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1. 发明授权

US09616097B2 Formulations of guanylate cyclase C agonists and methods of use 有权
公开(公告)号：US09616097B2
公开(公告)日：2017-04-11
申请号：US13421769
申请日：2012-03-15
申请人： Stephen Comiskey , Rong Feng , John Foss , Kunwar Shailubhai
发明人： Stephen Comiskey , Rong Feng , John Foss , Kunwar Shailubhai
IPC分类号： A61K38/10 , A61K38/12 , A61K9/16 , A61K9/20 , A61K9/48 , A61K45/06 , C07K7/08 , C07K7/64
CPC分类号： A61K38/10 , A61K9/1623 , A61K9/1652 , A61K9/1676 , A61K9/2054 , A61K9/4858 , A61K9/4866 , A61K38/12 , A61K45/06 , C07K7/08 , C07K7/64 , A61K2300/00
摘要： The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.

2. 发明授权

US4637626A Portable, foldable and convertible luggage trolley 失效
标题翻译：便携式，可折叠和可转换的行李手推车
公开(公告)号：US4637626A
公开(公告)日：1987-01-20
申请号：US667331
申请日：1984-11-01
申请人： Janet M. P. Foss , John Foss , Christopher G. Brooks , Myron H. Ridgely
发明人： Janet M. P. Foss , John Foss , Christopher G. Brooks , Myron H. Ridgely
IPC分类号： A45C13/38 , B62B3/02 , B67B3/02
CPC分类号： B62B3/02 , A45C13/385 , B62B2202/24 , Y10T16/451 , Y10T16/50
摘要： This disclosure relates to a portable, foldable and convertible luggage trolley which includes first and second base supports joined by a pivot so as to be folded between a nested position and a position in side-by-side coplanar relationship, the first and second base supports carrying first and second sets of wheels, another pivot joining a handle to the first base support and still another pivot for pivotally connecting a luggage restraining member to the second base support whereby the handle and luggage restraining member are each pivoted between an operative generally normal position relative to the first and second base supports and an inoperative position in generally nested relationship thereto, a pivoted lock responsive to movement of the handle to its operative position to automatically lock the handle thereat, and another lock automatically moved to its locked position during pivotal movement of the luggage restraining member to its operative position to maintain the same locked thereat.
摘要翻译：本公开涉及一种便携式，可折叠和可转换的行李车，其包括通过枢轴连接以便在嵌套位置和并排共面关系的位置之间折叠的第一和第二基部支撑件，第一和第二基部支撑件承载第一组和第二组轮子，另一枢轴将把手连接到第一基座支撑件以及另一个枢轴，用于将行李限制构件枢转地连接到第二基座支撑件，由此手柄和行李限制构件各自枢转在可操作的大致正常位置相对于第一和第二基座支撑件和与其大致嵌套关系的不工作位置，枢转锁定件响应于手柄的运动到其操作位置以自动锁定手柄，并且另一个锁定在枢转运动期间自动地移动到其锁定位置的行李限制构件到其操作位置以保持相同的lo 塞在那里

3. 发明申请

US20060090573A1 THERMAL TRANSIENT ANEMOMETER HAVING SENSING CELL ASSEMBLY 有权
标题翻译：具有感应电池组件的热瞬态电位器
公开(公告)号：US20060090573A1
公开(公告)日：2006-05-04
申请号：US10978629
申请日：2004-11-01
申请人： John Foss
发明人： John Foss
IPC分类号： G01P5/06
CPC分类号： G01F1/684 , F01P2025/52 , G01F1/696 , G01P5/001 , G01P5/12
摘要： A thermal transient anemometer provides mass flow rate or volume flow rate over smaller discrete regions of a larger flow field, i.e., the distribution of such rates over a predefined, larger area. The thermal transient anemometer comprises two components: a frame with a plurality of sensing cells each having a resistance wire grid and a control unit which includes an energy source which heats the resistance wire grid of each cell, measurement circuitry for determining the decay of resistance of the grid wires as they cool and computational circuitry which determines the mass or volume flow rate through each cell based upon such decay function.
摘要翻译：热瞬态风速计在较大流场的较小离散区域上提供质量流率或体积流量，即在预定义的更大区域上的这种速率的分布。热瞬变风速计包括两个部件：具有多个感测单元的框架，每个感测单元各自具有电阻线栅格和控制单元，该控制单元包括加热每个单元的电阻线栅格的能量源，用于确定电阻的电阻的衰减的测量电路电网线路冷却，计算电路根据这种衰减功能确定通过每个电池的质量或体积流量。

4. 发明授权

US4505495A Portable, foldable and convertible luggage trolley 失效
标题翻译：便携式，可折叠和可转换的行李手推车
公开(公告)号：US4505495A
公开(公告)日：1985-03-19
申请号：US449824
申请日：1982-12-14
申请人： Janet M. P. Foss , John Foss , Christopher G. Brooks , Myron H. Ridgely
发明人： Janet M. P. Foss , John Foss , Christopher G. Brooks , Myron H. Ridgely
IPC分类号： B62B3/02
CPC分类号： B62B3/02 , B62B2205/00 , Y10T16/451
摘要： This disclosure relates to a portable, foldable and convertible luggage trolley which includes first and second base supports joined by a pivot so as to be folded between a nested position and a position in side-by-side coplanar relationship, the first and second base supports carrying first and second sets of wheels, another pivot joining a handle to the first base support and still another pivot for pivotally connecting a luggage restraining member to the second base support, a plurality of locks for holding the handle in a position normal to the first base support, the handle being formed by handle members foldable between side-by-side and nested positions, the luggage restraining member further functioning as a carriage for the second set of wheels so that the same can be moved between operative ground engaging and inoperative nonground engaging positions when the first and second base supports are in their respective side-by-side and nested positions, and means for joining one of the handle members to another of the handle members through either a pivoted or a telescopic connection.
摘要翻译：本公开涉及一种便携式，可折叠和可转换的行李车，其包括通过枢轴连接以便在嵌套位置和并排共面关系的位置之间折叠的第一和第二基部支撑件，第一和第二基部支撑件承载第一组和第二组轮，将手柄连接到第一基座支撑件的另一枢轴和用于将行李限制构件枢转地连接到第二基座支撑件的另一个枢轴，用于将手柄保持在与第一基座支撑件垂直的位置的多个锁所述手柄由在并排和嵌套位置之间可折叠的手柄构件形成，所述行李限制构件还用作用于所述第二组车轮的滑架，使得所述手柄构件能够在操作地面接合和不工作之间移动当第一和第二基座支撑件处于它们各自的并排和嵌套位置时的接合位置，以及用于接合其中之一的装置通过枢转或伸缩连接将手柄部件移动到另一个手柄部件。

5. 发明申请

US20050193743A1 High-pressure cryogenic gas for treatment processes 审中-公开
标题翻译：高压低温气体用于处理工艺
公开(公告)号：US20050193743A1
公开(公告)日：2005-09-08
申请号：US10794113
申请日：2004-03-05
申请人： John Foss , Robert Oesterreich
发明人： John Foss , Robert Oesterreich
IPC分类号： C21D1/613 , C21D1/62 , F17C9/02 , F25J3/00
CPC分类号： C21D1/613 , C21D1/62
摘要： The present invention relates to cryogenic processes and systems for making and using high-pressure gas to quench or rapidly cool metals or other heated materials. The gas is preferably produced without pumps, compressors, and large high-pressure bulk storage tanks. The apparatus producing such gas comprises a cryogenic bulk storage tank, a pressure building apparatus, and a high-pressure vaporizer. A dew point monitor can be used to check gas purity to ensure uniform quenching and to prevent damage to the treated parts by, for example, water vapor. The method and system also may include a system that monitors the temperature, pressure, and level of liquid cryogen in the bulk storage tank and automatically calls in a refill for the storage tank.
摘要翻译：本发明涉及用于制造和使用高压气体淬火或快速冷却金属或其它加热材料的低温工艺和系统。该气体优选地在没有泵，压缩机和大型高压大容量储罐的情况下生产。制造这种气体的装置包括低温散装储罐，压力建筑装置和高压蒸发器。可以使用露点监测器来检查气体纯度，以确保均匀的淬火，并防止例如水蒸汽损坏处理过的部件。该方法和系统还可以包括监测大容量储罐中的液体冷冻剂的温度，压力和水平的系统，并自动调用储存罐的再填充物。

6. 发明授权

US06813902B2 Systems and methods for increasing production of spheroidal glass particles in vertical glass furnaces 有权
标题翻译：用于增加垂直玻璃熔炉中球形玻璃颗粒生产的系统和方法
公开(公告)号：US06813902B2
公开(公告)日：2004-11-09
申请号：US09981740
申请日：2001-10-19
申请人： Eric Streicher , John Foss , Mahendra L. Joshi , Harley A. Borders
发明人： Eric Streicher , John Foss , Mahendra L. Joshi , Harley A. Borders
IPC分类号： C03B1910
CPC分类号： C03B19/1025 , Y02P40/57
摘要： A retrofit technology for air-fuel fired, vertical glass furnace for oxygen firing or boosting to provide additional heat to the process to increase furnace production capacity. The additional firing using oxygen is strategically controlled to enable enhanced radiation from oxygen flame for the spheroidizing process without negative effects on the overall process. With proper implementation, an increased production from 50% to 200%, depending on the size of the spheres, can be achieved while maintaining acceptable product quality. Processes in accordance with the present invention can be performed using one of a number of methods of oxygen boosting.
摘要翻译：一种用于空燃燃烧的立式玻璃炉的改造技术，用于氧燃烧或增压，为该方法提供额外的热量以增加炉的生产能力。战略性地控制使用氧气的额外燃烧，以便能够增强氧化焰的辐射用于球化过程，而不会对整体过程产生负面影响。通过适当实施，可以在保持可接受的产品质量的同时，将产量从50％提高到200％，这取决于球体的尺寸。可以使用多种氧增压方法之一来执行根据本发明的方法。

7. 发明授权

US5921091A Liquid air food freezer and method 失效
标题翻译：液体空气食品冷冻机及方法
公开(公告)号：US5921091A
公开(公告)日：1999-07-13
申请号：US943332
申请日：1997-10-03
申请人： John Foss , Mike Mitcheltree , Pascal Schvester , Kent Renz , Joseph E. Paganessi , Lisa D. Hunter , Reena V. Patel , Darrin Baumunk
发明人： John Foss , Mike Mitcheltree , Pascal Schvester , Kent Renz , Joseph E. Paganessi , Lisa D. Hunter , Reena V. Patel , Darrin Baumunk
IPC分类号： F25D3/10 , A23B4/06 , A23B7/04 , A23L3/36 , A23L3/375 , F25D3/11 , F25D29/00 , F25D13/06
CPC分类号： F25D3/11 , A23L3/362 , A23L3/363 , A23L3/375 , F25D29/001
摘要： A cryogenic freezing method uses a mixture of liquid nitrogen and liquid oxygen in amounts approximating the composition of atmospheric air to freeze food products. The mixture preferably includes 18% to 25% oxygen and the balance nitrogen, with small amounts of residuals which are commonly found in air. The present invention involves replacing a liquid carbon dioxide or liquid nitrogen cooling medium which is used in known cryogenic freezers with a liquid nitrogen and liquid oxygen mixture. The liquid nitrogen and oxygen mixture can be used according the present invention in many of the known freezers using liquid carbon dioxide or liquid nitrogen as a cooling medium, including tunnel freezers, spiral freezers, and immersion freezers. The use of a liquid nitrogen and liquid oxygen mixture improves the efficiency of a freezer because the cold vapors are not exhausted from the freezer. In addition, the leakage of vapors from the freezer into the room air will not create unsafe conditions for workers.
摘要翻译：低温冷冻方法使用液态氮和液态氧的混合物，其量接近大气的组成以冷冻食品。混合物优选包含18％至25％的氧气和余量为的氮气，其中少量残余物通常存在于空气中。本发明涉及用液氮和液氧混合物代替在已知的低温冷冻箱中使用的液态二氧化碳或液氮冷却介质。根据本发明，可以使用液态二氧化碳或液氮作为冷却介质，包括隧道式冷冻机，螺旋冷冻机和浸入式冷冻机，在许多已知的冷冻机中使用液氮和氧气混合物。使用液氮和液氧混合物可以提高冷冻机的效率，因为冷蒸汽不会从冷冻机中排出。此外，蒸汽从冷冻室泄漏到室内空气中也不会给工人造成不安全的状况。

8. 发明申请

US20120237593A1 Formulations of Guanylate Cyclase C Agonists and Methods of Use 有权
标题翻译：鸟苷酸环化酶C激动剂的配方及使用方法
公开(公告)号：US20120237593A1
公开(公告)日：2012-09-20
申请号：US13421769
申请日：2012-03-15
申请人： Stephen Comiskey , Rong Feng , John Foss , Kunwar Shailubhai
发明人： Stephen Comiskey , Rong Feng , John Foss , Kunwar Shailubhai
IPC分类号： A61K38/10 , A61K9/00 , A61P1/04 , A61P31/04 , A61J1/03 , A61P1/00 , A61P1/10 , A61P29/00 , B05D3/00 , A61K9/48 , A61P35/00
CPC分类号： A61K38/10 , A61K9/1623 , A61K9/1652 , A61K9/1676 , A61K9/2054 , A61K9/4858 , A61K9/4866 , A61K38/12 , A61K45/06 , C07K7/08 , C07K7/64 , A61K2300/00
摘要： The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.
摘要翻译：本发明提供了鸟苷酸环化酶-C（“GCC”）激动剂肽的低剂量制剂及其使用方法。本发明的制剂可以单独施用或与一种或多种另外的治疗剂，优选cGMP依赖性磷酸二酯酶抑制剂或泻药一起施用。

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