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1. 发明申请

US20190255105A1 ANTIVIRAL COMPOSITION AND APPLICATIONS OF IRON-DOPED APATITE NANOPARTICLES 审中-公开
公开(公告)号：US20190255105A1
公开(公告)日：2019-08-22
申请号：US15902272
申请日：2018-02-22
申请人： Jessica M. Gregory , Jack L. Skinner , Marisa L. Pedulla , M. Katie Hailer
发明人： Jessica M. Gregory , Jack L. Skinner , Marisa L. Pedulla , M. Katie Hailer
IPC分类号： A61K33/42 , A61K9/51 , A61K9/00 , A61P31/22
摘要： Iron-doped apatite nanoparticles (IDANPs) are useful for the prevention, treatment, or alleviation of signs or symptoms associated with viral activation or infection. IDANPs have demonstrated a significant influence over herpes simplex virus 1 (HSV-1) infection of two mammalian cell lines. Specifically, IDANPs decreased HSV-1 infection of African Green Monkey kidney epithelial (Vero) cells by 84% and HSV-1 infection of human lung bronchus (BEAS-2B) cells by 71%. IDANPs consist of hydroxyapatite (HA) doped with iron. HA is a mineral known to be biocompatible and analogous to the inorganic constituent of mammalian bone and teeth and has been approved by the Food and Drug Administration (FDA) for many applications in medicine and dentistry. Lactate Dehydrogenase (LDH) and XTT (2,3-Bis 2-methoxy-4-nitro-5-sulfophenyl-2H-tetrazolium-5-carboxanilide inner salt) cytotoxicity assays revealed that IDANPs are largely non-toxic to Vero, BEAS-2B, and human cervical cancer (HeLa) cells lines. HSV-1 afflicted individuals in the United States have been estimated as high as ⅔ the population. Because IDANPs dramatically decrease HSV-1 infection and are largely non-toxic, their application as an antiviral agent is evident. Further, although iron(III) alone has been shown to diminish replication of deoxyribonucleic acid (DNA)- and ribonucleic acid (RNA)-containing viruses, IDANP cytotoxicity studies indicate that encasement and delivery of iron within an apatite unit cell structure diminishes significantly, and in some cases eliminates, cytotoxicity posed by the introduction of iron(III) alone.

2. 发明授权

US10392612B1 Method of particulate transport via small-scale morphology materials 有权
公开(公告)号：US10392612B1
公开(公告)日：2019-08-27
申请号：US15166192
申请日：2016-05-26
申请人： Jessica M. Gregory , Katie Hailer , Marisa Pedulla , Jack Skinner
发明人： Jessica M. Gregory , Katie Hailer , Marisa Pedulla , Jack Skinner
IPC分类号： C12N11/04 , C12N7/00 , C12N11/08
摘要： Small scale morphology materials transport particles and viruses from within the material to a living or non-living surface or artificial representation thereof. These materials are polymer composite and have features or are measured in their entirety to be less than 100 microns.

3. 发明授权

US10532070B2 Antiviral composition and applications of iron-doped apatite nanoparticles 有权
公开(公告)号：US10532070B2
公开(公告)日：2020-01-14
申请号：US15902272
申请日：2018-02-22
申请人： Jessica M. Gregory , Jack L. Skinner , Marisa L. Pedulla , M. Katie Hailer
发明人： Jessica M. Gregory , Jack L. Skinner , Marisa L. Pedulla , M. Katie Hailer
IPC分类号： A61K9/51 , A61K9/00 , A61K33/42 , A61P31/22
摘要： Iron-doped apatite nanoparticles (IDANPs) are useful for the prevention, treatment, or alleviation of signs or symptoms associated with viral activation or infection. IDANPs have demonstrated a significant influence over herpes simplex virus 1 (HSV-1) infection of two mammalian cell lines. Specifically, IDANPs decreased HSV-1 infection of African Green Monkey kidney epithelial (Vero) cells by 84% and HSV-1 infection of human lung bronchus (BEAS-2B) cells by 71%. IDANPs consist of hydroxyapatite (HA) doped with iron. HA is a mineral known to be biocompatible and analogous to the inorganic constituent of mammalian bone and teeth and has been approved by the Food and Drug Administration (FDA) for many applications in medicine and dentistry. Lactate Dehydrogenase (LDH) and XTT (2,3-Bis 2-methoxy-4-nitro-5-sulfophenyl-2H-tetrazolium-5-carboxanilide inner salt) cytotoxicity assays revealed that IDANPs are largely non-toxic to Vero, BEAS-2B, and human cervical cancer (HeLa) cells lines. HSV-1 afflicted individuals in the United States have been estimated as high as ⅔ the population. Because IDANPs dramatically decrease HSV-1 infection and are largely non-toxic, their application as an antiviral agent is evident. Further, although iron(III) alone has been shown to diminish replication of deoxyribonucleic acid (DNA)- and ribonucleic acid (RNA)-containing viruses, IDANP cytotoxicity studies indicate that encasement and delivery of iron within an apatite unit cell structure diminishes significantly, and in some cases eliminates, cytotoxicity posed by the introduction of iron(III) alone.

4. 发明授权

US11191721B1 Particle delivery via small-scale morphology materials for antibacterial applications 有权
公开(公告)号：US11191721B1
公开(公告)日：2021-12-07
申请号：US16421108
申请日：2019-05-23
申请人： Jessica M. Gregory , Jack L. Skinner , Marisa L. Pedulla , M. Katie Hailer
发明人： Jessica M. Gregory , Jack L. Skinner , Marisa L. Pedulla , M. Katie Hailer
IPC分类号： A61K9/00 , A61K9/70 , A61K35/76 , C12N7/00 , A61K47/02 , A61K47/34 , A01N25/34 , A01N25/10 , A23L3/3463 , D01D5/00 , A01N63/00
摘要： Disclosed herein is a particle delivery system comprising electrospun nanofiber comprised of coaxial fiber with a microfluidic core. Iron-doped apatite nanoparticles (IDANPs) have demonstrated a unique influence over phage killing of bacteria, whereby, IDANP-exposed bacterial cultures experience 2× the bacterial death as controls. IDANPs consist of hydroxyapatite (HA) doped with iron. HA is a mineral known to be biocompatible and analogous to the inorganic constituent of mammalian bone and teeth and has been approved by the Food and Drug Administration (FDA) for many applications in medicine and dentistry. Previous work has shown that for IDANPs to enhance antibacterial activity of phage to the greatest extent, bacterial cultures should be exposed to IDANPs for 1 hr prior to phage introduction. Biocompatible polymer materials which encase IDANPs and/or phage can be used to disseminate IDANPs and/or phage in a controlled manner into a physiological system for treatment of bacterial infection. When components of said materials contain micro- or nano-scale components, high surface-to-volume ratio for treatment delivery is garnered.

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