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1. 发明授权

US08653283B2 Anticancer agents 有权
标题翻译：抗癌剂
公开(公告)号：US08653283B2
公开(公告)日：2014-02-18
申请号：US13263141
申请日：2010-04-16
申请人： Michael D. Burkart , James J. La Clair , MinJin Kang , Brian D. Jones , Alexander L. Mandel , Wei-Luen Yu , Justin C. Hammons
发明人： Michael D. Burkart , James J. La Clair , MinJin Kang , Brian D. Jones , Alexander L. Mandel , Wei-Luen Yu , Justin C. Hammons
IPC分类号： C07D307/77
CPC分类号： C07D493/18
摘要： The present disclosure relates generally to compositions and methods for treating cancer. In some aspects, novel spirohexenolides and methods of using and producing them are described.
摘要翻译：本公开一般涉及用于治疗癌症的组合物和方法。在一些方面，描述了新颖的螺烯烯内酯及其使用和制备方法。

2. 发明申请

US20080241943A1 Subnanomolar Precipitator of Thiophilic Metals 审中-公开
标题翻译：亚磷酸钠沉淀剂
公开(公告)号：US20080241943A1
公开(公告)日：2008-10-02
申请号：US11791128
申请日：2005-11-18
申请人： Kim D. Janda , Tobin J. Dickerson , James J. La Clair
发明人： Kim D. Janda , Tobin J. Dickerson , James J. La Clair
IPC分类号： G01N33/20 , C07D333/72 , C07D333/50 , C07D409/02
CPC分类号： G01N33/5308 , G01N33/582 , G01N33/84
摘要： A fluorescent dye-doped crystalline assay is employed for selection and detection of thiophilic heavy metal ions. While comparable in analytical performance to known solution based methodologies, the formation of crystalline analytes provides for signal amplification, and consequently, a powerful platform whose analysis is directly amenable to high-throughput video capture systems. In a microcapillary format, this assay is capable of screening hundreds of samples per day for the presence of subnanomolar concentrations of Hg2+ using a conventional fluorescence microscope.
摘要翻译：荧光染料掺杂结晶测定用于选择和检测嗜硫酸重金属离子。尽管分析性能与已知的基于解决方案的方法相当，但结晶分析物的形成提供了信号放大，因此提供了一个强大的平台，其分析直接适用于高吞吐量视频捕获系统。在微毛细管形式中，该测定法能够使用常规荧光显微镜每天筛选数百个样品以存在亚纳摩尔浓度的Hg 2+。

3. 发明申请

US20120083527A1 Anticancer Agents 有权
标题翻译：抗癌剂
公开(公告)号：US20120083527A1
公开(公告)日：2012-04-05
申请号：US13263141
申请日：2010-04-16
申请人： Michael D. Burkart , James J. La Clair , Minjin Kang , Brian D. Jones , Alexander L. Mandel , Wei-Luen Yu , Justin C. Hammons
发明人： Michael D. Burkart , James J. La Clair , Minjin Kang , Brian D. Jones , Alexander L. Mandel , Wei-Luen Yu , Justin C. Hammons
IPC分类号： A61K31/365 , C12P17/18 , C12N9/96 , G01N33/53 , C07D493/16 , A61P35/00
CPC分类号： C07D493/18
摘要： The present disclosure relates generally to compositions and methods for treating cancer. In some aspects, novel spirohexenolides and methods of using and producing them are described.
摘要翻译：本公开一般涉及用于治疗癌症的组合物和方法。在一些方面，描述了新颖的螺烯烯内酯及其使用和制备方法。

4. 发明授权

US07706984B2 Method and device for identifying molecular species 失效
标题翻译：识别分子物种的方法和装置
公开(公告)号：US07706984B2
公开(公告)日：2010-04-27
申请号：US10797900
申请日：2004-03-10
申请人： James J. La Clair
发明人： James J. La Clair
IPC分类号： G06F19/00
CPC分类号： G06F19/702 , G06F19/16
摘要： The invention relates to a device and a method for analyzing the interaction between one or more molecular species the method comprising the steps of creating streams of digital data, transferring the stream of digital data through a substrate, manipulating the molecular structure of the substrate by adding or subtracting molecules or groups of molecules to be examined to or from the substrate, receiving the streams of digital data transferred through the substrate, decoding the identity of an examined molecule or group of molecules interacting with the substrate by deciphering how the molecules affinity to another molecule or group of molecules or molecular sensor or group of molecular sensors alters the stream of digital data. The invention relates further to a method for identifying molecular species, and to a device for identifying molecular species and to a substrate for analyzing the interaction and for identifying molecular species.
摘要翻译：本发明涉及一种用于分析一个或多个分子物种之间的相互作用的装置和方法，所述方法包括以下步骤：产生数字数据流，通过基底转移数字数据流，通过加入基质来操纵基底的分子结构或从底物中减去待检测的分子或分子组，接收通过底物转移的数字数据流，通过解密分子与另一种亲和力的方式来解码与底物相互作用的检查分子或分子组的身份的身份分子或分子组或分子传感器或分子传感器组改变数字数据流。本发明进一步涉及用于鉴定分子物种的方法，以及用于鉴定分子种类和底物的装置，用于分析相互作用和鉴定分子种类。

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