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1. 发明申请

US20070253960A1 Pharmaceutical removal of vascular extensions from a degenerating disc 审中-公开
标题翻译：药物从退化椎间盘移除血管延伸
公开(公告)号：US20070253960A1
公开(公告)日：2007-11-01
申请号：US11413346
申请日：2006-04-28
申请人： Josee Roy , Susan Drapeau , Jeffrey Marx
发明人： Josee Roy , Susan Drapeau , Jeffrey Marx
IPC分类号： A61K39/395
CPC分类号： A61K31/16 , A61K31/337 , A61K31/573 , A61K38/179 , A61K38/18 , A61K2039/505
摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disc includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disc. Disruption of vascular elements includes causing the vascular extensions to retract from the disc, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
摘要翻译：本发明提供了一种通过施用破坏椎间盘中的神经元和/或血管元件（通常是退化的椎间盘）的治疗剂来减轻椎间盘突出症的方法。盘中的神经元元件的破坏包括破坏神经末梢而基本上不影响神经的中枢体，抑制神经末梢的激活，并抑制神经末梢进入椎间盘的生长。血管元件的破坏包括使血管延伸部从椎间盘缩回，或抑制这种延伸的形成。治疗剂可以通过体内泵，推注或贮库局部给药，或者可以全身给药。

2. 发明申请

US20070253928A1 Pharmaceutical removal of neuronal extensions from a degenerating disc 有权
标题翻译：药物从退化椎间盘移除神经元延伸
公开(公告)号：US20070253928A1
公开(公告)日：2007-11-01
申请号：US11413363
申请日：2006-04-28
申请人： Josee Roy , Susan Drapeau , Jeffrey Marx
发明人： Josee Roy , Susan Drapeau , Jeffrey Marx
IPC分类号： A61K39/08 , A61K38/20 , A61K38/17 , A61K31/4709 , A61K31/737 , A61K31/655 , A61K31/56 , A61K31/485 , A61K31/225 , A61K31/125 , A61K31/11
CPC分类号： A61K38/4893 , A61K31/11 , A61K31/125 , A61K31/225 , A61K31/4709 , A61K31/485 , A61K31/496 , A61K31/5415 , A61K31/55 , A61K31/56 , A61K31/65 , A61K31/655 , A61K31/737 , A61K33/02 , A61K36/31 , A61K36/9066 , A61K38/168 , A61K38/4886 , C12Y304/24069
摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
摘要翻译：本发明提供了一种通过施用破坏椎间盘中的神经元和/或血管元件（通常是退化的椎间盘）的治疗剂来减轻椎间盘突出症的方法。磁盘中的神经元元件的破坏包括破坏神经末梢，而不会显着影响神经的中枢体，抑制神经末梢的激活，并抑制神经末梢进入椎间盘的生长。血管元件的破坏包括使血管延伸部从圆盘缩回，或抑制这种延伸部的形成。治疗剂可以通过体内泵，推注或贮库局部给药，或者可以全身给药。

3. 发明申请

US20070027081A1 Mechanisms of osteoinduction by LIM mineralization protein-1 (LMP-1) 有权
标题翻译： LIM矿化蛋白-1（LMP-1）诱导骨诱导机制
公开(公告)号：US20070027081A1
公开(公告)日：2007-02-01
申请号：US11385612
申请日：2006-03-21
申请人： Jeffrey Marx , William McKay , Scott Boden
发明人： Jeffrey Marx , William McKay , Scott Boden
IPC分类号： A61K38/17 , A61K38/00
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-1, to overcome the dose-related translational barriers for BMP-2 therapeutics.
摘要翻译：本发明涉及用于治疗受损骨患者的方法和组合物。具体地，本发明涉及包括LIM矿化蛋白（特别是LMP-1）的小分子和肽模拟物的组合治疗策略，以克服BMP-2治疗剂的剂量相关翻译屏障。

4. 发明申请

US20060280718A1 Compositions and methods for treating pain 有权
标题翻译：用于治疗疼痛的组合物和方法
公开(公告)号：US20060280718A1
公开(公告)日：2006-12-14
申请号：US11444077
申请日：2006-05-31
申请人： Josee Roy , Jeffrey Marx
发明人： Josee Roy , Jeffrey Marx
IPC分类号： A61K31/765 , A61K31/718 , A61K31/717 , A61K31/77
CPC分类号： A61K31/765 , A61K9/0014 , A61K9/0019 , A61K31/00 , A61K45/06 , A61K47/10 , A61L31/06 , A61L31/16 , A61L2300/402 , A61L2400/06 , C08L71/02
摘要： In the present invention, Applicants demonstrate the effect of a biomembrane sealing agent on the development of chronic pain following tissue injury as well as acute pain in a model of acute inflammation. Applicants demonstrate the ability of this class of agents referred to as “biomembrane sealing agents” to reduce the severity of hyperalgesia and allodynia following mechanical insult to the nervous system as well as their ability to reduce acute pain in a model of acute inflammation. Applicant describes the use of injectable or depot formulations of biomembrane sealing agent(s) for prophylactic treatment such as they could be administered after the insult (i.e. post-injury or post-surgery) but before the onset of acute or chronic pain. Alternatively, biomembrane sealing agents could be used to reduce the severity of acute or chronic pain after onset.
摘要翻译：在本发明中，申请人证明了生物膜密封剂对组织损伤后慢性疼痛的发展以及急性炎症模型中的急性疼痛的影响。申请人证明了这种被称为“生物膜密封剂”的药剂在机械损伤神经系统以及在急性炎症模型中减少急性疼痛的能力的降低痛觉痛和异常性疼痛的严重性的能力。申请人描述了用于预防性治疗的生物膜密封剂的可注射或储存制剂的使用，例如它们可以在侮辱（即损伤后或术后）之后但在急性或慢性疼痛发作之前施用。或者，可以使用生物膜密封剂来降低发作后的急性或慢性疼痛的严重性。

5. 发明申请

US20060184131A1 Delivery device for biological composites and method of preparation thereof 有权
标题翻译：生物复合材料输送装置及其制备方法
公开(公告)号：US20060184131A1
公开(公告)日：2006-08-17
申请号：US11384576
申请日：2006-03-20
申请人： James Murphy , Charanpreet Bagga , Robert Chiasera , Erik Erbe , Jeffrey Marx
发明人： James Murphy , Charanpreet Bagga , Robert Chiasera , Erik Erbe , Jeffrey Marx
IPC分类号： A61M5/00
CPC分类号： A61L27/46 , A61B17/8816 , A61B17/8825 , A61L27/54 , A61L27/56 , A61L2300/00 , A61M5/34 , A61M25/0097
摘要： An apparatus for the delivery of a biological composite and a method, kit, and system for preparing a biological composite is described herein. The biological composite includes both inorganic and biological materials.
摘要翻译：本文描述了用于递送生物复合材料的装置和用于制备生物复合材料的方法，试剂盒和系统。生物复合材料包括无机和生物材料。

6. 发明申请

US20080166755A9 Intracellular delivery of osteoinductive proteins and peptides 有权
标题翻译：骨诱导蛋白和肽的细胞内递送
公开(公告)号：US20080166755A9
公开(公告)日：2008-07-10
申请号：US10806915
申请日：2004-03-23
申请人： Frances Titus , Jeffrey Marx , Scott Boden , Sangwook Yoon , Susan Drapeau
发明人： Frances Titus , Jeffrey Marx , Scott Boden , Sangwook Yoon , Susan Drapeau
IPC分类号： C12P21/02 , C07K14/475 , C07H21/04
CPC分类号： C07K14/005 , A61K38/00 , C07K14/43581 , C07K14/4702 , C07K14/475 , C07K14/495 , C07K14/51 , C07K2319/00 , C12N2740/16322
摘要： The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.
摘要翻译：本发明提供了包含蛋白转导结构域和骨诱导多肽的融合多肽，以及使用这些多肽诱导成骨和促进蛋白多糖合成的方法。本发明还提供已经证明在体内诱导骨形成的能力的骨诱导肽。

7. 发明申请

US20090054313A9 METHOD FOR INDUCING DEPOSITION AND MATURATION OF BONE COMPRISING A CO-THERAPEUTIC REGIMEN OF LMP-1 AND BMP-2 有权
标题翻译：用于诱导包含LMP-1和BMP-2的治疗方案的骨的沉积和成熟的方法
公开(公告)号：US20090054313A9
公开(公告)日：2009-02-26
申请号：US11385612
申请日：2006-03-21
申请人： Jeffrey Marx , William McKay , Scott Boden
发明人： Jeffrey Marx , William McKay , Scott Boden
IPC分类号： A61K38/17 , A61K38/00
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-1, to overcome the dose-related translational barriers for BMP-2 therapeutics.
摘要翻译：本发明涉及用于治疗受损骨患者的方法和组合物。具体地，本发明涉及包括LIM矿化蛋白（特别是LMP-1）的小分子和肽模拟物的组合治疗策略，以克服BMP-2治疗剂的剂量相关翻译屏障。

8. 发明申请

US20070259044A1 Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use 有权
标题翻译：包含用于治疗神经元损伤的生物膜密封剂的组合物和使用方法
公开(公告)号：US20070259044A1
公开(公告)日：2007-11-08
申请号：US11418152
申请日：2006-05-03
申请人： Josee Roy , William McKay , Jeffrey Marx
发明人： Josee Roy , William McKay , Jeffrey Marx
IPC分类号： A61K38/20 , A61K38/18 , A61K38/11 , A61K38/05 , A61K31/65 , A61K31/56 , A61K9/14
CPC分类号： A61K33/06 , A61K9/0019 , A61K31/56 , A61K31/65 , A61K31/765 , A61K47/10
摘要： The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
摘要翻译：本发明提供用于治疗神经元损伤的组合物，试剂盒和方法。在一个实施方案中，组合物包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，直接施用于病理状况的部位或其附近的生物膜密封剂和/或生物活性剂，以及任何其组合。或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

9. 发明申请

US20070253930A1 Pharmaceutical removal of vascular and/or neuronal extensions form a degenerating disc 有权
标题翻译：血管和/或神经元延伸的药物去除形成退化的椎间盘
公开(公告)号：US20070253930A1
公开(公告)日：2007-11-01
申请号：US11414689
申请日：2006-04-28
申请人： Josee Roy , Susan Drapeau , Jeffrey Marx
发明人： Josee Roy , Susan Drapeau , Jeffrey Marx
IPC分类号： A61K38/21 , A61K38/18
CPC分类号： A61K38/1825 , A61K38/185 , A61K38/1858 , A61K38/2093 , A61K38/212
摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
摘要翻译：本发明提供了一种通过施用破坏椎间盘中的神经元和/或血管元件（通常是退化的椎间盘）的治疗剂来减轻椎间盘突出症的方法。磁盘中的神经元元件的破坏包括破坏神经末梢，而不会显着影响神经的中枢体，抑制神经末梢的激活，并抑制神经末梢进入椎间盘的生长。血管元件的破坏包括使血管延伸部从圆盘缩回，或抑制这种延伸部的形成。治疗剂可以通过体内泵，推注或贮库局部给药，或者可以全身给药。

10. 发明申请

US20060093729A1 Process for producing rigid reticulated articles 有权
标题翻译：刚性网状制品的制造方法
公开(公告)号：US20060093729A1
公开(公告)日：2006-05-04
申请号：US11245369
申请日：2005-10-06
申请人： Jeffrey Marx , Bradley Heckendorf , James Johnson , John Venarsky
发明人： Jeffrey Marx , Bradley Heckendorf , James Johnson , John Venarsky
IPC分类号： A61L27/32
CPC分类号： A61L27/425 , A61L27/306 , A61L27/32 , A61L27/427 , A61L27/56
摘要： A method for forming a ceramic article useful as a bone substitute and having an outer surface defining a shape having a bulk volume and having open, interconnecting openings extending throughout the volume and opening through the surface, includes, providing an organic open-pore structure, coating surface of pores of the structure with a ceramic slip, pyrolyzing the organic structure to leave a ceramic structure having struts defining a plurality of interconnecting interstices, and providing within the interstices a porous osteoconductive composition exposed to the interconnecting openings. In a preferred embodiment, the ceramic slip includes a strong, supportive ceramic material and a separate osteoconductive material.
摘要翻译：一种用于形成可用作骨替代物并且具有限定具有本体体积的形状的外表面并且具有贯穿整个体积延伸并且穿过该表面的开口的开放互连开口的陶瓷制品的方法包括提供有机开孔结构，用陶瓷滑动涂覆结构的孔的表面，热解有机结构以留下具有限定多个互连间隙的支柱的陶瓷结构，并在空隙内提供暴露于互连开口的多孔骨传导组合物。在优选实施例中，陶瓷滑移包括强的支撑陶瓷材料和单独的骨传导材料。

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