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1. 发明授权

US08298543B2 Identification and application of antibiotic synergy 有权
标题翻译：鉴定和应用抗生素协同作用
公开(公告)号：US08298543B2
公开(公告)日：2012-10-30
申请号：US13102856
申请日：2011-05-06
申请人： Vickie Brown-Driver , Kedar GC , John M. Finn , Robert Haselbeck , Mark Hilgers , Karen Shaw , Mark Stidham
发明人： Vickie Brown-Driver , Kedar GC , John M. Finn , Robert Haselbeck , Mark Hilgers , Karen Shaw , Mark Stidham
IPC分类号： A61K31/00 , A61K31/43 , A61K39/00
CPC分类号： A61K31/43 , A61K31/545 , A61K39/40 , A61K45/06 , Y02A50/469 , Y02A50/47 , Y02A50/482 , Y02A50/484 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a β-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS. Further provided is a method of discovering synergists for antibiotics including: a) expressing in a cell an antisense nucleic acid against a nucleic acid encoding a gene product so as to reduce the activity or amount of the gene product in the cell, thereby producing a cell sensitized to an antibiotic; b) characterizing the sensitization of the cell to the antibiotic and selecting pairs of antibiotics and genes that result in antibiotic efficacy at one-fifth or less the concentration required in the absence of the antisense gene; c) screening for chemical compounds that inhibit the gene product corresponding to the selected synergistic gene; and d) selecting or creating chemical analogs that inhibit the gene product corresponding to the selected synergistic gene such that the inhibition occurs in the bacteria.
摘要翻译：本发明提供了一种可用于治疗人和动物细菌感染的药物组合物，其包括对有需要的人或动物施用抗生素有效组合的β-内酰胺抗生素和任何细菌肽聚糖生物合成酶的抑制剂，特别是 GlmU，GlmU，MurA，MurB，MurC，MurD，MurE，MurF，MurG，MraY，和UppS。进一步提供了发现抗生素增效剂的方法，包括：a）在细胞中表达反义核酸对编码基因产物的核酸，以降低细胞中基因产物的活性或数量，从而产生细胞对抗生素敏感; b）表征细胞对抗生素的致敏性，并选择一组抗生素和基因，其抗生素效力为不存在反义基因所需浓度的五分之一或更低。 c）筛选抑制与所选协同基因相对应的基因产物的化合物; 和d）选择或产生抑制与所选择的协同基因相对应的基因产物的化学类似物，使得在细菌中发生抑制。

2. 发明申请

US20110294774A1 IDENTIFICATION AND APPLICATION OF ANTIBIOTIC SYNERGY 有权
标题翻译：抗生素合成的鉴定与应用
公开(公告)号：US20110294774A1
公开(公告)日：2011-12-01
申请号：US13102856
申请日：2011-05-06
申请人： Vickie Brown-Driver , Kedar GC , John M. Finn , Robert Haselbeck , Mark Hilgers , Karen Shaw , Mark Stidham
发明人： Vickie Brown-Driver , Kedar GC , John M. Finn , Robert Haselbeck , Mark Hilgers , Karen Shaw , Mark Stidham
IPC分类号： A61K31/545 , A61P31/04 , A61K31/43 , A61K31/431 , A61K31/546 , A61K31/5365
CPC分类号： A61K31/43 , A61K31/545 , A61K39/40 , A61K45/06 , Y02A50/469 , Y02A50/47 , Y02A50/482 , Y02A50/484 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a β-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS. Further provided is a method of discovering synergists for antibiotics including: a) expressing in a cell an antisense nucleic acid against a nucleic acid encoding a gene product so as to reduce the activity or amount of the gene product in the cell, thereby producing a cell sensitized to an antibiotic; b) characterizing the sensitization of the cell to the antibiotic and selecting pairs of antibiotics and genes that result in antibiotic efficacy at one-fifth or less the concentration required in the absence of the antisense gene; c) screening for chemical compounds that inhibit the gene product corresponding to the selected synergistic gene; and d) selecting or creating chemical analogs that inhibit the gene product corresponding to the selected synergistic gene such that the inhibition occurs in the bacteria.
摘要翻译：本发明提供了一种可用于治疗人和动物细菌感染的药物组合物，其包括对有需要的人或动物施用抗生素有效组合的β-内酰胺抗生素和任何细菌肽聚糖生物合成酶的抑制剂，特别是 GlmU，GlmU，MurA，MurB，MurC，MurD，MurE，MurF，MurG，MraY和UppS。进一步提供了发现抗生素增效剂的方法，包括：a）在细胞中表达反义核酸对抗编码基因产物的核酸，以降低细胞中基因产物的活性或数量，从而产生细胞对抗生素敏感; b）表征细胞对抗生素的致敏性，并选择一组抗生素和基因，其抗生素效力为不存在反义基因所需浓度的五分之一或更低。 c）筛选抑制与所选协同基因相对应的基因产物的化合物; 和d）选择或产生抑制与所选择的协同基因相对应的基因产物的化学类似物，使得在细菌中发生抑制。

3. 发明授权

US08021665B2 Identification and application of antibiotic synergy 有权
标题翻译：鉴定和应用抗生素协同作用
公开(公告)号：US08021665B2
公开(公告)日：2011-09-20
申请号：US11636379
申请日：2006-12-08
申请人： Vickie Brown-Driver , Kedar GC , John M. Finn , Robert Haselbeck , Mark Hilgers , Karen Shaw , Mark Stidham
发明人： Vickie Brown-Driver , Kedar GC , John M. Finn , Robert Haselbeck , Mark Hilgers , Karen Shaw , Mark Stidham
IPC分类号： A61K31/00 , A61K31/43 , A61K39/00
CPC分类号： A61K31/43 , A61K31/545 , A61K39/40 , A61K45/06 , Y02A50/469 , Y02A50/47 , Y02A50/482 , Y02A50/484 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a β-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS. Further provided is a method of discovering synergists for antibiotics including: a) expressing in a cell an antisense nucleic acid against a nucleic acid encoding a gene product so as to reduce the activity or amount of the gene product in the cell, thereby producing a cell sensitized to an antibiotic; b) characterizing the sensitization of the cell to the antibiotic and selecting pairs of antibiotics and genes that result in antibiotic efficacy at one-fifth or less the concentration required in the absence of the antisense gene; c) screening for chemical compounds that inhibit the gene product corresponding to the selected synergistic gene; and d) selecting or creating chemical analogs that inhibit the gene product corresponding to the selected synergistic gene such that the inhibition occurs in the bacteria.
摘要翻译：本发明提供了一种可用于治疗人和动物细菌感染的药物组合物，其包括对有需要的人或动物施用抗生素有效组合的β-内酰胺抗生素和任何细菌肽聚糖生物合成酶的抑制剂，特别是 GlmU，GlmU，MurA，MurB，MurC，MurD，MurE，MurF，MurG，MraY和UppS。进一步提供了发现抗生素增效剂的方法，包括：a）在细胞中表达反义核酸对抗编码基因产物的核酸，以降低细胞中基因产物的活性或数量，从而产生细胞对抗生素敏感; b）表征细胞对抗生素的致敏性，并选择一组抗生素和基因，其抗生素效力为不存在反义基因所需浓度的五分之一或更低。 c）筛选抑制与所选协同基因相对应的基因产物的化合物; 和d）选择或产生抑制与所选择的协同基因相对应的基因产物的化学类似物，使得在细菌中发生抑制。

4. 发明授权

US5635449A Arylthioalkyl- and arylthioalkenylphosphonic acids and derivatives thereof useful as herbicidal agents 失效
标题翻译：芳硫基烷基和芳硫基链烯基膦酸及其衍生物可用作除草剂
公开(公告)号：US5635449A
公开(公告)日：1997-06-03
申请号：US418985
申请日：1995-04-07
申请人： Charles M. Langevine , John M. Finn
发明人： Charles M. Langevine , John M. Finn
IPC分类号： A01N57/22 , C07F9/38 , C07F9/40 , A01N57/30
CPC分类号： C07F9/4006 , A01N57/22 , C07F9/3808 , C07F9/3826 , C07F9/4015
摘要： The present invention provides arylthioalkyl- and arylthioalkenylphosphonic acids and derivatives thereof having the structural formula I ##STR1## Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
摘要翻译：本发明提供具有结构式I（I）的芳硫基烷基 - 和芳硫基链烯基膦酸及其衍生物。进一步提供了包含用于控制不期望的植物物种的那些化合物的组合物和方法。

5. 发明授权

US5405827A 5-heterocyclic 2-(2-imidazolin-2-yl)pyridines, useful as herbicidal agents 失效
标题翻译： 5-杂环的2-（2-咪唑啉-2-基）吡啶，可用作除草剂
公开(公告)号：US5405827A
公开(公告)日：1995-04-11
申请号：US140776
申请日：1993-10-21
申请人： John M. Finn
发明人： John M. Finn
IPC分类号： A01N43/50 , A01N43/62 , A01N43/74 , A01N43/90 , A01N47/16 , A01N47/38 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D411/04 , C07D411/14 , C07D413/04 , C07D413/14 , C07D471/14
CPC分类号： C07D401/04 , A01N43/50 , A01N43/62 , A01N43/74 , A01N43/90 , A01N47/16 , A01N47/38 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D411/04 , C07D411/14 , C07D413/04 , C07D413/14 , C07D471/14
摘要： 5-Heterocyclic 2-(2-imidazolin-2-yl)pyridine compounds which are effective for the control of undesirable plant species are described. Also described are a method for the herbicidal use of said compounds and a method for their preparation.
摘要翻译：描述了有效控制不期望的植物物种的5-杂环2-（2-咪唑啉-2-基）吡啶化合物。还描述了所述化合物的除草方法及其制备方法。

6. 发明授权

US5252538A (2-imidazolin-2-yl) fused heteropyridine compounds, intermediates for the preparation of and use of said compounds as herbicidal agents 失效
标题翻译：（2-咪唑啉-2-基）稠合的杂吡啶化合物，用于制备和使用所述化合物作为除草剂的中间体
公开(公告)号：US5252538A
公开(公告)日：1993-10-12
申请号：US465569
申请日：1990-01-16
申请人： Barrington Cross , Marinus Los , Robert F. Doehner, Jr. , David W. Ladner , Jerry L. Johnson , Michael E. Jung , Victor M. Kamhi , Shin-Shyong Tseng , John M. Finn , Peter J. Wepplo
发明人： Barrington Cross , Marinus Los , Robert F. Doehner, Jr. , David W. Ladner , Jerry L. Johnson , Michael E. Jung , Victor M. Kamhi , Shin-Shyong Tseng , John M. Finn , Peter J. Wepplo
IPC分类号： A01N43/90 , C07D401/04 , C07D471/04 , C07D491/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/10 , C07D491/14 , C07D491/147 , C07D495/04 , C07D497/04 , C07D498/04 , C07D498/22 , C07D513/04 , A01N43/36 , A01N43/40
CPC分类号： A01N43/90 , C07D401/04 , C07D471/04 , C07D491/04 , C07D491/10 , C07D491/14 , C07D495/04 , C07D497/04 , C07D513/04
摘要： There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
摘要翻译：提供了新颖的（2-咪唑啉-2-基）稠合的杂吡啶化合物和用于制备其的中间体化合物，以及用于控制多种多年生植物物种的方法。

7. 发明授权

US5026859A Alkyl esters of 5-heterocyclic-pyridine-2,3-dicarboxylic acids 失效
标题翻译： 5-杂环 - 吡啶-2,3-二羧酸的烷基酯
公开(公告)号：US5026859A
公开(公告)日：1991-06-25
申请号：US457607
申请日：1989-12-27
申请人： John M. Finn
发明人： John M. Finn
IPC分类号： A01N43/50 , A01N43/62 , A01N43/74 , A01N43/90 , A01N47/16 , A01N47/38 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D411/04 , C07D411/14 , C07D413/04 , C07D413/14 , C07D471/14
CPC分类号： C07D401/04 , A01N43/50 , A01N43/62 , A01N43/74 , A01N43/90 , A01N47/16 , A01N47/38 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D411/04 , C07D411/14 , C07D413/04 , C07D413/14 , C07D471/14
摘要： There are provided alkyl esters of 5-heterocyclic-pyridine-2,3-dicarboxylic acids useful as intermediates for the preparation of highly effective 5-heterocyclic-2-(2-imidazolin-2-yl)pyridine herbicidal agents and methods for the preparation thereof.
摘要翻译：提供了可用作制备高效5-杂环-2-（2-咪唑啉-2-基）吡啶除草剂的中间体的5-杂环 - 吡啶-2,3-二羧酸的烷基酯及其制备方法其中。

8. 发明授权

US06391877B1 Aryl sulfonamides and sulfamide derivatives and uses thereof 失效
标题翻译：芳基磺酰胺和磺酰胺衍生物及其用途
公开(公告)号：US06391877B1
公开(公告)日：2002-05-21
申请号：US09709036
申请日：2000-11-08
申请人： Imadul Islam , Daljit S. Dhanoa , John M. Finn , Ping Du , Charles Gluchowski , Yoon T. Jeon
发明人： Imadul Islam , Daljit S. Dhanoa , John M. Finn , Ping Du , Charles Gluchowski , Yoon T. Jeon
IPC分类号： A61K3118
CPC分类号： C07D405/12 , C07C311/18 , C07C311/29 , C07C311/39 , C07C2601/14 , C07C2602/10 , C07D207/48 , C07D211/96 , C07D215/06 , C07D215/54 , C07D217/26 , C07D241/44
摘要： This invention is directed to novel aryl sulfonamide and sulfamide compounds which bind selectively to and inhibit the activity of the human Y5 receptor. This invention is also related to uses of these compounds for the treatment of feeding disorders such as obesity, anorexia nervosa, bulimia nervosa, and abnormal conditions such as sexual/reproductive disorders, depression, epileptic seizure, hypertension, cerebral hemorrhage, congestive heart failure or sleep disturbances and for the treatment of any disease in which antagonism of a Y5 receptor may be useful.
摘要翻译：本发明涉及新的芳基磺酰胺和磺酰胺化合物，它们选择性地结合并抑制人Y5受体的活性。本发明还涉及这些化合物用于治疗哺乳障碍如肥胖症，神经性厌食症，神经性贪食症和异常病症如性/生殖障碍，抑郁症，癫痫发作，高血压，脑出血，充血性心力衰竭或睡眠障碍和用于治疗任何可能使用Y5受体拮抗作用的疾病。

9. 发明授权

US5225564A 5-heterocyclic 2-(2-imidazolin-2-yl)pyridines, useful as herbicidal agents and methods for the preparation thereof 失效
标题翻译：可用作除草剂的5-杂环2-（2-咪唑啉-2-基）吡啶及其制备方法
公开(公告)号：US5225564A
公开(公告)日：1993-07-06
申请号：US694708
申请日：1991-05-02
申请人： John M. Finn
发明人： John M. Finn
IPC分类号： A01N43/50 , A01N43/62 , A01N43/74 , A01N43/90 , A01N47/16 , A01N47/38 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D411/04 , C07D411/14 , C07D413/04 , C07D413/14 , C07D471/14
CPC分类号： C07D401/04 , A01N43/50 , A01N43/62 , A01N43/74 , A01N43/90 , A01N47/16 , A01N47/38 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D411/04 , C07D411/14 , C07D413/04 , C07D413/14 , C07D471/14
摘要： 5-Heterocyclic 2-(2-imidazolin-2-yl)pyridine compounds which are effective for the control of undesirable plant species are described. Also described are a method for the herbicidal use of said compounds and a method for their preparation.
摘要翻译：描述了有效控制不期望的植物物种的5-杂环2-（2-咪唑啉-2-基）吡啶化合物。还描述了所述化合物的除草方法及其制备方法。

10. 发明申请

US20180274198A1 Device for Securing Covers of Drainage Holes and the Like 审中-公开
公开(公告)号：US20180274198A1
公开(公告)日：2018-09-27
申请号：US15934207
申请日：2018-03-23
申请人： John M. Finn
发明人： John M. Finn
IPC分类号： E02D29/14
CPC分类号： E02D29/1427
摘要： A device for securing a cover having an opening therethrough over a well, drywell, or like structure having an upwardly facing horizontal base surface surrounding a bottom opening of the well includes an upper member positioned on the cover, a lower member positioned horizontally upward against the horizontal base surface, and a connecting rod that operatively connects the upper to the lower member and maintains a tension force between them via the connecting rod to secure the cover in position. A connector on the rod allows the lower member to pivot to a vertical position alongside the rod for insertion through the hole in the cover. In this way, the device can be installed with the cover in situ. The connector also provides translational movement of the lower member along the rod to provide, or remove, the tension. A locking element connected to the rod allows adjusting of the tension.

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