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1. 发明申请

US20150320844A1 TARGETING OF GLYCOPROTEIN THERAPEUTICS 有权
标题翻译： GLYCOPROTEIN治疗方案的目标
公开(公告)号：US20150320844A1
公开(公告)日：2015-11-12
申请号：US14534328
申请日：2014-11-06
申请人： James Stefano
发明人： James Stefano
IPC分类号： A61K38/47 , A61K47/48
CPC分类号： A61K38/47 , A61K47/60 , A61K47/61 , A61K47/64 , C12N9/2465 , C12N9/96 , C12Y302/01022
摘要： Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.
摘要翻译：描述了制备治疗性糖蛋白的配体缀合的聚合物缀合物的方法。通过用高分子量聚合物（例如PEG，聚唾液酸等）掩蔽天然碳水化合物和其它表面决定簇来实现糖蛋白靶向特定组织的改进，其又用靶特异性配体装饰。在一些实施方案中，这种缀合物或快速可降解的掩蔽基团中的酸不稳定键可以允许聚合物从糖蛋白的细胞内释放，例如在溶酶体中发现的条件下。

2. 发明授权

US08124073B2 Targeting of glycoprotein therapeutics 有权
标题翻译：靶向糖蛋白治疗
公开(公告)号：US08124073B2
公开(公告)日：2012-02-28
申请号：US11970907
申请日：2008-01-08
申请人： James Stefano
发明人： James Stefano
IPC分类号： A61K38/54 , A61K38/43 , A61K31/00 , A61K38/47 , A61K38/00 , A61K38/14 , C12N9/40 , C12N9/96
CPC分类号： A61K38/47 , A61K47/60 , A61K47/61 , A61K47/64 , C12N9/2465 , C12N9/96 , C12Y302/01022
摘要： Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.
摘要翻译：描述了制备治疗性糖蛋白的配体缀合的聚合物缀合物的方法。通过用高分子量聚合物（例如PEG，聚唾液酸等）掩蔽天然碳水化合物和其它表面决定簇来实现糖蛋白靶向特定组织的改进，其又用靶特异性配体装饰。在一些实施方案中，这种缀合物或快速可降解的掩蔽基团中的酸不稳定键可以允许聚合物从糖蛋白的细胞内释放，例如在溶酶体中发现的条件下。

3. 发明授权

US06568327B1 Trading card having postal markings and method for producing same 失效
标题翻译：具有邮政标记的交易卡及其生产方法
公开(公告)号：US06568327B1
公开(公告)日：2003-05-27
申请号：US09627538
申请日：2000-07-28
申请人： Guy Jones , James Stefano
发明人： Guy Jones , James Stefano
IPC分类号： B42D1500
CPC分类号： B42D15/02
摘要： A trading card and method for producing a trading card are provided. The trading card includes a picture printed on a substrate. The card is mailed to obtain a postmark printed on the card from the postal service. Preferably, a date and/or location is selected to correspond with an event associated with the picture on the card. The trading card is then mailed to obtain a postmark having a date and/or location corresponding with the selected date and/or location. After the card is mailed it may be trimmed to a smaller size. More specifically, the card may be trimmed to a size having a length and/or height that is smaller than the minimum height and/or length allowed for mailing under postal regulations. The mailed cards are then packaged either individually or with other mailed or unmailed cards.
摘要翻译：提供了一种用于生产交易卡的交易卡和方法。交易卡包括印刷在基板上的图像。邮寄邮件以从邮政服务中获取印在卡上的邮戳。优选地，选择日期和/或位置以对应于与卡上的图片相关联的事件。然后将交易卡邮寄以获得具有与所选日期和/或位置相对应的日期和/或位置的邮戳。卡片邮寄后，可能会将其修剪成较小的尺寸。更具体地，可以将卡片修剪成具有小于根据邮政规定邮寄的最小高度和/或长度的长度和/或高度的尺寸。然后邮寄的卡单独包装或与其他邮寄或未邮寄的卡片包装。

4. 发明授权

US09441029B2 VEGF antagonist compositions and uses thereof 有权
标题翻译： VEGF拮抗剂组合物及其用途
公开(公告)号：US09441029B2
公开(公告)日：2016-09-13
申请号：US13814182
申请日：2011-08-05
申请人： James Stefano , Clark Pan , Huawei Qiu , Michael O'Callaghan , Gloria Matthews
发明人： James Stefano , Clark Pan , Huawei Qiu , Michael O'Callaghan , Gloria Matthews
IPC分类号： A61K38/00 , C07K14/435 , C07K14/71 , C12N9/12
CPC分类号： C12N9/12 , C07K14/71 , C12Y207/10001
摘要： The invention provides compositions and methods for treating a disease or disorder associated with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.
摘要翻译：本发明提供用于治疗与血管内皮生长因子（VEGF）相关的疾病或病症的组合物和方法。具体地，本发明涉及提供VEGF拮抗作用的低聚VEGF结合结构域，从而治疗与之相关的疾病。

5. 发明授权

US07341720B2 Targeting of glycoprotein therapeutics 有权
标题翻译：靶向糖蛋白治疗
公开(公告)号：US07341720B2
公开(公告)日：2008-03-11
申请号：US11398949
申请日：2006-04-05
申请人： James Stefano
发明人： James Stefano
IPC分类号： A61K38/54 , A61K38/43 , A61K38/16 , C12N9/40 , C07K16/00
CPC分类号： A61K38/47 , A61K47/60 , A61K47/61 , A61K47/64 , C12N9/2465 , C12N9/96 , C12Y302/01022
摘要： Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.
摘要翻译：描述了制备治疗性糖蛋白的配体缀合的聚合物缀合物的方法。通过用高分子量聚合物（例如PEG，聚唾液酸等）掩蔽天然碳水化合物和其它表面决定簇来实现糖蛋白靶向特定组织的改进，其又用靶特异性配体装饰。在一些实施方案中，这种缀合物或快速可降解的掩蔽基团中的酸不稳定键可以允许聚合物从糖蛋白的细胞内释放，例如在溶酶体中发现的条件下。

6. 发明申请

US20120141507A1 TARGETING OF GLYCOPROTEIN THERAPEUTICS 有权
标题翻译： GLYCOPROTEIN治疗方案的目标
公开(公告)号：US20120141507A1
公开(公告)日：2012-06-07
申请号：US13354855
申请日：2012-01-20
申请人： James Stefano
发明人： James Stefano
IPC分类号： A61K39/395 , A61P43/00 , C07K17/06 , A61K38/47 , C12N9/96
CPC分类号： A61K38/47 , A61K47/60 , A61K47/61 , A61K47/64 , C12N9/2465 , C12N9/96 , C12Y302/01022
摘要： Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.
摘要翻译：描述了制备治疗性糖蛋白的配体缀合的聚合物缀合物的方法。通过用高分子量聚合物（例如PEG，聚唾液酸等）掩蔽天然碳水化合物和其它表面决定簇来实现糖蛋白靶向特定组织的改进，其又用靶特异性配体装饰。在一些实施方案中，这种缀合物或快速可降解的掩蔽基团中的酸不稳定键可以允许聚合物从糖蛋白的细胞内释放，例如在溶酶体中发现的条件下。

7. 发明授权

US08906379B2 Targeting of glycoprotein therapeutics 有权
标题翻译：靶向糖蛋白治疗
公开(公告)号：US08906379B2
公开(公告)日：2014-12-09
申请号：US13354855
申请日：2012-01-20
申请人： James Stefano
发明人： James Stefano
IPC分类号： A61K39/00 , A61K38/54 , A61K38/43 , A61K38/47 , C12N9/96 , C12N9/14 , C12N9/38 , C07K16/00 , A61K47/48
CPC分类号： A61K38/47 , A61K47/60 , A61K47/61 , A61K47/64 , C12N9/2465 , C12N9/96 , C12Y302/01022
摘要： Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.
摘要翻译：描述了制备治疗性糖蛋白的配体缀合的聚合物缀合物的方法。通过用高分子量聚合物（例如PEG，聚唾液酸等）掩蔽天然碳水化合物和其它表面决定簇来实现糖蛋白靶向特定组织的改进，其又用靶特异性配体装饰。在一些实施方案中，这种缀合物或快速可降解的掩蔽基团中的酸不稳定键可以允许聚合物从糖蛋白的细胞内释放，例如在溶酶体中发现的条件下。

8. 发明申请

US20130324465A1 VEGF ANTAGONIST COMPOSITIONS AND USES THEREOF 有权
标题翻译： VEGF拮抗剂组合物及其用途
公开(公告)号：US20130324465A1
公开(公告)日：2013-12-05
申请号：US13814182
申请日：2011-08-05
申请人： James Stefano , Clark Pan , Huawei Qiu , Michael O'Callaghan , Gloria Matthews
发明人： James Stefano , Clark Pan , Huawei Qiu , Michael O'Callaghan , Gloria Matthews
IPC分类号： C07K14/71 , C12N9/12
CPC分类号： C12N9/12 , C07K14/71 , C12Y207/10001
摘要： The invention provides compositions and methods for treating a disease or disorder associated with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.
摘要翻译：本发明提供用于治疗与血管内皮生长因子（VEGF）相关的疾病或病症的组合物和方法。具体地，本发明涉及提供VEGF拮抗作用的低聚VEGF结合结构域，从而治疗与之相关的疾病。

9. 发明申请

US20080226658A1 TARGETING OF GLYCOPROTEIN THERAPEUTICS 有权
标题翻译： GLYCOPROTEIN治疗方案的目标
公开(公告)号：US20080226658A1
公开(公告)日：2008-09-18
申请号：US11970907
申请日：2008-01-08
申请人： James Stefano
发明人： James Stefano
IPC分类号： A61K39/00
CPC分类号： A61K38/47 , A61K47/60 , A61K47/61 , A61K47/64 , C12N9/2465 , C12N9/96 , C12Y302/01022
摘要： Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.
摘要翻译：描述了制备治疗性糖蛋白的配体缀合的聚合物缀合物的方法。通过用高分子量聚合物（例如PEG，聚唾液酸等）掩蔽天然碳水化合物和其它表面决定簇来实现糖蛋白靶向特定组织的改进，其又用靶特异性配体装饰。在一些实施方案中，这种缀合物或快速可降解的掩蔽基团中的酸不稳定键可以允许聚合物从糖蛋白的细胞内释放，例如在溶酶体中发现的条件下。

10. 发明申请

US20060228348A1 Targeting of glycoprotein therapeutics 有权
标题翻译：靶向糖蛋白治疗
公开(公告)号：US20060228348A1
公开(公告)日：2006-10-12
申请号：US11398949
申请日：2006-04-05
申请人： James Stefano
发明人： James Stefano
IPC分类号： A61K38/47 , A61K38/16 , A61K39/395
CPC分类号： A61K38/47 , A61K47/60 , A61K47/61 , A61K47/64 , C12N9/2465 , C12N9/96 , C12Y302/01022
摘要： Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.
摘要翻译：描述了制备治疗性糖蛋白的配体缀合的聚合物缀合物的方法。通过用高分子量聚合物（例如PEG，聚唾液酸等）掩蔽天然碳水化合物和其它表面决定簇来实现糖蛋白靶向特定组织的改进，其又用靶特异性配体装饰。在一些实施方案中，这种缀合物或快速可降解的掩蔽基团中的酸不稳定键可以允许聚合物从糖蛋白的胞内释放，例如在溶酶体中发现的条件下。

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