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    • 4. 发明申请
    • Compositions and methods for treating pain
    • 用于治疗疼痛的组合物和方法
    • US20060280718A1
    • 2006-12-14
    • US11444077
    • 2006-05-31
    • Josee RoyJeffrey Marx
    • Josee RoyJeffrey Marx
    • A61K31/765A61K31/718A61K31/717A61K31/77
    • A61K31/765A61K9/0014A61K9/0019A61K31/00A61K45/06A61K47/10A61L31/06A61L31/16A61L2300/402A61L2400/06C08L71/02
    • In the present invention, Applicants demonstrate the effect of a biomembrane sealing agent on the development of chronic pain following tissue injury as well as acute pain in a model of acute inflammation. Applicants demonstrate the ability of this class of agents referred to as “biomembrane sealing agents” to reduce the severity of hyperalgesia and allodynia following mechanical insult to the nervous system as well as their ability to reduce acute pain in a model of acute inflammation. Applicant describes the use of injectable or depot formulations of biomembrane sealing agent(s) for prophylactic treatment such as they could be administered after the insult (i.e. post-injury or post-surgery) but before the onset of acute or chronic pain. Alternatively, biomembrane sealing agents could be used to reduce the severity of acute or chronic pain after onset.
    • 在本发明中,申请人证明了生物膜密封剂对组织损伤后慢性疼痛的发展以及急性炎症模型中的急性疼痛的影响。 申请人证明了这种被称为“生物膜密封剂”的药剂在机械损伤神经系统以及在急性炎症模型中减少急性疼痛的能力的降低痛觉痛和异常性疼痛的严重性的能力。 申请人描述了用于预防性治疗的生物膜密封剂的可注射或储存制剂的使用,例如它们可以在侮辱(即损伤后或术后)之后但在急性或慢性疼痛发作之前施用。 或者,可以使用生物膜密封剂来降低发作后的急性或慢性疼痛的严重性。