion proteins, antibodies, affibodies, and other reagents that disrupt interactions between ephrins and ephrin receptors. Specifically disclosed are reagents comprising soluble ephrins and soluble ephrin receptors. Also disclosed are methods of using these reagents for the increasing or decreasing cellular proliferation, for example, for alleviation, prevention, or treatment of one or more symptoms of a disease or disorder, including a disease or disorder of the gastrointestinal tract, reproductive tract, skin, or hematopoietic system.
摘要翻译：披露的是核酸，肽，蛋白质，融合蛋白，抗体，亲和体和其他试剂，其破坏了ephrins和ephrin受体之间的相互作用。具体公开的是包含可溶性ephrins和可溶性ephrin受体的试剂。还公开了使用这些试剂来增加或减少细胞增殖的方法，例如缓解，预防或治疗疾病或病症的一种或多种症状，包括胃肠道疾病或病症，生殖道，皮肤或造血系统。

5. 发明授权

US10030261B2 Method and product for localized or spatial detection of nucleic acid in a tissue sample 有权
公开(公告)号：US10030261B2
公开(公告)日：2018-07-24
申请号：US14111482
申请日：2012-04-13
申请人： Jonas Frisen , Patrik Ståhl , Joakim Lundeberg
发明人： Jonas Frisen , Patrik Ståhl , Joakim Lundeberg
IPC分类号： C12Q1/6837 , C12Q1/6834 , C40B20/02 , C12Q1/6841 , C12Q1/6844
摘要： The present invention relates to methods and products for the localized or spatial detection of nucleic acid in a tissue sample and in particular to a method for localized detection of nucleic acid in a tissue sample comprising: (a) providing an array comprising a substrate on which multiple species of capture probes are directly or indirectly immobilized such that each species occupies a distinct position on the array and is oriented to have a free 3′ end to enable said probe to function as a primer for a primer extension or ligation reaction, wherein each species of said capture probe comprises a nucleic acid molecule with 5′ to 3′: (i) a positional domain that corresponds to the position of the capture probe on the array, and (ii) a capture domain; (b) contacting said array with a tissue sample such that the position of a capture probe on the array may be correlated with a position in the tissue sample and allowing nucleic acid of the tissue sample to hybridize to the capture domain in said capture probes; (c) generating DNA molecules from the captured nucleic acid molecules using said capture probes as extension or ligation primers, wherein said extended or ligated DNA molecules are tagged by virtue of the positional domain; (d) optionally generating a complementary strand of said tagged DNA and/or optionally amplifying said tagged DNA; (e) releasing at least part of the tagged DNA molecules and/or their complements or amplicons from the surface of the array, wherein said part includes the positional domain or a complement thereof; and (f) directly or indirectly analyzing the sequence of the released DNA molecules.

6. 发明申请

US20090232775A1 Compounds and methods for increasing neurogenesis 审中-公开
标题翻译：用于增加神经发生的化合物和方法
公开(公告)号：US20090232775A1
公开(公告)日：2009-09-17
申请号：US12228207
申请日：2008-08-11
申请人： Goran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellstrom , Johan Haggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Ronnholm , Lilian Wikstrom , Olof Zachrisson
发明人： Goran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellstrom , Johan Haggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Ronnholm , Lilian Wikstrom , Olof Zachrisson
IPC分类号： A61K35/12 , A61K38/23 , C12N5/02
CPC分类号： A61K35/30 , A61K31/675 , A61K38/2278 , A61K38/23 , A61K38/26
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis modulating agents. Novel methods for treating neurological disorders using neurogenesis modulating agents are disclosed.
摘要翻译：本发明涉及通过将神经元组织与神经发生调节剂接触来促进神经发生的方法。公开了使用神经发生调节剂治疗神经障碍的新方法。

7. 发明授权

US07320872B2 Ependymal neural stem cells and method for their isolation 有权
标题翻译：室管膜神经干细胞及其分离方法
公开(公告)号：US07320872B2
公开(公告)日：2008-01-22
申请号：US10183728
申请日：2002-06-27
申请人： Ann Marie Janson , Jonas Frisen , Clas Johansson , Stefan Momma , Diana Clarke , Ming Zhao , Urban Lendahl , Kioumars Delfani
发明人： Ann Marie Janson , Jonas Frisen , Clas Johansson , Stefan Momma , Diana Clarke , Ming Zhao , Urban Lendahl , Kioumars Delfani
IPC分类号： G01N33/567
CPC分类号： C12N5/0623 , A61K35/12
摘要： The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis transmembrane conductance regulator), and which cell also comprises at least one cilium. The invention also relates to preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells, in vitro and in vivo assays based thereon and various other uses of the novel ependymal cells according to the invention.
摘要翻译：本发明涉及室管膜神经CNS干细胞，该细胞表达蛋白Notch1以及至少一种选自Notch 2，Notch 3，CAR（跨膜蛋白结合腺病毒）和CFTR囊性纤维化跨膜电导的表面蛋白调节剂），哪个细胞还包含至少一个纤毛。本发明还涉及包括室管膜神经CNS干细胞的药物制剂，其中基于其的体外和体内测定法以及根据本发明的新型室管膜细胞的各种其它用途的制剂。

8. 发明申请

US20080031870A1 Method of proliferation in neurogenic regions 审中-公开
标题翻译：神经源性区域增殖方法
公开(公告)号：US20080031870A1
公开(公告)日：2008-02-07
申请号：US11732203
申请日：2007-04-02
申请人： Johan Holmberg , Jonas Frisen
发明人： Johan Holmberg , Jonas Frisen
IPC分类号： A61K38/17 , A61K39/395 , A61P25/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A01K2267/0318 , A01K2267/0356 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2319/30 , C12N2800/30
摘要： Novel methods for the use of modulators to modulate an activity of a neural stem cell or a neural progenitor cell in vivo or in vitro are provided. The disclosure provides novel methods for the treatment of neurological diseases and disorders.
摘要翻译：提供了使用调节剂在体内或体外调节神经干细胞或神经祖细胞的活性的新方法。本公开提供了治疗神经疾病和病症的新方法。

9. 发明申请

US20060079448A1 Compounds and methods for increasing neurogenesis 审中-公开
公开(公告)号：US20060079448A1
公开(公告)日：2006-04-13
申请号：US11288495
申请日：2005-11-28
申请人： Goran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellstrom , Johan Haggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Ronnholm , Lilian Wikstrom , Olof Zachrisson
发明人： Goran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellstrom , Johan Haggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Ronnholm , Lilian Wikstrom , Olof Zachrisson
IPC分类号： A61K38/22 , A61K38/23
CPC分类号： A61K35/30 , A61K31/675 , A61K38/2278 , A61K38/23 , C12N5/0619 , C12N2501/01 , C12N2501/60
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis modulating agents. Novel methods for treating neurological disorders using neurogenesis modulating agents are disclosed.

10. 发明申请

US20050209142A1 Compounds and methods for increasing neurogenesis 审中-公开
标题翻译：用于增加神经发生的化合物和方法
公开(公告)号：US20050209142A1
公开(公告)日：2005-09-22
申请号：US10993667
申请日：2004-11-19
申请人： Goran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellstrom , Johan Haggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Ronnholm , Lilian Wikstrom , Olof Zachrisson
发明人： Goran Bertilsson , Rikard Erlandsson , Jonas Frisen , Anders Haegerstrand , Jessica Heidrich , Nina Hellstrom , Johan Haggblad , Katarina Jansson , Jarkko Kortesmaa , Per Lindquist , Hanna Lundh , Jacqueline McGuire , Alex Mercer , Karl Nyberg , Amina Ossoinak , Cesare Patrone , Harriet Ronnholm , Lilian Wikstrom , Olof Zachrisson
IPC分类号： A61K35/30 , A61K38/22 , A61K38/23 , A61K38/26
CPC分类号： A61K35/30 , A61K31/675 , A61K38/2278 , A61K38/23 , A61K38/26
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis modulating agents. Novel methods for treating neurological disorders using neurogenesis modulating agents are disclosed.
摘要翻译：本发明涉及通过将神经元组织与神经发生调节剂接触来促进神经发生的方法。公开了使用神经发生调节剂治疗神经障碍的新方法。

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