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1. 发明申请

US20090052850A1 Micro-well plates and methods of fabricating and selectively blackening the same 审中-公开
标题翻译：微孔板以及制造和选择性地使其变黑的方法
公开(公告)号：US20090052850A1
公开(公告)日：2009-02-26
申请号：US11906314
申请日：2007-10-01
申请人： Loic Barbedette , John Hansson , Richard Strack , Kevin Tabor , Michael Weisser
发明人： Loic Barbedette , John Hansson , Richard Strack , Kevin Tabor , Michael Weisser
IPC分类号： G02B6/04 , C12M1/34 , C12M3/00
CPC分类号： B01L3/50857 , B01L2200/12 , B01L2300/0654 , B01L2300/0819 , B01L2300/168 , G01N21/253 , G01N2201/08
摘要： Well plates adaptable for specimen sampling in the biological, chemical and pharmaceutical sciences are fabricated by dissolving fusedly-retained cores from the cladding material of a fused fiber plate to define a capillary plate including first and second faces and a plurality of through-voids into which fluidic samples may be deposited for analysis. Closed-bottom wells are defined by bonding one of the first and second faces to a base plate or by securing into well-sealing positions over the open ends of selected through-voids optical elements, each of which optical elements exhibits a predetermined optical property. Cladding material including reducible ions is exposed to a reducing atmosphere in order to blacken selected regions of a well plate, thereby enhancing sample analysis by reducing such disadvantageous phenomena as autofluorescence.
摘要翻译：适用于生物，化学和药学科学中样品取样的孔板通过将熔融保留的芯从熔融纤维板的包层材料中溶解来限定包括第一和第二表面的毛细管板和多个通孔，可以沉积流体样品用于分析。通过将第一和第二面之一接合到基板或通过固定到选定的通孔光学元件的开口端上的良好密封位置来限定闭合底部的孔，每个光学元件具有预定的光学特性。包括可还原离子的包层材料暴露于还原气氛中，以使孔板的选定区域变黑，从而通过减少诸如自发荧光的不利现象来增强样品分析。

2. 发明授权

US07229200B1 Light conductive rod elements and light-delivery tool including a base for introducing light into a light conductive rod element 有权
标题翻译：导光杆元件和光输送工具，其包括用于将光引入光导棒元件的基座
公开(公告)号：US07229200B1
公开(公告)日：2007-06-12
申请号：US10976236
申请日：2004-10-27
申请人： Thomas Bender , Anthony Cappabianca , John Hansson , Michael Weisser
发明人： Thomas Bender , Anthony Cappabianca , John Hansson , Michael Weisser
IPC分类号： F21W131/202
CPC分类号： A61C19/004 , G02B6/0008 , G02B6/262
摘要： A light-conductive rod element includes a solid rod-shaped body having a side surface extending along a longitudinal rod axis between a first light-input end and a second light-redirecting end. The rod element is fabricated from a material exhibiting a refractive index greater than the refractive index of air in order to facilitate total internal reflection. The light-redirecting end includes at least a first planar face extending along a first plane definable by a first normal that is pitched with respect to the rod axis such that light propagating by total internal reflection between the first and second ends that impinges on the interface defined by the rod-element material and air at the first planar face is redirected by at least one of (i) reflection and (ii) refraction. Refracted components of light exit the rod body through the first planar face and reflected components of light exit the rod body through the side surface. The rod element is selectively coupleable with a handle that facilitates the selective introduction of light into the light-input end and, in combination with the handle, forms a light-delivery tool for delivering light to a region of interest.
摘要翻译：导光杆元件包括实心棒状体，其具有沿第一光输入端和第二光重定向端之间的纵向杆轴线延伸的侧表面。杆元件由表现出大于空气折射率的折射率的材料制成，以促进全内反射。光重定向端包括至少第一平面，第一平面沿着第一平面延伸，第一平面可由第一法线定义，第一平面相对于杆轴线倾斜，使得通过第一和第二端之间的全内反射传播的光照射在界面由杆元件材料限定并且在第一平面处的空气通过（i）反射和（ii）折射中的至少一个被重定向。光的折射分量通过第一平面而离开棒体，光的反射分量通过侧表面离开棒体。杆元件选择性地与手柄联接，手柄有助于将光选择性地引入光输入端，并且与手柄组合形成用于将光传送到感兴趣区域的光递送工具。

3. 发明授权

US07280727B1 Micro-well and methods of fabricating and selectively blackening the same 有权
标题翻译：微孔以及制造和选择性黑化的方法
公开(公告)号：US07280727B1
公开(公告)日：2007-10-09
申请号：US10935541
申请日：2004-09-07
申请人： Loic Barbedette , John Hansson , Richard Strack , Kevin Tabor , Michael Weisser
发明人： Loic Barbedette , John Hansson , Richard Strack , Kevin Tabor , Michael Weisser
IPC分类号： G02B6/04 , C12M1/34 , C12M3/00
CPC分类号： B01L3/50857 , B01L2200/12 , B01L2300/0654 , B01L2300/0819 , B01L2300/168 , G01N21/253 , G01N2201/08
摘要： Well plates adaptable for specimen sampling in the biological, chemical and pharmaceutical sciences are fabricated by dissolving fusedly-retained cores from the cladding material of a fused fiber plate to define a capillary plate including first and second faces and a plurality of through-voids into which fluidic samples may be deposited for analysis. Closed-bottom wells are defined by bonding one of the first and second faces to a base plate or by securing into well-sealing positions over the open ends of selected through-voids optical elements, each of which optical elements exhibits a predetermined optical property. Cladding material including reducible ions is exposed to a reduction atmosphere in order to blacken selected regions of a well plate, thereby enhancing sample analysis by reducing such disadvantageous phenomena as autofluorescence.
摘要翻译：适用于生物，化学和药学科学中样品取样的孔板通过将熔融保留的芯从熔融纤维板的包层材料中溶解来限定包括第一和第二表面的毛细管板和多个通孔，可以沉积流体样品用于分析。通过将第一和第二面之一接合到基板或通过固定到选定的通孔光学元件的开口端上的良好密封位置来限定闭合底部的孔，每个光学元件具有预定的光学特性。包括可还原离子的包层材料暴露于还原气氛中，以使孔板的选定区域变黑，从而通过减少诸如自发荧光的不利现象来增强样品分析。

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