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1. 发明申请

US20090186819A1 FORMULATION OF INSULINOTROPIC PEPTIDE CONJUGATES 审中-公开
标题翻译：胰岛素诱导剂配方
公开(公告)号：US20090186819A1
公开(公告)日：2009-07-23
申请号：US12333276
申请日：2008-12-11
申请人： Marieve Carrier , Byeong Seon Chang , Omar Quraishi , Thomas R. Ulich , Maggie Wang , Jean-Philippe Estradier
发明人： Marieve Carrier , Byeong Seon Chang , Omar Quraishi , Thomas R. Ulich , Maggie Wang , Jean-Philippe Estradier
IPC分类号： A61K38/38 , A61P3/10
CPC分类号： A61K9/0019 , A61K47/643
摘要： The present invention provides pharmaceutical formulations comprising insulinotropic peptide conjugates, particularly a conjugate of albumin to exendin-4, or a derivative thereof, and methods of administration thereof. The present invention also provides methods for treating diabetes and insulinotropic peptides related diseases or conditions by administering the pharmaceutical formulations described herein.
摘要翻译：本发明提供包含促胰岛素肽缀合物，特别是白蛋白与毒蜥外泌肽-4的缀合物或其衍生物的药物制剂及其施用方法。本发明还提供了通过施用本文所述的药物制剂治疗糖尿病和促胰岛素肽相关疾病或病症的方法。

2. 发明申请

US20080167231A1 Modified Corticotropin Releasing Factor Peptides and Uses Thereof 失效
标题翻译：改性促肾上腺皮质激素释放因子肽及其用途
公开(公告)号：US20080167231A1
公开(公告)日：2008-07-10
申请号：US11873291
申请日：2007-10-16
申请人： Thomas R. Ulich , Jean-Philippe Estradier , Karen Thibaudeau
发明人： Thomas R. Ulich , Jean-Philippe Estradier , Karen Thibaudeau
IPC分类号： A61K38/00 , C07K16/00
CPC分类号： C07K14/57509 , A61K38/00 , A61K47/64 , A61K47/643 , A61K47/644 , A61K47/6889
摘要： The present invention relates to compounds comprising modified corticotrophin releasing factor peptide and specifically urocortin and urocortin-related peptides, modified derivatives thereof, and conjugates of such modified peptides and derivatives to serum components, preferably serum proteins or peptides. The compounds and conjugates of the invention comprise a reactive group, which is covalently attached to a modified peptide or derivative, optionally through a linking group. The present invention also provides methods for the covalent attachment of a modified peptide or derivative to a serum protein or peptide to form a conjugate of the invention. The conjugates of the invention preferably exhibit a longer in vivo circulating half-life compared to the corresponding unconjugated peptides. The conjugates of the invention also retain at least some of the biological activity of the unconjugated peptides, and preferably exhibit increased biological activity compared to the unconjugated peptides. The present invention also provides methods for the treatment and prevention of a disease or disorder comprising the administration of one or more of the compounds or conjugates of the invention to a subject in need of such treatment or prevention.
摘要翻译：本发明涉及包含修饰的促肾上腺皮质激素释放因子肽，特别是尿皮质素和尿皮质素相关肽，其修饰的衍生物，以及这些修饰肽和衍生物与血清成分，优选血清蛋白或肽的缀合物的化合物。本发明的化合物和缀合物包含反应性基团，其任选地通过连接基团共价连接到修饰的肽或衍生物上。本发明还提供了将修饰的肽或衍生物共价连接到血清蛋白或肽以形成本发明的缀合物的方法。与相应的未结合的肽相比，本发明的缀合物优选表现出更长的体内循环半衰期。本发明的缀合物还保留非共轭肽的至少一些生物活性，并且与非共轭多肽相比优选表现出增加的生物学活性。本发明还提供了治疗和预防疾病或病症的方法，包括将本发明的一种或多种化合物或缀合物施用于需要这种治疗或预防的受试者。

3. 发明申请

US20090054332A1 THOMBOPOIETIN PEPTIDE CONJUGATES 审中-公开
标题翻译： THOMBOPOIETIN胶原蛋白
公开(公告)号：US20090054332A1
公开(公告)日：2009-02-26
申请号：US12143780
申请日：2008-06-21
申请人： Jean-Philippe Estradier , Martin Robitaille , Karen Thibaudeau , Dominique P. Bridon , Xicai Huang , Omar Quraishi , Nathalie Bousquet-Gagnon
发明人： Jean-Philippe Estradier , Martin Robitaille , Karen Thibaudeau , Dominique P. Bridon , Xicai Huang , Omar Quraishi , Nathalie Bousquet-Gagnon
IPC分类号： A61K38/16 , C07K7/06 , C07K7/08 , C07K1/14 , C07K14/76 , C07K19/00
CPC分类号： A61K47/644 , A61K47/60 , A61K47/643 , A61K47/65
摘要： The present invention relates to compounds comprising modified thrombopoietin peptides and conjugates of such modified peptides to serum components, typically serum proteins or peptides. The compounds and conjugates of the invention comprise a reactive group or a residue of a reactive group, which is covalently attached to a modified peptide, optionally through a linking group. The present invention also provides methods for the covalent attachment of a modified peptide to a serum protein or peptide to form a conjugate of the invention. The conjugates of the invention typically exhibit a longer in vivo circulating half-life compared to the corresponding unconjugated peptides. The conjugates of the invention also retain at least some of the biological activity of the unconjugated peptides, and typically exhibit increased biological activity compared to the unconjugated peptides. The present invention also provides methods for the treatment and prevention of a disease or disorder comprising the administration of one or more of the compounds or conjugates of the invention to a subject in need of such treatment or prevention.
摘要翻译：本发明涉及包含修饰的血小板生成素肽和这种修饰肽与血清成分（通常为血清蛋白或肽）的缀合物的化合物。本发明的化合物和缀合物包含反应性基团或反应性基团的残基，其可任选地通过连接基团与修饰的肽共价连接。本发明还提供了将修饰的肽共价连接到血清蛋白或肽以形成本发明的缀合物的方法。与相应的未结合的肽相比，本发明的缀合物通常表现出较长的体内循环半衰期。本发明的缀合物还保留非共轭肽的至少一些生物活性，并且与非共轭多肽相比通常表现出增加的生物学活性。本发明还提供了治疗和预防疾病或病症的方法，包括将本发明的一种或多种化合物或缀合物施用于需要这种治疗或预防的受试者。

4. 发明授权

US07982018B2 Modified corticotropin releasing factor peptides and uses thereof 失效
标题翻译：修饰的促肾上腺皮质激素释放因子肽及其用途
公开(公告)号：US07982018B2
公开(公告)日：2011-07-19
申请号：US11873291
申请日：2007-10-16
申请人： Thomas R. Ulich , Jean-Philippe Estradier , Karen Thibaudeau
发明人： Thomas R. Ulich , Jean-Philippe Estradier , Karen Thibaudeau
IPC分类号： A61K38/35 , A61K38/38 , C07K14/695 , C07K14/76 , C07K14/765
CPC分类号： C07K14/57509 , A61K38/00 , A61K47/64 , A61K47/643 , A61K47/644 , A61K47/6889
摘要： The present invention relates to compounds comprising modified corticotrophin releasing factor peptide and specifically urocortin and urocortin-related peptides, modified derivatives thereof, and conjugates of such modified peptides and derivatives to serum components, preferably serum proteins or peptides. The compounds and conjugates of the invention comprise a reactive group, which is covalently attached to a modified peptide or derivative, optionally through a linking group. The present invention also provides methods for the covalent attachment of a modified peptide or derivative to a serum protein or peptide to form a conjugate of the invention. The conjugates of the invention preferably exhibit a longer in vivo circulating half-life compared to the corresponding unconjugated peptides. The conjugates of the invention also retain at least some of the biological activity of the unconjugated peptides, and preferably exhibit increased biological activity compared to the unconjugated peptides. The present invention also provides methods for the treatment and prevention of a disease or disorder comprising the administration of one or more of the compounds or conjugates of the invention to a subject in need of such treatment or prevention.
摘要翻译：本发明涉及包含修饰的促肾上腺皮质激素释放因子肽，特别是尿皮质素和尿皮质素相关肽，其修饰的衍生物，以及这些修饰肽和衍生物与血清成分，优选血清蛋白或肽的缀合物的化合物。本发明的化合物和缀合物包含反应性基团，其任选地通过连接基团共价连接到修饰的肽或衍生物上。本发明还提供了将修饰的肽或衍生物共价连接到血清蛋白或肽以形成本发明的缀合物的方法。与相应的未结合的肽相比，本发明的缀合物优选表现出更长的体内循环半衰期。本发明的缀合物还保留非共轭肽的至少一些生物活性，并且与非共轭多肽相比优选表现出增加的生物学活性。本发明还提供了治疗和预防疾病或病症的方法，包括将本发明的一种或多种化合物或缀合物施用于需要这种治疗或预防的受试者。

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