会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明授权
    • bbc3 Gene promoter and methods for identifying modulators of apoptosis and bbc3 gene expression using a bbc3 gene promoter
    • bbc3基因启动子和使用bbc3基因启动子鉴定凋亡调节剂和bbc3基因表达的方法
    • US07202024B2
    • 2007-04-10
    • US09953133
    • 2001-09-17
    • Jia-Wen HanThomas Chittenden
    • Jia-Wen HanThomas Chittenden
    • C12Q1/68
    • G01N33/5023G01N33/5008G01N33/5011G01N2500/20G01N2510/00
    • The present invention is directed to methods for identifying compounds that modulate apoptosis, directly or indirectly, as measured by changes in expression of the bbc3 gene or a reporter gene, or by changes in the apoptotic character of a cell. The present invention is also directed to methods for identifying compounds that modulate expression of the bbc3 gene and a method for identifying compounds that interact with a promoter of the bbc3 gene. The present invention is further directed to a method for modulating apoptosis in a cell, a method for modulating bbc3 gene expression in a cell, a process for making a modulator of apoptosis, and a process for making a modulator of bbc3 gene expression. Finally, the present invention is directed to compounds identified by each of the methods of this invention, and to promoters of the bbc3 gene and sequences homologous thereto.
    • 本发明涉及通过bbc3基因或报道基因的表达变化或细胞凋亡特性的变化来测定直接或间接调节凋亡的化合物的方法。 本发明还涉及用于鉴定调节bbc3基因表达的化合物的方法和用于鉴定与bbc3基因的启动子相互作用的化合物的方法。 本发明还涉及调节细胞凋亡的方法,调节细胞中bbc3基因表达的方法,制备凋亡调节剂的方法以及制备bbc3基因表达调节剂的方法。 最后,本发明涉及由本发明的每种方法鉴定的化合物,以及bbc3基因的启动子和与其同源的序列。