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1. 发明授权

US09459261B2 Methods and compositions for diagnosis and prognosis of renal injury and renal failure 有权
标题翻译：肾损伤和肾衰竭的诊断和预后的方法和组成
公开(公告)号：US09459261B2
公开(公告)日：2016-10-04
申请号：US14241005
申请日：2012-08-24
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
IPC分类号： G01N31/00 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/50 , G01N2800/60
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Heat shock 70 kDa protein 1, Alpha-1-antitrypsin Neutrophil elastase complex, Stromelysin-1:Metalloproteinase inhibitor 2 complex, 72 kDa type IV collagenase:Metalloproteinase inhibitor 2 complex, Insulin-like growth factor 1 receptor, Myeloid differentiation primary response protein MyD88, Neuronal cell adhesion molecule, and Tumor necrosis factor ligand superfamily member 10 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自热休克70kDa蛋白1，α-1-抗胰蛋白胨中性粒细胞弹性蛋白酶复合物，溶血素蛋白酶-1：金属蛋白酶抑制剂2复合物的肾损伤标记物，72kDa IV型胶原酶：金属蛋白酶抑制剂2复合物，胰岛素样生长因子1受体，骨髓分化初级应答蛋白MyD88，神经元细胞粘附分子和肿瘤坏死因子配体超家族成员10作为肾损伤中的诊断和预后生物标志物。

2. 发明授权

US09229010B2 Methods and compositions for diagnosis and prognosis of renal injury and renal failure 有权
标题翻译：肾损伤和肾衰竭的诊断和预后的方法和组成
公开(公告)号：US09229010B2
公开(公告)日：2016-01-05
申请号：US13148029
申请日：2010-02-05
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
IPC分类号： G01N31/00 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/60
摘要： Disclosed are methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, disclosed are assays that detect one or more markers selected from the group consisting of Prostatic acid phosphatase, Lactotransfenin, Soluble erythropoietin receptor, Von Willebrand factor, Soluble endothelial protein C receptor, and Beta-2-glycoprotein 1 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：公开了用于在遭受或怀疑患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，公开了检测一种或多种选自前列腺酸性磷酸酶，乳糖转移蛋白，可溶性促红细胞生成素受体，血管性血友病因子，可溶内皮蛋白C受体和β-2-糖蛋白1的标记物作为诊断和预后生物标志物的测定法肾损伤。

3. 发明申请

US20150168422A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：US20150168422A1
公开(公告)日：2015-06-18
申请号：US14117344
申请日：2012-05-12
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
IPC分类号： G01N33/68 , G01N33/74
CPC分类号： G01N33/6869 , G01N33/74 , G01N2333/495 , G01N2333/545 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Transforming growth factor beta-1, Transforming growth factor beta-2, Transforming growth factor beta-3, and Interleukin-1 receptor-like 1 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自以下的肾损伤标志物：转化生长因子β-1，转化生长因子β-2，转化生长因子β-3和白细胞介素-1 1受体样1作为肾损伤的诊断和预后生物标志物。

4. 发明授权

US08778615B2 Methods and compositions for diagnosis and prognosis of renal injury and renal failure 有权
标题翻译：肾损伤和肾衰竭的诊断和预后的方法和组成
公开(公告)号：US08778615B2
公开(公告)日：2014-07-15
申请号：US13125360
申请日：2009-10-21
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
IPC分类号： G01N33/53 , C12Q1/37 , A61K39/395 , G01N33/50
CPC分类号： G01N33/573 , G01N33/5088 , G01N33/5091 , G01N33/6893 , G01N2800/347 , G01N2800/50 , G01N2800/56 , G01N2800/60
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Cytoplasmic aspartate aminotransferase, soluble Tumor necrosis factor receptor superfamily member 5, soluble CD40 Ligand, soluble C-X-C Motif chemokine 16, S100-A12, Eotaxin, soluble E-selectin, Fibronectin, Granulocyte colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor, Heparin-binding growth factor 2, soluble Hepatocyte growth factor receptor, Interleukin-1 receptor antagonist, Interleukin-1 beta, Interleukin-10, Interleukin-15, Interleukin-3, Myeloperoxidase, Nidogen-1, soluble Oxidized low-density lipoprotein receptor 1, Pappalysin-1, soluble P-selectin glycoprotein ligand 1, Antileukoproteinase, soluble Kit ligand, Tissue inhibitor of metalloproteinase 1, Tissue inhibitor of metalloproteinase 2, soluble Tumor necrosis factor, soluble Vascular cell adhesion molecule 1, and Vascular endothelial growth factor A as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测一种或多种选自下组的测定法：细胞质天冬氨酸氨基转移酶，可溶性肿瘤坏死因子受体超家族成员5，可溶性CD40配体，可溶性CXC基序趋化因子16，S100-A12，嗜酸细胞活化趋化因子，可溶性E-选择素，纤连蛋白，粒细胞集落刺激因子，粒细胞 - 巨噬细胞集落刺激因子，肝素结合生长因子2，可溶性肝细胞生长因子受体，白细胞介素-1受体拮抗剂，白细胞介素-1β，白介素-10，白细胞介素 -15，白细胞介素-3，髓过氧化物酶，Nidogen-1，可溶性氧化低密度脂蛋白受体1，Pappalysin-1，可溶性P-选择蛋白糖蛋白配体1，抗白细胞蛋白酶，可溶性Kit配体，金属蛋白酶1组织抑制剂，金属蛋白酶组织抑制剂 2，可溶性肿瘤坏死因子，可溶性血管细胞粘附分子1和血管内皮生长因子A作为诊断和预后 c生物标志物在肾损伤。

5. 发明申请

US20140147864A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：US20140147864A1
公开(公告)日：2014-05-29
申请号：US13978529
申请日：2012-01-08
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Proheparin-binding EGF-like growth factor, Tenascin C, Angiopoietin-related protein 4, Fibroblast growth factor 19, Fibroblast growth factor 21, Heparin-binding growth factor 1, Angiopoietin-related protein 6, Proepiregulin, Probetacellulin, Amphiregulin, Angiogenin, Thrombospondin-2, and Collagen alpha-1 (XVIII) chain as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自由Proheparin结合的EGF样生长因子，腱生蛋白C，促血管生成素相关蛋白4，成纤维细胞生长因子19，成纤维细胞生长因子21，肝素结合生长因子1，促血管生成素相关蛋白6，前列腺素，前分泌细胞素，双调蛋白，血管生成素，血小板反应素-2和胶原α-1（XVIII）链作为肾损伤中的诊断和预后生物标志物。

6. 发明申请

US20120264629A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：US20120264629A1
公开(公告)日：2012-10-18
申请号：US13389351
申请日：2010-08-06
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
IPC分类号： G01N33/566 , G01N27/26 , C40B30/04 , G01N21/64 , G01N27/62 , G01N30/00
CPC分类号： G01N33/6893 , G01N2333/4728 , G01N2333/775 , G01N2800/347 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Beta-2-glycoprotein 1 as a diagnostic and prognostic biomarker in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测β-2-糖蛋白1作为肾损伤中的诊断和预后生物标志物的测定法。

7. 发明申请

US20120059250A1 Power Injectable Port Identification 审中-公开
标题翻译：电力注入端口识别
公开(公告)号：US20120059250A1
公开(公告)日：2012-03-08
申请号：US13290249
申请日：2011-11-07
申请人： Jeff GRAY , Marcia BUISER
发明人： Jeff GRAY , Marcia BUISER
IPC分类号： A61B6/00
CPC分类号： A61M39/0208 , A61B6/481 , A61M2039/0238
摘要： An implantable port for accessing internal body structures, the port comprises a proximal housing including an opening providing access to an interior of the port and a distal housing adapted for assembly with the proximal housing, the distal housing including a reservoir which, when the distal housing is mated with the proximal housing is in fluid communication with the opening of the proximal housing in combination with a radiopaque element in one of the proximal and distal housings, a shape of the radiopaque element identifying, when imaged, a structural characteristic of the port not otherwise identifiable visually.
摘要翻译：一种用于进入内部主体结构的可植入端口，所述端口包括近端壳体，所述近端壳体包括提供进入所述端口内部的开口和适于与所述近端壳体组装的远端壳体，所述远端壳体包括储存器，所述远端壳体当所述远端壳体与近侧壳体配合，与近侧壳体的开口与近端和远端壳体之一中的不透射线元件组合流体连通，不透射元件的形状在成像时识别端口的结构特征视觉上可以识别。

8. 发明申请

US20110207161A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：US20110207161A1
公开(公告)日：2011-08-25
申请号：US13125454
申请日：2009-10-21
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
IPC分类号： C12Q1/37 , C12Q1/26 , G01N33/48
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/60
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble CD44 antigen, Angiopoietin-1, soluble Angiopoietin-1 receptor, C—X—C chemokine motif 5, soluble Endoglin, soluble Tumor-associated calcium signal transducer 1, Erythropoietin, soluble Fractalkine, Heme oxygenase 1, soluble Interleukin-1 receptor type II, soluble Interleukin-6 receptor subunit-alpha, Lymphotactin, Lymphotoxin-alpha, Stromelysin-1, C—C motif chemokine 22, C—C motif chemokine 5, and Thrombospondin-1 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测一种或多种选自以下的标记的测定法：可溶性CD44抗原，促血管生成素-1，可溶性促生成素-1受体，C-X-C趋化因子基序5，可溶内皮糖蛋白，可溶性肿瘤 - 相关的钙信号传导器1，促红细胞生成素，可溶性Fractalkine，血红素加氧酶1，II型可溶性白细胞介素-1受体，可溶性白细胞介素-6受体亚基α，淋巴细胞趋化因子，淋巴毒素-α，溶基素-1，C-C基序趋化因子22，C -C基序趋化因子5和血小板反应蛋白-1作为肾损伤中的诊断和预后生物标志物。

9. 发明申请

US20110195429A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：US20110195429A1
公开(公告)日：2011-08-11
申请号：US13061413
申请日：2009-08-28
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
IPC分类号： G01N33/53 , G01N33/573
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble p-selectin, protein NOV homolog, soluble epidermal growth factor receptor, netrin-4, haptoglobin, heat shock protein beta-1, alpha-1-antitrypsin, leukocyte elastase, soluble tumor necrosis factor receptor superfamily member 6, soluble tumor necrosis factor ligand superfamily member 6, soluble intercellular adhesion molecule 2, active caspase-3, and soluble platelet endothelial cell adhesion molecule as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测一种或多种选自以下的标记的测定法：可溶性P-选择素，蛋白质NOV同系物，可溶性表皮生长因子受体，netrin-4，触珠蛋白，热休克蛋白β-1，α 1-抗胰蛋白酶，白细胞弹性蛋白酶，可溶性肿瘤坏死因子受体超家族成员6，可溶性肿瘤坏死因子配体超家族成员6，可溶性细胞间粘附分子2，活性半胱天冬酶-3和可溶性血小板内皮细胞粘附分子作为诊断和预后生物标志物肾损伤。

10. 发明授权

US07977068B2 Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries 有权
公开(公告)号：US07977068B2
公开(公告)日：2011-07-12
申请号：US12020482
申请日：2008-01-25
申请人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
发明人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
IPC分类号： C12N1/21 , C12N15/74 , C12P21/02 , C12Q1/68 , C12Q1/70 , C07K16/18 , A61K31/70
CPC分类号： C07K16/00 , C07K2317/55 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N15/625
摘要： The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.

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