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1. 发明授权

US08101714B2 Teleost derived antimicrobial polypeptides 有权
标题翻译： Teleost衍生的抗微生物多肽
公开(公告)号：US08101714B2
公开(公告)日：2012-01-24
申请号：US10588417
申请日：2005-02-18
申请人： Donald L. Evans , Harjeet Kaur , Liliana Jaso-Friedmann , John H. Leary, III , Kesavannair Praveen
发明人： Donald L. Evans , Harjeet Kaur , Liliana Jaso-Friedmann , John H. Leary, III , Kesavannair Praveen
IPC分类号： C07K14/00
CPC分类号： C07K14/461 , C12Q1/18 , G01N2333/4603
摘要： The invention is directed to an isolated polypeptide which (a) is obtainable from a teleost; (b) has antimicrobial activity; (c) binds to oligoguanosine and/or CpG (SEQ ID NO:7); (d) comprises 58 strongly basic amino acids selected from the group consisting of K and R; (e) comprises 50 hydrophobic amino acids selected from the group consisting of A, I, L, F, W and V; (f) comprises 50 polar amino acids selected from the group consisting of N, C, Q, S, T and Y and (g) contains 11 lysine-rich motifs and antimicrobial fragments thereof as well as methods for preparing said polypeptides, compositions and libraries comprising said polypeptide(s) and uses of said polypeptide(s), particularly in treating microbial infections. The invention is further directed to a nucleic acid(s) encoding said polypeptide, microarrays comprising said nucleic acid(s) and uses for said nucleic acid(s). Furthermore, the invention is directed to an antibody which birds to the polypeptide of the present invention and uses for said antibodies.
摘要翻译：本发明涉及一种分离的多肽，其（a）可从硬骨肉汤获得; （b）具有抗菌活性; （c）结合寡聚腺苷和/或CpG（SEQ ID NO：7）; （d）包含58个选自K和R的强碱性氨基酸; （e）包含50个选自A，I，L，F，W和V的疏水性氨基酸; （f）包含50个选自N，C，Q，S，T和Y的极性氨基酸，（g）含有富含赖氨酸的11个基序及其抗微生物片段，以及制备所述多肽，组合物和包含所述多肽的文库和所述多肽的用途，特别是用于治疗微生物感染。本发明还涉及编码所述多肽的核酸，包含所述核酸的微阵列和所述核酸的用途。此外，本发明涉及对本发明的多肽的鸟类和用于所述抗体的抗体。

2. 发明申请

US20090311278A1 Novel teleost derived antimicrobial polypeptides 有权
标题翻译：新型超高斯衍生的抗微生物多肽
公开(公告)号：US20090311278A1
公开(公告)日：2009-12-17
申请号：US10588417
申请日：2005-02-18
申请人： Donald L. Evans , Harjeet Kaur , Liliana Jaso-Friedmann , John H. Leary, III , Kesavannair Praveen, III
发明人： Donald L. Evans , Harjeet Kaur , Liliana Jaso-Friedmann , John H. Leary, III , Kesavannair Praveen, III
IPC分类号： A61K39/00 , C07K14/46 , C40B40/10 , C12P21/02 , C07H21/04 , C12N15/63 , C12N1/21 , A61K38/17 , A61K31/7088 , C40B40/08 , C40B30/00
CPC分类号： C07K14/461 , C12Q1/18 , G01N2333/4603
摘要： The invention is directed to an isolated polypeptide which (a) is obtainable from a teleost; (b) has antimicrobial activity; (c) binds to oligoguanosine and/or CpG (SEQ ID NO:7); (d) comprises 58 strongly basic amino acids selected from the group consisting of K and R; (e) comprises 50 hydrophobic amino acids selected from the group consisting of A, I, L, F, W and V; (f) comprises 50 polar amino acids selected from the group consisting of N, C, Q, S, T and Y and (g) contains 11 lysine-rich motifs and antimicrobial fragments thereof as well as methods for preparing said polypeptides, compositions and libraries comprising said polypeptide(s) and uses of said polypeptide(s), particularly in treating microbial infections. The invention is further directed to a nucleic acid(s) encoding said polypeptide, microarrays comprising said nucleic acid(s) and uses for said nucleic acid(s). Furthermore, the invention is directed to an antibody which birds to the polypeptide of the present invention and uses for said antibodies.
摘要翻译：本发明涉及一种分离的多肽，其（a）可从硬骨肉汤获得; （b）具有抗菌活性; （c）结合寡聚腺苷和/或CpG（SEQ ID NO：7）; （d）包含58个选自K和R的强碱性氨基酸; （e）包含50个选自A，I，L，F，W和V的疏水性氨基酸; （f）包含50个选自N，C，Q，S，T和Y的极性氨基酸，（g）含有富含赖氨酸的11个基序及其抗微生物片段，以及制备所述多肽，组合物和包含所述多肽的文库和所述多肽的用途，特别是用于治疗微生物感染。本发明还涉及编码所述多肽的核酸，包含所述核酸的微阵列和所述核酸的用途。此外，本发明涉及对本发明的多肽的鸟类和用于所述抗体的抗体。

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