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    • 1. 发明授权
    • Sterile de-molding apparatus and method
    • 无菌脱模装置及方法
    • US08550799B2
    • 2013-10-08
    • US13311616
    • 2011-12-06
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleGiovanni Rodriguez
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleGiovanni Rodriguez
    • B29C45/17B29C45/44
    • B29C45/1701B29C37/0007B29C45/006B29C45/1753B29C45/40B29C45/42B29C2045/1797B29C2791/005
    • At least one of first and second mold portions defines a mold cavity to receive molten plastic and form therefrom at least one molded part, and is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the mold portions and permitting the passage of a fluid sterilant therein. A fluid sterilant source is connectable in fluid communication with the fluid passageway for introducing the sterilant therein in the open position, contacting with the sterilant the surfaces of the first and second mold portions forming the fluid passageway and located adjacent to the at least one mold cavity, but not contacting an interior surface of a molded part within the mold cavity, to sterilize the exposed mold surfaces and thereby prevent contamination of the molded part.
    • 第一和第二模具部分中的至少一个限定了模腔以接收熔融塑料并从其形成至少一个模制部件,并且可以在(i)用于密封模腔或空腔的闭合位置和相对于另一模制部件 其中至少一部分,以及(ii)在模具部分之间限定流体通道并允许其中的流体灭菌剂通过的打开位置。 流体灭菌剂源可连接到流体通道,用于将灭菌剂在其中引入打开位置,与杀菌剂接触,形成第一和第二模具部分的形成流体通道的表面并且邻近于至少一个模腔 但是不与模腔内的模制部件的内表面接触,对暴露的模具表面进行消毒,从而防止模制部件的污染。
    • 3. 发明申请
    • Adjustable Filling and Sealing Method and Apparatus Therefor
    • 可调灌装封口方法及其设备
    • US20120138186A1
    • 2012-06-07
    • US13352235
    • 2012-01-17
    • Daniel PyBenoit AdamoJohn Guthy
    • Daniel PyBenoit AdamoJohn Guthy
    • B65B1/04
    • B65B3/006A61L2/10A61M5/1782B29C66/80B65B3/003B65B43/00B65B51/00Y10T29/49716
    • An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one filling or needle assembly and is adjustable to receive a plurality of filling or needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of containers or vials that are to be filled concurrently and adjusting an assembly to include at least one filling or needle assembly and at least one seal assembly. A number of the filling or needle assemblies and the seal assemblies equals the number of containers or vials.
    • 组件包括支撑和驱动组件,第一结构和第二结构。 第一结构与支撑和驱动组件可操作地连通并由其支撑。 第一结构包括至少一个填充物或针头组件,并且可调节以容纳多个填充物或针头组件。 第二个结构由支撑和驱动组件支撑。 第二结构包括至少一个密封组件,并且可调节以接收多个密封组件。 一种方法包括确定要同时填充的多个容器或小瓶,并且调整组件以包括至少一个填充物或针组件和至少一个密封组件。 许多填充物或针组件和密封组件等于容器或小瓶的数量。
    • 4. 发明授权
    • Sterile de-molding apparatus and method
    • 无菌脱模装置及方法
    • US07874129B2
    • 2011-01-25
    • US12371601
    • 2009-02-14
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleM. Jeffrey Willey
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleM. Jeffrey Willey
    • B65B3/02B65B5/02
    • B65B3/022
    • Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.
    • 用于模制和填充具有本体的装置的装置,该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件,包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔,其形状形成封闭件和主体,以及基本上无菌的表面,其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分,其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具,以基本上防止污染物从模制机器和工具通过。
    • 7. 发明授权
    • Sterile de-molding apparatus and method
    • 无菌脱模装置及方法
    • US08181431B2
    • 2012-05-22
    • US13012074
    • 2011-01-24
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleM. Jeffrey Willey
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleM. Jeffrey Willey
    • B65B3/02B65B5/02
    • B65B3/022
    • Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.
    • 用于模制和填充具有本体的装置的装置,该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件,包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔,其形状形成封闭件和主体,以及基本上无菌的表面,其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分,其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具,以基本上防止污染物从模制机器和工具通过。
    • 8. 发明授权
    • Sterile de-molding apparatus and method
    • 无菌脱模装置及方法
    • US08071009B2
    • 2011-12-06
    • US11582291
    • 2006-10-17
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleGiovanni Rodriguez
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleGiovanni Rodriguez
    • B29C45/04
    • B29C45/1701B29C37/0007B29C45/006B29C45/1753B29C45/40B29C45/42B29C2045/1797B29C2791/005
    • An apparatus and method are provided for molding sterile parts. The apparatus has a first mold portion and a second mold portion. At least one of the first and second mold portions defines a mold cavity configured to receive a molten plastic and form therefrom at least one molded part At least one of the first and second mold portions is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the first and second mold portions and permitting the passage of a fluid sterilant therein. A fluid source that contains or otherwise generates a fluid sterilant, such as vaporized hydrogen peroxide, is connectable in fluid communication with the fluid passageway for introducing the sterilant into the fluid passageway with at least one of the first and second mold portions in the open position, and in turn contacting with the sterilant the surfaces of the first and second mold portions forming the fluid passageway and located adjacent to the at least one mold cavity, but not contacting an interior surface of a molded part within the mold cavity, to sterilize the exposed mold surfaces and thereby prevent contamination of the molded part.
    • 提供了用于模制无菌部件的装置和方法。 该装置具有第一模具部分和第二模具部分。 第一模具部分和第二模具部分中的至少一个限定了模腔,其被配置为容纳熔融塑料并从其形成至少一个模制部件。第一模具部分和第二模具部分中的至少一个可相对于彼此移动, 用于密封模腔或空腔并在其中模制至少一个部件的位置,以及(ii)限定第一和第二模具部分之间的流体通道并允许其中的流体灭菌剂通过的打开位置。 包含或以其它方式产生流体灭菌剂的流体源例如蒸发的过氧化氢可连接到流体通道,用于将灭菌剂引入流体通道,其中第一和第二模具部分中的至少一个处于打开位置 并且又与灭菌剂接触形成第一和第二模具部分的表面,形成流体通道并且位于与至少一个模具腔相邻但不与模具腔内的模制部件的内表面接触,以消毒 暴露的模具表面,从而防止模制部件的污染。
    • 9. 发明申请
    • Sterile De-Molding Apparatus and Method
    • 无菌脱模装置及方法
    • US20110113729A1
    • 2011-05-19
    • US13012074
    • 2011-01-24
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleM. Jeffrey Willey
    • Daniel PyBenoit AdamoJohn GuthyNathaniel HouleM. Jeffrey Willey
    • B65B55/02B65B47/00B65B5/02
    • B65B3/022
    • Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.
    • 用于模制和填充具有本体的装置的装置,该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件,包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔,其形状形成封闭件和主体,以及基本上无菌的表面,其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分,其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具,以基本上防止污染物从模制机器和工具通过。