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1. 发明申请

US20070276435A1 VASCULAR CLOSURE DEVICES AND METHODS PROVIDING HEMOSTATIC ENHANCEMENT 有权
标题翻译：血管闭塞装置和提供血液增生的方法
公开(公告)号：US20070276435A1
公开(公告)日：2007-11-29
申请号：US11772718
申请日：2007-07-02
申请人： Zia Yassinzadeh , Jeffrey Weitz , Alan Stafford
发明人： Zia Yassinzadeh , Jeffrey Weitz , Alan Stafford
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00659 , A61B2017/00676 , A61B2017/00778 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/3484 , A61B2090/032
摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with chemical and/or biological agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A chemical and/or biological sealing member disposed proximal the expansible member is then displaced so as to expose a chemical and/or biological region or release region of the device. At least one chemical and/or biological agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.
摘要翻译：描述了药物洗脱血管闭合装置和用于闭合设置在组织管的远端处的血管穿刺部位的方法。装置和方法依赖于身体自身机制的组合，以实现与化学和/或生物剂的止血以加速止血过程。一种方法包括以下步骤：通过组织管道引入闭合装置，并在血管内的装置的远端部署可膨胀构件以封闭穿刺部位。设置在可膨胀构件附近的化学和/或生物密封构件然后被移位，以暴露设备的化学和/或生物区域或释放区域。此后，至少一种化学和/或生物剂从该装置中释放并进入组织道，以加速该道中的闭塞过程。

2. 发明申请

US20070196347A1 Methods for preventing neurological events 审中-公开
标题翻译：预防神经系统事件的方法
公开(公告)号：US20070196347A1
公开(公告)日：2007-08-23
申请号：US10567737
申请日：2004-08-12
申请人： Anthony Chan , Jeffrey Weitz , Jack Hirsh , Paul Tressel , Roy Berry
发明人： Anthony Chan , Jeffrey Weitz , Jack Hirsh , Paul Tressel , Roy Berry
IPC分类号： A61K38/55 , A61K31/727
CPC分类号： A61K31/726 , A61K38/57 , A61K47/61 , A61K2300/00
摘要： The present invention relates to therapeutic methods for preventing or reducing neurological events utilizing a glycosaminoglycan and a serpin, including complexes and conjugates thereof. Methods of the present invention may be advantageous for preventing or reducing neurological events prior to, or during medical or surgical procedures, and after a neurological event. In particular, the present invention deals with neurological events associated with the generation of emboli that can lodge in the brain and/or cerebral circulation during cardiac surgery.
摘要翻译：本发明涉及使用糖胺聚糖和丝氨酸蛋白酶抑制或减少神经系统事件的治疗方法，包括其复合物和缀合物。本发明的方法可有利于预防或减少在医疗或外科手术之前或在医疗或手术过程之后以及在神经系统事件之后的神经系统事件。特别地，本发明涉及与心脏手术期间可能存在于脑和/或脑循环中的栓塞的产生相关的神经学事件。

3. 发明申请

US20050032745A1 Modified low molecular weight heparin that inhibits clot associated coagulation factors 审中-公开
标题翻译：改进的低分子量肝素抑制凝块相关的凝血因子
公开(公告)号：US20050032745A1
公开(公告)日：2005-02-10
申请号：US10622425
申请日：2003-07-21
申请人： Jeffrey Weitz , Jack Hirsh
发明人： Jeffrey Weitz , Jack Hirsh
IPC分类号： A61K31/727 , C08B37/00 , C08B37/10
CPC分类号： A61K31/727 , C08B37/0078
摘要： The present invention provides compositions and methods for the treatment of cardiovascular diseases. More particularly, the present invention relates to modifying thrombus formation by administering an agent which, inter alia, is capable of (1) inactivating fluid-phase thrombin and thrombin which is bound either to fibrin in a clot or to some other surface by catalyzing antithrombin; and (2) inhibiting thrombin generation by catalyzing factor Xa inactivation by antithrombin III (ATIII). The compositions and methods of the present invention are particularly useful for preventing thrombosis in the circuit of cardiac bypass apparatus and in patients undergoing renal dialysis, and for treating patients suffering from or at risk of suffering from thrombus-related cardiovascular conditions, such as unstable angina, acute myocardial infarction (heart attack), cerebrovascular accidents (stroke), pulmonary embolism, deep vein thrombosis, arterial thrombosis, etc.
摘要翻译：本发明提供了用于治疗心血管疾病的组合物和方法。更具体地，本发明涉及通过施用特别是能够（1）通过催化抗凝血酶（1）灭活血凝块中的纤维蛋白或凝血酶结合到其它表面的凝血酶的试剂来改变血栓形成 ; 和（2）通过用抗凝血酶III（ATIII）催化因子Xa灭活抑制凝血酶产生。本发明的组合物和方法特别可用于预防心脏旁路装置和经历肾透析患者的血栓形成，并且用于治疗患有血栓相关心血管疾病或患有血栓相关心血管病症的患者，例如不稳定型心绞痛，急性心肌梗死（心脏病发作），脑血管意外（中风），肺栓塞，深静脉血栓形成，动脉血栓形成等。

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