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1. 发明申请

US20100088142A1 Bulk Material Ship Routing and Inventory Management Schedule Optimization 有权
标题翻译：散装物料运输路线和库存管理计划优化
公开(公告)号：US20100088142A1
公开(公告)日：2010-04-08
申请号：US12584239
申请日：2009-09-01
申请人： Amr S. El-Bakry , Jin-Hwa Song , Vikas Goel , Kevin C. Furman , Federico D. Carvallo , Sangbum Lee , James Dreher , Aristides Miroyannis , Richard Perry Connell
发明人： Amr S. El-Bakry , Jin-Hwa Song , Vikas Goel , Kevin C. Furman , Federico D. Carvallo , Sangbum Lee , James Dreher , Aristides Miroyannis , Richard Perry Connell
IPC分类号： G06Q10/00
CPC分类号： G06Q10/087 , G06Q10/06312 , G06Q10/08
摘要： The present invention is a computational system to generate feasible marine transportation schedules given a proposed bulk material supply chain. The decision support tool will fulfill the objectives and scope defined above. The technology employed will require (a) the use of mathematical programming modeling techniques (mixed integer linear programming) to mathematically formulate the business problem, and (b) advanced proprietary solution methods to produce solutions satisfying all constraints of the mathematical model while optimizing an objective function. The decision support tool has the following capabilities: Read input data, Generate feasible bulk material ship Schedule, Evaluate bulk material ship Schedule with User-defined Objective Function, Allow Case comparison, Graphical user interface (GUI) for specifying input data and displaying results.
摘要翻译：本发明是一种计算系统，用于在提供的散装物料供应链的情况下生成可行的海运运输计划。决策支持工具将实现上述目标和范围。所使用的技术将需要（a）使用数学规划建模技术（混合整数线性规划）来数学地制定业务问题，（b）高级专有解决方案，以产生满足数学模型的所有约束的解决方案，同时优化目标功能。决策支持工具具有以下功能：读取输入数据，生成可行的散装物料船舶计划，使用用户定义的目标函数，允许案例比较，用于指定输入数据和显示结果的图形用户界面（GUI）来评估批量物料运输计划。

2. 发明申请

US20070173918A1 APPARATUS AND METHODS FOR LOCATING AN OSTIUM OF A VESSEL 审中-公开
标题翻译：用于定位船舶动力学的装置和方法
公开(公告)号：US20070173918A1
公开(公告)日：2007-07-26
申请号：US11537569
申请日：2006-09-29
申请人： James Dreher , Amr Salahieh , Jeffrey Krolik
发明人： James Dreher , Amr Salahieh , Jeffrey Krolik
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2002/821 , A61F2250/0039
摘要： Apparatus and methods for locating an ostium of a branch vessel include a delivery catheter having a distal end sized for introduction into the branch, and locator elements including first ends fixed to the distal end and second ends free from the distal ends. The locator elements are compressible from a transverse, deployed condition to an axial, contracted condition, wherein the second ends are disposed proximal to the first ends. During use, the catheter is directed through a guide catheter into the ostium with the locator elements compressed, and the locator elements are deployed within the branch in the contracted condition. The catheter is partially withdrawn from the branch, the locator elements resiliently expanding towards the deployed condition as they enter the main vessel. The catheter may be used to deliver a stent into the branch with the expanded locator elements facilitating positioning the stent.
摘要翻译：用于定位分支容器的口的装置和方法包括具有尺寸适于引入分支的远端的输送导管，以及包括固定到远端的第一端和没有远端的第二端的定位器元件。定位元件从横向展开状态可压缩到轴向收缩状态，其中第二端靠近第一端设置。在使用期间，将导管引导通过引导导管进入口中，定位器元件被压缩，并且定位器元件在收缩状态下部署在分支内。导管部分地从分支中取出，定位元件在进入主容器时朝展开状态弹性膨胀。导管可用于将支架输送到分支中，扩张的定位器元件便于定位支架。

3. 发明申请

US20120035623A1 APPARATUS AND METHODS FOR TISSUE CLOSURE 有权
标题翻译：用于组织闭合的装置和方法
公开(公告)号：US20120035623A1
公开(公告)日：2012-02-09
申请号：US13144291
申请日：2010-01-11
申请人： Celso Bagaoisan , Suresh Pai , James Dreher
发明人： Celso Bagaoisan , Suresh Pai , James Dreher
IPC分类号： A61B17/04
CPC分类号： A61B17/0482 , A61B17/0057 , A61B17/0469 , A61B17/0493 , A61B2017/00637 , A61B2017/00663 , A61B2017/00672 , A61B2017/00858 , A61B2017/0472 , A61B2017/06042 , A61B2017/2911 , A61B2017/2946
摘要： Apparatus and methods are provided for treating a tissue opening, for example a trocar opening used in a minimally invasive surgical procedure. In a tissue closure device, a finger guard or shield can be used, handle or holding area or areas can be used, and positioning indicators can be used. A resiliently flexible target material can also be used for reliably holding a suture during the procedure. Introducers can be used having a suture holder, an alignment indicator and insertion limits.
摘要翻译：提供了用于治疗组织开口的装置和方法，例如用于微创外科手术的套管针开口。在组织闭合装置中，可以使用手指护罩或护罩，可以使用手柄或保持区域或区域，并且可以使用定位指示器。弹性柔性的目标材料也可用于在手术过程中可靠地保持缝合线。引导者可以使用缝合线夹，对准指示器和插入限制。

4. 发明申请

US20070173921A1 FLARED STENTS AND APPARATUS AND METHODS FOR DELIVERING THEM 审中-公开
标题翻译：装饰性手套及装置及其输送方法
公开(公告)号：US20070173921A1
公开(公告)日：2007-07-26
申请号：US11554560
申请日：2006-10-30
申请人： Mark Wholey , Farhad Khosravl , James Dreher , Jeffrey Krolik
发明人： Mark Wholey , Farhad Khosravl , James Dreher , Jeffrey Krolik
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/07 , A61F2/915 , A61F2/958 , A61F2002/061 , A61F2002/821 , A61F2002/8486 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2230/0054 , A61F2250/0018 , A61F2250/0039
摘要： Apparatus and methods are provided for securing a stent-graft deployed within an aorta relative to a renal artery. A distal end of a delivery device may be introduced into the aorta, the distal end carrying a stent thereon. The distal end may be advanced through an opening in the stent-graft at least partially into the renal artery, and the stent may be expanded to anchor the stent-graft relative to the renal artery and/or secure the stent relative to the renal artery. An exemplary flaring stent is also disclosed.
摘要翻译：提供了用于固定相对于肾动脉部署在主动脉内的支架移植物的装置和方法。输送装置的远端可以被引入主动脉，远端在其上承载支架。远端可以穿过支架移植物中的开口至少部分地进入肾动脉，并且支架可以被扩张以相对于肾动脉锚定支架移植物和/或相对于肾动脉固定支架。还公开了示例性的扩口支架。

5. 发明申请

US20070073376A1 STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELIVERING THEM 有权
标题翻译： STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELMER THEM
公开(公告)号：US20070073376A1
公开(公告)日：2007-03-29
申请号：US11466445
申请日：2006-08-22
申请人： Jeffrey Krolik , Eliot Kim , James Dreher , Farhad Khosravi
发明人： Jeffrey Krolik , Eliot Kim , James Dreher , Farhad Khosravi
IPC分类号： A61F2/84 , A61F2/90
CPC分类号： A61F2/958 , A61F2/91 , A61F2/915 , A61F2002/30322 , A61F2002/821 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0039 , A61M25/1002
摘要： A stent includes a first flaring portion including first and second sets of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second main portion connected to the first flaring portion. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The second portion resists expansion when the first portion is flared. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.
摘要翻译：支架包括第一扩张部分，其包括当支架从收缩状态扩张到扩张状态时向外张开的第一组和第二组细胞，以及连接到第一扩张部分的第二主要部分。在使用期间，支架在收缩状态下被引入主容器中，并且将第一部分定位成邻近口。第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。当第一部分展开时，第二部分抵抗扩张。支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

6. 发明授权

US08926639B2 Apparatus and methods for tissue closure 有权
标题翻译：用于组织闭合的装置和方法
公开(公告)号：US08926639B2
公开(公告)日：2015-01-06
申请号：US13144291
申请日：2010-01-11
申请人： Celso Bagaoisan , Suresh Pai , James Dreher
发明人： Celso Bagaoisan , Suresh Pai , James Dreher
IPC分类号： A61B17/04 , A61B17/00 , A61B17/06 , A61B17/29
CPC分类号： A61B17/0482 , A61B17/0057 , A61B17/0469 , A61B17/0493 , A61B2017/00637 , A61B2017/00663 , A61B2017/00672 , A61B2017/00858 , A61B2017/0472 , A61B2017/06042 , A61B2017/2911 , A61B2017/2946
摘要： Apparatus and methods are provided for treating a tissue opening, for example a trocar opening used in a minimally invasive surgical procedure. In a tissue closure device, a finger guard or shield can be used, handle or holding area or areas can be used, and positioning indicators can be used. A resiliently flexible target material can also be used for reliably holding a suture during the procedure. Introducers can be used having a suture holder, an alignment indicator and insertion limits.
摘要翻译：提供了用于治疗组织开口的装置和方法，例如用于微创外科手术的套管针开口。在组织闭合装置中，可以使用手指护罩或护罩，可以使用手柄或保持区域或区域，并且可以使用定位指示器。弹性柔性的目标材料也可用于在手术过程中可靠地保持缝合线。引导者可以使用缝合线夹，对准指示器和插入限制。

7. 发明授权

US08374898B2 Bulk material ship routing and inventory management schedule optimization 有权
标题翻译：批量物料船舶路线和库存管理进度优化
公开(公告)号：US08374898B2
公开(公告)日：2013-02-12
申请号：US12584239
申请日：2009-09-01
申请人： Amr S. El-Bakry , Jin-Hwa Song , Vikas Goel , Kevin C. Furman , Federico D. Carvallo , Sangbum Lee , James Dreher , Aristides Miroyannis , Richard Perry Connell
发明人： Amr S. El-Bakry , Jin-Hwa Song , Vikas Goel , Kevin C. Furman , Federico D. Carvallo , Sangbum Lee , James Dreher , Aristides Miroyannis , Richard Perry Connell
IPC分类号： G06Q10/00
CPC分类号： G06Q10/087 , G06Q10/06312 , G06Q10/08
摘要： The present invention is a computational system to generate feasible marine transportation schedules given a proposed bulk material supply chain. The decision support tool will fulfill the objectives and scope defined above. The technology employed will require (a) the use of mathematical programming modeling techniques (mixed integer linear programming) to mathematically formulate the business problem, and (b) advanced proprietary solution methods to produce solutions satisfying all constraints of the mathematical model while optimizing an objective function. The decision support tool has the following capabilities: Read input data, Generate feasible bulk material ship Schedule, Evaluate bulk material ship Schedule with User-defined Objective Function, Allow Case comparison, Graphical user interface (GUI) for specifying input data and displaying results.
摘要翻译：本发明是一种计算系统，用于在提供的散装物料供应链的情况下生成可行的海运运输计划。决策支持工具将实现上述目标和范围。所使用的技术将需要（a）使用数学规划建模技术（混合整数线性规划）来数学地制定业务问题，（b）高级专有解决方案，以产生满足数学模型的所有约束的解决方案，同时优化目标功能。决策支持工具具有以下功能：读取输入数据，生成可行的散装物料船舶计划，使用用户定义的目标函数，允许案例比较，用于指定输入数据和显示结果的图形用户界面（GUI）来评估批量物料运输计划。

8. 发明授权

US08044137B2 Materials formable in situ within a medical device 有权
公开(公告)号：US08044137B2
公开(公告)日：2011-10-25
申请号：US12970515
申请日：2010-12-16
申请人： Farhad Khosravi , James Dreher
发明人： Farhad Khosravi , James Dreher
IPC分类号： C08L33/06 , A61M29/04 , A61F2/02 , A61F2/94
CPC分类号： A61L24/046 , A61F2/07 , Y10S623/926 , C08L71/02
摘要： Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the polymer precursor undergo covalent bonding in situ to form a solid and nonbiodegradable material having a swellability less than about 20% v/v and a Young's modulus of at least about 100 kPa within about 30 seconds to about 30 minutes of initiating a chemical reaction of the functional groups to form the solid material.

9. 发明申请

US20110092613A1 MATERIALS FORMABLE IN SITU WITHIN A MEDICAL DEVICE 有权
标题翻译：在医疗设备中的原材料
公开(公告)号：US20110092613A1
公开(公告)日：2011-04-21
申请号：US12970515
申请日：2010-12-16
申请人： Farhad Khosravi , James Dreher
发明人： Farhad Khosravi , James Dreher
IPC分类号： C08L33/08
CPC分类号： A61L24/046 , A61F2/07 , Y10S623/926 , C08L71/02
摘要： Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the polymer precursor undergo covalent bonding in situ to form a solid and nonbiodegradable material having a swellability less than about 20% v/v and a Young's modulus of at least about 100 kPa within about 30 seconds to about 30 minutes of initiating a chemical reaction of the functional groups to form the solid material.
摘要翻译：本发明的某些实施方案包括通过向患者内的空间引入溶解在可流动的水溶液中的至少约10,000分子量的水溶性聚合物前体形成材料。聚合物前体上的官能团原位进行共价键合以形成具有小于约20％v / v的溶胀性和至少约100kPa的杨氏模量的固体和不可生物降解的材料，在约30秒至约30分钟内引发官能团化学反应形成固体物质。

10. 发明申请

US20070073388A1 FLARED STENTS AND APPARATUS AND METHODS FOR DELIVERING THEM 审中-公开
标题翻译：装饰性手套和装置及其输送方法
公开(公告)号：US20070073388A1
公开(公告)日：2007-03-29
申请号：US11466439
申请日：2006-08-22
申请人： Jeffrey Krolik , Eliot Kim , James Dreher
发明人： Jeffrey Krolik , Eliot Kim , James Dreher
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/91 , A61F2/915 , A61F2002/30322 , A61F2002/821 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0039 , A61M25/1002
摘要： Flared stents are disclosed, and apparatus and methods for delivering such stents into a bifurcation between a main vessel and a branch vessel. The stent includes a first tubular portion a second flaring portion that may be flared radially outwardly to contact the ostium. The stent may include variable mechanical properties along its length. The stent may be delivered using a catheter including proximal and distal ends, the stent overlying first and second balloons on the distal end. During use, the catheter is advanced through an ostium into the branch to place the stent within the branch. The first balloon is expanded to flare the stent to contact a wall of the ostium, thereby causing the stent to migrate partially into the ostium. The second balloon is expanded to filly expand the stent within the ostium and branch.
摘要翻译：公开了扩口支架，以及用于将这种支架输送到主血管和分支血管之间的分叉中的装置和方法。支架包括第一管状部分，第二扩张部分可以径向向外张开以接触口。支架可以包括沿其长度的可变机械特性。可以使用包括近端和远端的导管递送支架，支架覆盖在远端上的第一和第二气囊。在使用期间，导管通过口进入分支以将支架置于分支内。扩张第一个气囊以使支架扩张以接触口的壁，从而使支架部分地迁移到口中。第二个气球膨胀到在口腔和支管内部扩张支架。

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