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1. 发明申请

US20050164998A1 Steroid extraction process from urine sources 有权
标题翻译：来自尿源的类固醇提取过程
公开(公告)号：US20050164998A1
公开(公告)日：2005-07-28
申请号：US11055257
申请日：2005-02-10
申请人： John Lomans , Carmen Leiva-paredes
发明人： John Lomans , Carmen Leiva-paredes
IPC分类号： A61K31/56 , C07J1/00
CPC分类号： A61K31/56 , C07J1/00
摘要： A process in which urine is optionally filtered to remove solid extraneous matter and optionally treated so as to reduce the phenolic content of the urine to give and the resulting fluid is then subjected to a solid extraction of the major concentration steroids content therefrom by a first suitable resin (to yield a first resin laden with major concentration steroids and a minor concentration steroid laden first liquid remainder). The minor concentration steroid liquid remainder is subjected to a solid extraction of the minor concentration steroid content therefrom by a second suitable resin (to yield a second resin laden with minor concentration steroids and a second liquid remainder). The first and second resins laden with their respective steroids are then eluted and the eluates are collected separately and optionally subjected to further purification and chromatographic separations, with each resulting separate collection being analyzed for the steroid content thereof. The separate analyzed materials are dried and stored for recombination in an appropriate manner to meet a desired profile. The ultimate product has very nearly the same steroid components and concentrations from batch to batch.
摘要翻译：其中任选地过滤尿液以去除固体外来物质并任选地处理尿液以减少尿液的酚含量并使所得流体通过第一适合的方式从其中固体提取主要浓度类固醇含量树脂（以产生具有主要浓度类固醇的第一树脂和载有少量固体的第一液体剩余物）。通过第二合适的树脂（稍微浓缩类固醇和第二液体余量）产生次要浓度的类固醇液体残余物从其中提取少量的类固醇含量。然后洗脱含有它们各自类固醇的第一种和第二种树脂，分离收集洗脱液，任选进行进一步纯化和色谱分离，分析每种所得的单独收集物的类固醇含量。将分离的分析的材料干燥并以适当的方式储存以进行重组以满足期望的分布。最终产品具有几乎相同的类固醇成分和浓度从批次到批次。

2. 发明授权

US08349819B2 Steroid extraction process from urine sources 有权
标题翻译：来自尿源的类固醇提取过程
公开(公告)号：US08349819B2
公开(公告)日：2013-01-08
申请号：US11055257
申请日：2005-02-10
申请人： John Lomans , Carmen Leiva-paredes
发明人： John Lomans , Carmen Leiva-paredes
IPC分类号： A01N45/00 , A61K31/56 , A61K35/22 , C07J3/00
CPC分类号： A61K31/56 , C07J1/00
摘要： A process in which urine is optionally filtered to remove solid extraneous matter and optionally treated so as to reduce the phenolic content of the urine to give and the resulting fluid is then subjected to a solid extraction of the major concentration steroids content therefrom by a first suitable resin (to yield a first resin laden with major concentration steroids and a minor concentration steroid laden first liquid remainder). The minor concentration steroid liquid remainder is subjected to a solid extraction of the minor concentration steroid content therefrom by a second suitable resin (to yield a second resin laden with minor concentration steroids and a second liquid remainder). The first and second resins laden with their respective steroids are then eluted and the eluates are collected separately and optionally subjected to further purification and chromatographic separations, with each resulting separate collection being analyzed for the steroid content thereof. The separate analyzed materials are dried and stored for recombination in an appropriate manner to meet a desired profile. The ultimate product has very nearly the same steroid components and concentrations from batch to batch.
摘要翻译：其中任选地过滤尿液以去除固体外来物质并任选地处理尿液以减少尿液的酚含量并使所得流体通过第一适合的方式从其中固体提取主要浓度类固醇含量树脂（以产生具有主要浓度类固醇的第一树脂和载有少量固体的第一液体剩余物）。通过第二合适的树脂（稍微浓缩类固醇和第二液体余量）产生次要浓度的类固醇液体残余物从其中提取少量的类固醇含量。然后洗脱含有它们各自类固醇的第一种和第二种树脂，分离收集洗脱液，任选进行进一步纯化和色谱分离，分析每种所得的单独收集物的类固醇含量。将分离的分析的材料干燥并以适当的方式储存以进行重组以满足期望的分布。最终产品具有几乎相同的类固醇成分和浓度从批次到批次。

3. 发明授权

US06855704B2 Process for isolating conjugated estrogens 有权
标题翻译：分离结合型雌激素的方法
公开(公告)号：US06855704B2
公开(公告)日：2005-02-15
申请号：US10266754
申请日：2002-10-09
申请人： John Lomans , Carmen Leiva-Paredes
发明人： John Lomans , Carmen Leiva-Paredes
IPC分类号： A61K31/56 , C07J1/00
CPC分类号： C07J1/00 , A61K31/56
摘要： The present invention relates to a process for extracting conjugated estrogens from pregnant mare urine. The present invention further relates to a process for obtaining a natural mixture of conjugated estrogens. The mixture of conjugated estrogens can be used to prepare products for estrogen replacement therapy or hormone replacement therapy. More specifically, the process for extracting conjugated estrogens from PMU comprises the steps of (a) contacting a mare urine material (MUM) with a resin to adsorb phenolic components, (b) contacting the phenolics-depleted MUM of step (a) with a resin to adsorb the stone and equilin, the major estrogen components, (c) containing the major estrogen-depleted MUM of step (b) with a resin to adsorb the minor estrogen components, (d) separately desorbing the major estrogen components and the minor estrogen components from the resins used in steps (b) and (c), and (e) separately treating the desorbed material form step (d) to obtain crystals of the major estrogen components and the minor estrogen components.
摘要翻译：本发明涉及一种从怀孕母乳中提取结合性雌激素的方法。本发明还涉及获得共轭雌激素的天然混合物的方法。共轭雌激素的混合物可用于制备用于雌激素替代疗法或激素替代疗法的产品。更具体地说，从PMU中提取结合的雌激素的方法包括以下步骤：（a）使母体尿物质（MUM）与树脂接触以吸附酚类成分，（b）使步骤（a）中的酚类贫化的MUM与树脂吸附石头和平衡，主要雌激素成分，（c）含有步骤（b）的主要雌激素缺乏MUM与树脂吸附少量雌激素组分，（d）分别解吸主要雌激素成分和次要来自步骤（b）和（c）中使用的树脂的雌激素组分，和（e）分别处理脱附的物质形成步骤（d）以获得主要雌激素组分和次要雌激素组分的晶体。

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