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    • 1. 发明授权
    • Conjugated biological molecules and their preparation
    • 共轭生物分子及其制备
    • US08816051B2
    • 2014-08-26
    • US13077980
    • 2011-03-31
    • Stephen James BrocchiniAntony Robert GodwinElisa PedoneJi-Won ChoiSunil Shaunak
    • Stephen James BrocchiniAntony Robert GodwinElisa PedoneJi-Won ChoiSunil Shaunak
    • C07K1/13A61K47/48
    • A61K47/48215A61K47/60
    • Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z1 and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Z1 and Z2 together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a C1-5 alkylene or alkenylene chain; and B is a bond or a C1-4 alkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.
    • 通式(I)的新型生物活性化合物,其中X和X'之一表示聚合物,另一个表示氢原子; 每个Q独立地表示连接基团; W表示吸电子部分或可通过还原吸电子部分制备的部分; 或者如果X'代表聚合物,则X-Q-W一起可以代表吸电子基团; 此外,如果X表示聚合物,则X'和吸电子基团W与中间原子一起可以形成环; Z 1和Z 2各自独立地表示衍生自生物分子的基团,其各自经由亲核部分与A和B连接; 或Z 1和Z 2一起表示衍生自经由两个亲核部分与A和B连接的生物分子的单一基团; A是C 1-5亚烷基或亚烯基链; 和B是键或C 1-4亚烷基或亚烯基链; 通过将所述分子中的亲核基团,优选通过二硫桥将合适的聚合物与合适的生物活性分子结合而形成。
    • 10. 发明申请
    • LED DRIVER APPARATUS
    • LED驱动装置
    • US20130147382A1
    • 2013-06-13
    • US13693570
    • 2012-12-04
    • Wan-jik LeeJi-won ChoiChang-sik Lim
    • Wan-jik LeeJi-won ChoiChang-sik Lim
    • H05B37/02
    • H05B37/02G09G3/3406H05B33/0815H05B33/0848H05B33/0887
    • A light emitting diode (LED) driver apparatus is provided. The LED driver apparatus includes an input unit, a PWM signal generation unit, a DC-DC converter, an LED driving unit, and a synchronization unit. The input unit is configured to receive a dimming signal. The PWM signal generation unit is configured to generate a PWM signal using an oscillator having a preset frequency. The DC-DC converter is configured to provide a driving voltage to an LED array using the generated PWM signal. The LED driving unit is configured to drive the LED array using the received dimming signal. The synchronization unit is configured to reset the oscillator based on a driving state of the LED array.
    • 提供了一种发光二极管(LED)驱动器装置。 LED驱动器装置包括输入单元,PWM信号生成单元,DC-DC转换器,LED驱动单元和同步单元。 输入单元被配置为接收调光信号。 PWM信号生成单元被配置为使用具有预设频率的振荡器来产生PWM信号。 DC-DC转换器被配置为使用所生成的PWM信号向LED阵列提供驱动电压。 LED驱动单元被配置为使用所接收的调光信号来驱动LED阵列。 同步单元被配置为基于LED阵列的驱动状态来重置振荡器。