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1. 发明申请

US20130171233A1 COMPOSITIONS AND METHODS FOR INDUCING IMMUNE TOLERANCE 有权
标题翻译：用于诱导免疫耐受性的组合物和方法
公开(公告)号：US20130171233A1
公开(公告)日：2013-07-04
申请号：US13261580
申请日：2011-07-29
申请人： James C. Paulson , Matthew MacAuley , David Nemazee
发明人： James C. Paulson , Matthew MacAuley , David Nemazee
IPC分类号： A61K39/385 , A61K9/127
CPC分类号： A61K39/0008 , A61K9/127 , A61K39/001 , A61K39/35 , A61K39/385 , A61K47/6911 , A61K2039/5154 , A61K2039/5158 , A61K2039/55555
摘要： The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition that co-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.
摘要翻译：本发明提供用于诱导免疫耐受的脂质体组合物。化合物通常包含显示特异性抗原的脂质体，以及用于在B细胞上表达的唾液酸结合Ig样凝集素（Siglec）的结合部分。本发明还提供了诱导受试者中蛋白质或多肽抗原（例如，蛋白质抗原）的耐受性的方法。所述方法包括对受试者施用共同呈递在B淋巴细胞上表达的Siglec的抗原和聚糖配体的药物组合物。

2. 发明授权

US5800815A Antibodies to P-selectin and their uses 失效
标题翻译： P-选择素的抗体及其用途
公开(公告)号：US5800815A
公开(公告)日：1998-09-01
申请号：US202047
申请日：1994-02-25
申请人： Robert W. Chestnut , Margaret J. Polley , James C. Paulson , S. Tarran Jones , Jose W. Saldanha , Mary M. Bendig , Michael Kriegler , Carl Perez , Robert Bayer , Michael Nunn
发明人： Robert W. Chestnut , Margaret J. Polley , James C. Paulson , S. Tarran Jones , Jose W. Saldanha , Mary M. Bendig , Michael Kriegler , Carl Perez , Robert Bayer , Michael Nunn
IPC分类号： A61K38/00 , C07K14/705 , C07K16/28 , A61K39/395 , C07H21/04 , C12N5/12
CPC分类号： C07K16/2854 , C07K14/70564 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2319/00
摘要： The present invention relates to compositions and methods for treating inflammation and other pathological conditions using novel blocking P-selectin antibodies that inhibit adhesion of leukocytes to activated platelets and/or to activated vascular endothelium in vivo. Both murine and humanized antibodies are provided.
摘要翻译：本发明涉及使用抑制白细胞粘附于活化血小板和/或体内活化血管内皮的新型阻断P-选择素抗体来治疗炎症和其它病理状况的组合物和方法。提供鼠和人源化抗体。

3. 发明授权

US4307726A Diagnostic evaluation, measurement, and analysis of functional activity in body organs that utilize transmembrane ion polarization and depolarization 失效
标题翻译：使用跨膜离子极化和去极化的身体器官功能活动的诊断评估，测量和分析
公开(公告)号：US4307726A
公开(公告)日：1981-12-29
申请号：US71992
申请日：1979-09-04
申请人： James C. Paulson , Robert D. Pfeifer
发明人： James C. Paulson , Robert D. Pfeifer
IPC分类号： A61B5/05
CPC分类号： A61B5/0507 , A61B5/05 , A61B5/4519
摘要： Beams of coherent microwaves or other frequencies of highly directional electromagnetic radiation are passed through the living human body to detect and provide a quantitative analysis of functional activity in the central nervous system and/or in muscle tissue such as that of the heart. Organs to be analyzed are situated in the space of an electrostatic field of oscillating intensity. The directional beam is passed through a body organ situated in this way. The method is of use in detecting degenerative subcortical disease in the brain (e.g., Sulphatide Lipidosis), tissue damage to nerve fibers due to toxic chemicals, and other types of tissue-based functional abnormality. Functional condition of brain and heart generally can be readily analyzed without exposure to ionizing radiation.
摘要翻译：相干微波或高频定向电磁辐射的其他频率的光束通过活的人体，以检测并提供中枢神经系统和/或肌肉组织（例如心脏）的功能活性的定量分析。要分析的器官位于振荡强度的静电场的空间中。定向梁穿过以这种方式设置的身体器官。该方法可用于检测大脑中的退行性皮质下疾病（例如硫酸亚油脂），由于毒性化学物质引起的对神经纤维的组织损伤以及其它类型的基于组织的功能异常。脑和心脏的功能状况通常可以容易地分析而不暴露于电离辐射。

4. 发明授权

US09326939B2 Liposome targeting compounds and related uses 有权
标题翻译：脂质体靶向化合物及相关用途
公开(公告)号：US09326939B2
公开(公告)日：2016-05-03
申请号：US13261581
申请日：2011-07-29
申请人： James C. Paulson , Weihsu Claire Chen , Norihito Kawasaki , Corwin Nycholat
发明人： James C. Paulson , Weihsu Claire Chen , Norihito Kawasaki , Corwin Nycholat
IPC分类号： A61K9/127 , A61K39/00 , A61K31/715 , A61K49/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/715 , A61K39/00 , A61K49/0084
摘要： The present invention provides liposome targeting compounds for targeting cells expressing sialic acid binding Ig-like lectin (Siglec). The liposome compounds typically comprise a binding moiety that is a glycan ligand of the Siglec on the target cell. The liposome compounds also incorporate or encapsulate a biological agent (e.g., an antigen or a therapeutic agent) that can be delivered to the target cell to modulate or kill the target cell. The invention also provides methods of using the liposome targeting compounds for targeted delivery of antigen and for modulating immune cells or immune responses.
摘要翻译：本发明提供用于靶向表达唾液酸结合Ig样凝集素（Siglec）的细胞的脂质体靶向化合物。脂质体化合物通常包含作为靶细胞上Siglec的聚糖配体的结合部分。脂质体化合物还掺入或包封可以递送至靶细胞以调节或杀死靶细胞的生物试剂（例如，抗原或治疗剂）。本发明还提供了使用靶向靶向化合物靶向递送抗原和调节免疫细胞或免疫应答的方法。

5. 发明申请

US20130164364A1 LIPOSOME TARGETING COMPOUNDS AND RELATED USES 有权
标题翻译：脂质组合物和相关用途
公开(公告)号：US20130164364A1
公开(公告)日：2013-06-27
申请号：US13261581
申请日：2011-07-29
申请人： James C. Paulson , Weihsu Claire Chen , Norihito Kawasaki , Corwin Nycholat
发明人： James C. Paulson , Weihsu Claire Chen , Norihito Kawasaki , Corwin Nycholat
IPC分类号： A61K9/127 , A61K39/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/715 , A61K39/00 , A61K49/0084
摘要： The present invention provides liposome targeting compounds for targeting cells expressing sialic acid binding Ig-like lectin (Siglec). The liposome compounds typically comprise a binding moiety that is a glycan ligand of the Siglec on the target cell. The liposome compounds also incorporate or encapsulate a biological agent (e.g., an antigen or a therapeutic agent) that can be delivered to the target cell to modulate or kill the target cell. The invention also provides methods of using the liposome targeting compounds for targeted delivery of antigen and for modulating immune cells or immune responses.
摘要翻译：本发明提供用于靶向表达唾液酸结合Ig样凝集素（Siglec）的细胞的脂质体靶向化合物。脂质体化合物通常包含作为靶细胞上Siglec的聚糖配体的结合部分。脂质体化合物还掺入或包封可以递送至靶细胞以调节或杀死靶细胞的生物试剂（例如，抗原或治疗剂）。本发明还提供了使用靶向靶向化合物靶向递送抗原和调节免疫细胞或免疫应答的方法。

6. 发明授权

US06399336B1 Practical in vitro sialylation of recombinant glycoproteins 失效
公开(公告)号：US06399336B1
公开(公告)日：2002-06-04
申请号：US09007741
申请日：1998-01-15
申请人： James C. Paulson , Robert J. Bayer , Eric Sjoberg
发明人： James C. Paulson , Robert J. Bayer , Eric Sjoberg
IPC分类号： C12P100
CPC分类号： C12P21/005 , C12N9/1048
摘要： This invention provides methods for practical in vitro sialylation of glycoproteins, including recombinantly produced glycoproteins. The methods are useful for large-scale modification of sialylation patterns.

7. 发明授权

US5409817A Use of trans-sialidase and sialyltransferase for synthesis of sialyl.alpha.2.fwdarw.3.beta.galactosides 失效
标题翻译：使用唾液酸酶和唾液酸转移酶合成唾液酸α2->3β半乳糖苷
公开(公告)号：US5409817A
公开(公告)日：1995-04-25
申请号：US57528
申请日：1993-05-04
申请人： Yukishige Ito , James C. Paulson
发明人： Yukishige Ito , James C. Paulson
IPC分类号： C12N9/10 , C12N9/12 , C12N9/24 , C12P19/26 , C12P19/44 , C12N11/00 , C12P19/00 , C12P19/18
CPC分类号： C12N9/1241 , C12N9/1081 , C12N9/2402 , C12P19/26 , C12Y302/01018
摘要： A single vessel cyclic synthesis process for preparation of a sialyl.alpha.2.fwdarw.3.beta.galactoside is disclosed. In accordance with this process, a sialyltransferase acceptor is sialylated in an aqueous reaction medium by an .alpha.(2,3)sialyl transferase and CMP-sialic acid to form a sialyl donor substrate and CMP. In the presence of the trans-sialidase of Trypanosoma crusi, that sialyl donor substrate provides a sialyl group for a trans-sialidase acceptor, thereby preparing the sialyl.alpha.2.fwdarw.3.beta.galactoside. The .alpha.(2,3)sialyltransferase acceptor is reformed upon trans-sialidation of the latter acceptor, and the sialyl donor substrate is reformed using the .alpha.(2,3)sialyltransferase and a CMP-sialic acid recycling system that combines CMP with sialic acid that is also present in the vessel. The K.sub.m /V.sub.max value for the .alpha.(2,3)sialyltransferase acceptor is less than one-tenth the value of K.sub.m /V.sub.max of the trans-sialidase acceptor for the .alpha.(2,3)sialyltransferase.
摘要翻译：公开了用于制备唾液酸α2->3β半乳糖苷的单容器循环合成方法。根据该方法，唾液酸转移酶受体通过α（2,3）唾液酸转移酶和CMP-唾液酸在水性反应介质中唾液酸化以形成唾液酸供体底物和CMP。在克氏锥虫的唾液酸酶的存在下，唾液酸供体底物为唾液酸酶受体提供唾液酸基，从而制备唾液酸α2->3β半乳糖苷。将α（2,3）唾液酸转移酶受体通过后一个受体的反式唾液酸化进行重组，并且使用α（2,3）唾液酸转移酶和将CMP与唾液酸组合的CMP-唾液酸回收系统重组唾液酸供体底物这也存在于船上。 α（2,3）唾液酸转移酶受体的Km / Vmax值小于α（2,3）唾液酸转移酶的唾液酸酶受体的Km / Vmax值的十分之一。

8. 发明授权

US09522183B2 Compositions and methods for inducing immune tolerance 有权
标题翻译：诱导免疫耐受的组合物和方法
公开(公告)号：US09522183B2
公开(公告)日：2016-12-20
申请号：US13261580
申请日：2011-07-29
申请人： James C. Paulson , Matthew Macauley , David Nemazee
发明人： James C. Paulson , Matthew Macauley , David Nemazee
IPC分类号： A61K39/385 , A61K9/127 , A61K39/00 , A61K39/35 , A61K47/48
CPC分类号： A61K39/0008 , A61K9/127 , A61K39/001 , A61K39/35 , A61K39/385 , A61K47/6911 , A61K2039/5154 , A61K2039/5158 , A61K2039/55555
摘要： The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec)expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition that co-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.
摘要翻译：本发明提供用于诱导免疫耐受的脂质体组合物。化合物通常包含显示特异性抗原的脂质体，以及用于在B细胞上表达的唾液酸结合Ig样凝集素（Siglec）的结合部分。本发明还提供了诱导受试者中蛋白质或多肽抗原（例如，蛋白质抗原）的耐受性的方法。所述方法包括对受试者施用共同呈递在B淋巴细胞上表达的Siglec的抗原和聚糖配体的药物组合物。

9. 发明申请

US20160060324A1 Methods and Compositions for Treating Bleeding Disorders 审中-公开
标题翻译：治疗出血障碍的方法和组成
公开(公告)号：US20160060324A1
公开(公告)日：2016-03-03
申请号：US14786419
申请日：2014-04-18
申请人： James C. PAULSON , Matthew MACAULEY , Fabian PFRENGLE , THE SCRIPPS RESEARCH INSTITUTE
发明人： James C. Paulson , Matthew Macauley , Fabian Pfrengle
IPC分类号： C07K14/755 , A61K38/37 , A61K47/48
CPC分类号： C07K14/755 , A61K38/00 , A61K38/37 , A61K47/6425
摘要： The present invention provides immune conjugates for inducing antigen specific immune tolerance to coagulation Factor VIII. The immune conjugates contain a FVIII protein or antigenic fragment that is conjugated to a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods of using the FVIII immune conjugates to induce immune tolerance to FVIII in a subject. Additionally provided in the invention are methods for treating bleeding disorders such as hemophilia A via the use of the FVIII immune conjugates and an unconjugated FVIII with coagulating activity.
摘要翻译：本发明提供用于诱导对凝血因子VIII的抗原特异性免疫耐受性的免疫结合物。免疫缀合物含有与B细胞上表达的唾液酸结合Ig样凝集素（Siglec）的结合部分缀合的FVIII蛋白或抗原性片段。本发明还提供使用FVIII免疫缀合物诱导受试者对FVIII的免疫耐受的方法。本发明另外提供的是通过使用FVIII免疫缀合物和具有凝结活性的非共轭FVIII来治疗出血性疾病如血友病A的方法。

10. 发明授权

US5962294A Compositions and methods for the identification and synthesis of sialyltransferases 失效
标题翻译：用于鉴定和合成唾液酸转移酶的组合物和方法
公开(公告)号：US5962294A
公开(公告)日：1999-10-05
申请号：US102385
申请日：1993-08-04
申请人： James C. Paulson , Xiaohong Wen , Brian Livingston , William Gillespie , Sorge Kelm , Alma L. Burlingame , Katalin Medzihradszky
发明人： James C. Paulson , Xiaohong Wen , Brian Livingston , William Gillespie , Sorge Kelm , Alma L. Burlingame , Katalin Medzihradszky
IPC分类号： C12N15/09 , C07H21/04 , C12N5/10 , C12N9/10 , C12N15/54 , C12P21/02 , C12Q1/68
CPC分类号： C12N9/1081 , C07K2319/02
摘要： DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of sialyltransferase.
摘要翻译：提供了编码含有同源性保守区域的唾液酸转移酶的DNA分离物以及获得这种DNA的方法以及用于重组产生唾液酸转移酶的表达系统。

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