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    • 1. 发明授权
    • Identification and application of antibiotic synergy
    • 鉴定和应用抗生素协同作用
    • US08298543B2
    • 2012-10-30
    • US13102856
    • 2011-05-06
    • Vickie Brown-DriverKedar GCJohn M. FinnRobert HaselbeckMark HilgersKaren ShawMark Stidham
    • Vickie Brown-DriverKedar GCJohn M. FinnRobert HaselbeckMark HilgersKaren ShawMark Stidham
    • A61K31/00A61K31/43A61K39/00
    • A61K31/43A61K31/545A61K39/40A61K45/06Y02A50/469Y02A50/47Y02A50/482Y02A50/484A61K2300/00
    • The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a β-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS. Further provided is a method of discovering synergists for antibiotics including: a) expressing in a cell an antisense nucleic acid against a nucleic acid encoding a gene product so as to reduce the activity or amount of the gene product in the cell, thereby producing a cell sensitized to an antibiotic; b) characterizing the sensitization of the cell to the antibiotic and selecting pairs of antibiotics and genes that result in antibiotic efficacy at one-fifth or less the concentration required in the absence of the antisense gene; c) screening for chemical compounds that inhibit the gene product corresponding to the selected synergistic gene; and d) selecting or creating chemical analogs that inhibit the gene product corresponding to the selected synergistic gene such that the inhibition occurs in the bacteria.
    • 本发明提供了一种可用于治疗人和动物细菌感染的药物组合物,其包括对有需要的人或动物施用抗生素有效组合的β-内酰胺抗生素和任何细菌肽聚糖生物合成酶的抑制剂,特别是 GlmU,GlmU,MurA,MurB,MurC,MurD,MurE,MurF,MurG,MraY,和UppS。 进一步提供了发现抗生素增效剂的方法,包括:a)在细胞中表达反义核酸对编码基因产物的核酸,以降低细胞中基因产物的活性或数量,从而产生细胞 对抗生素敏感; b)表征细胞对抗生素的致敏性,并选择一组抗生素和基因,其抗生素效力为不存在反义基因所需浓度的五分之一或更低。 c)筛选抑制与所选协同基因相对应的基因产物的化合物; 和d)选择或产生抑制与所选择的协同基因相对应的基因产物的化学类似物,使得在细菌中发生抑制。
    • 2. 发明申请
    • IDENTIFICATION AND APPLICATION OF ANTIBIOTIC SYNERGY
    • 抗生素合成的鉴定与应用
    • US20110294774A1
    • 2011-12-01
    • US13102856
    • 2011-05-06
    • Vickie Brown-DriverKedar GCJohn M. FinnRobert HaselbeckMark HilgersKaren ShawMark Stidham
    • Vickie Brown-DriverKedar GCJohn M. FinnRobert HaselbeckMark HilgersKaren ShawMark Stidham
    • A61K31/545A61P31/04A61K31/43A61K31/431A61K31/546A61K31/5365
    • A61K31/43A61K31/545A61K39/40A61K45/06Y02A50/469Y02A50/47Y02A50/482Y02A50/484A61K2300/00
    • The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a β-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS. Further provided is a method of discovering synergists for antibiotics including: a) expressing in a cell an antisense nucleic acid against a nucleic acid encoding a gene product so as to reduce the activity or amount of the gene product in the cell, thereby producing a cell sensitized to an antibiotic; b) characterizing the sensitization of the cell to the antibiotic and selecting pairs of antibiotics and genes that result in antibiotic efficacy at one-fifth or less the concentration required in the absence of the antisense gene; c) screening for chemical compounds that inhibit the gene product corresponding to the selected synergistic gene; and d) selecting or creating chemical analogs that inhibit the gene product corresponding to the selected synergistic gene such that the inhibition occurs in the bacteria.
    • 本发明提供了一种可用于治疗人和动物细菌感染的药物组合物,其包括对有需要的人或动物施用抗生素有效组合的β-内酰胺抗生素和任何细菌肽聚糖生物合成酶的抑制剂,特别是 GlmU,GlmU,MurA,MurB,MurC,MurD,MurE,MurF,MurG,MraY和UppS。 进一步提供了发现抗生素增效剂的方法,包括:a)在细胞中表达反义核酸对抗编码基因产物的核酸,以降低细胞中基因产物的活性或数量,从而产生细胞 对抗生素敏感; b)表征细胞对抗生素的致敏性,并选择一组抗生素和基因,其抗生素效力为不存在反义基因所需浓度的五分之一或更低。 c)筛选抑制与所选协同基因相对应的基因产物的化合物; 和d)选择或产生抑制与所选择的协同基因相对应的基因产物的化学类似物,使得在细菌中发生抑制。
    • 3. 发明授权
    • Identification and application of antibiotic synergy
    • 鉴定和应用抗生素协同作用
    • US08021665B2
    • 2011-09-20
    • US11636379
    • 2006-12-08
    • Vickie Brown-DriverKedar GCJohn M. FinnRobert HaselbeckMark HilgersKaren ShawMark Stidham
    • Vickie Brown-DriverKedar GCJohn M. FinnRobert HaselbeckMark HilgersKaren ShawMark Stidham
    • A61K31/00A61K31/43A61K39/00
    • A61K31/43A61K31/545A61K39/40A61K45/06Y02A50/469Y02A50/47Y02A50/482Y02A50/484A61K2300/00
    • The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a β-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS. Further provided is a method of discovering synergists for antibiotics including: a) expressing in a cell an antisense nucleic acid against a nucleic acid encoding a gene product so as to reduce the activity or amount of the gene product in the cell, thereby producing a cell sensitized to an antibiotic; b) characterizing the sensitization of the cell to the antibiotic and selecting pairs of antibiotics and genes that result in antibiotic efficacy at one-fifth or less the concentration required in the absence of the antisense gene; c) screening for chemical compounds that inhibit the gene product corresponding to the selected synergistic gene; and d) selecting or creating chemical analogs that inhibit the gene product corresponding to the selected synergistic gene such that the inhibition occurs in the bacteria.
    • 本发明提供了一种可用于治疗人和动物细菌感染的药物组合物,其包括对有需要的人或动物施用抗生素有效组合的β-内酰胺抗生素和任何细菌肽聚糖生物合成酶的抑制剂,特别是 GlmU,GlmU,MurA,MurB,MurC,MurD,MurE,MurF,MurG,MraY和UppS。 进一步提供了发现抗生素增效剂的方法,包括:a)在细胞中表达反义核酸对抗编码基因产物的核酸,以降低细胞中基因产物的活性或数量,从而产生细胞 对抗生素敏感; b)表征细胞对抗生素的致敏性,并选择一组抗生素和基因,其抗生素效力为不存在反义基因所需浓度的五分之一或更低。 c)筛选抑制与所选协同基因相对应的基因产物的化合物; 和d)选择或产生抑制与所选择的协同基因相对应的基因产物的化学类似物,使得在细菌中发生抑制。