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1. 发明授权

US08653327B2 Linear DNA molecule delivery using PEGylated quantum dots for stable transformation in plants 有权
标题翻译：使用聚乙二醇化量子点的线性DNA分子递送用于植物中的稳定转化
公开(公告)号：US08653327B2
公开(公告)日：2014-02-18
申请号：US13178199
申请日：2011-07-07
申请人： Narasimha C. Samboju , Kerrm Y. Yau , Frank Burroughs , Jayakumar P. Samuel , Steven R. Webb
发明人： Narasimha C. Samboju , Kerrm Y. Yau , Frank Burroughs , Jayakumar P. Samuel , Steven R. Webb
IPC分类号： C07K14/415 , A01H5/10 , A01H1/04 , A01H1/02 , B82Y30/00 , B82Y10/00 , B82Y5/00 , C12N15/87
CPC分类号： C12N15/8206 , B82Y5/00 , C12N15/8207 , C12N15/8221
摘要： Methods for introducing a linear nucleic acid molecule of interest into a cell comprising a cell wall include use of nanoparticles coated with polyethylene glycol. In some embodiments, the cell comprising a cell wall is a plant cell. Methods include genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall. Transgenic plants include a nucleic acid molecule of interest produced by regeneration of whole plants from plant cells transformed with linear nucleic acid molecules.
摘要翻译：将目的线性核酸分子引入到包含细胞壁的细胞中的方法包括使用涂覆有聚乙二醇的纳米颗粒。在一些实施方案中，包含细胞壁的细胞是植物细胞。方法包括遗传或其他修饰植物和用于治疗或预防包含细胞壁的植物细胞中的疾病。转基因植物包括由用线性核酸分子转化的植物细胞再生整株植物产生的目的核酸分子。

2. 发明授权

US08609420B2 Quantum dot carrier peptide conjugates suitable for imaging and delivery applications in plants 有权
标题翻译：量子点载体肽缀合物，适用于植物中的成像和递送应用
公开(公告)号：US08609420B2
公开(公告)日：2013-12-17
申请号：US13427750
申请日：2012-03-22
申请人： Jayakumar P. Samuel , Narasimha C. Samboju , Kerrm Y. Yau , Gaofeng Lin , Steven R. Webb , Frank Burroughs
发明人： Jayakumar P. Samuel , Narasimha C. Samboju , Kerrm Y. Yau , Gaofeng Lin , Steven R. Webb , Frank Burroughs
IPC分类号： C07K14/415 , C12N15/87 , C12N15/74 , A01H5/10 , B82Y10/00 , B82Y30/00 , B82Y5/00
CPC分类号： C12N15/8206 , B82Y5/00 , C12N15/8207 , C12N15/8221
摘要： Provided are methods for introducing a molecule of interest into a plant cell having a cell wall by using a QD-peptide conjugate having a quantum dot (QD) with one or more cell penetrating peptides (CPPs). Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.
摘要翻译：提供通过使用具有一个或多个细胞穿透肽（CPP）的具有量子点（QD）的QD-肽缀合物将感兴趣的分子引入具有细胞壁的植物细胞的方法。提供用于遗传或其他修饰植物以及用于治疗或预防包含细胞壁的植物细胞中的疾病的方法。

3. 发明申请

US20110247100A1 PLANT PEPTIDE GAMMA-ZEIN FOR DELIVERY OF BIOMOLECULES INTO PLANT CELLS 有权
标题翻译：用于将生物分子植入植物细胞的植物肽GAMMA-ZEIN
公开(公告)号：US20110247100A1
公开(公告)日：2011-10-06
申请号：US13042565
申请日：2011-03-08
申请人： Narasimha C. Samboju , Jayakumar P. Samuel , Gaofeng Lin , Steven R. Webb , Frank Burroughs
发明人： Narasimha C. Samboju , Jayakumar P. Samuel , Gaofeng Lin , Steven R. Webb , Frank Burroughs
IPC分类号： A01H5/00 , C12N5/04 , C12N5/10 , C12N9/00
CPC分类号： C12N15/8206
摘要： A method of introducing a molecule of interest into a plant cell having a cell wall includes interacting a gamma-zein peptide with a molecule of interest to form a gamma-zein linked structure. The gamma-zein linked structure is then placed in contact with the plant cell having a cell wall, and allowing uptake of the gamma-zein linked structure into the plant cell. Alternatively, a gene of interest can be expressed in a plant cell having an intact cell wall by interacting a gamma-zein peptide with the gene of interest to form a gamma-zein linked gene structure, allowing uptake of the gamma-zein linked gene structure into the plant cell, and expressing the gene of interest in the plant cell and its progeny.
摘要翻译：将感兴趣的分子引入具有细胞壁的植物细胞中的方法包括将γ-玉米醇溶蛋白肽与感兴趣的分子相互作用以形成γ-玉米醇溶蛋白连接的结构。然后将γ-玉米醇溶蛋白连接的结构与具有细胞壁的植物细胞接触，并允许将γ-玉米醇溶蛋白连接的结构摄取到植物细胞中。或者，通过将γ-玉米醇溶蛋白肽与感兴趣的基因相互作用以形成γ-玉米醇溶蛋白连接的基因结构，可以在具有完整细胞壁的植物细胞中表达感兴趣的基因，从而允许γ-玉米醇溶蛋白连接的基因结构进入植物细胞，并在植物细胞及其后代中表达感兴趣的基因。

4. 发明授权

US09187755B2 Nanoparticle mediated delivery of sequence specific nucleases 有权
标题翻译：纳米颗粒介导的序列特异性核酸酶的递送
公开(公告)号：US09187755B2
公开(公告)日：2015-11-17
申请号：US12755447
申请日：2010-04-07
申请人： Jayakumar P. Samuel , Joseph F. Petolino , Narasimha C. Samboju , Steven R. Webb , Kerrm Y. Yau
发明人： Jayakumar P. Samuel , Joseph F. Petolino , Narasimha C. Samboju , Steven R. Webb , Kerrm Y. Yau
IPC分类号： C12N15/82
CPC分类号： C12N15/902 , C12N5/04 , C12N9/22 , C12N9/96 , C12N15/8206 , C12Y301/21004
摘要： Provided are methods for introducing a sequence-specific nuclease into a plant cell comprising a cell wall. Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.
摘要翻译：提供了将序列特异性核酸酶引入包含细胞壁的植物细胞中的方法。提供用于遗传或其他修饰植物和用于治疗或预防包含细胞壁的植物细胞中的疾病的方法。

5. 发明授权

US08283522B2 Herbicide resistance genes 有权
标题翻译：除草剂抗性基因
公开(公告)号：US08283522B2
公开(公告)日：2012-10-09
申请号：US12091896
申请日：2006-10-27
申请人： Terry R. Wright , Justin M. Lira , Terence Anthony Walsh , Donald J. Merlo , Jayakumar P. Samuel , Gaofeng Lin
发明人： Terry R. Wright , Justin M. Lira , Terence Anthony Walsh , Donald J. Merlo , Jayakumar P. Samuel , Gaofeng Lin
IPC分类号： C12N15/82
CPC分类号： C12N15/8274 , C12N9/0071 , C12N15/8275
摘要： The subject invention provides novel plants that are not only resistant to 2,4-D, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention “stacked” together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-12 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.
摘要翻译：本发明提供了不仅对2,4-D有抗性的新型植物，而且还提供了对吡啶氧基乙酸酯除草剂的抗性。迄今为止，没有任何期望或建议，通过引入单一基因可以产生具有这两种有利性质的植物。本发明还包括产生本发明一种或多种与一种或多种除草剂抗性基因堆叠在一起的酶的植物。本发明能够以新的方式使用除草剂的新型组合。此外，本发明提供了防止对一种或多种除草剂如草甘膦具有抗性的杂草的发育和控制菌株的新方法。根据本发明使用的优选酶和基因在本文中称为AAD-12（丙烯酰氧基烷酸酯加氧酶）。这种高度新颖的发现是显着的除草剂耐受性作物性状和选择性标记机会的基础。

6. 发明授权

US08581036B2 Plant peptide gamma-zein for delivery of biomolecules into plant cells 有权
标题翻译：植物肽γ-玉米蛋白，用于将生物分子递送到植物细胞中
公开(公告)号：US08581036B2
公开(公告)日：2013-11-12
申请号：US13042565
申请日：2011-03-08
申请人： Narasimha C. Samboju , Jayakumar P. Samuel , Gaofeng Lin , Steven R. Webb , Frank Burroughs
发明人： Narasimha C. Samboju , Jayakumar P. Samuel , Gaofeng Lin , Steven R. Webb , Frank Burroughs
IPC分类号： C12N15/82 , C12N15/87 , C12N5/00 , C12N5/02 , C12N15/29
CPC分类号： C12N15/8206
摘要： A method of introducing a molecule of interest into a plant cell having a cell wall includes interacting a gamma-zein peptide with a molecule of interest to form a gamma-zein linked structure. The gamma-zein linked structure is then placed in contact with the plant cell having a cell wall, and allowing uptake of the gamma-zein linked structure into the plant cell. Alternatively, a gene of interest can be expressed in a plant cell having an intact cell wall by interacting a gamma-zein peptide with the gene of interest to form a gamma-zein linked gene structure, allowing uptake of the gamma-zein linked gene structure into the plant cell, and expressing the gene of interest in the plant cell and its progeny.
摘要翻译：将感兴趣的分子引入具有细胞壁的植物细胞中的方法包括将γ-玉米醇溶蛋白肽与感兴趣的分子相互作用以形成γ-玉米醇溶蛋白连接的结构。然后将γ-玉米醇溶蛋白连接的结构与具有细胞壁的植物细胞接触，并允许将γ-玉米醇溶蛋白连接的结构摄取到植物细胞中。或者，通过将γ-玉米醇溶蛋白肽与感兴趣的基因相互作用以形成γ-玉米醇溶蛋白连接的基因结构，可以在具有完整细胞壁的植物细胞中表达感兴趣的基因，从而允许γ-玉米醇溶蛋白连接的基因结构进入植物细胞，并在植物细胞及其后代中表达感兴趣的基因。

7. 发明授权

US08722410B2 Methods for transferring molecular substances into plant cells 有权
标题翻译：将分子物质转移到植物细胞中的方法
公开(公告)号：US08722410B2
公开(公告)日：2014-05-13
申请号：US12245685
申请日：2008-10-03
申请人： Jayakumar P. Samuel , Frank Burroughs , Suraj Dixit , Mark W. Zettler
发明人： Jayakumar P. Samuel , Frank Burroughs , Suraj Dixit , Mark W. Zettler
IPC分类号： C12N15/87 , A01H5/10 , B82Y5/00 , B82Y30/00 , B82Y10/00
CPC分类号： C12N15/8207 , C12N15/8206
摘要： Provided are methods for introducing a molecule of interest into a plant cell comprising a cell wall. Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.
摘要翻译：提供了将感兴趣的分子引入包含细胞壁的植物细胞中的方法。提供用于遗传或其他修饰植物和用于治疗或预防包含细胞壁的植物细胞中的疾病的方法。

8. 发明授权

US08575424B2 Production of functionalized linear DNA cassette and quantum dot/nanoparticle mediated delivery in plants 有权
标题翻译：生产功能化的线性DNA盒和量子点/纳米颗粒介导的植物递送
公开(公告)号：US08575424B2
公开(公告)日：2013-11-05
申请号：US13178235
申请日：2011-07-07
申请人： Kerrm Y. Yau , Jayakumar P. Samuel , Frank Burroughs , Narasimha C. Samboju , Steven R. Webb
发明人： Kerrm Y. Yau , Jayakumar P. Samuel , Frank Burroughs , Narasimha C. Samboju , Steven R. Webb
IPC分类号： C12N15/82 , C12N15/87 , C12N5/00 , C12N5/02 , C12N15/29
CPC分类号： C12N15/8206 , B82Y5/00 , C12N15/8201 , C12N15/8207 , C12N15/87 , C12Q2600/13
摘要： Methods for introducing a functionalized linear nucleic acid cassette molecule of interest into a plant cell comprising a cell wall include use of nanoparticles. In some embodiments, the cell comprising a cell wall is a cultured plant cell. Methods include genetically or otherwise modifying plant cells and for treating or preventing disease in any plant, especially crop plants. Transgenic plants include a nucleic acid molecule of interest produced by regeneration of whole plants from plant cells transformed with functionalized linear nucleic acid cassette molecules.
摘要翻译：将功能化的线性核酸盒分子引入到包含细胞壁的植物细胞中的方法包括使用纳米颗粒。在一些实施方案中，包含细胞壁的细胞是培养的植物细胞。方法包括遗传或其他修饰植物细胞和用于治疗或预防任何植物，特别是作物植物中的疾病。转基因植物包括通过使用官能化的线性核酸盒分子转化的植物细胞再生整个植物产生的目的核酸分子。

9. 发明申请

US20120244569A1 QUANTUM DOT CARRIER PEPTIDE CONJUGATES SUITABLE FOR IMAGING AND DELIVERY APPLICATIONS IN PLANTS 有权
标题翻译：量子载体肽适合在植物中成像和递送应用
公开(公告)号：US20120244569A1
公开(公告)日：2012-09-27
申请号：US13427750
申请日：2012-03-22
申请人： Jayakumar P. SAMUEL , Narasimha C. SAMBOJU , Kerrm Y. YAU , Gaofeng LIN , Steven R. WEBB , Frank BURROUGHS
发明人： Jayakumar P. SAMUEL , Narasimha C. SAMBOJU , Kerrm Y. YAU , Gaofeng LIN , Steven R. WEBB , Frank BURROUGHS
IPC分类号： C12N15/82 , G01N21/17 , C12N5/04 , B82Y5/00
CPC分类号： C12N15/8206 , B82Y5/00 , C12N15/8207 , C12N15/8221
摘要： Provided are methods for introducing a molecule of interest into a plant cell having a cell wall by using a QD-peptide conjugate having a quantum dot (QD) with one or more cell penetrating peptides (CPPs). Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.
摘要翻译：提供了通过使用具有一个或多个细胞穿透肽（CPP）的具有量子点（QD）的QD-肽缀合物将感兴趣的分子引入具有细胞壁的植物细胞的方法。提供用于遗传或其他修饰植物和用于治疗或预防包含细胞壁的植物细胞中的疾病的方法。

10. 发明申请

US20110203017A1 Novel Herbicide Resistance Genes 有权
标题翻译：新型除草剂抗性基因
公开(公告)号：US20110203017A1
公开(公告)日：2011-08-18
申请号：US12091896
申请日：2006-10-27
申请人： Terry R. Wright , Justin M. Lira , Terence Anthony Walsh , Donald J. Merlo , Jayakumar P. Samuel , Gaofeng Lin
发明人： Terry R. Wright , Justin M. Lira , Terence Anthony Walsh , Donald J. Merlo , Jayakumar P. Samuel , Gaofeng Lin
IPC分类号： A01H5/00 , C12N5/10 , A01N55/00 , A01N39/04 , C07H21/04 , A01P13/00 , A01H5/10
CPC分类号： C12N15/8274 , C12N9/0071 , C12N15/8275
摘要： The subject invention provides novel plants that are not only resistant to 2,4-D, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention “stacked” together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-12 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.
摘要翻译：本发明提供了不仅对2,4-D有抗性的新型植物，而且还提供了对吡啶氧基乙酸酯除草剂的抗性。迄今为止，没有任何期望或建议，通过引入单一基因可以产生具有这两种有利性质的植物。本发明还包括与一种或多种其它除草剂抗性基因一起产生本发明一种或多种酶“堆叠”的植物。本发明能够以新的方式使用除草剂的新型组合。此外，本发明提供了防止对一种或多种除草剂如草甘膦具有抗性的杂草的发育和控制菌株的新方法。根据本发明使用的优选酶和基因在本文中称为AAD-12（丙烯酰氧基烷酸酯加氧酶）。这种高度新颖的发现是显着的除草剂耐受性作物性状和选择性标记机会的基础。

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