专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08497269B2 Phthalazine compounds as p38 map kinase modulators and methods of use thereof 有权
标题翻译：酞嗪化合物作为p38映射激酶调节剂及其使用方法
公开(公告)号：US08497269B2
公开(公告)日：2013-07-30
申请号：US13123889
申请日：2009-10-07
申请人： Andrew Tasker , James R. Falsey , Robert M. Rzasa , Bradley J. Herberich , Dawei Zhang
发明人： Andrew Tasker , James R. Falsey , Robert M. Rzasa , Bradley J. Herberich , Dawei Zhang
IPC分类号： C07D487/04 , A61K31/50 , A01N43/58
CPC分类号： C07D401/12 , C07D237/30 , C07D237/32 , C07D237/34 , C07D401/04 , C07D403/04 , C07D413/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A4, L, R1, R2, R3, R5 and m are as defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, ankylosing spondylitis, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。该化合物具有通式I，其中A4，L，R1，R2，R3，R5和m如本文所定义。本发明还包括药物组合物，其包含一种或多种式I化合物，用于治疗p38地图激酶介导的疾病包括类风湿性关节炎，牛皮癣，慢性阻塞性肺病，强直性脊柱炎，疼痛和其它炎症性疾病的化合物和组合物的用途，如以及可用于制备式I化合物的中间体和方法。

2. 发明授权

US07511044B2 Vanilloid receptor ligands and their use in treatments 失效
标题翻译：香草素受体配体及其在治疗中的应用
公开(公告)号：US07511044B2
公开(公告)日：2009-03-31
申请号：US11056568
申请日：2005-02-11
申请人： Hui-Ling Wang , Chenera Balan , Elizabeth M. Doherty , James R. Falsey , Vijay Keshav Gore , Jodie Katon , Mark H. Norman
发明人： Hui-Ling Wang , Chenera Balan , Elizabeth M. Doherty , James R. Falsey , Vijay Keshav Gore , Jodie Katon , Mark H. Norman
IPC分类号： C07D403/04 , A61K31/496
CPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Pyrimidine ethers and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：嘧啶醚和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经痛维持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统内脏运动紊乱，泌尿生殖道，胃肠道或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病，胃溃疡，杜腹部溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

3. 发明授权

US08318718B2 Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors 有权
标题翻译：吡啶和嘧啶衍生物作为磷酸二酯酶10抑制剂
公开(公告)号：US08318718B2
公开(公告)日：2012-11-27
申请号：US12619573
申请日：2009-11-16
申请人： Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
发明人： Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
IPC分类号： A61K31/4439 , A61K31/437 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/397 , C07D401/12 , C07D471/04 , C07D473/00 , C07D413/14 , C07D401/14 , A61P25/00
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , C07D473/00
摘要： Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译：吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。

4. 发明授权

US08247409B2 Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use 失效
标题翻译：噻吩并[2,3-d]嘧啶和噻吩并哒嗪化合物及其使用方法
公开(公告)号：US08247409B2
公开(公告)日：2012-08-21
申请号：US12616646
申请日：2009-11-11
申请人： Fang-Tsao Hong , James R. Falsey , Seifu Tadesse , Andrew Tasker
发明人： Fang-Tsao Hong , James R. Falsey , Seifu Tadesse , Andrew Tasker
IPC分类号： A61K31/5052 , A61K31/5377 , C07D413/14 , C07D487/04 , A61P17/00 , A61P19/00 , A61P25/00 , A61P31/12 , A61P11/00
CPC分类号： C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。该化合物具有通式I，其中A1，A2，B，R2和R3在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

5. 发明申请

US20120040983A1 Phthalazine Compounds as P38 Map Kinase Modulators and Methods of Use Thereof 有权
标题翻译：酞嗪化合物作为P38映射激酶调节剂及其使用方法
公开(公告)号：US20120040983A1
公开(公告)日：2012-02-16
申请号：US13123889
申请日：2009-10-07
申请人： Andrew Tasker , James R. Falsey , Robert M. Rzasa , Bradley J. Herberich , Dawei Zhang
发明人： Andrew Tasker , James R. Falsey , Robert M. Rzasa , Bradley J. Herberich , Dawei Zhang
IPC分类号： C07D401/04 , A61K31/50 , C07D413/02 , A61P25/28 , A61P3/10 , A61P11/06 , A61P31/12 , A61P1/04 , A61P19/02 , A61P11/00 , A61P9/10 , A61P31/18 , A61P25/00 , A61P37/08 , A61P17/00 , A61P19/00 , A61P31/22 , A61P17/06 , A61K31/501
CPC分类号： C07D401/12 , C07D237/30 , C07D237/32 , C07D237/34 , C07D401/04 , C07D403/04 , C07D413/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A4, L, R1, R2, R3, R5 and m are as defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, ankylosing spondylitis, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。该化合物具有通式I，其中A4，L，R1，R2，R3，R5和m如本文所定义。本发明还包括药物组合物，其包含一种或多种式I化合物，用于治疗p38地图激酶介导的疾病包括类风湿性关节炎，牛皮癣，慢性阻塞性肺病，强直性脊柱炎，疼痛和其它炎症性疾病的化合物和组合物的用途，如以及可用于制备式I化合物的中间体和方法。

6. 发明授权

US07745449B2 Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use 有权
标题翻译：噻吩并[2,3-d]嘧啶和噻吩并哒嗪化合物及其使用方法
公开(公告)号：US07745449B2
公开(公告)日：2010-06-29
申请号：US11789189
申请日：2007-04-23
申请人： Fang-Tsao Hong , James R. Falsey , Robert M. Rzasa , Seifu Tadesse , Andrew Tasker
发明人： Fang-Tsao Hong , James R. Falsey , Robert M. Rzasa , Seifu Tadesse , Andrew Tasker
IPC分类号： C07D495/04 , C07D413/12 , A61K31/519 , A61K31/5355 , A61P29/00 , A61P23/00 , C07D413/04 , C07D513/04 , A61K31/5025
CPC分类号： C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。该化合物具有通式I，其中A1，A2，B，R2和R3在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

7. 发明授权

US08637500B2 Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors 有权
标题翻译：氨基吡啶和羧基吡啶化合物作为磷酸二酯酶10抑制剂
公开(公告)号：US08637500B2
公开(公告)日：2014-01-28
申请号：US12639931
申请日：2009-12-16
申请人： Jennifer R. Allen , Ning Chen , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Essa Hu Harrington , Matthew R. Kaller , Roxanne K. Kunz , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Aaron C. Siegmund , Guomin Yao
发明人： Jennifer R. Allen , Ning Chen , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Essa Hu Harrington , Matthew R. Kaller , Roxanne K. Kunz , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Aaron C. Siegmund , Guomin Yao
IPC分类号： A61K31/551 , A61K31/553 , A61K31/5377 , A61K31/497 , C07D243/08 , C07D267/10 , C07D401/12 , C07D401/14 , C07D413/14
CPC分类号： C07D401/04 , C07D213/74 , C07D213/84 , C07D401/12 , C07D401/14 , C07D407/14 , C07D409/14 , C07D413/14
摘要： Pyridine and pyrimidine compounds: or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined in the specification; or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, and ring A are as defined in the specification; and or a pharmaceutically acceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6, R7, R9, X1, X2, and ring A are as defined in the specification; compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译：吡啶和嘧啶化合物或其药学上可接受的盐，其中m，n，R1，R2，R3，R4，R5，R6，R7，X1，X2，X3，X4，X5，X6，X7，X8和Y为如说明书中所定义; 或其药学上可接受的盐，其中环A，m，n，y，R2，R3，R4，R5，R6，R7，R8，R9，X1，X2和环A如说明书中所定义; 和其药学上可接受的盐，其中m，n，y，R2，R3，R4，R5，R6，R7，R9，X1，X2和环A如说明书中所定义; 含有它们的组合物，以及制备这些化合物的方法。本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。

8. 发明申请

US20110118234A1 Urea Compounds as Gamma Secretase Modulators 审中-公开
标题翻译：尿素化合物作为γ分泌酶调节剂
公开(公告)号：US20110118234A1
公开(公告)日：2011-05-19
申请号：US12990999
申请日：2009-05-04
申请人： Kaustav Biswas , Jian J. Chen , James R. Falsey , Vijay Keshav Gore , Qingyian Liu , Vu Van Ma , Stephanie J. Mercede , Robert M. Rzasa , Christopher M. Tegley , Jiawang Zhu
发明人： Kaustav Biswas , Jian J. Chen , James R. Falsey , Vijay Keshav Gore , Qingyian Liu , Vu Van Ma , Stephanie J. Mercede , Robert M. Rzasa , Christopher M. Tegley , Jiawang Zhu
IPC分类号： A61K31/55 , C07D213/53 , A61K31/44 , C07D405/12 , A61K31/4433 , C07D413/12 , A61K31/5377 , C07D403/12 , A61K31/47 , A61K31/4439 , A61K31/444 , A61P25/28
CPC分类号： C07D213/40 , C07D213/61 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds Formula (I) that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译：本发明提供了作为γ-分泌酶调节剂的式（I）化合物，因此可用于治疗通过调节γ-分泌酶如阿尔茨海默病可治疗的疾病。还提供含有这些化合物的药物组合物和制备这些化合物的方法。

9. 发明授权

US07897619B2 Heterocyclic modulators of PKB 有权
标题翻译： PKB的杂环调节剂
公开(公告)号：US07897619B2
公开(公告)日：2011-03-01
申请号：US12218754
申请日：2008-07-16
申请人： Qingping Zeng , Dawei Zhang , Guomin Yao , George E. Wohlhieter , Xianghong Wang , James Rider , Andreas Reichelt , Holger Monenschein , Fang-Tsao Hong , James R. Falsey , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
发明人： Qingping Zeng , Dawei Zhang , Guomin Yao , George E. Wohlhieter , Xianghong Wang , James Rider , Andreas Reichelt , Holger Monenschein , Fang-Tsao Hong , James R. Falsey , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
IPC分类号： A61K31/47 , A61K31/416 , C07D217/02 , C07D231/56
CPC分类号： C07D413/04 , C07D263/48 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04
摘要： The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译：本发明涉及用于治疗由蛋白激酶B（PKB）介导的疾病的式I的杂环化合物及其组合物，其中变量具有本文提供的定义。本发明还涉及这些化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

10. 发明申请

US20100125074A1 Thieno-[2,3-d]Pyrimidine and Thieno-Pyridazine Compounds and Methods of Use 失效
标题翻译：噻吩并[2,3-d]嘧啶和噻吩并哒嗪化合物及其使用方法
公开(公告)号：US20100125074A1
公开(公告)日：2010-05-20
申请号：US12616646
申请日：2009-11-11
申请人： Fang-Tsao Hong , James R. Falsey , Robert M. Rzasa , Seifu Tadesse , Andrew Tasker
发明人： Fang-Tsao Hong , James R. Falsey , Robert M. Rzasa , Seifu Tadesse , Andrew Tasker
IPC分类号： A61K31/5025 , C07D413/14 , C07D487/04 , A61K31/5377 , A61P17/00 , A61P19/00 , A61P25/00 , A61P31/12 , A61P11/00
CPC分类号： C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。该化合物具有通式I，其中A1，A2，B，R2和R3在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式