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1. 发明授权

US07329498B2 HPV CD8+ T-cell epitopes 失效
标题翻译： HPV CD8 + T细胞表位
公开(公告)号：US07329498B2
公开(公告)日：2008-02-12
申请号：US11528029
申请日：2006-09-26
申请人： Fiona Harding , Jeanette Marie Mucha
发明人： Fiona Harding , Jeanette Marie Mucha
IPC分类号： C12Q1/68
CPC分类号： G01N33/6878 , A61K2039/525 , C07K14/005 , C12N7/00 , C12N2710/20022 , G01N33/505 , G01N2333/70517 , G01N2333/70578
摘要： The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention provides modified epitopes suitable for use in prophylactic and/or therapeutic vaccines.In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In particular, the present invention provides means to identify CD8+ T-cell epitopes in HPV strains such as HPV 16 and HPV 18. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
摘要翻译：本发明提供了鉴定任何目的蛋白质中功能性CD8 + T细胞表位的方法。本发明还提供各种蛋白质的CD8 + T细胞表位。在另外的实施方案中，本发明提供了适用于预防和/或治疗性疫苗的表位。在特别优选的实施方案中，本发明提供了适用于预防和/或治疗疫苗的修饰表位。在一些优选实施方案中，本发明提供用于开发HPV疫苗，特别是用于预防高危HPV病毒感染的多价疫苗的方法。特别地，本发明提供鉴定HPV菌株如HPV16和HPV18中的CD8 + T细胞表位的方法。在另外的实施方案中，本发明提供了用于开发针对高风险HPV类型的治疗性疫苗的手段，发展感染个体的良性和/或恶性肿瘤。本发明还提供了适用于预防和治疗疫苗的表位。

2. 发明授权

US07153659B2 HPV CD8+ T-cell epitopes 有权
标题翻译： HPV CD8 + T细胞表位
公开(公告)号：US07153659B2
公开(公告)日：2006-12-26
申请号：US10924377
申请日：2004-08-23
申请人： Fiona Harding , Jeanette Marie Mucha
发明人： Fiona Harding , Jeanette Marie Mucha
IPC分类号： C12Q1/68
CPC分类号： G01N33/6878 , A61K2039/525 , C07K14/005 , C12N7/00 , C12N2710/20022 , G01N33/505 , G01N2333/70517 , G01N2333/70578
摘要： The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention provides modified epitopes suitable for use in prophylactic and/or therapeutic vaccines.In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In particular, the present invention provides means to identify CD8+ T-cell epitopes in HPV strains such as HPV 16 and HPV 18. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
摘要翻译：本发明提供了鉴定任何目的蛋白质中功能性CD8 + T细胞表位的方法。本发明还提供各种蛋白质的CD8 + T细胞表位。在另外的实施方案中，本发明提供了适用于预防和/或治疗性疫苗的表位。在特别优选的实施方案中，本发明提供了适用于预防和/或治疗疫苗的修饰表位。在一些优选实施方案中，本发明提供用于开发HPV疫苗，特别是用于预防高危HPV病毒感染的多价疫苗的方法。特别地，本发明提供鉴定HPV菌株如HPV16和HPV18中的CD8 + T细胞表位的方法。在另外的实施方案中，本发明提供了用于开发针对高风险HPV类型的治疗性疫苗的手段，发展感染个体的良性和/或恶性肿瘤。本发明还提供了适用于预防和治疗疫苗的表位。

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