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1. 发明申请

US20140192042A1 SYSTEM AND METHOD FOR OPTICAL THREE-DIMENSIONAL PARTICLE LOCALIZATION 有权
标题翻译：用于光学三维粒子定位的系统和方法
公开(公告)号：US20140192042A1
公开(公告)日：2014-07-10
申请号：US13734438
申请日：2013-01-04
申请人： Jason McClure
发明人： Jason McClure
IPC分类号： G06T15/50
CPC分类号： G02B21/16 , G02B21/367 , G06K9/00134 , G06K9/00208 , G06K9/2018 , G06K9/6249
摘要： Embodiments include methods that may be used to optically obtain the precise three-dimensional location of multiple objects from one or more two dimensional images. An optical point spread function having a transverse shape which varies with axial distance may be implemented to obtain depth information. The transverse variation in the PSF with depth may be produced using a cylindrical lens. The objects may be imaged by a focal plane array detector. One or more 2D images may be used to find the 3D location of the objects using sparse signal reconstruction methods.
摘要翻译：实施例包括可用于光学地获得来自一个或多个二维图像的多个物体的精确三维位置的方法。可以实现具有随轴距变化的横向形状的光点扩散函数以获得深度信息。具有深度的PSF中的横向变化可以使用柱面透镜来产生。物体可以由焦平面阵列检测器成像。可以使用一个或多个2D图像来使用稀疏信号重建方法来找到对象的3D位置。

2. 发明申请

US20110175185A1 SOLID STATE BACK-ILLUMINATED PHOTON SENSOR 有权
标题翻译：固态背光照明传感器
公开(公告)号：US20110175185A1
公开(公告)日：2011-07-21
申请号：US13010328
申请日：2011-01-20
申请人： William Edward Asher , Michael Alan Case , Jason McClure
发明人： William Edward Asher , Michael Alan Case , Jason McClure
IPC分类号： H01L31/0232
CPC分类号： H01L27/14685 , H01L27/14621 , H01L27/1464 , H01L31/02162
摘要： A backside-illuminated image sensor is disclosed having improved quantum efficiency (QE) in the near infrared wavelengths (NIR: 750-1100 nm) with minimal optical interference fringes produced by multiple reflected rays within the photosensitive Si region of the sensor, which may be a charge-coupled device, a complementary metal oxide sensor or an electron-multiplication sensor. The invention comprises a fringe suppression layer applied to the backside surface of the photosensitive Si region of a detector (Si substrate) whereby the fringe suppression layer functions in concert with the Si substrate to reduce the occurrence of interference fringes in the NIR while maintaining a high QE over a broad range of wavelengths (300-1100 nm). The combination of a fringe suppression layer applied to a Si substrate provides a new class of back illuminated solid state detectors for imaging.
摘要翻译：公开了背照式图像传感器，其在近红外波长（NIR：750-1100nm）中具有改善的量子效率（QE），具有由传感器的感光Si区域内的多个反射光线产生的最小光学干涉条纹，其可以是电荷耦合器件，互补金属氧化物传感器或电子倍增传感器。本发明包括施加到检测器（Si衬底）的感光Si区域的背面的边缘抑制层，由此边缘抑制层与Si衬底一起起作用，以减少NIR中的干涉条纹的发生，同时保持高在宽范围的波长（300-1100nm）上的QE。施加到Si衬底的边缘抑制层的组合提供了一类用于成像的背照式固态检测器。

3. 发明申请

US20130182250A1 ANASTIGMATIC IMAGING SPECTROGRAPH 有权
公开(公告)号：US20130182250A1
公开(公告)日：2013-07-18
申请号：US13350060
申请日：2012-01-13
申请人： Jason McClure
发明人： Jason McClure
IPC分类号： G01J3/28
CPC分类号： G01J3/0291 , G01J3/0208 , G01J3/18 , G01J3/2823
摘要： An apparatus and method are disclosed for producing spectrographic images free of SI, SII, and SIII field aberrations. The apparatus includes a focusing element placed at a distance from a dispersing element equal to the radius of curvature of the focusing element. The apparatus further includes at least one correcting plate for adding or subtracting abberations.
摘要翻译：公开了用于产生没有SI，SII和SIII场像差的光谱图像的装置和方法。该设备包括聚焦元件，该聚焦元件与等于聚焦元件的曲率半径的分散元件相距一定距离。该装置还包括至少一个用于增加或减去剔除的校正板。

4. 发明授权

US10168329B2 N-acetyl-D-glucosamine for enhanced specificity of Strep A immunoassay 有权
公开(公告)号：US10168329B2
公开(公告)日：2019-01-01
申请号：US13563542
申请日：2012-07-31
申请人： Peter Yan-Guo Ren , Jason McClure , Kevin S. Richardson
发明人： Peter Yan-Guo Ren , Jason McClure , Kevin S. Richardson
IPC分类号： G01N33/558 , G01N33/569 , G01N33/543
摘要： Methods, compositions and kits for detecting Group A streptococcus in a biological sample are described. More particularly, the present disclosure provides an immunoassay in which the specificity of detection of Group A streptococcus is enhanced by addition of N-acetyl-D-glucosamine. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of streptococcal infection in a human subject.

5. 发明授权

US09024945B2 System and method for optical three-dimensional particle localization 有权
标题翻译：光学三维粒子定位的系统和方法
公开(公告)号：US09024945B2
公开(公告)日：2015-05-05
申请号：US13734438
申请日：2013-01-04
申请人： Jason McClure
发明人： Jason McClure
IPC分类号： G06T13/20 , G02B21/16 , G02B21/36
CPC分类号： G02B21/16 , G02B21/367 , G06K9/00134 , G06K9/00208 , G06K9/2018 , G06K9/6249
摘要： Embodiments include methods that may be used to optically obtain the precise three-dimensional location of multiple objects from one or more two dimensional images. An optical point spread function having a transverse shape which varies with axial distance may be implemented to obtain depth information. The transverse variation in the PSF with depth may be produced using a cylindrical lens. The objects may be imaged by a focal plane array detector. One or more 2D images may be used to find the 3D location of the objects using sparse signal reconstruction methods.
摘要翻译：实施例包括可用于光学地获得来自一个或多个二维图像的多个物体的精确三维位置的方法。可以实现具有随轴距变化的横向形状的光点扩散函数以获得深度信息。具有深度的PSF中的横向变化可以使用柱面透镜来产生。物体可以由焦平面阵列检测器成像。可以使用一个或多个2D图像来使用稀疏信号重建方法来找到对象的3D位置。

6. 发明申请

US20130196337A1 N-ACETYL-D-GLUCOSAMINE FOR ENHANCED SPECIFICITY OF STREP A IMMUNOASSAY 审中-公开
标题翻译： N-乙酰-D-GLUCOSAMINE用于增强免疫功能的特异性
公开(公告)号：US20130196337A1
公开(公告)日：2013-08-01
申请号：US13563542
申请日：2012-07-31
申请人： Peter Yan-Guo Ren , Jason McClure , Kevin S. Richardson
发明人： Peter Yan-Guo Ren , Jason McClure , Kevin S. Richardson
IPC分类号： G01N33/569
CPC分类号： G01N33/56944 , G01N33/54393 , G01N33/558
摘要： Methods, compositions and kits for detecting Group A streptococcus in a biological sample are described. More particularly, the present disclosure provides an immunoassay in which the specificity of detection of Group A streptococcus is enhanced by addition of N-acetyl-D-glucosamine. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of streptococcal infection in a human subject.
摘要翻译：描述了用于检测生物样品中A组链球菌的方法，组合物和试剂盒。更具体地，本公开提供了其中通过加入N-乙酰基-D-葡糖胺来增强检测A组链球菌的特异性的免疫测定。这些方法，组合物和试剂盒在人类受试者的链球菌感染的便利，可靠和早期诊断中是有用的。

7. 发明授权

US08436423B2 Solid state back-illuminated photon sensor 有权
标题翻译：固态背照光子传感器
公开(公告)号：US08436423B2
公开(公告)日：2013-05-07
申请号：US13010328
申请日：2011-01-20
申请人： William Edward Asher , Michael Alan Case , Jason McClure
发明人： William Edward Asher , Michael Alan Case , Jason McClure
IPC分类号： H01L29/00
CPC分类号： H01L27/14685 , H01L27/14621 , H01L27/1464 , H01L31/02162
摘要： A backside-illuminated image sensor is disclosed having improved quantum efficiency (QE) in the near infrared wavelengths (NIR: 750-1100 nm) with minimal optical interference fringes produced by multiple reflected rays within the photosensitive Si region of the sensor, which may be a charge-coupled device, a complementary metal oxide sensor or an electron-multiplication sensor. The invention comprises a fringe suppression layer applied to the backside surface of the photosensitive Si region of a detector (Si substrate) whereby the fringe suppression layer functions in concert with the Si substrate to reduce the occurrence of interference fringes in the NIR while maintaining a high QE over a broad range of wavelengths (300-1100 nm). The combination of a fringe suppression layer applied to a Si substrate provides a new class of back illuminated solid state detectors for imaging.
摘要翻译：公开了背照式图像传感器，其在近红外波长（NIR：750-1100nm）中具有改善的量子效率（QE），具有由传感器的感光Si区域内的多个反射光线产生的最小光学干涉条纹，其可以是电荷耦合器件，互补金属氧化物传感器或电子倍增传感器。本发明包括施加到检测器（Si衬底）的感光Si区域的背面的边缘抑制层，由此边缘抑制层与Si衬底一起起作用，以减少NIR中的干涉条纹的发生，同时保持高在宽范围的波长（300-1100nm）上的QE。施加到Si衬底的边缘抑制层的组合提供了一类用于成像的背照式固态检测器。

8. 发明授权

US07999933B2 Method for calibrating imaging spectrographs 有权
标题翻译：校准成像光谱仪的方法
公开(公告)号：US07999933B2
公开(公告)日：2011-08-16
申请号：US12541586
申请日：2009-08-14
申请人： Jason McClure
发明人： Jason McClure
IPC分类号： G01J3/00
CPC分类号： G01J3/28 , G01J2003/2866
摘要： Disclosed is a method for calibrating optical spectrographs, and in particular optical spectrographs having focal plane array detectors. The method comprises the steps of detecting a spectrum of a known source, referencing a table of known spectral wavelengths and relative intensities, and deriving a spectrograph model based on the spectrograph's physical properties to approximate the observed spectrum, wherein non-linear optimization techniques refine the theoretical model parameters, thereby minimizing the residual difference between observed and calculated spectral intensities in an iterative process producing a set of physical model parameters that best describe the modeling spectrograph for calibration of subsequent spectral acquisitions.
摘要翻译：公开了一种用于校准光学光谱仪的方法，特别是具有焦平面阵列检测器的光学光谱仪。该方法包括以下步骤：检测已知源的光谱，参考已知光谱波长和相对强度的表格，以及基于所述光谱仪的物理特性导出近似观测光谱的光谱仪模型，其中非线性优化技术改进理论模型参数，从而最小化迭代过程中观察和计算的光谱强度之间的剩余差异，产生最佳描述建模光谱仪的一组物理模型参数，用于后续光谱采集的校准。

9. 发明申请

US20060068208A1 Techniques to improve polyurethane membranes for implantable glucose sensors 审中-公开
公开(公告)号：US20060068208A1
公开(公告)日：2006-03-30
申请号：US11280102
申请日：2005-11-16
申请人： Mark Tapsak , Rathbun Rhodes , Mark Shults , Jason McClure
发明人： Mark Tapsak , Rathbun Rhodes , Mark Shults , Jason McClure
IPC分类号： B32B27/40
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
摘要： The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.

10. 发明授权

US08773659B2 Anastigmatic imaging spectrograph 有权
标题翻译：无意识成像光谱仪
公开(公告)号：US08773659B2
公开(公告)日：2014-07-08
申请号：US13350060
申请日：2012-01-13
申请人： Jason McClure
发明人： Jason McClure
IPC分类号： G01J3/28
CPC分类号： G01J3/0291 , G01J3/0208 , G01J3/18 , G01J3/2823
摘要： An apparatus and method are disclosed for producing spectrographic images free of SI, SII, and SIII field aberrations. The apparatus includes a focusing element placed at a distance from a dispersing element equal to the radius of curvature of the focusing element. The apparatus further includes at least one correcting plate for adding or subtracting abberations.
摘要翻译：公开了用于产生没有SI，SII和SIII场像差的光谱图像的装置和方法。该设备包括聚焦元件，该聚焦元件与等于聚焦元件的曲率半径的分散元件相距一定距离。该装置还包括至少一个用于增加或减去剔除的校正板。

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