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1. 发明申请

US20090148436A1 ANTIBODY TO GDF8 AND USES THEREOF 有权
标题翻译：抗GDF8的抗体及其用途
公开(公告)号：US20090148436A1
公开(公告)日：2009-06-11
申请号：US12262712
申请日：2008-10-31
申请人： Edward Roland LaVallie , Lisa Anne Collins-Racie , Christopher John Corcoran , Lioudmila Gennadievna Tchistiakova , John Adam Nowak , Riyez Karim , Xiang-Yang Tan , Kimberly Ann Marquette , Geertruida Machteld Veldman
发明人： Edward Roland LaVallie , Lisa Anne Collins-Racie , Christopher John Corcoran , Lioudmila Gennadievna Tchistiakova , John Adam Nowak , Riyez Karim , Xiang-Yang Tan , Kimberly Ann Marquette , Geertruida Machteld Veldman
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N5/10 , A61P21/00 , A61P19/08 , A61P3/00 , A61P25/00 , C12N15/63 , C12P21/00 , G01N33/53
CPC分类号： C07K16/22 , A61K39/395 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译：本公开提供了与生长和分化因子-8（GDF8）相关的新分子，特别是GDF8特异性表位和GDF8的其他特异性拮抗剂，特别是抗GDF8抗体或抗原结合蛋白或其片段，其可抑制GDF8活性和信号体外和/或体内。本公开还提供用于检测和定量GDF8的免疫测定。本公开还提供了用于诊断，预防，改善和治疗GDF8相关疾病例如肌肉，骨骼和胰岛素代谢退行性的方法。最后，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种疾病的药物。

2. 发明授权

US5470176A System and method for controlling emissions created by spraying liquids from moving vehicles 失效
标题翻译：用于控制从移动车辆喷洒液体产生的排放的系统和方法
公开(公告)号：US5470176A
公开(公告)日：1995-11-28
申请号：US248501
申请日：1994-05-19
申请人： John Corcoran , Ikbal A. Molvi , Joseph W. Hower , William A. Moseley
发明人： John Corcoran , Ikbal A. Molvi , Joseph W. Hower , William A. Moseley
IPC分类号： B01D46/42 , B01D46/54 , B01D50/00 , E01C19/17 , B01D45/00 , E01C23/00
CPC分类号： B01D46/446 , B01D46/0013 , B01D46/0024 , B01D50/002 , E01C19/17 , E01C19/176 , B01D2273/28 , B01D2275/305
摘要： A system and a method for controlling emissions caused by spraying a heated liquid paving composition from a moving vehicle make use of a vacuum hood mountable to the vehicle and a fan for creating a partial vacuum within the hood to draw air containing emissions into the hood for collection. A filter or other suitable apparatus is used to extract emissions before the air is discharged to the atmosphere. In a preferred embodiment, a subsystem directs air toward a region containing emissions to cool the pavement surface or control dispersion. A shroud structure may also be provided to confine the emissions during collection. In another embodiment, a fine spray of water or moist air is directed toward the emissions area.
摘要翻译：用于控制从移动车辆喷射加热的液体铺路组合物引起的排放物的系统和方法使用可安装到车辆的真空罩和用于在罩内产生部分真空的风扇，以将含有排放物的空气抽吸到罩中采集。在空气排放到大气之前，使用过滤器或其它合适的装置来提取排放物。在优选实施例中，子系统将空气引向包含排放物的区域以冷却路面或控制分散体。还可以提供护罩结构以在收集期间限制排放物。在另一个实施方案中，水或潮湿空气的细微喷雾被引向排放区域。

3. 发明申请

US20070244716A1 METHODS AND APPARATUS FOR COLLECTING DATA RELATING TO MEDICAL SCIENCE LIAISONS 审中-公开
标题翻译：收集与医学科学相关的数据的方法和装置
公开(公告)号：US20070244716A1
公开(公告)日：2007-10-18
申请号：US11279521
申请日：2006-04-12
申请人： Neil Baptista , Josh Wolf , John Corcoran , Michael Taylor
发明人： Neil Baptista , Josh Wolf , John Corcoran , Michael Taylor
IPC分类号： G06Q10/00 , G06F3/048
CPC分类号： G06Q50/22
摘要： The present invention is directed towards improving communication methodologies for medical science liaisons. In one aspect, the present invention is a method for collection of data relating to medical science liaisons. The method may comprise displaying a first input screen, said screen comprising fields which accept the input of messages and categories for said messages, wherein said categories are limited to a predetermined number of subjects; displaying a second input screen, said screen comprising fields which accept input of profile data, said profile data comprising data corresponding to a given medical professional; and displaying a third input screen, said screen comprising fields which accept input of activity data, said activity data comprising data corresponding to a given activity of a medical science liaison.
摘要翻译：本发明旨在改进医学联络人的通信方法。一方面，本发明是用于收集有关医学科学联络者的数据的方法。该方法可以包括显示第一输入屏幕，所述屏幕包括接受消息的输入的字段和用于所述消息的类别，其中所述类别限于预定数量的被摄体; 显示第二输入屏幕，所述屏幕包括接受简档数据输入的字段，所述简档数据包括对应于给定医疗专业人员的数据; 以及显示第三输入屏幕，所述屏幕包括接受活动数据输入的字段，所述活动数据包括对应于医学科学联络人的给定活动的数据。

4. 发明申请

US20070244715A1 METHODS AND APPARATUS FOR COLLECTING DATA RELATING TO MEDICAL SCIENCE LIAISONS 审中-公开
标题翻译：收集与医学科学相关的数据的方法和装置
公开(公告)号：US20070244715A1
公开(公告)日：2007-10-18
申请号：US11279516
申请日：2006-04-12
申请人： Neil Baptista , Josh Wolf , John Corcoran , Michael Taylor
发明人： Neil Baptista , Josh Wolf , John Corcoran , Michael Taylor
IPC分类号： G06Q10/00 , G06F3/048
CPC分类号： G06Q50/22 , G06Q10/06
摘要： The present invention is directed to methods and systems for analyzing data relating to medical science liaisons. In one aspect, the present invention is a method for analyzing data relating to medical science liaisons. The method may comprise displaying a first input screen comprising input fields which receive data corresponding to activities of medical science liaisons; displaying a second input screen comprising input fields which receive data corresponding to the results of activities of medical science liaisons; determining a time-based subset of said received data corresponding to a given business objective; and displaying an output screen comprising a time-based visual depiction of said subset of data.
摘要翻译：本发明涉及用于分析与医学联络相关的数据的方法和系统。一方面，本发明是用于分析与医学科技联络有关的数据的方法。该方法可以包括显示包括输入字段的第一输入屏幕，所述输入字段接收对应于医学联络人的活动的数据; 显示第二输入屏幕，其包括输入字段，其接收对应于医学联络人的活动结果的数据; 确定对应于给定业务目标的所述接收数据的基于时间的子集; 以及显示包括所述数据子集的基于时间的视觉描述的输出屏幕。

5. 发明授权

US07118902B2 Modified ADAMTS4 molecules and method of use thereof 失效
标题翻译：修饰的ADAMTS4分子及其使用方法
公开(公告)号：US07118902B2
公开(公告)日：2006-10-10
申请号：US10628432
申请日：2003-07-29
申请人： Christopher John Corcoran , Carl R. Flannery , Weilan Zeng , Lisa A. Racie , Thomas McDonagh , Bethany A. Freeman , Katy E. Georgiadis , Edward R. LaVallie
发明人： Christopher John Corcoran , Carl R. Flannery , Weilan Zeng , Lisa A. Racie , Thomas McDonagh , Bethany A. Freeman , Katy E. Georgiadis , Edward R. LaVallie
IPC分类号： C12N15/57 , C12N9/64 , C12N15/01 , C12N15/79
CPC分类号： C12N9/6489 , A61K2039/505
摘要： The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
摘要翻译：本发明涉及与相应的天然未修饰蛋白相比具有改进的稳定性的修饰的ADAMTS4蛋白。修饰的ADAMTS4蛋白可以大量表达和分离，从而进一步表征蛋白质，如晶体学和酶动力学研究。纯化的稳定蛋白质也有助于抗ADAMTS抗体的产生和ADAMTS酶抑制剂的开发。

6. 发明授权

US06926233B1 Automatic formation flight control system (AFFCS)—a system for automatic formation flight control of vehicles not limited to aircraft, helicopters, or space platforms 有权
标题翻译：自动飞行控制系统（AFFCS） - 一种不限于飞机，直升机或太空平台的车辆自动飞行控制系统
公开(公告)号：US06926233B1
公开(公告)日：2005-08-09
申请号：US10784660
申请日：2004-02-21
申请人： James John Corcoran, III
发明人： James John Corcoran, III
IPC分类号： B64C3/00 , B64C9/00 , B64C13/18 , B64C13/20 , G05D1/10
CPC分类号： G05D1/104 , B64C13/20
摘要： A totally integrated system for automatic formation flight control of multiple vehicles not limited to aircraft, helicopters, or space platforms. For instance, the system may be used to control any number of aircraft in a pre-determined flight formation and provide “positive” identification, control and discrete communications between any number of vehicles. Thus the invention prevents mid-air collisions between vehicles in formation flight. The system generally includes a processor located on the vehicles to enable communications, unique position computations and control messaging between any number of aircraft in formation flight, a communications transceiver located on the vehicle that provides discrete communication links to any number of aircraft in formation flight an autopilot and a display. The processor may take into consideration velocity, direction, winds aloft, wing tip clearance of any number of vehicles. On aircraft, the system will display the current formation and vehicles relative position under control by this invention. The system may be overridden in flight.
摘要翻译：一种完全集成的系统，用于多种车辆的自动飞行控制，不限于飞机，直升机或空间平台。例如，该系统可以用于在预定的飞行形成中控制任何数量的飞行器，并且在任何数量的车辆之间提供“正”的识别，控制和离散通信。因此，本发明防止在飞行中的车辆之间的空中碰撞。该系统通常包括位于车辆上的处理器，以实现任何数量的飞行中飞机之间的通信，独特的位置计算和控制消息传送，位于车辆上的通信收发器，其提供到地层飞行中任意数量的飞行器的离散通信链路自动驾驶仪和显示屏。处理器可以考虑速度，方向，风高，任何车辆的翼尖间隙。在飞机上，系统将显示本发明控制下的当前形成和车辆相对位置。系统可能在飞行中被覆盖。

7. 发明授权

US5297893A System and method for controlling emissions created by spraying liquids from moving vehicles 失效
公开(公告)号：US5297893A
公开(公告)日：1994-03-29
申请号：US000748
申请日：1993-01-05
申请人： John Corcoran , Joseph W. Hower , William A. Moseley
发明人： John Corcoran , Joseph W. Hower , William A. Moseley
IPC分类号： B01D46/42 , B01D46/54 , B01D50/00 , E01C19/17 , B01D45/00 , E01C23/00
CPC分类号： E01C19/176 , E01C19/17
摘要： A system and a method for controlling emissions caused by spraying liquids from a moving vehicle onto a pavement surface use a vacuum hood mountable to the vehicle and a fan for creating a partial vacuum within the hood to draw air containing emissions into the hood for collection. A filter or other suitable apparatus is used to extract the emissions before the air is discharged to the atmosphere. The vacuum hood is located above the sprayed surface and is preferably located behind the nozzle. It has a primary opening at its forward end for collection of air adjacent the nozzle and a smaller, auxiliary opening behind the primary opening.

8. 发明申请

US20100074935A1 RECOMBINANT LUBRICIN MOLECULES AND USES THEREOF 有权
标题翻译：重组润滑剂分子及其用途
公开(公告)号：US20100074935A1
公开(公告)日：2010-03-25
申请号：US12622141
申请日：2009-11-19
申请人： Carl Ralph Flannery , Christopher John Corcoran , Bethany Annis Freeman , Lisa A. Collins-Racie
发明人： Carl Ralph Flannery , Christopher John Corcoran , Bethany Annis Freeman , Lisa A. Collins-Racie
IPC分类号： A61K9/00 , C07K14/00 , A61P19/04 , A61K38/14 , A61K38/19
CPC分类号： A61K38/1709 , A61K38/00 , A61K38/18 , A61K38/19 , A61K45/06 , C07K14/47 , C07K14/475 , C07K16/18
摘要： Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.
摘要翻译：重组润滑剂分子及其用途。提供新的重组润滑剂分子及其用作润滑剂，抗粘合剂和/或关节内补充剂用于例如滑膜关节，半月板，腱，腹膜，心包和胸膜。

9. 发明授权

US07625731B2 Aggrecanase structure 失效
公开(公告)号：US07625731B2
公开(公告)日：2009-12-01
申请号：US11467138
申请日：2006-08-24
申请人： Lydia Mosyak , Thomas Saltmarsh Rush, III , Stephane Hubert Olland , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Stewart Andrews Mackie
发明人： Lydia Mosyak , Thomas Saltmarsh Rush, III , Stephane Hubert Olland , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Stewart Andrews Mackie
IPC分类号： C12N9/00 , C12N11/16 , C12N9/14 , C12N9/48 , C12N9/50 , C12N9/64
CPC分类号： C12N9/6421 , C07K2299/00 , C30B7/00
摘要： This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.

10. 发明授权

US07615363B2 Aggrecanase structure 失效
标题翻译：聚集蛋白酶结构
公开(公告)号：US07615363B2
公开(公告)日：2009-11-10
申请号：US11467135
申请日：2006-08-24
申请人： Lidia Mosyak , Thomas Saltmarsh Rush, III , Xiaotian Zhong , Thomas E. McDonagh , Katy E. Georgiadis , Phaik-Eng Sum , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Ravindra Kumar , Tracy Hebert , Stephane Hubert Olland , Stewart Andrews Mackie
发明人： Lidia Mosyak , Thomas Saltmarsh Rush, III , Xiaotian Zhong , Thomas E. McDonagh , Katy E. Georgiadis , Phaik-Eng Sum , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Ravindra Kumar , Tracy Hebert , Stephane Hubert Olland , Stewart Andrews Mackie
IPC分类号： C12N9/00 , G01N31/00
CPC分类号： C12N9/6421 , C07K2299/00 , C07K2319/00
摘要： This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
摘要翻译：本发明涉及聚集蛋白聚糖酶多肽和聚集蛋白聚糖蛋白聚糖酶多肽/配体复合物，聚集蛋白聚糖蛋白聚糖酶和聚集蛋白聚糖酶多肽/配体复合物的晶体，以及相关的方法和软件系统。

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