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1. 发明申请

US20090136561A1 Non-peptidyl agents with pHSP20-like activity, and uses thereof 审中-公开
标题翻译：具有pHSP20-样活性的非肽基试剂及其应用
公开(公告)号：US20090136561A1
公开(公告)日：2009-05-28
申请号：US12288458
申请日：2008-10-20
申请人： Moritz von Rechenberg , John M. Peltier , Sudhir R. Sahasrabudhe , Srdjan Askovic , Robert Selliah , Thomas Zarembinski
发明人： Moritz von Rechenberg , John M. Peltier , Sudhir R. Sahasrabudhe , Srdjan Askovic , Robert Selliah , Thomas Zarembinski
IPC分类号： A61L27/54 , A61K31/352 , A61K31/47 , A61K31/4409 , C12N5/00 , A61P21/00 , C12Q1/02 , C07D215/12 , C07D311/02 , C07D213/56
CPC分类号： A61K31/00 , A61K31/352 , A61K31/433 , A61K31/4409
摘要： The present invention provides compositions and methods for modulating smooth muscle cells. The present invention also provides methods of identifying small molecule candidate therapeutic agents for modulating smooth muscle.
摘要翻译：本发明提供调节平滑肌细胞的组合物和方法。本发明还提供鉴定用于调节平滑肌的小分子候选治疗剂的方法。

2. 发明授权

US08518959B2 Quinoxaline derivatives as antitumor agents 失效
标题翻译：喹喔啉衍生物作为抗肿瘤剂
公开(公告)号：US08518959B2
公开(公告)日：2013-08-27
申请号：US11883092
申请日：2006-01-25
申请人： Robert R. Becklin , Cindy Lou Chepanoske , John M. Peltier , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah , Keith Simmon , Brent R. Stockwell , Raj Gopal Venkat , Moritz von Rechenberg , Eugene Y. Zhen
发明人： Robert R. Becklin , Cindy Lou Chepanoske , John M. Peltier , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah , Keith Simmon , Brent R. Stockwell , Raj Gopal Venkat , Moritz von Rechenberg , Eugene Y. Zhen
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： A61K31/495 , C07D239/90 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/6872
摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.
摘要翻译：本发明涉及筛选结合配偶体，特别是结合配偶体对于erastin的生物学活性（例如VDAC如VDAC3）的生物学活性的方法。本发明还提供了有效杀死癌细胞与erastin及相关化合物或衍生物的试剂和方法。

3. 发明申请

US20090214465A1 Quinoxaline Derivatives as Antitumor Agents 失效
标题翻译：喹喔啉衍生物作为抗肿瘤剂
公开(公告)号：US20090214465A1
公开(公告)日：2009-08-27
申请号：US11883092
申请日：2006-01-25
申请人： Robert R. Becklin , Cindy Lou Chepanoske , John M. Peltier , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah , Keith Simmon , Brent R. Stockwell , Raj Gopal Venkat , Moritz von Rechenberg , Eugene Y. Zhen
发明人： Robert R. Becklin , Cindy Lou Chepanoske , John M. Peltier , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah , Keith Simmon , Brent R. Stockwell , Raj Gopal Venkat , Moritz von Rechenberg , Eugene Y. Zhen
IPC分类号： A61K38/20 , A61K31/496 , A61K38/21 , A61K39/395 , C12N5/00 , C07D239/72 , C12Q1/68 , C12Q1/02 , G01N33/53 , A61K38/16 , A61K31/7052 , C07D243/08 , C07D403/02 , A61K31/551 , A61K31/55 , A61P35/00
CPC分类号： A61K31/495 , C07D239/90 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/6872
摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.
摘要翻译：本发明涉及筛选结合配偶体，特别是结合配偶体对于erastin的生物学活性（例如VDAC如VDAC3）的生物学活性的方法。本发明还提供了有效杀死癌细胞与erastin及相关化合物或衍生物的试剂和方法。

4. 发明申请

US20080201095A1 Method for Calibrating an Analytical Instrument 审中-公开
标题翻译：校准仪器的方法
公开(公告)号：US20080201095A1
公开(公告)日：2008-08-21
申请号：US12030039
申请日：2008-02-12
申请人： Ping F. Yip , Brian C. Mansfield , John M. Peltier , Paolo Lecchi , Greg P. Bertenshaw , Wesley S. Wiggins
发明人： Ping F. Yip , Brian C. Mansfield , John M. Peltier , Paolo Lecchi , Greg P. Bertenshaw , Wesley S. Wiggins
IPC分类号： G01D18/00
CPC分类号： G01N21/274 , H01J49/0009
摘要： Methods are provided for calibrating analytical instruments that comprise a quantitative device, such as spectrometers, particularly where a complex mixture is analyzed over a broad spectral range. Associated computer and analytical systems as well as software are also provided.
摘要翻译：提供了用于校准包含定量装置（如光谱仪）的分析仪器的方法，特别是在宽光谱范围内分析复杂混合物的情况下。还提供相关的计算机和分析系统以及软件。

5. 发明授权

US07825227B2 Method for purification of a protein complex and identification of its components 失效
标题翻译：蛋白质复合物的纯化方法及其成分的鉴定
公开(公告)号：US07825227B2
公开(公告)日：2010-11-02
申请号：US10984958
申请日：2004-11-09
申请人： John J. Boniface , Vladimir Kery , John M. Peltier , Paul B. Robbins , Justin Savage , Moritz Von Rechenberg
发明人： John J. Boniface , Vladimir Kery , John M. Peltier , Paul B. Robbins , Justin Savage , Moritz Von Rechenberg
IPC分类号： A23J1/00 , C12P21/04
CPC分类号： C07K5/1021 , C07K1/22 , C07K5/101
摘要： The present invention provides a method for purifying a protein complex and the components comprising the complex from a cell, a cell or tissue lysate or a whole organism by employing a combined set of affinity tags of high affinity, specificity and ease of elution. The method involves using a protein or a peptide modified to contain one or more affinity tags separated by one or more specific protease cleavage sites to isolate any interacting proteins or fragments thereof. Specifically exemplified is a method employing a modified bait containing AviTag or GST and a removal tag of His6 hexapeptide positioned proximal to the bait such that any excess bait can be efficiently removed from the purified complex yielding enriched interacting proteins prior to subjecting the complex for further identification of individual components. The identification of the proteins or fragments thereof contained in the protein complex will provide new targets for the identification of new pharmaceuticals and diagnostic tools.
摘要翻译：本发明提供一种通过使用高亲和力，特异性和容易洗脱的组合的一组亲和标签来纯化蛋白质复合物和包含来自细胞，细胞或组织裂解物或整个生物体的复合物的组分的方法。所述方法包括使用经修饰的蛋白质或肽含有由一个或多个特异性蛋白酶切割位点分离的一个或多个亲和标签，以分离任何相互作用的蛋白质或其片段。具体举例说明了使用含有AviTag或GST的修饰诱饵和位于诱饵附近的His6六肽的去除标签的方法，使得任何过量的诱饵可以在将复合物进一步鉴定之前从纯化的复合物中有效地除去产生富集的相互作用蛋白质的单个组件。包含在蛋白质复合物中的蛋白质或其片段的鉴定将为鉴定新的药物和诊断工具提供新的目标。

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