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1. 发明申请

US20080045949A1 Method of treating degenerative spinal disorders 审中-公开
标题翻译：治疗退行性脊柱疾病的方法
公开(公告)号：US20080045949A1
公开(公告)日：2008-02-21
申请号：US11455401
申请日：2006-06-19
申请人： Margaret Hunt , David Hooper , Alain Meunier , James Jara-Almonte
发明人： Margaret Hunt , David Hooper , Alain Meunier , James Jara-Almonte
IPC分类号： A61B17/58
CPC分类号： C07K16/241 , A61B17/7023 , A61B17/7061 , A61B17/7062 , A61F2002/30075 , A61F2002/30677 , A61F2002/444 , A61F2210/0061 , A61K2039/505
摘要： The present invention describes methods for treating a degenerative intervertebral disc disorder comprising implanting a disc stabilization device into a subject and administering at least one therapeutic agent which promotes healing of the disc to the subject. The invention also includes methods of promoting healing of damaged or degenerated intervertebral discs comprising decreasing the load of the disc through a disc stabilization device and inhibiting the inflammatory process. Also described are hydrogels for use in combination with extradiscal stabilization devices, as intradiscal stabilization devices, as drug carriers, and as combinations thereof.
摘要翻译：本发明描述了用于治疗退行性椎间盘障碍的方法，包括将椎间盘稳定装置植入受试者体内并施用至少一种促进椎间盘愈合的治疗剂。本发明还包括促进损伤或退化的椎间盘愈合的方法，其包括通过椎间盘稳定装置降低椎间盘的负荷并抑制炎性过程。还描述了与用于与硬币外稳定装置组合使用的水凝胶，作为椎间体内稳定装置，作为药物载体，以及作为其组合。

2. 发明授权

US06953455B2 Medicine delivery system 失效
标题翻译：药物输送系统
公开(公告)号：US06953455B2
公开(公告)日：2005-10-11
申请号：US10207934
申请日：2002-07-30
申请人： Steven T. Cho , Keith Cromack , James Jara-Almonte , Don J VerLee
发明人： Steven T. Cho , Keith Cromack , James Jara-Almonte , Don J VerLee
IPC分类号： A61K9/22 , A61M5/142 , A61M31/00
CPC分类号： A61K9/0024 , A61M5/14276 , A61M31/002 , A61M2205/0244
摘要： A medicine delivery system (10) implantable into a human or animal body includes a medicine delivery unit (14) and a control unit (12). A membrane (26) seals the delivery opening (22) of a medicine compartment (18) and is pre-stressed by an amount less than the predetermined elastic deformation and rupture point limits of the membrane (26). A release element (28) associated with compartment (18) causes the membrane (26) to be stressed beyond the deformation and rupture point limits in response to a control signal (78). Release element (28) ruptures the membrane (26) along a predetermined rupture pattern to permit a first membrane portion (35), forming a hinged lid, to separate from a second membrane portion (37) along the predetermined rupture pattern while remaining attached to the second membrane portion at a hinge (39).
摘要翻译：植入人体或动物体内的药物输送系统（10）包括药物输送单元（14）和控制单元（12）。膜（26）密封药物隔室（18）的输送口（22），并且预压力小于膜（26）的预定弹性变形和破裂点极限的量。与隔室（18）相关联的释放元件（28）响应于控制信号（78）使膜（26）被应力超过变形和破裂点限制。释放元件（28）沿着预定的破裂图案破裂膜（26），以允许形成铰接盖的第一膜部分（35）沿着预定的破裂图案与第二膜部分（37）分离，同时保持附着于铰链（39）处的第二膜部分。

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