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1. 发明授权

US06969843B1 Light standard for microscopy 失效
标题翻译：显微镜标准
公开(公告)号：US06969843B1
公开(公告)日：2005-11-29
申请号：US10273332
申请日：2002-10-17
申请人： James M. Beach , Robert A. Ross , Josef K. Hudson
发明人： James M. Beach , Robert A. Ross , Josef K. Hudson
IPC分类号： G01J1/04 , G01J1/32 , G01N21/27 , G01N21/64 , G02B21/08 , G02B21/36
CPC分类号： G01N21/6458 , G01J1/32 , G01N21/274 , G02B21/086 , G02B21/365
摘要： The disclosed light standard system provides flat field illumination through the use of an integrating light chamber which is in communication with a microprocessor. The light chamber has at least one high performance light source, such as LED's, recessed within the walls and positioned to prevent light from directly exiting the chamber. A photosensor monitors multiple parameters within the chamber and interacts with the microprocessor to control intensity, temperature and wavelengths. The lights standard operates in benchmark, ratio light, linearity and transient response modes with all parameters being programmable and storable within said microprocessor.
摘要翻译：所公开的光标准系统通过使用与微处理器通信的积分光室提供平坦场照明。光室具有至少一个高性能的光源，例如LED，凹陷在壁内并被定位成防止光直接离开室。光电传感器监测室内的多个参数，并与微处理器相互作用以控制强度，温度和波长。灯标准以基准，比例光，线性度和瞬态响应模式运行，所有参数均可编程并存储在所述微处理器内。

2. 发明申请

US20080255457A1 Method For Evaluating Relative Oxygen Saturation in Body Tissues 有权
标题翻译：评价身体组织相对氧饱和度的方法
公开(公告)号：US20080255457A1
公开(公告)日：2008-10-16
申请号：US10593175
申请日：2005-03-18
申请人： Bahram Khoobehi , James M. Beach
发明人： Bahram Khoobehi , James M. Beach
IPC分类号： A61B6/00 , G01N33/483
CPC分类号： A61B5/14555
摘要： A new method was discovered to analyze continuous spectral curves to determine relative hemoglobin oxygen saturation, using spectral curves collected from a continuous range of wavelengths from about 530 nm to about 584 nm, including spectra from transmitted or reflected light. Using isosbestic points and curve areas, a relative saturation index was calculated. With this method, noninvasive, in vivo measurement of relative oxygen saturation was made using light reflected from blood vessels in the eye and to map and measure relative changes in hemoglobin oxygen saturation in primate retinal vessels and optic nerve head in response to controlled changes in inspired oxygen and intraocular pressure (IOP). This method could also measure oxygen saturation from other blood vessels that reflect light sufficient to give a clear spectra from the blood hemoglobin. Changes in blood oxygen saturation can be monitored with this method for early detection of disease.
摘要翻译：发现了一种新的方法来分析连续光谱曲线以确定相对血红蛋白氧饱和度，使用从约530nm至约584nm的连续波长范围收集的光谱曲线，包括来自透射或反射光的光谱。使用等腰点和曲线区域，计算相对饱和指数。使用这种方法，使用从眼睛中的血管反射的光进行非侵入性体内相对氧饱和度的测量，并且根据受启发的受控变化映射和测量灵长动物视网膜血管和视神经头中血红蛋白氧饱和度的相对变化氧气和眼内压（IOP）。该方法还可以测量反射足以产生来自血液血红蛋白的清晰光谱的其他血管的氧饱和度。用这种早期检测疾病的方法可以监测血氧饱和度的变化。

3. 发明授权

US5489771A LED light standard for photo- and videomicroscopy 失效
标题翻译： LED照明和视频显微镜标准
公开(公告)号：US5489771A
公开(公告)日：1996-02-06
申请号：US137827
申请日：1993-10-15
申请人： James M. Beach , Brian R. Duling
发明人： James M. Beach , Brian R. Duling
IPC分类号： G01J3/10 , H05B37/02 , H05B39/04 , H05B35/00 , H05B37/00
CPC分类号： G01J3/10 , H05B37/02 , H05B39/042
摘要： The invention relates to a light calibration system consisting of a compact LED source with feedback control of intensity. The source is positioned in the focal plane of the microscope objective and produces flat-field illumination of up to 31 microwatts. The source can be easily used to determine the performance of microscope optics and camera response. It can also be used as a standard light source for calibration of experimental systems. Selectable light intensities are produced by controlling the LED input power via a feedback circuit consisting of a photodiode that detects output light intensity. Spectral coverage extends between 550 nm and 670 nm using green, yellow and red LEDS mounted side-by-side and which are individually selected. The LED chips are encapsulated in plastic diffusers which homogenize the light, and a flat field of illumination is obtained through a thin 1 mm diameter aperture positioned directly over each chip. Provision is made for insertion of Ronchi rulings over the aperture to enable measurements of contrast modulation in a uniform field. The light can be pulse-modulated to assess camera response times and the device can be synchronized with video frames. Narrow bandpass interference filters can be placed between the objective lens and the LED source to produce monochromatic light without affecting the spacing of controlled light intensities since emission spectra do not appreciably shift over the range of LED powers chosen in this design.
摘要翻译：本发明涉及由强度反馈控制的紧凑型LED源组成的光校准系统。光源定位在显微镜物镜的焦平面上，产生高达31微瓦的平场照明。源可以很容易地用于确定显微镜光学和相机响应的性能。它也可以用作实验系统校准的标准光源。通过由检测输出光强度的光电二极管组成的反馈电路控制LED输入功率，可以产生可选择的光强度。光谱覆盖范围在550 nm到670 nm之间，使用绿色，黄色和红色LEDS并排安装，并分别选择。 LED芯片封装在均匀化光的塑料扩散器中，并且通过直接位于每个芯片上方的1mm直径的狭缝获得平坦的照明场。规定了在孔径上插入Ronchi规则，以便能够在均匀场中测量对比度调制。可以对光进行脉冲调制，以评估相机响应时间，并且可以将设备与视频帧同步。可以将窄带通干涉滤光器放置在物镜和LED源之间以产生单色光，而不影响受控光强度的间隔，因为发射光谱在该设计中选择的LED功率范围内不会明显偏移。

4. 发明授权

US4069895A Oil leak scavenger apparatus 失效
标题翻译：漏油检漏仪
公开(公告)号：US4069895A
公开(公告)日：1978-01-24
申请号：US685099
申请日：1976-05-10
申请人： James M. Beach , Elbert R. Eastin
发明人： James M. Beach , Elbert R. Eastin
IPC分类号： F01M11/04 , F16N31/02 , F16N31/00
CPC分类号： F01M11/045
摘要： An oil leak scavenger apparatus for collecting oil drippings of automobile vehicles which is mounted externally to engine crankcases, transmission housings, and other oil containing units is provided. The scavenger apparatus comprises: (a) an oil collector; (b) a reservoir in fluid communication with the oil collector; (c) a vacuum source in fluid communication with the reservoir; and (d) a vacuum metering valve positioned intermediate the vacuum source and the reservoir. In one embodiment the reservoir is also in fluid communication with the oil containing unit of the automobile, and a check valve is positioned intermediate the reservoir and the oil containing unit of the automobile thus allowing the collected oil to return to its source when the engine is not running.
摘要翻译：提供了一种用于收集汽车车辆油滴的漏油检漏装置，其安装在发动机曲轴箱，变速器壳体和其它含油单元外部。除菌装置包括：（a）集油器; （b）与集油器流体连通的储存器; （c）与储存器流体连通的真空源; 和（d）位于真空源和储存器之间的真空计量阀。在一个实施例中，储存器还与汽车的含油单元流体连通，并且止回阀位于储存器和汽车的储油单元之间，从而当发动机为不运行

5. 发明授权

US07949387B2 Method for evaluating relative oxygen saturation in body tissues 有权
标题翻译：评估身体组织中相对氧饱和度的方法
公开(公告)号：US07949387B2
公开(公告)日：2011-05-24
申请号：US10593175
申请日：2005-03-18
申请人： Bahram Khoobehi , James M. Beach
发明人： Bahram Khoobehi , James M. Beach
IPC分类号： A61B6/00
CPC分类号： A61B5/14555
摘要： A new method was discovered to analyze continuous spectral curves to determine relative hemoglobin oxygen saturation, using spectral curves collected from a continuous range of wavelengths from about 530 nm to about 584 nm, including spectra from transmitted or reflected light. Using isosbestic points and curve areas, a relative saturation index was calculated. With this method, noninvasive, in vivo measurement of relative oxygen saturation was made using light reflected from blood vessels in the eye and to map and measure relative changes in hemoglobin oxygen saturation in primate retinal vessels and optic nerve head in response to controlled changes in inspired oxygen and intraocular pressure (IOP). This method could also measure oxygen saturation from other blood vessels that reflect light sufficient to give a clear spectra from the blood hemoglobin. Changes in blood oxygen saturation can be monitored with this method for early detection of disease.
摘要翻译：发现了一种新的方法来分析连续光谱曲线以确定相对血红蛋白氧饱和度，使用从约530nm至约584nm的连续波长范围收集的光谱曲线，包括来自透射或反射光的光谱。使用等腰点和曲线区域，计算相对饱和指数。使用这种方法，使用从眼睛中的血管反射的光进行非侵入性体内相对氧饱和度的测量，并且根据受启发的受控变化映射和测量灵长动物视网膜血管和视神经头中血红蛋白氧饱和度的相对变化氧气和眼内压（IOP）。该方法还可以测量反射足以产生来自血液血红蛋白的清晰光谱的其他血管的氧饱和度。用这种早期检测疾病的方法可以监测血氧饱和度的变化。

6. 发明授权

US07774036B2 Automatic registration of images 有权
标题翻译：自动注册图像
公开(公告)号：US07774036B2
公开(公告)日：2010-08-10
申请号：US11146278
申请日：2005-06-07
申请人： Gisli Hreinn Halldorsson , Einar Stefansson , Jon Atli Benediktsson , Robert Arnar Karlsson , Sveinn Hakon Hardarson , Thor Eysteinsson , James M. Beach
发明人： Gisli Hreinn Halldorsson , Einar Stefansson , Jon Atli Benediktsson , Robert Arnar Karlsson , Sveinn Hakon Hardarson , Thor Eysteinsson , James M. Beach
IPC分类号： A61B5/1455
CPC分类号： A61B3/1241 , A61B5/14555 , A61B5/7264
摘要： The example embodiments relate to a system for automatically evaluating oxygen saturation of the optic nerve and retina, including an image capturing system which includes a fundus camera, a four wavelengths beam splitter, a digital image capturing device, a computer system, and image processing software for registering and analyzing multi-spectral images of the retina, and for evaluating oxygen saturation level.
摘要翻译：示例性实施例涉及用于自动评估视神经和视网膜的氧饱和度的系统，包括包括眼底照相机，四波长分束器，数字图像捕获装置，计算机系统和图像处理软件的图像捕获系统用于登记和分析视网膜的多光谱图像，并用于评估氧饱和度水平。

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