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1. 发明授权

US07166698B2 Mammalian gene, bcl-w, belongs to the bcl-2 family of apoptosis-controlling genes 失效
标题翻译：哺乳动物基因bcl-w属于凋亡控制基因的bcl-2家族
公开(公告)号：US07166698B2
公开(公告)日：2007-01-23
申请号：US09925674
申请日：2001-08-09
申请人： Suzanne Cory , Jerry McKee Adams , Leonie M. Gibson , Shaun P. Holmgreen
发明人： Suzanne Cory , Jerry McKee Adams , Leonie M. Gibson , Shaun P. Holmgreen
IPC分类号： C07K1/00 , C07K14/00 , C12P21/06 , C12N5/00 , C12N15/00 , C12N15/63 , C07H21/02
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention is broadly directed to therapeutic molecules capable of inter alia modulating apoptosis in mammalian cells. The therapeutic molecules of the present invention encompass genetic sequences and chemical entities capable of regulating expression of a novel mammalian gene belonging to the bcl-2 family and which promotes cell survival. The therapeutic molecules of the present invention may have further utility in delaying cell cycle entry. In addition, the present invention extends to chemical entities capable of modulating activity and function of the translation product of said novel gene of the bcl-2 family. The present invention also extends to the translation product of the novel gene of the bcl-2 family and its use in, for example, therapy, diagnosis, antibody generation and as a screening tool for therapeutic molecules capable of modulating physiological cell death or survival and/or modulating cell cycle entry.
摘要翻译：本发明广泛地涉及能够特别调节哺乳动物细胞凋亡的治疗分子。本发明的治疗分子包括能够调节属于bcl-2家族的新型哺乳动物基因的表达并促进细胞存活的遗传序列和化学实体。本发明的治疗分子可以在延迟细胞周期进入方面具有进一步的实用性。此外，本发明延伸到能够调节bcl-2家族的所述新基因的翻译产物的活性和功能的化学实体。本发明还延伸到bcl-2家族的新基因的翻译产物及其在例如治疗，诊断，抗体产生中的用途以及用于调节生理细胞死亡或存活的治疗分子的筛选工具，以及 /或调节细胞周期进入。

2. 发明申请

US20100197711A1 BENZOTHIAZOLE COMPOUNDS 审中-公开
标题翻译：苯并噻唑化合物
公开(公告)号：US20100197711A1
公开(公告)日：2010-08-05
申请号：US12678836
申请日：2007-09-27
申请人： Keith Geoffrey Watson , Guillaume Laurent Lessene , Jonathan Bayldon Baell , David Ching Siang Huang , Ian Philip Street , Jerry McKee Adams , Peter Malcolm Colman , Brad Edmund Sleebs , Brian John Smith , Peter Edward Czabotar
发明人： Keith Geoffrey Watson , Guillaume Laurent Lessene , Jonathan Bayldon Baell , David Ching Siang Huang , Ian Philip Street , Jerry McKee Adams , Peter Malcolm Colman , Brad Edmund Sleebs , Brian John Smith , Peter Edward Czabotar
IPC分类号： A61K31/428 , C07D277/82 , C07D417/12 , C12N5/09 , A61K31/506 , A61K31/4439 , A61P29/00 , A61P35/00 , A61P37/00 , A61P35/02 , A61P19/02
CPC分类号： C07D417/12 , C07D277/82 , C07D417/14
摘要： The present invention relates to benzothiazole compounds that mimic the activity of BH3 only proteins and are capable of binding to and neutralizing pro survival Bcl 2 proteins. The invention also relates to the use of such compounds in the regulation of cell death or cell survival and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death or cell survival.
摘要翻译：本发明涉及苯并噻唑化合物，其类似于仅BH3蛋白的活性并且能够结合和中和生存的Bcl 2蛋白。本发明还涉及这些化合物在调节细胞死亡或细胞存活以及治疗和/或预防与细胞死亡或细胞存活失调相关的疾病或病症中的用途。

3. 发明授权

US06790637B1 Mammalian gene, BCL-W, belongs to the BCL-2 family of apoptosis-controlling genes 失效
标题翻译：哺乳动物基因BCL-W属于BCL-2细胞凋亡控制基因家族
公开(公告)号：US06790637B1
公开(公告)日：2004-09-14
申请号：US09155327
申请日：1999-03-29
申请人： Suzanne Cory , Jerry McKee Adams , Leonie M. Gibson , Shaun P. Holmgreen
发明人： Suzanne Cory , Jerry McKee Adams , Leonie M. Gibson , Shaun P. Holmgreen
IPC分类号： C12P2106
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention is broadly directed to therapeutic molecules capable of inter alia modulating apoptosis in mammalian cells. The therapeutic molecules of the present invention encompass genetic sequences and chemical entities capable of regulating expression of a novel mammalian gene belonging to the bcl-2 family and which promotes cell survival. The therapeutic molecules of the present invention may have further utility in delaying cell cycle entry. In addition, the present invention extends to chemical entities capable of modulating activity and function of the translation product of said novel gene of the bcl-2 family. The present invention also extends to the translation product of the novel gene of the bcl-2 family and its use in, for example, therapy, diagnosis, antibody generation and as a screening tool for therapeutic molecules capable of modulating physiological cell death or survival and/or modulating cell cycle entry.
摘要翻译：本发明广泛地涉及能够特别调节哺乳动物细胞凋亡的治疗分子。本发明的治疗分子包括能够调节属于bcl-2家族的新型哺乳动物基因的表达并促进细胞存活的遗传序列和化学实体。本发明的治疗分子可以在延迟细胞周期进入方面具有进一步的实用性。此外，本发明延伸到能够调节bcl-2家族的所述新基因的翻译产物的活性和功能的化学实体。本发明还延伸到bcl-2家族的新基因的翻译产物及其在例如治疗，诊断，抗体产生中的用途以及用于调节生理细胞死亡或存活的治疗分子的筛选工具，以及 /或调节细胞周期进入。

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