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2. 发明申请

US20100216729A1 Cancer cell growth inhibition by black bean (Phaseolus vulgaris L) extracts 审中-公开
标题翻译：黑豆（Phaseolus vulgaris L）提取物对癌细胞生长的抑制作用
公开(公告)号：US20100216729A1
公开(公告)日：2010-08-26
申请号：US12771991
申请日：2010-04-30
申请人： Janet A. Gutierrez-Uribe , Sergio R.O. Serna-Saldivar , Jorge E. Moreno-Cuevas , Carmen Hernandez-Brenes , Elsa M. Guajardo-Touche
发明人： Janet A. Gutierrez-Uribe , Sergio R.O. Serna-Saldivar , Jorge E. Moreno-Cuevas , Carmen Hernandez-Brenes , Elsa M. Guajardo-Touche
IPC分类号： A61K31/7048 , A61P35/00 , A61P35/02 , A61P3/06 , A61P1/16 , A61P5/30 , A61K31/352 , A61K47/26 , A61K47/22
CPC分类号： A61K36/48 , A23L5/43 , A23L11/00 , A23L11/20 , A23L33/105 , A23V2002/00 , A23V2200/308 , A23V2250/21 , A23V2200/02 , A23V2250/2116 , A23V2250/2104
摘要： A group of phytochemical compounds extracted from whole germinated or not germinated black beans (Phaseolus vulgaris L) and/or their dry milled fractions such as seed coats or hulls and cotyledons is described. These phytochemicals are classified as phenolics, such as polyphenols, flavonoids, coumarins, and tannins, triterpenes such as saponins, phytosterols and other antioxidant compounds that proved to be effective to decrease cancer proliferation of hormone dependent mammary (MCF-7), hormone independent hepatic (HepG2) and colon (Caco2) cancer cells. They also effectively protect against chemical damage induced with DMBA and furthermore prevented cancer induced by this chemical in Wistar rats and also reduced tumor size when consumed after tumor detection. Methanol, acetone, ethanol, water and mixtures of these solvents were used to obtain the extracts from raw, cooked, and germinated black beans of different varieties, both from the whole grain and the hulls. The black bean malting process produced extracts rich in aglycone forms of the previous mentioned compounds that were more biologically active against MCF-7 cancer cell proliferation. Both raw extracts, C-18 HPLC refined extracts and fractionated extracts may be used in the treatment, prophylaxis, amelioration or defense against a variety of hormone dependent and independent cancers. The extracts and compounds have additional utilities, e.g., lower cholesterol or lower oxidation of LDL and/or inhibit cholesterol synthesis (or the enzyme therefor) and/or reduce liver fibrosis and/or reduce symptoms of menopause and/or stimulate calcium absorption and/or have estrogenic activity such as feminizing estrogenic activity and/or are antioxidants, for instance, as an active ingredient in a nutritional supplement and/or as a food, cosmetic or pharmaceutical antioxidants or colorants.
摘要翻译：描述了从全发芽或未发芽的黑豆（菜豆）和/或其干研磨级分提取的一组植物化学化合物，例如种皮或外壳和子叶。这些植物化学物质被分类为酚类，如多酚类，类黄酮类，香豆素类，单宁类，三萜类如皂角苷类，植物甾醇类和其他抗氧化剂，被证明有效减少激素依赖性乳腺癌（MCF-7），激素依赖性肝癌（HepG2）和结肠（Caco2）癌细胞。它们还有效防止了DMBA引起的化学损伤，并进一步防止了Wistar大鼠中这种化学物质引起的癌症，并且在肿瘤检测后消耗时也减少了肿瘤的大小。使用甲醇，丙酮，乙醇，水和这些溶剂的混合物，从全谷物和船体获得来自不同品种的未加工的，熟的和发芽的黑豆的提取物。黑豆芽菜过程产生富含前面提到的化合物的糖苷配基形式的提取物，其对MCF-7癌细胞增殖具有更高的生物学活性。原始提取物，C-18 HPLC精制提取物和分级提取物均可用于治疗，预防，改善或防御各种激素依赖性和独立性癌症。提取物和化合物具有额外的用途，例如降低胆固醇或降低LDL的氧化和/或抑制胆固醇合成（或其酶）和/或减少肝纤维化和/或减少更年期症状和/或刺激钙吸收和/ 或具有雌激素活性如雌激素雌激素活性和/或是抗氧化剂，例如营养补充剂和/或作为食品，化妆品或药物抗氧化剂或着色剂中的活性成分。

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