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1. 发明申请

US20110184033A1 Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same 有权
标题翻译：多巴胺3（D3）受体的选择性配体及其使用方法
公开(公告)号：US20110184033A1
公开(公告)日：2011-07-28
申请号：US13060306
申请日：2009-08-27
申请人： Shaomeng Wang , Jianyong Chen , Gregory Collins , James H. Woods , Beth Levant
发明人： Shaomeng Wang , Jianyong Chen , Gregory Collins , James H. Woods , Beth Levant
IPC分类号： A61K31/427 , C07D277/82 , A61P25/28 , A61P25/08 , A61P25/30 , A61P25/22
CPC分类号： C07D277/82 , C07D417/12
摘要： Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C═O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.
摘要翻译：公开了多巴胺3（D3）受体的有效和选择性配体。 D3受体配体具有结构式（I），其中X为C = O或SO 2，R 1为C 1-6烷基，R 2为芳基，杂芳基，芳基， - （CH 2）1-3芳基或 - （CH 2） 3杂芳基，n为0或1.D3受体配体在治疗其中D3受体的调节提供益处的疾病和病症方面也被公开。

2. 发明申请

US20090082445A1 GOSSYPOL CO-CRYSTALS AND THE USE THEREOF 审中-公开
标题翻译： GOSSYPOL CO晶体及其用途
公开(公告)号：US20090082445A1
公开(公告)日：2009-03-26
申请号：US12242419
申请日：2008-09-30
申请人： Shaomeng Wang , Jianyong Chen
发明人： Shaomeng Wang , Jianyong Chen
IPC分类号： A61K31/19 , A61P35/00
CPC分类号： A61K31/11
摘要： This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
摘要翻译：本发明涉及包含（ - ） - 棉酚与C 1-8羧酸或C 1-8磺酸的共晶体的组合物，其可用作Bcl-2家族蛋白质的抑制剂。本发明还涉及（ - ） - 棉酚与C 1-8羧酸或C 1-8磺酸的共晶体在细胞中诱导细胞凋亡和促使细胞诱导凋亡细胞死亡的用途。

3. 发明授权

US09356967B2 Secure on-demand supply method and system and traffic type acquisition method 有权
标题翻译：安全的按需供应方式和系统和流量类型获取方法
公开(公告)号：US09356967B2
公开(公告)日：2016-05-31
申请号：US14235926
申请日：2012-05-30
申请人： Jianyong Chen , Xiaohua Chen , Zhaoji Lin
发明人： Jianyong Chen , Xiaohua Chen , Zhaoji Lin
IPC分类号： H04L29/06 , H04L12/851
CPC分类号： H04L63/20 , H04L47/2408 , H04L63/0227 , H04L63/0428 , H04L63/105 , H04L63/205
摘要： A secure on-demand supply method is disclosed. The method includes: a configuration parameter of a security function module is determined according to a security level set for requested traffic by a user, and/or an application scenario of a user terminal, and/or a traffic type; the security function module is configured by using the configuration parameter; and security protection is carried out on traffic data of the user. A traffic type acquisition method for protecting security of a specific user and/or traffic is disclosed. The method includes: a traffic identifier of data is acquired by using a traffic type classification function of a Quality of Service (QoS) function module, to protect the security of the specific user and/or traffic. The disclosure can provide various traffic security assurances according to security requirements of different users for different traffics.
摘要翻译：公开了一种安全的按需供应方法。该方法包括：根据用户为所请求的流量设置的安全级别和/或用户终端的应用场景和/或流量类型来确定安全功能模块的配置参数; 安全功能模块通过配置参数进行配置; 并对用户的业务数据进行安全保护。公开了一种用于保护特定用户和/或业务的安全性的流量类型获取方法。该方法包括：通过使用服务质量（QoS）功能模块的业务类型分类功能获取数据的业务标识符，以保护特定用户和/或业务的安全性。本公开可以根据不同用户对不同业务的安全要求提供各种业务安全保证。

4. 发明申请

US20140196113A1 Secure on-demand supply method and system and traffic type acquisition method 有权
标题翻译：安全的按需供应方式和系统和流量类型获取方法
公开(公告)号：US20140196113A1
公开(公告)日：2014-07-10
申请号：US14235926
申请日：2012-05-30
申请人： Jianyong Chen , Xiaohua Chen , Zhaoji Lin
发明人： Jianyong Chen , Xiaohua Chen , Zhaoji Lin
IPC分类号： H04L29/06
CPC分类号： H04L63/20 , H04L47/2408 , H04L63/0227 , H04L63/0428 , H04L63/105 , H04L63/205
摘要： A secure on-demand supply method is disclosed. The method includes: a configuration parameter of a security function module is determined according to a security level set for requested traffic by a user, and/or an application scenario of a user terminal, and/or a traffic type; the security function module is configured by using the configuration parameter; and security protection is carried out on traffic data of the user. A traffic type acquisition method for protecting security of a specific user and/or traffic is disclosed. The method includes: a traffic identifier of data is acquired by using a traffic type classification function of a Quality of Service (QoS) function module, to protect the security of the specific user and/or traffic. A secure on-demand supply system and a traffic type acquisition method are disclosed. The disclosure can provide various traffic security assurances according to security requirements of different users for different traffics. The system of the disclosure satisfies security requirements of various users and various traffics, provides personalized security assurances for the users, and enhances user experience.
摘要翻译：公开了一种安全的按需供应方法。该方法包括：根据用户为所请求的流量设置的安全级别和/或用户终端的应用场景和/或流量类型来确定安全功能模块的配置参数; 安全功能模块通过配置参数进行配置; 并对用户的业务数据进行安全保护。公开了一种用于保护特定用户和/或业务的安全性的流量类型获取方法。该方法包括：通过使用服务质量（QoS）功能模块的业务类型分类功能获取数据的业务标识符，以保护特定用户和/或业务的安全性。公开了安全的点播供应系统和流量类型获取方法。本公开可以根据不同用户对不同业务的安全要求提供各种业务安全保证。本公开的系统满足各种用户和各种业务的安全需求，为用户提供个性化的安全保证，增强用户体验。

5. 发明授权

US08486981B2 Selective ligands for the dopamine 3 (D3) receptor and methods of using the same 有权
标题翻译：多巴胺3（D3）受体的选择性配体及其使用方法
公开(公告)号：US08486981B2
公开(公告)日：2013-07-16
申请号：US13406803
申请日：2012-02-28
申请人： Shaomeng Wang , Jianyong Chen , Gregory Collins , Beth Levant , James H. Woods
发明人： Shaomeng Wang , Jianyong Chen , Gregory Collins , Beth Levant , James H. Woods
IPC分类号： A61K31/4245 , A61K31/428 , C07D271/06 , C07D277/82
CPC分类号： C07D277/82 , C07D417/12
摘要： Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.
摘要翻译：公开了多巴胺3（D3）受体的有效和选择性配体。 D3受体配体具有结构式：其中R 1是C 1-6烷基或C 3-6环烷基; 或其中R 2被一个或两个卤素或OC 1-3烷基取代。

6. 发明申请

US20100317661A1 SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF 失效
公开(公告)号：US20100317661A1
公开(公告)日：2010-12-16
申请号：US12815113
申请日：2010-06-14
申请人： Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
发明人： Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
IPC分类号： A61K31/5377 , C07D487/10 , A61K31/407 , C12N5/00 , A61P35/00 , A61P17/14 , A61P1/00 , A61K31/496 , A61K31/4178
CPC分类号： C07D487/10 , C07D491/107 , C12N5/0693 , C12N2501/48
摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

7. 发明授权

US07557251B2 Production of gossypol co-crystals 有权
标题翻译：生产棉酚共晶体
公开(公告)号：US07557251B2
公开(公告)日：2009-07-07
申请号：US11729638
申请日：2007-03-29
申请人： Shaomeng Wang , Jianyong Chen , John F. W. Keana , Ming Guo
发明人： Shaomeng Wang , Jianyong Chen , John F. W. Keana , Ming Guo
IPC分类号： C07C39/12 , C07C39/38 , C07C39/10 , C07C53/08
CPC分类号： C07B57/00 , A61K31/192 , A61K31/78 , C07C45/516 , C07C45/79 , C07C45/85 , C07C47/57 , C07C51/487 , C07C53/08
摘要： This invention relates to relates to methods for producing gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals. The invention also relates to pharmaceutical compositions comprising gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals and the use of gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
摘要翻译：本发明涉及生产棉酚乙酸共晶体和（ - ） - 棉酚乙酸共晶体的方法。本发明还涉及包含棉酚乙酸共晶和（ - ） - 棉酚乙酸共晶体的药物组合物，以及使用棉酚乙酸共晶体和（ - ） - 棉酚乙酸共晶体诱导细胞凋亡细胞和致敏细胞诱导凋亡细胞死亡。

8. 发明申请

US20080132485A1 Conformationally Constrained Smac Mimetics And The Uses Thereof 失效
标题翻译：构象约束Smac模拟物及其用途
公开(公告)号：US20080132485A1
公开(公告)日：2008-06-05
申请号：US11632079
申请日：2005-07-11
申请人： Shaomeng Wang , Haiying Sun , Zaneta Nikolovksa-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
发明人： Shaomeng Wang , Haiying Sun , Zaneta Nikolovksa-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
IPC分类号： A61K31/55 , A61P35/00 , C07D487/00 , A61K31/395 , A61K31/435 , C07D225/00 , C07D221/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
摘要翻译：本发明涉及Smac的构象约束模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。

9. 发明申请

US20070104322A1 Digital signature method based on braid groups conjugacy and verify method thereof 有权
标题翻译：基于编织组共轭的数字签名方法及其验证方法
公开(公告)号：US20070104322A1
公开(公告)日：2007-05-10
申请号：US10579801
申请日：2004-11-12
申请人： Yong Ding , Jianyong Chen , Zhiwei Peng
发明人： Yong Ding , Jianyong Chen , Zhiwei Peng
IPC分类号： H04L9/28
CPC分类号： H04L9/3073 , H04L9/302 , H04L9/3249 , H04L2209/68
摘要： The present invention discloses a digital signature scheme based on braid group conjugacy problem and a verifying method thereof, wherein the signatory S selects three braids xεLBm(l), x′εBn(l), aεBn(l), and considers braid pair (x′,x) as a public key of S, braid a as a private key of S; Signatory S uses hash function h for a message M needing signature to get y=h(M)εBn(l); generating a braid bεRBn−1−m(l) randomly, then signing the message M with the own private key a and the braid b generated randomly to obtain Sign(M)=a−1byb−1a; a signature verifying party V obtains the public key of S, calculating the message M by employing a system parameter hash function h, obtaining the y=h(M); judging whether sign(M) and y are conjugate or not, if not, sign(M) is an illegal signature, the verification fails; if yes, sign(M) is a legal signature of message M; the present invention avoids the problem of k-CSP in SCSS signature scheme of prior art, and improves the security of signature algorithm and reduces the number of braids involved and the number for conjugacy decision without reducing security, thereby improving the operation efficiency of signature.
摘要翻译：本发明公开了一种基于编织群共轭问题的数字签名方案及其验证方法，其中签名者S选择三个辫子bra B m SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB （l），aepsilonB（1），并将辫子对（x'，x）视为S的公钥，辫子a作为S的私钥; 签名者S使用哈希函数h来获得需要签名的消息M，以获得y = h（M）epsilonB（1）; 随机生成辫子bepsilonRB n-1-m（l），然后用自己的私钥a签署消息M，随机生成辫子b以获得Sign（M）= a＆ 1 BYB -1; 签名验证方V获得S的公开密钥，通过采用系统参数散列函数h来计算消息M，获得y = h（M）; 判断符号（M）和y是否是共轭的，如果不是，则（M）是非法签名，验证失败; 如果是，则（M）是消息M的合法签名; 本发明避免了现有技术的SCSS签名方案中的k-CSP问题，提高了签名算法的安全性，减少了涉及的辫子数量和共轭决定的数量，而不降低安全性，从而提高了签名的操作效率。

10. 发明申请

US20060178435A1 Apogossypolone and the uses thereof 审中-公开
标题翻译：聚鸟苷酮及其用途
公开(公告)号：US20060178435A1
公开(公告)日：2006-08-10
申请号：US11265576
申请日：2005-11-02
申请人： Shaomeng Wang , Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang
发明人： Shaomeng Wang , Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang
IPC分类号： C07C50/32 , A61K31/12 , A61K31/122 , A61K31/22
CPC分类号： C07C50/30 , A45C11/00 , A45C11/04 , A45C13/42 , C07C39/14 , C07C46/00 , C07C50/32 , C07C67/08 , C07C67/29 , C07C69/017 , C07C69/21
摘要： The invention relates to the compound apogossypolone and salts and prodrugs thereof. Apogossypolone functions as an inhibitor of Bcl-2 family proteins. The invention also relates to the use of apogossypolone for inhibiting hyperproliferative cell growth, for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
摘要翻译：本发明涉及化合物果糖酚及其盐和前药。聚鸟苷酸作为Bcl-2家族蛋白的抑制剂起作用。本发明还涉及用于抑制过度增殖细胞生长，用于诱导细胞凋亡和促进细胞诱导凋亡细胞死亡的用途。

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