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1. 发明授权

US06444821B1 Crystals of piperidine derivatives, intermediates for production of the same, and process for producing the same 有权
公开(公告)号：US06444821B1
公开(公告)日：2002-09-03
申请号：US09776854
申请日：2001-02-06
申请人： Akiko Fujii , Mie Kubo , Tomoya Yamamoto , Jiro Shimada , Ryuichi Mihara , Hirokazu Naora , Koji Asai
发明人： Akiko Fujii , Mie Kubo , Tomoya Yamamoto , Jiro Shimada , Ryuichi Mihara , Hirokazu Naora , Koji Asai
IPC分类号： C07D40112
摘要： Monohydrate and trihydrate crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino) ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride having excellent stability.

2. 发明授权

US5965442A Method of altering enzymes and a novel neopullulanase 失效
标题翻译：改变酶的方法和新型的新型尿蛋白酶
公开(公告)号：US5965442A
公开(公告)日：1999-10-12
申请号：US339715
申请日：1994-11-14
申请人： Hiroki Kaneko , Toshikazu Takada , Jiro Shimada , Takashi Kuriki , Michiyo Yanase , Hiroki Takata , Shigetaka Okada
发明人： Hiroki Kaneko , Toshikazu Takada , Jiro Shimada , Takashi Kuriki , Michiyo Yanase , Hiroki Takata , Shigetaka Okada
IPC分类号： C12N9/44 , C12N15/11 , C12N15/54 , C12N15/56 , C12N15/70
CPC分类号： C12N9/2451 , C12Y302/01135
摘要： An enzyme is altered by introducing an additional hydrophobic group to enhance the hydrophobic environment in the enzyme so as to interfere with entrance of a water molecule. In this connection, the site of introduction and kind of hydrophobic group to be introduced are selected on the basis of comprehensive analysis of amino acid sequence, three-dimensional structure, reaction mechanism or the like of the target enzyme. Using this method, an amino acid residue of neopullulanase derived from Bacillus stearothermophilus was replaced by another amino acid.
摘要翻译：通过引入另外的疏水基团来增强酶中的疏水环境来改变酶，从而干扰水分子的入口。在这方面，基于目标酶的氨基酸序列，三维结构，反应机理等的综合分析，选择待引入的疏水基团的种类和种类。使用该方法，由嗜热脂肪芽孢杆菌衍生的新来的尿蓝酵母酶的氨基酸残基被另一个氨基酸取代。

3. 发明授权

US4305009A Low power consumption high speed transistor circuit comprising a complementary circuit 失效
标题翻译：低功耗高速晶体管电路，包括互补电路
公开(公告)号：US4305009A
公开(公告)日：1981-12-08
申请号：US058603
申请日：1979-07-18
申请人： Yoichi Miyagawa , Jiro Shimada , Hiroshi Iguchi
发明人： Yoichi Miyagawa , Jiro Shimada , Hiroshi Iguchi
IPC分类号： H03K3/356 , H03K5/02 , H03K17/04 , H03K17/687 , H03K19/00 , H03K19/017 , H03K19/0185 , H03K19/094
CPC分类号： H03K19/0013 , H03K19/01721 , H03K19/018521 , H03K3/356104 , H03K5/023
摘要： A low-power consumption, high-speed electronic switching system has a pair of complementary switching means connected between opposite polarity terminals of the voltage source and an output terminal. The pair of switches provides a variable impedance for applying one or the other of the polarities and said output terminal. To speed an appearance of that polarity, an inverter is coupled between an input and an output terminal via a differentiating capacitor. The differentiated inverter output speeds the appearance of the switched output signal during the interval before the complementary input becomes effective thereat.
摘要翻译：低功耗高速电子开关系统具有连接在电压源的相反极性端子和输出端子之间的一对互补开关装置。一对开关提供用于施加一个或另一个极性的可变阻抗和所述输出端子。为了加速该极性的出现，逆变器通过微分电容器耦合在输入端和输出端之间。差分反相器输出在互补输入在此之前的间隔期间加速了开关输出信号的出现。

4. 发明授权

US07523026B2 Proteome analysis method and proteome analysis system 失效
标题翻译：蛋白质组学分析方法和蛋白质组学分析系统
公开(公告)号：US07523026B2
公开(公告)日：2009-04-21
申请号：US10454490
申请日：2003-06-05
申请人： Kenichiro Tsuda , Jiro Shimada , Minoru Asogawa , Kenichi Kamijyo , Toshimasa Yamazaki
发明人： Kenichiro Tsuda , Jiro Shimada , Minoru Asogawa , Kenichi Kamijyo , Toshimasa Yamazaki
IPC分类号： G06G7/48
CPC分类号： G01N33/6848 , G01N33/6818 , G06F19/16
摘要： A proteome analysis method includes using a tandem type mass spectrometer to calculate bond dissociation energy by using molecular simulation, using the bond dissociation energy to obtain prediction information including a cleavage pattern of a peptide and/or peak positions in a mass spectrum and/or the intensity ratio of the mass spectrum, and identifying a protein by using the prediction information and experiment information.
摘要翻译：蛋白质组分析方法包括使用串联型质谱仪通过使用分子模拟来计算键解离能，使用键离解能获得包括肽的切割模式和/或质谱中的峰位置的预测信息和/或质谱强度比，通过使用预测信息和实验信息鉴定蛋白质。

5. 发明申请

US20070061119A1 Molecular simulation method and apparatus 审中-公开
标题翻译：分子模拟方法和装置
公开(公告)号：US20070061119A1
公开(公告)日：2007-03-15
申请号：US11520588
申请日：2006-09-14
申请人： Jiro Shimada , Hiroaki Fukunishi
发明人： Jiro Shimada , Hiroaki Fukunishi
IPC分类号： G06G7/48 , G06G7/58
CPC分类号： G16B15/00 , G16C10/00
摘要： In molecular simulation including the step of calculating non-bonding interactions in a system having particles with electric charges, using a multigrid method, upon determining the electric charges at grid points in a coarser grid of a higher level that is one step higher than the level to be observed, when a pair of grid points in the observed level, or a pair of particles in the observed level, both coincide with the grid points of the grid of the higher level, the charges at the grid points of the higher level are determined so that the energy of the pair in the higher level becomes equal to the correct energy value in the observed level.
摘要翻译：在分子模拟中，包括在具有电荷的粒子的系统中计算非结合相互作用的步骤，使用多栅格方法，在确定比水平高一级的较高级别的较粗糙的网格中的网格点处的电荷时，要观察的是，当观察到的水平的一对网格点或观察到的水平面上的一对粒子都与较高层次的网格的网格点一致时，较高层的网格点的电荷为确定该对的能量在上一级变得等于所观测水平的正确能量值。

6. 发明授权

US06232323B1 Crystals of piperidine derivatives, intermediates for production of the same, and process for producing the same 失效
标题翻译：哌啶衍生物的晶体，其制备的中间体及其制备方法
公开(公告)号：US06232323B1
公开(公告)日：2001-05-15
申请号：US09672080
申请日：2000-09-29
申请人： Akiko Fujii , Mie Kubo , Tomoya Yamamoto , Jiro Shimada , Ryuichi Mihara , Hirokazu Naora , Koji Asai
发明人： Akiko Fujii , Mie Kubo , Tomoya Yamamoto , Jiro Shimada , Ryuichi Mihara , Hirokazu Naora , Koji Asai
IPC分类号： A61K31445
CPC分类号： C07D211/70
摘要： Monohydrate and trihydrate crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino) ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride having excellent stability.
摘要翻译： N-（2-（4-（5H-二苯并[a，d]环庚烯-5-亚基） - 哌啶子基）乙基）-1-甲酰基-4-哌啶甲酰胺盐酸盐的一水合物和三水合物晶体。

7. 发明授权

US06184233B2 Crystals of piperidine derivatives, intermediates for production of the same, and process for producing the same 失效
标题翻译：哌啶衍生物的晶体，其制备的中间体及其制备方法
公开(公告)号：US06184233B2
公开(公告)日：2001-02-06
申请号：US08735696
申请日：1996-10-23
申请人： Akiko Fujii , Mie Kubo , Tomoya Yamamoto , Jiro Shimada , Ryuichi Mihara , Hirokazu Naora , Koji Asai
发明人： Akiko Fujii , Mie Kubo , Tomoya Yamamoto , Jiro Shimada , Ryuichi Mihara , Hirokazu Naora , Koji Asai
IPC分类号： A61K31445
CPC分类号： C07D211/70
摘要： Monohydrate and trihydrate crystals of N-(2-(4-(5H dibenzo [a,d]cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride having excellent stability.
摘要翻译：具有优异稳定性的N-（2-（4-（5H-二苯并[a，d]环庚烯-5-亚基） - 哌啶子基）乙基）-1-甲酰基-4-哌啶甲酰胺盐酸盐的一水合物和三水合物晶体。

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