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1. 发明申请

US20130259898A1 Vaccine Composition 审中-公开
标题翻译：疫苗组成
公开(公告)号：US20130259898A1
公开(公告)日：2013-10-03
申请号：US13876089
申请日：2010-11-09
申请人： Megan Macleod , Amy McKee , John W. Kappler , Philippa Marrack
发明人： Megan Macleod , Amy McKee , John W. Kappler , Philippa Marrack
IPC分类号： A61K39/235 , A61K39/015 , A61K39/02 , A61K39/002 , A61K39/12 , A61K39/145
CPC分类号： A61K39/39 , A61K39/00 , A61K39/002 , A61K39/015 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/235 , A61K2039/55505 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , Y02A50/412
摘要： Disclosed are compositions and the use of the compositions for protection against pathogens comprising an isolated internal pathogenic protein, a TLR agonist and an aluminum salt.
摘要翻译：公开了组合物和组合物用于防止包含分离的内部致病性蛋白质，TLR激动剂和铝盐的病原体的用途。

2. 发明申请

US20120128646A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE DISEASE 审中-公开
标题翻译：治疗自身免疫疾病的方法和组合
公开(公告)号：US20120128646A1
公开(公告)日：2012-05-24
申请号：US13147921
申请日：2010-02-16
申请人： Kathryn Haskins , Thomas Delong , John W. Kappler , Brian Stadinski , Nichole Reisdorph , Rick Reisdorph
发明人： Kathryn Haskins , Thomas Delong , John W. Kappler , Brian Stadinski , Nichole Reisdorph , Rick Reisdorph
IPC分类号： A61K38/02 , C07K7/08 , A61P3/10 , G01N33/566 , A61K31/715 , A61K35/14 , C07K2/00 , C12Q1/02
CPC分类号： C07K14/505 , A61K38/00 , C07K14/575 , G01N33/6893 , G01N2800/042
摘要： The present invention is related to the development and treatment of autoimmune disease. Autoimmune diseases can result from tissue damage caused by the activation of autoreactive T cells by autoantigens. For example, peptide fragments of naturally occurring proteins (i.e., for example, chromogranin A) may activate autoreactive T cells that result in the destruction of pancreatic β islet cells, possibly by the release of inflammatory cytokines (i.e., for example, interferon-γ). One naturally occurring biologically active chromogranin A peptide fragment, WE14, may comprise a diabetogenic autoantigen. Truncation and extension analysis of WE14 indicates that the stimulating binding register of WE14 occupies only half of the mouse IAg7 peptide binding groove, leaving positions p1 to p4 empty. Inhibition of autoantigen-autoreactive T cell binding may provide therapeutic as well a prophylactic treatments for autoimmune diseases
摘要翻译：本发明涉及自身免疫性疾病的发展和治疗。自身免疫性疾病可以由自身抗原激活自身反应性T细胞引起的组织损伤引起。例如，天然存在的蛋白质（即，例如嗜铬粒蛋白A）的肽片段可能激活导致胰腺BGF破坏的自身反应性T细胞; 胰岛细胞，可能通过释放炎性细胞因子（例如，干扰素-γ）。一种天然存在的生物活性嗜铬粒蛋白A肽片段WE14可以包含致糖基自身抗原。 WE14的截断和延伸分析表明，WE14的刺激结合寄存器仅占小鼠IAg7肽结合槽的一半，使位置p1至p4空。自身抗原 - 自身反应性T细胞结合的抑制可以提供治疗性以及自身免疫性疾病的预防性治疗

3. 发明授权

US07169570B2 Method to identify regulators of cellular activation using Bcl10 有权
标题翻译：使用Bcl10鉴定细胞活化调节剂的方法
公开(公告)号：US07169570B2
公开(公告)日：2007-01-30
申请号：US10795157
申请日：2004-03-04
申请人： Brian C. Schaefer , Philippa Marrack , John W. Kappler
发明人： Brian C. Schaefer , Philippa Marrack , John W. Kappler
IPC分类号： C12Q1/02 , G01N33/53 , G01N33/68
CPC分类号： G01N33/5041 , G01N33/5035 , G01N33/5047
摘要： Disclosed are methods for evaluating the activation of Bcl10 in a cell in response to a putative stimulus, as well as methods for evaluating or identifying a regulatory compound which regulates activation of Bcl10-mediated signal transduction. These methods utilize the discovery of the activation-dependent formation in a cell of Bcl10 aggregates in a cell.
摘要翻译：公开了用于评估响应于推定的刺激的细胞中Bcl10的活化的方法，以及用于评估或鉴定调节Bcl10介导的信号转导活化的调节化合物的方法。这些方法利用细胞中Bcl10聚集体的细胞中活化依赖性形成的发现。

4. 发明授权

US5820866A Product and process for T cell regulation 失效
标题翻译： T细胞调节的产物和方法
公开(公告)号：US5820866A
公开(公告)日：1998-10-13
申请号：US207481
申请日：1994-03-04
申请人： John W. Kappler , Philippa Marrack
发明人： John W. Kappler , Philippa Marrack
IPC分类号： C12N15/09 , A61K35/12 , A61K35/18 , A61K39/00 , A61K48/00 , A61P37/00 , C07K14/47 , C07K14/74 , C07K14/77 , C07K14/80 , C07K19/00 , C12N5/10 , C12N15/85 , A61K39/385
CPC分类号： C07K14/80 , C07K14/70539 , C07K14/77 , C12N15/8509 , A01K2217/05 , A01K2217/30 , A01K2267/0325 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a product and process for regulating the activity of T cells using major histocompatibility complexes (MHC) stably linked to antigenic peptides. Disclosed is an antigenic peptide covalently linked to a major histocompatibility complex (MHC) protein by a novel linker, thereby enabling the formation of a stable peptide-MHC complex, alone or in combination with additional MHC protein chains, capable of being recognized by a T cell receptor (TCR). Also disclosed is a nucleic molecule having a sequence encoding a Peptide-L-MHC molecule comprising an antigenic peptide joined by a linker to an MHC segment. The invention is additionally directed to formulations comprising an antigenic peptide joined by a linker to an MHC segment anchored in a lipid-containing substrate. Pharmaceutical reagents are also disclosed which contain an antigenic peptide joined by a linker to an MHC segment combined with a suitable carrier that is capable of presenting the Peptide-L-MHC molecule so that it is capable of being recognized by a T cell receptor.
摘要翻译：本发明涉及使用与抗原肽稳定连接的主要组织相容性复合物（MHC）来调节T细胞的活性的产物和方法。公开了通过新的接头共价连接到主要组织相容性复合物（MHC）蛋白的抗原肽，从而能够单独或与额外的MHC蛋白链组合形成稳定的肽-MHC复合物，其能够被T 细胞受体（TCR）还公开了具有编码肽-L-MHC分子的序列的核酸分子，其包含通过接头连接到MHC片段的抗原肽。本发明另外涉及包含通过接头连接到锚定在含脂质底物中的MHC区段的抗原肽的制剂。还公开了药物试剂，其含有通过接头连接到与能够呈递肽-L-MHC分子的合适载体的MHC区段的抗原肽，使得其能够被T细胞受体识别。

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