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1. 发明申请

US20070184447A1 Chemo-centric selection of disease-related genetic profiles 失效
标题翻译：以化学为中心的疾病相关遗传图谱选择
公开(公告)号：US20070184447A1
公开(公告)日：2007-08-09
申请号：US10590256
申请日：2005-02-24
申请人： Jeffrey Strovel , David Bol , Paul Young
发明人： Jeffrey Strovel , David Bol , Paul Young
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： Methods for the identification of disease-related gene sets and expression nprofiles, based on common chemical modulation using a specific chemical compound are disclosed.
摘要翻译：公开了基于使用特定化合物的常规化学调节的鉴定疾病相关基因组和表达谱的方法。

2. 发明申请

US20100249111A1 MULTI-RING COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：多环化合物及其用途
公开(公告)号：US20100249111A1
公开(公告)日：2010-09-30
申请号：US12451112
申请日：2008-04-25
申请人： Norman E. Ohler , Jeffrey W. Watthey , Jeffrey Strovel , Sheela K. Chellappan
发明人： Norman E. Ohler , Jeffrey W. Watthey , Jeffrey Strovel , Sheela K. Chellappan
IPC分类号： A61K31/55 , A61P35/00 , A61P35/04 , C07D401/06 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D401/12 , C07D413/10 , A61K31/5377 , C07D401/10
CPC分类号： C07D211/46 , C07C235/50 , C07C2601/14 , C07D207/09 , C07D211/00 , C07D211/14 , C07D211/34 , C07D295/13 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/14 , C07D453/02
摘要： Chemical agents, such as derivatives of hydroxy benzene moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译：化学试剂，例如羟基苯部分的衍生物和类似的杂环结构，包括其盐，其作为抗癌剂和抗肿瘤剂，特别是其中这些试剂调节细胞中存在的酶和结构多肽的活性，例如作为癌细胞，或其中调节细胞系统（包括癌细胞）中基因表达水平的方法，以及含有这些试剂的药物组合物以及使用这些作为治疗剂的方法的药物组合物代理商

3. 发明申请

US20080025981A1 Cancer-linked genes as targets for chemotherapy 审中-公开
标题翻译：癌症相关基因为化疗靶向
公开(公告)号：US20080025981A1
公开(公告)日：2008-01-31
申请号：US11599845
申请日：2006-11-15
申请人： Paul Young , Reinhard Ebner , Zoe Weaver , Jeffrey Strovel , Stephen Horrigan , Martin Shea , Bernd Weigle , Michael Rieger , Jennifer Rick , Colyn Cain
发明人： Paul Young , Reinhard Ebner , Zoe Weaver , Jeffrey Strovel , Stephen Horrigan , Martin Shea , Bernd Weigle , Michael Rieger , Jennifer Rick , Colyn Cain
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30 , C12Q1/68
CPC分类号： G01N33/5011 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with methods for assaying for potential antitumor agents based on their modulation of the expression of these cancer-related genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing cancer using the gene sequences as well as the polypeptide sequences.
摘要翻译：公开了与癌基因序列和衍生的氨基酸序列，以及基于它们对这些癌症相关基因表达的调节来测定潜在的抗肿瘤剂的方法。还公开了与所公开的多肽反应的抗体以及使用抗体治疗癌性病症的方法，例如使用抗体靶向靶细胞体内的癌细胞用于递送治疗剂的目的。还描述了使用基因序列以及多肽序列诊断癌症的方法。

4. 发明授权

US08129519B2 Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof 有权
标题翻译：芴，蒽，呫吨，二苯并one酮和吖啶的衍生物及其用途
公开(公告)号：US08129519B2
公开(公告)日：2012-03-06
申请号：US12451313
申请日：2008-05-09
申请人： Wieslaw M. Cholody , Yi Zang , Karina Zuck , Jeffrey W. H. Watthey , Zoe Ohler , Jeffrey Strovel , Norman E. Ohler , Sheela Chellappan , Janak Padia
发明人： Wieslaw M. Cholody , Yi Zang , Karina Zuck , Jeffrey W. H. Watthey , Zoe Ohler , Jeffrey Strovel , Norman E. Ohler , Sheela Chellappan , Janak Padia
IPC分类号： C07D345/00
CPC分类号： A61K31/395 , A61K31/18 , A61K31/409 , A61K31/435 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07C311/20 , C07C2601/14 , C07D211/96 , C07D295/26
摘要： Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译：化学试剂，如芴，蒽，呫吨，二苯并uber酮和吖啶的二磺酰胺衍生物，以及类似的杂环结构（包括其盐），其作为抗癌剂和抗肿瘤剂，特别是当这些试剂调节Wnt的活性时并且用于减少存在于细胞（例如癌细胞）中或在其中调节细胞系统（包括癌细胞）中的基因表达水平的细胞中的β-联蛋白水平，以及用于制备这些试剂，以及含有这些试剂如活性成分的药物组合物和使用它们作为治疗剂的方法。

5. 发明申请

US20070059697A1 Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods 审中-公开
标题翻译：使用分子细胞遗传学方法确定癌症相关基因和治疗靶点
公开(公告)号：US20070059697A1
公开(公告)日：2007-03-15
申请号：US10553098
申请日：2004-04-15
申请人： Jeffrey Strovel , Colyn Cain , Stephen Horrigan , Meena Augustus
发明人： Jeffrey Strovel , Colyn Cain , Stephen Horrigan , Meena Augustus
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16
摘要： Methods for identifying potential therapeutic agents, such as anti-tumor agents, based on their modulation of the expression of specified genes, especially genes mapping to specific chromosomal regions, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, including detecting changes in levels of gene copy number and/or level of amplification of the said gene, or sets of genes, to detect and/or diagnose the cancer. Methods for detecting or determining functionally related genes, as well as methods for treating cancer based on targeting expression products of such genes, determining genes involved in the cancerous process and the success and/or response rates and survival statistics for cancer patients on treatment are encompassed by the invention. Also encompassed are methods involving determining the modulated expression of the genes in these regions of interest (ROIs) as pharmacodynamic/pharmacogenetic /surrogate markers and/or for patient profiling prior to accrual for clinical trials/treatments based on the identification of these genes as validated gene/drug targets in various cancer tissue types.
摘要翻译：公开了基于其对特定基因的表达调控，特别是映射到特定染色体区域的基因的潜在治疗剂如抗肿瘤剂的方法。还描述了作为这些基因的表达或表达模式的癌症或潜在癌症病症的诊断方法，包括检测所述基因的基因拷贝数和/或扩增水平的变化，或一组基因，以检测和/或诊断癌症。包括用于检测或确定功能相关基因的方法，以及基于这些基因的靶向表达产物治疗癌症的方法，确定参与癌症过程的基因以及癌症患者治疗的成功和/或应答率和存活统计数据。通过本发明。还包括涉及将这些感兴趣区域（ROI）中的基因的调节表达作为药效学/药物代谢/替代标记物确定的方法和/或基于鉴定这些被验证的临床试验/治疗之前的患者分析基因/药物靶标在各种癌组织类型。

6. 发明申请

US20060134622A1 Amplified cancer target genes useful in diagnosis and thereapeutic screening 审中-公开
标题翻译：扩增的癌症靶基因可用于诊断和治疗筛选
公开(公告)号：US20060134622A1
公开(公告)日：2006-06-22
申请号：US10540311
申请日：2003-12-19
申请人： Meena Augustus , Stephen Horrigan , Colyn Cain , Jeffrey Strovel
发明人： Meena Augustus , Stephen Horrigan , Colyn Cain , Jeffrey Strovel
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/574 , G01N33/57415 , G01N33/78 , G01N2500/00 , G01N2800/52
摘要： A gene useful as a prognostic indicator of survival of patients afflicted with cancers such as breast cancer is described. Also disclosed are methods for screening potential therapeutic agents, such as antitumor agents, based on their modulation of the expression of a TRIP13 gene, or splice variants thereof, along with methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, including changes in copy number. Also disclosed are methods for detecting or determining functionally related genes, where disruption of TRIP13 may affect such related-gene expression, as well as methods for treating cancer based on targeting expression products of such genes and determining genes involved in the cancerous process. Methods for identifying, detecting and following patients and others having high levels of amplification/expression of the gene before treatment where differences after treatment serve as markers for indication of success of treatment or for identifying individuals who would benefit from such treatment using this gene marker as a diagnostic and/or prognostic and/or pharmacodynamic or surrogate marker are described.
摘要翻译：描述了可用作患有诸如乳腺癌之类的患者的存活的预后指标的基因。还公开了用于筛选潜在治疗剂，例如抗肿瘤剂的方法，其基于它们对TRIP13基因或其剪接变体的表达的调节，以及作为表达结果诊断癌性或潜在癌性病症的方法，或这些基因的表达模式，包括拷贝数的变化。还公开了用于检测或确定功能相关基因的方法，其中TRIP13的破坏可能影响这种相关基因表达，以及基于这些基因的靶向表达产物和确定参与癌症过程的基因来治疗癌症的方法。用于鉴定，检测和跟踪患者和其他在治疗前具有高水平的基因的扩增/表达的方法，其中治疗之后的差异用作指示治疗成功的标志物或用于鉴定将使用该基因标记从这种治疗中受益的个体描述了诊断和/或预后和/或药效学或替代标记。

7. 发明授权

US09120754B2 Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof 有权
标题翻译：芴，蒽，呫吨，二苯并one酮和吖啶的衍生物及其用途
公开(公告)号：US09120754B2
公开(公告)日：2015-09-01
申请号：US13361761
申请日：2012-01-30
申请人： Wieslaw M. Cholody , Yi Zang , Karina Zuck , Jeffrey W. H. Watthey , Zoe Ohler , Jeffrey Strovel , Gene Ohler , Sheela Chellappan , Janak Padia
发明人： Wieslaw M. Cholody , Yi Zang , Karina Zuck , Jeffrey W. H. Watthey , Zoe Ohler , Jeffrey Strovel , Gene Ohler , Sheela Chellappan , Janak Padia
IPC分类号： C07D211/96 , C07C311/20 , C07D295/26
CPC分类号： A61K31/395 , A61K31/18 , A61K31/409 , A61K31/435 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07C311/20 , C07C2601/14 , C07D211/96 , C07D295/26
摘要： Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译：化学试剂，如芴，蒽，呫吨，二苯并uber酮和吖啶的二磺酰胺衍生物，以及类似的杂环结构（包括其盐），其作为抗癌剂和抗肿瘤剂，特别是当这些试剂调节Wnt的活性时并且用于减少存在于细胞（例如癌细胞）中或在其中调节细胞系统（包括癌细胞）中的基因表达水平的细胞中的β-联蛋白水平，以及用于制备这些试剂，以及含有这些试剂如活性成分的药物组合物和使用它们作为治疗剂的方法。

8. 发明申请

US20120129837A1 Derivatives of Fluorene, Anthracene, Xanthene, Dibenzosuberone and Acridine and Uses Thereof 有权
标题翻译：芴，蒽，呫吨，二苯并uber酮和吖啶的衍生物及其用途
公开(公告)号：US20120129837A1
公开(公告)日：2012-05-24
申请号：US13361761
申请日：2012-01-30
申请人： Wieslaw M. Cholody , Yi Zang , Norman E. Ohler , Sheela Chellappan , Janak Padia , Karina Zuck , Jeffrey W.H. Watthey , Zoe Ohler , Jeffrey Strovel
发明人： Wieslaw M. Cholody , Yi Zang , Norman E. Ohler , Sheela Chellappan , Janak Padia , Karina Zuck , Jeffrey W.H. Watthey , Zoe Ohler , Jeffrey Strovel
IPC分类号： A61K31/553 , A61K31/473 , A61K31/18 , A61K31/4545 , A61K31/5377 , A61K31/55 , A61K31/551 , C07D403/12 , C07D401/14 , C07C311/37 , C07D401/12 , C07D413/12 , A61P35/00 , A61P35/04 , A61K31/395
CPC分类号： A61K31/395 , A61K31/18 , A61K31/409 , A61K31/435 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07C311/20 , C07C2601/14 , C07D211/96 , C07D295/26
摘要： Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译：化学试剂，如芴，蒽，呫吨，二苯并uber酮和吖啶的二磺酰胺衍生物，以及类似的杂环结构（包括其盐），其作为抗癌剂和抗肿瘤剂，特别是当这些试剂调节Wnt的活性时并且用于减少存在于细胞（例如癌细胞）中或在其中调节细胞系统（包括癌细胞）中的基因表达水平的细胞中的β-连环蛋白水平，以及用于制备这些试剂，以及含有这些试剂如活性成分的药物组合物和使用它们作为治疗剂的方法。

9. 发明申请

US20100137354A1 DERIVATIVES OF FLUORENE, ANTHRACENE, XANTHENE, DIBENZOSUBERONE AND ACRIDINE AND USES THEREOF 有权
标题翻译：荧光素，蒽醌，呫吨酮，二苯唑酮和吖啶的衍生物及其用途
公开(公告)号：US20100137354A1
公开(公告)日：2010-06-03
申请号：US12451313
申请日：2008-05-09
申请人： Wieslaw M. Cholody , Yi Zang , Karina E. Zuck , Jeffrey W.H. Watthey , Zoe Ohler , Jeffrey Strovel , Norman E. Ohler , Sheela K. Chellappan , Janak Padia
发明人： Wieslaw M. Cholody , Yi Zang , Karina E. Zuck , Jeffrey W.H. Watthey , Zoe Ohler , Jeffrey Strovel , Norman E. Ohler , Sheela K. Chellappan , Janak Padia
IPC分类号： A61K31/435 , C07D403/12 , C07D219/08 , C07C321/02 , A61K31/18 , A61P35/00
CPC分类号： A61K31/395 , A61K31/18 , A61K31/409 , A61K31/435 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07C311/20 , C07C2601/14 , C07D211/96 , C07D295/26
摘要： Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译：化学试剂，如芴，蒽，呫吨，二苯并uber酮和吖啶的二磺酰胺衍生物，以及类似的杂环结构（包括其盐），其作为抗癌剂和抗肿瘤剂，特别是当这些试剂调节Wnt的活性时并且用于减少存在于细胞（例如癌细胞）中或在其中调节细胞系统（包括癌细胞）中的基因表达水平的细胞中的β-联蛋白水平，以及用于制备这些试剂，以及含有这些试剂如活性成分的药物组合物和使用它们作为治疗剂的方法。

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