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1. 发明申请

US20050171602A1 Antimicrobial indwelling voice prosthesis 有权
标题翻译：抗生素留置声假体
公开(公告)号：US20050171602A1
公开(公告)日：2005-08-04
申请号：US11093351
申请日：2005-03-29
申请人： Jeffrey Goldberg , Edmund Seder , Jesse Nelson , Juan Madrigal
发明人： Jeffrey Goldberg , Edmund Seder , Jesse Nelson , Juan Madrigal
IPC分类号： A61F2/20 , A61L27/54
CPC分类号： A61F2/203 , A61L27/54 , A61L2300/404 , A61L2300/606
摘要： A voice prosthesis comprising a tubular body portion, a valve and a valve seat disposed within the body portion. The valve seat is further comprised of a medical grade elastomer containing a dispersion of an antimicrobial agent. This valve seat extends the life of the prosthesis by retarding the growth of microorganisms. The body portion of the prosthesis may also contain an antimicrobial agent at a concentration that is non-toxic to the tissue it contacts.
摘要翻译：一种声音假体，包括管状主体部分，阀和设置在主体部分内的阀座。阀座还包含含有抗微生物剂分散体的医用级弹性体。该阀座通过延缓微生物的生长来延长假体的寿命。假体的身体部分还可以含有与其接触的组织无毒的浓度的抗微生物剂。

2. 发明申请

US20060287722A1 Voice Prosthesis Device 审中-公开
标题翻译：语音假肢装置
公开(公告)号：US20060287722A1
公开(公告)日：2006-12-21
申请号：US11421898
申请日：2006-06-02
申请人： Jesse Nelson
发明人： Jesse Nelson
IPC分类号： A61F2/20
CPC分类号： A61F2/203
摘要： A voice prosthesis device provides a passageway between a tracheal end of the device and an esophageal end of the device. A valve in the passageway includes a seat having a first hardness and a movable valve member having a second hardness harder than the first hardness. The movable valve member closes against the seat to close the valve.
摘要翻译：声音假体装置在装置的气管端与装置的食道端之间提供通道。通道中的阀包括具有第一硬度的座和具有比第一硬度硬的第二硬度的可动阀构件。可移动阀构件抵靠阀座关闭以关闭阀。

3. 发明申请

US20050256573A1 Medical devices having antimicrobial properties 有权
标题翻译：具有抗菌性能的医疗器械
公开(公告)号：US20050256573A1
公开(公告)日：2005-11-17
申请号：US10990168
申请日：2004-11-15
申请人： Edmund Seder , Jesse Nelson
发明人： Edmund Seder , Jesse Nelson
IPC分类号： A61F2/20 , A61L27/54
CPC分类号： A61L27/54 , A61F2/203 , A61L2300/104 , A61L2300/202 , A61L2300/21 , A61L2300/404
摘要： Microbial growth on the surface of a valve of a voice prosthesis and optionally the cartridge or ring supporting the valve, is inhibited by providing antimicrobial activity at a level sufficient to retard growth of a microbial film by dispersing an inorganic antimicrobial agent such as silver oxide or an organic antimicrobial agent such as triclosan or butyl paraben dispersed in a medical grade silicone elastomer. The valve, ring or cartridge is in contact with body fluids containing microorganisms and nutrients therefor. The antimicrobial surface can interfere with or inhibit the growth of a biofilm, bacterial layer or a yeast layer. The body of the prosthesis may also contain an antimicrobial surface as long as it is non-toxic to the tissue it contacts.
摘要翻译：通过提供足够的抗微生物活性以抑制微生物膜的生长，通过分散无机抗微生物剂如氧化银或氧化银的方式来抑制语音假体的瓣膜表面和任选地支撑瓣膜的药筒或环的表面上的微生物生长分散在医用级硅橡胶弹性体中的有机抗微生物剂如三氯生或对羟基苯甲酸丁酯。阀，环或药筒与含有微生物和营养物的体液接触。抗微生物表面可以干扰或抑制生物膜，细菌层或酵母层的生长。假体的主体也可以含有抗微生物表面，只要它对其接触的组织无毒。

4. 发明申请

US20060276893A1 Voice prosthesis device 有权
标题翻译：声音假体装置
公开(公告)号：US20060276893A1
公开(公告)日：2006-12-07
申请号：US11145791
申请日：2005-06-06
申请人： Jesse Nelson
发明人： Jesse Nelson
IPC分类号： A61F2/20
CPC分类号： A61F2/203
摘要： A voice prosthesis device for insertion into a tracheoesophageal opening of a wearer and a method of making it. The device comprises a barrel providing a first passageway therethrough, a tracheal flange adjacent a tracheal end of the barrel and an esophageal flange adjacent an esophageal end of the barrel. The tracheal flange and esophageal flange aid in retaining the voice prosthesis device in the tracheoesophageal opening. The first passageway may include a first stop extending inwardly from a sidewall of the first passageway between the tracheal and esophageal ends and a plurality of second stops extending inwardly from the sidewall of the first passageway between the first stop and the esophageal end of the first passageway. A valve mechanism between the first stop and the second stops permits flow through the first passageway from the tracheal end and impedes flow through the first passageway from the esophageal end. At least one second passageway may be provided on the valve mechanism. The at least one second passageway intersects a sidewall of the first passageway when the valve mechanism is inserted into the first passageway. The second passageway contains a material to fix the valve mechanism in the first passageway.
摘要翻译：用于插入佩戴者的气管食管开口的声音假体装置及其制造方法。该装置包括提供穿过其中的第一通道的桶，邻近筒的气管端的气管法兰和邻近食管端的食管法兰。气管法兰和食管法兰有助于将声音假体装置保留在气管食管开口中。第一通道可以包括从气管和食管端之间的第一通道的侧壁向内延伸的第一止动件和从第一通道的第一止动件和食管端之间的第一通道的侧壁向内延伸的多个第二止动件。在第一止挡件和第二止挡件之间的阀机构允许从气管端流过第一通道并阻止从食管端流过第一通道。至少一个第二通道可以设置在阀机构上。当阀机构插入第一通道中时，至少一个第二通道与第一通道的侧壁相交。第二通道包含用于将阀机构固定在第一通道中的材料。

5. 发明申请

US20050020844A1 Antimicrobial elastomer composition and method for making 有权
标题翻译：抗菌弹性体组合物及其制造方法
公开(公告)号：US20050020844A1
公开(公告)日：2005-01-27
申请号：US10923138
申请日：2004-08-19
申请人： Jesse Nelson
发明人： Jesse Nelson
IPC分类号： A61F2/20 , A61L27/54 , C07F7/02
CPC分类号： A61K31/28 , A61F2/203 , A61L27/18 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/606 , C08F290/06 , C08G77/04 , C08L83/04
摘要： A method for making an elastomeric material containing an antimicrobial composition such as a dispersion of silver oxide that is suitable for implantation within the body. The elastomer made in accordance with this method extends the amount of work-time available for processing the elastomer into an article as compared with the work-time available when using prior art compounding methods.
摘要翻译：制备含有抗微生物组合物的弹性体材料的方法，所述抗微生物组合物例如适于植入体内的氧化银分散体。与使用现有技术的复合方法相比，根据该方法制造的弹性体将可加工弹性体的工作时间量与可用的工作时间相比延长。

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