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1. 发明授权

US07202024B2 bbc3 Gene promoter and methods for identifying modulators of apoptosis and bbc3 gene expression using a bbc3 gene promoter 失效
标题翻译： bbc3基因启动子和使用bbc3基因启动子鉴定凋亡调节剂和bbc3基因表达的方法
公开(公告)号：US07202024B2
公开(公告)日：2007-04-10
申请号：US09953133
申请日：2001-09-17
申请人： Jia-Wen Han , Thomas Chittenden
发明人： Jia-Wen Han , Thomas Chittenden
IPC分类号： C12Q1/68
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/5011 , G01N2500/20 , G01N2510/00
摘要： The present invention is directed to methods for identifying compounds that modulate apoptosis, directly or indirectly, as measured by changes in expression of the bbc3 gene or a reporter gene, or by changes in the apoptotic character of a cell. The present invention is also directed to methods for identifying compounds that modulate expression of the bbc3 gene and a method for identifying compounds that interact with a promoter of the bbc3 gene. The present invention is further directed to a method for modulating apoptosis in a cell, a method for modulating bbc3 gene expression in a cell, a process for making a modulator of apoptosis, and a process for making a modulator of bbc3 gene expression. Finally, the present invention is directed to compounds identified by each of the methods of this invention, and to promoters of the bbc3 gene and sequences homologous thereto.
摘要翻译：本发明涉及通过bbc3基因或报道基因的表达变化或细胞凋亡特性的变化来测定直接或间接调节凋亡的化合物的方法。本发明还涉及用于鉴定调节bbc3基因表达的化合物的方法和用于鉴定与bbc3基因的启动子相互作用的化合物的方法。本发明还涉及调节细胞凋亡的方法，调节细胞中bbc3基因表达的方法，制备凋亡调节剂的方法以及制备bbc3基因表达调节剂的方法。最后，本发明涉及由本发明的每种方法鉴定的化合物，以及bbc3基因的启动子和与其同源的序列。

2. 发明申请

US20130072439A1 PEPTIDOMIMETIC MACROCYCLES 审中-公开
标题翻译：胶原蛋白
公开(公告)号：US20130072439A1
公开(公告)日：2013-03-21
申请号：US13497522
申请日：2010-09-22
申请人： Huw M. Nash , Rosana Kapeller-Libermann , Jia-wen Han , Tomi K. Sawyer , Justin Noehre , Noriyuki Kawahata
发明人： Huw M. Nash , Rosana Kapeller-Libermann , Jia-wen Han , Tomi K. Sawyer , Justin Noehre , Noriyuki Kawahata
IPC分类号： A61K38/16 , A61K38/12 , C07K14/00 , C07K7/64
CPC分类号： A61K38/16 , A61K38/00 , A61K38/12 , C07K7/50 , C07K7/64 , C07K14/00
摘要： Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an a,a-disubstituted amino acid, or may comprise a crosslinker linking the a-positions of at least two amino acids or at least one of said two amino acids may be an a,a-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
摘要翻译：公开了包含螺旋的拟肽大环化合物，例如α螺旋，以及使用这种大环化合物治疗诸如癌症的疾病的方法。在其它方面，拟肽大环化合物包含a，α-二取代的氨基酸，或可以包含连接至少两个氨基酸的a-位的交联剂或所述两个氨基酸中的至少一个可以是a，氨基酸。进一步包括靶向Wnt信号通路的组分，例如Tcf4- / 3-连环蛋白复合物。

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