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1. 发明授权

US5591606A Process for the production of A83543 compounds with Saccharopolyspora spinosa 失效
标题翻译：生产具有Saccharopolyspora spinosa的A83543化合物的方法
公开(公告)号：US5591606A
公开(公告)日：1997-01-07
申请号：US397306
申请日：1995-03-02
申请人： Jan R. Turner , Mary L. B. Huber , Mary C. Broughton , Jon S. Mynderse , James W. Martin
发明人： Jan R. Turner , Mary L. B. Huber , Mary C. Broughton , Jon S. Mynderse , James W. Martin
IPC分类号： A01N43/22 , C07H17/08 , C12P19/62 , C12P19/60
CPC分类号： A01N43/22 , C07H17/08 , C12P19/62 , C12R1/01 , Y10S435/822
摘要： New A83543 components, including fermentation products A83543Q, A83543R, A83543S and A83543T and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones are useful for the preparation of A83543 components. Methods for making the new A83543 components by culture of Saccharopolyspora spinosa NRRL 18823 are provided. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
摘要翻译：新A83543组分，包括发酵产物A83543Q，A83543R，A83543S和A83543T和N-甲基衍生物及其盐可用于防治昆虫和螨虫。假花粉可用于制备A83543组分。提供了通过培养Saccharopolyspora spinosa NRRL 18823制备新的A83543组分的方法。还提供了含有新A83543组分的杀虫剂和灭寄生组合物。

2. 发明授权

US4612330A Antiinflammatory method 失效
标题翻译：抗炎方法
公开(公告)号：US4612330A
公开(公告)日：1986-09-16
申请号：US697997
申请日：1985-02-04
申请人： Jon S. Mynderse , Rosanne Bonjouklian
发明人： Jon S. Mynderse , Rosanne Bonjouklian
IPC分类号： A61K31/557 , A61K31/19
CPC分类号： A61K31/557
摘要： This invention provides a method of treating inflammation and arthritis employing certain prostanoic acid derivatives. Pharmaceutical formulations employing these derivatives are also provided.
摘要翻译：本发明提供了使用某些前列腺酸衍生物治疗炎症和关节炎的方法。还提供了使用这些衍生物的药物制剂。

3. 发明授权

US5670486A A83543 compounds and process for production thereof 失效
标题翻译： A83543化合物及其制备方法
公开(公告)号：US5670486A
公开(公告)日：1997-09-23
申请号：US483440
申请日：1995-06-07
申请人： Jon S. Mynderse , James A. Mabe , Jan R. Turner , Mary L. B. Huber , Mary C. Broughton , Walter M. Nakatsukasa , Lawrence Creemer , Herbert A. Kirst , James W. Martin
发明人： Jon S. Mynderse , James A. Mabe , Jan R. Turner , Mary L. B. Huber , Mary C. Broughton , Walter M. Nakatsukasa , Lawrence Creemer , Herbert A. Kirst , James W. Martin
IPC分类号： A01N43/22 , C07H15/20 , C07H17/08 , C12P19/62 , A61K31/71 , C07H17/04
CPC分类号： C07H17/08 , A01N43/22 , C12P19/62 , C12R1/01 , Y10S424/08 , Y10S424/10 , Y10S435/822
摘要： New A83543 components, including fermentation products A83543K, A83543O, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
摘要翻译：包括发酵产物A83543K，A83543O，A83543P，A83543U，A83543V，A83543W和A83543Y和N-甲基衍生物及其盐的新A83543组分可用于防治昆虫和螨虫。新的A83543组分的假脂肪酸可用于制备A83543组分。提供了通过在合适的培养基中培养多孢孢杆菌NRRL 18395，NRRL 18537，NRRL 18538或NRRL 18539或NRRL 18743或NRRL 18719或NRRL 18823来制备新的A83543成分的方法。还提供了含有新A83543组分的杀虫剂和灭寄生组合物。

4. 发明授权

US4675408A Octahydroindolizinepropanoic acids and related compounds as enzyme inhibitors 失效
标题翻译：八氢吲哚丙酸和相关化合物作为酶抑制剂
公开(公告)号：US4675408A
公开(公告)日：1987-06-23
申请号：US871054
申请日：1986-06-05
申请人： Jon S. Mynderse , David S. Fukuda
发明人： Jon S. Mynderse , David S. Fukuda
IPC分类号： C07D455/02 , C07D471/04 , C07D209/02 , C07D221/00
CPC分类号： C07D471/04 , C07D455/02
摘要： Octahydro-5-oxoindolizine-6-propanoic acids and octahydro-6-oxopyrido[1,2-a]pyridine-7-propanoic acids, the decarboxy and related ester and perhydro derivatives thereof inhibit angiotensin I converting enzyme and are hypotensive agents. Hydrogenation of A58365 factors A and B, obtained by culturing Streptomyces chromofuscus, provides the ACE inhibitors. Also provided are O-acyl and O-sulfonyl derivatives of A and B factors which are useful in preparing deoxy factors A and B via hydrogenolysis.
摘要翻译：八氢-5-氧代二氢吲哚-6-丙酸和八氢-6-氧代吡啶并[1,2-a]吡啶-7-丙酸，脱羧及其相关酯和全氢衍生物抑制血管紧张素I转化酶，是降血糖药。通过培养链霉菌（Streptomyces chromofuscus）获得的A58365因子A和B的氢化提供了ACE抑制剂。还提供了A和B因子的O-酰基和O-磺酰基衍生物，其可用于通过氢解制备脱氧因子A和B.

5. 发明授权

US5631155A Saccharopolyspora spinosa strain 失效
标题翻译：多孢菌多孢菌菌株
公开(公告)号：US5631155A
公开(公告)日：1997-05-20
申请号：US484462
申请日：1995-06-07
申请人： Jan R. Turner , Mary L.B. Huber , Mary C. Broughton , Jon S. Mynderse , James W. Martin
发明人： Jan R. Turner , Mary L.B. Huber , Mary C. Broughton , Jon S. Mynderse , James W. Martin
IPC分类号： A01N43/22 , C07H17/08 , C12P19/62 , C12N1/20
CPC分类号： A01N43/22 , C07H17/08 , C12P19/62 , C12R1/01 , Y10S435/822
摘要： New A83543 components, including fermentation products A83543Q, A83543R, A83543S and A83543T and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones are useful for the preparation of A83543 components. Methods for making the new A83543 components by culture of Saccharopolyspora spinosa NRRL 18823 are provided. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
摘要翻译：包括发酵产物A83543Q，A83543R，A83543S和A83543T和N-甲基衍生物及其盐的新A83543组分可用于防治昆虫和螨虫。假花粉可用于制备A83543组分。提供了通过培养Saccharopolyspora spinosa NRRL 18823制备新的A83543组分的方法。还提供了含有新A83543组分的杀虫剂和灭寄生组合物。

6. 发明授权

US5028590A Derivatives of A54145 cyclic peptides 失效
标题翻译： A54145环肽衍生物
公开(公告)号：US5028590A
公开(公告)日：1991-07-02
申请号：US179929
申请日：1988-04-11
申请人： David S. Fukuda , Jon S. Mynderse
发明人： David S. Fukuda , Jon S. Mynderse
IPC分类号： A61K38/00 , C07K7/08
CPC分类号： C12R1/54 , C07K7/08 , A61K38/00 , Y02P20/55
摘要： A new group of cyclic peptide derivatives, the A54145 cyclic peptide derivatives, which have the general formula: ##STR1## wherein: R is C.sub.8 -C.sub.18 -alkyl, optionally substituted C.sub.8 -C.sub.18 -alkanoyl or C.sub.8 -C.sub.18 -alkenoyl;(R,R.sup.2)-Trp represents a group of formula ##STR2## (Lys-R.sup.1) represents --NH(CH.sub.2).sub.4 CH(NHR.sup.1)CO--; R.sup.1 is hydrogen or an amino-protecting group; andR.sup.2 is hydrogen; orR and R.sup.2, taken together, represent a C.sub.8 -C.sub.18 -alkylidene group;X is Ile or Val; andY is Glu or 3-MG;provided that: 1) when R.sup.1 =H, X=Ile and Y=Glu or 3-MG, R cannot be 8-methylnonanoyl, 8-methyldecanoyl or n-decanoyl; 2) when R.sup.1 =H, X=Val and Y=3-MG, R cannot be 8-methyldecanoyl; and 3) when R.sup.1 =H, X=Val and Y=Glu, R cannot be 8-methylnonanoyl; and 4) when R.sup.1 is an amino protecting group, R cannot be 8-methylnonanoyl, 8-methyldecanoyl, or n-decanoyl; and their salts are antibacterial agents or intermediates to such agents. Formula 1 compounds wherein R.sup.2 is hydrogen improve growth perforamnce in animals; thus, feed compositions for promoting growth in animals such as poultry and methods for increasing growth in animals using these compositions, are also provided.
摘要翻译：具有以下通式的新一组环肽衍生物A54145环肽衍生物：（R，R 2）TrpGlu（HO）Asn 1 + TR＆lt; IMAGE＆gt;其中：R为C 8 -C 18烷基，任选取代的C 8 - C18-烷酰基或C8-C18-烯酰基; （R，R 2）-Trp表示式（A 1-R 1）表示-NH（CH 2）4 CH（NHR 1）CO-的基团。 R1是氢或氨基保护基; R2是氢; 或R 1和R 2一起代表C 8 -C 18亚烷基; X是Ile或Val; Y为Glu或3-MG; 条件是：1）当R1 = H，X = Ile，Y = Glu或3-MG时，R不能是8-甲基壬酰基，8-甲基癸酰基或正癸酰基; 2）当R1 = H，X = Val和Y = 3-MG时，R不能是8-甲基癸酰基; 和3）当R1 = H，X = Val和Y = Glu时，R不能是8-甲基壬酰基; 和4）当R 1是氨基保护基时，R不能是8-甲基壬酰基，8-甲基癸酰基或正癸酰基; 并且它们的盐是这种试剂的抗菌剂或中间体。其中R2是氢的式1化合物改善动物中的生长穿孔; 因此，还提供了用于促进动物如家禽生长的饲料组合物和使用这些组合物增加动物生长的方法。

7. 发明授权

US4870185A Hapalindoles 失效
公开(公告)号：US4870185A
公开(公告)日：1989-09-26
申请号：US908746
申请日：1986-09-18
申请人： Rosanne Bonjouklian , Richard E. Moore , Jon S. Mynderse , Gregory M. L. Patterson , Tim A. Smitka
发明人： Rosanne Bonjouklian , Richard E. Moore , Jon S. Mynderse , Gregory M. L. Patterson , Tim A. Smitka
IPC分类号： A61K31/425 , A61K31/40 , A61K31/403 , A61K31/404 , A61P31/04 , A61P31/10 , C07D209/14 , C07D209/58 , C07D209/90 , C07D405/04 , C07D513/06 , C07D513/10 , C12P17/10 , C12P17/16 , C12P17/18 , C12R1/91
CPC分类号： C07D405/04 , C07D209/14 , C07D209/90 , C07D513/10 , C12P17/10 , C12P17/185
摘要： New alkaloids called hapalindoles J-Q and T-V, which are antibacterial and antifungal agents, and methods of preparing these alkaloids by culturing the blue-green alga Hapalosiphon fontinalis ATCC 39694, are provided.
摘要翻译：提供了称为hapalindoles J-Q和T-V的新生物碱，其为抗菌和抗真菌剂，以及通过培养蓝绿藻Hapalosiphon fontinalis ATCC 39694制备这些生物碱的方法。

8. 发明授权

US4594431A Octahydroindolizinepropanoic acids and related compounds as enzyme inhibitors 失效
标题翻译：八氢吲哚丙酸和相关化合物作为酶抑制剂
公开(公告)号：US4594431A
公开(公告)日：1986-06-10
申请号：US519360
申请日：1983-08-01
申请人： Jon S. Mynderse , David S. Fukuda
发明人： Jon S. Mynderse , David S. Fukuda
IPC分类号： A61K31/435 , A61P9/12 , C07D455/02 , C07D471/04 , C12N9/99 , C12P17/18 , C12R1/465 , C07D209/00 , C07D221/00
CPC分类号： C07D471/04 , C07D455/02
摘要： Octahydro-5-oxoindolizine-6-propanoic acids and octahydro-6-oxopyrido[1,2-A]pyridine-7-propanoic acids, the decarboxy and related ester and perhydro derivatives thereof inhibit angiotensin I converting enzyme and are hypotensive agents. Hydrogenation of A58365 factors A and B, obtained by culturing Streptomyces chromofuscus, provides the ACE inhibitors. Also provided are O-acyl and O-sulfonyl derivatives of A and B factors which are useful in preparing deoxy factors A and B via hydrogenolysis.
摘要翻译：八氢-5-氧代二氢吲哚-6-丙酸和八氢-6-氧代吡啶并[1,2-A]吡啶-7-丙酸，其脱羧基及其相关酯和全氢衍生物抑制血管紧张素I转化酶，并且是降血糖药。通过培养链霉菌（Streptomyces chromofuscus）获得的A58365因子A和B的氢化提供了ACE抑制剂。还提供A和B因子的O-酰基和O-磺酰基衍生物，其可用于通过氢解制备脱氧因子A和B.

9. 发明授权

US5840861A A83543 compounds and process for production thereof 失效
标题翻译： A83543化合物及其制备方法
公开(公告)号：US5840861A
公开(公告)日：1998-11-24
申请号：US385497
申请日：1995-02-08
申请人： Jon S. Mynderse , Mary C. Broughton , Walter M. Nakatsukasa , James A. Mabe , Jan R. Turner , Lawrence Creemer , Mary L. B. Huber , Herbert A. Kirst , James W. Martin
发明人： Jon S. Mynderse , Mary C. Broughton , Walter M. Nakatsukasa , James A. Mabe , Jan R. Turner , Lawrence Creemer , Mary L. B. Huber , Herbert A. Kirst , James W. Martin
IPC分类号： A01N43/22 , C07H15/20 , C07H17/08 , C12P19/62 , C07H17/04 , A61K31/70
CPC分类号： C07H17/08 , A01N43/22 , C12P19/62 , C12R1/01 , Y10S424/08 , Y10S424/10 , Y10S435/822
摘要： New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
摘要翻译：包括发酵产物A83543K，A835430，A83543P，A83543U，A83543V，A83543W和A83543Y和N-甲基衍生物及其盐的新A83543组分可用于防治昆虫和螨虫。新的A83543组分的假脂肪酸可用于制备A83543组分。提供了通过在合适的培养基中培养多孢孢杆菌NRRL 18395，NRRL 18537，NRRL 18538或NRRL 18539或NRRL 18743或NRRL 18719或NRRL 18823来制备新的A83543成分的方法。还提供了含有新A83543组分的杀虫剂和灭寄生组合物。

10. 发明授权

US5670364A A83543 compounds and process for production thereof 失效
标题翻译： A83543化合物及其制备方法
公开(公告)号：US5670364A
公开(公告)日：1997-09-23
申请号：US474026
申请日：1995-06-07
申请人： Jon S. Mynderse , James A. Mabe , Jan R. Turner , Mary L. B. Huber , Mary C. Broughton , Walter M. Nakatsukasa , Lawrence Creemer , Herbert A. Kirst , James W. Martin
发明人： Jon S. Mynderse , James A. Mabe , Jan R. Turner , Mary L. B. Huber , Mary C. Broughton , Walter M. Nakatsukasa , Lawrence Creemer , Herbert A. Kirst , James W. Martin
IPC分类号： A01N43/22 , C07H15/20 , C07H17/08 , C12P19/62 , C12N1/20 , A61K31/71 , C07H17/04
CPC分类号： C07H17/08 , A01N43/22 , C12P19/62 , C12R1/01 , Y10S424/08 , Y10S424/10 , Y10S435/822
摘要： New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
摘要翻译：包括发酵产物A83543K，A835430，A83543P，A83543U，A83543V，A83543W和A83543Y和N-甲基衍生物及其盐的新A83543组分可用于防治昆虫和螨虫。新的A83543组分的假脂肪酸可用于制备A83543组分。提供了通过在合适的培养基中培养多孢子虫NRRL 18395，NRRL 18537，NRRL 18538或NRRL 18539或NRRL 18743或NRRL 18719或NRRL 18823来制备新的A83543成分的方法。还提供了含有新A83543组分的杀虫剂和灭寄生组合物。

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