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1. 发明申请

US20120296208A1 Medical Microbubble Generation 审中-公开
标题翻译：医疗微泡生成
公开(公告)号：US20120296208A1
公开(公告)日：2012-11-22
申请号：US13565154
申请日：2012-08-02
申请人： James A. Keenan , Adrian Blenkinsop , Phillipe Genereux
发明人： James A. Keenan , Adrian Blenkinsop , Phillipe Genereux
IPC分类号： A61M37/00 , A61B8/00
CPC分类号： A61M37/0092 , A61B6/032 , A61B8/481 , A61B2017/320069 , A61K49/223 , A61M5/007 , A61M37/00 , A61N5/1001 , B01F5/0685 , B01F11/0071 , B01F13/0023 , B01F15/0225 , G01R33/5601
摘要： Medical apparatus and processes controllably generate medically useful micro or nano bubbles of medically desirable and controllably selectable size, size distribution, homogeneity and concentration (and/or other key bubble parameters) for patient infusion, and/or which may incorporate therapeutic or other agents for patient infusion and/or may be combined with therapeutic or other agents prior to infusion into patients. The bubble generation apparatus and processes controllably permit the adjustment and selection of key bubble parameters through bubble generation actuation and orientation techniques and through selection of bubble fluid compositions in order to facilitate medical research and/or to optimize treatment for imaging, therapy, sonoporation, inertial and non-inertial cavitation, and acoustic activation, among other medical uses. Disposable cartridges containing such bubbles are provided and may include means for patient infusion.
摘要翻译：医疗装置和过程可控制地产生医学上有用的微纳米气泡，其具有医学上期望和可控地选择的尺寸，尺寸分布，均匀性和浓度（和/或其他关键气泡参数）用于患者输注，和/或其可以结合治疗剂或其它药剂患者输注和/或可以在输入患者之前与治疗剂或其它试剂组合。气泡产生装置和过程可控地允许通过气泡产生致动和取向技术以及通过选择气泡流体组合物来调节和选择关键气泡参数，以便于医学研究和/或优化用于成像，治疗，声波，惯性的治疗和非惯性空化，以及声学激活等医疗用途。提供了包含这种气泡的一次性盒，并且可以包括用于患者输注的装置。

2. 发明授权

US08257338B2 Medical microbubble generation 有权
标题翻译：医用微泡生成
公开(公告)号：US08257338B2
公开(公告)日：2012-09-04
申请号：US12115299
申请日：2008-05-05
申请人： James A. Keenan , Adrian Blenkinsop , Phillipe Genereux
发明人： James A. Keenan , Adrian Blenkinsop , Phillipe Genereux
IPC分类号： A61M31/00
CPC分类号： A61M37/0092 , A61B6/032 , A61B8/481 , A61B17/320068 , A61K49/223 , A61M5/007 , A61M37/00 , A61N5/1001 , B01F5/0685 , B01F11/0071 , B01F13/0023 , B01F15/0225 , G01R33/5601
摘要： Medical apparatus and processes controllably generate medically useful micro or nano bubbles of medically desirable and controllably selectable size, size distribution, homogeneity and concentration (and/or other key bubble parameters) for patient infusion, and/or which may incorporate therapeutic or other agents for patient infusion and/or may be combined with therapeutic or other agents prior to infusion into patients. The bubble generation apparatus and processes controllably permit the adjustment and selection of key bubble parameters through bubble generation actuation and orientation techniques and through selection of bubble fluid compositions in order to facilitate medical research and/or to optimize treatment for imaging, therapy, sonoporation, inertial and non-inertial cavitation, and acoustic activation, among other medical uses. Disposable cartridges containing such bubbles are provided and may include means for patient infusion.
摘要翻译：医疗装置和过程可控制地产生医学上有用的微纳米气泡，其具有医学上期望和可控地选择的尺寸，尺寸分布，均匀性和浓度（和/或其他关键气泡参数）用于患者输注，和/或其可以结合治疗剂或其它药剂患者输注和/或可以在输入患者之前与治疗剂或其它试剂组合。气泡产生装置和过程可控地允许通过气泡产生致动和取向技术以及通过选择气泡流体组合物来调节和选择关键气泡参数，以便于医学研究和/或优化用于成像，治疗，声波，惯性的治疗和非惯性空化，以及声学激活等医疗用途。提供了包含这种气泡的一次性盒，并且可以包括用于患者输注的装置。

3. 发明授权

US08679051B2 Microbubble medical devices 有权
标题翻译：微泡医疗器械
公开(公告)号：US08679051B2
公开(公告)日：2014-03-25
申请号：US12683601
申请日：2010-01-07
申请人： James A Keenan , Junjie Gu , Philippe Joel Genereux , Adrian T Bienkinsop , David H Gerwing , Sebastien Roy Fournier , Sarah Katherine Dobbin
发明人： James A Keenan , Junjie Gu , Philippe Joel Genereux , Adrian T Bienkinsop , David H Gerwing , Sebastien Roy Fournier , Sarah Katherine Dobbin
IPC分类号： A61M37/00
CPC分类号： A61M37/0092 , A61B6/032 , A61B8/481 , A61B17/320068 , A61K49/223 , A61M5/007 , A61M37/00 , A61N5/1001 , B01F5/0685 , B01F11/0071 , B01F13/0023 , B01F15/0225 , G01R33/5601
摘要： Method and medical devices for generating and stabilizing micro- or nano-bubbles, and systems and methods for therapeutic applications using the bubbles, are provided. The micro-bubbles may be used to enhance therapeutic benefits such as ultrasound-guided precision drug delivery and real-time verification, acoustic activation of large tumor masses, enhanced acoustic activation through longer retention of therapeutic agents at the point of interest, enhancement of high intensity focused ultrasound treatments, light activation of photodynamic drugs at a depth within a patient using extracorporeal light sources, probes, or sonoluminescence, and initiation of time reversal acoustics focused ultrasound to permit highly localized treatment.
摘要翻译：提供用于产生和稳定微泡或纳米气泡的方法和医疗装置，以及使用气泡的治疗应用的系统和方法。微气泡可用于增强治疗益处，例如超声引导精密药物递送和实时验证，大肿瘤块的声激活，通过在感兴趣的时间点延长保留治疗剂的增强的声激活，增强高强度聚焦超声治疗，使用体外光源，探针或声致发光的患者内深度的光动力药物的光活化，以及引发时间反转声学聚焦超声以允许高度局部化的治疗。

4. 发明申请

US20080269668A1 Medical Microbubble Generation 有权
标题翻译：医疗微泡生成
公开(公告)号：US20080269668A1
公开(公告)日：2008-10-30
申请号：US12115299
申请日：2008-05-05
申请人： James A. Keenan , Adrian Blenkinsop , Phillipe Genereux
发明人： James A. Keenan , Adrian Blenkinsop , Phillipe Genereux
IPC分类号： A61M37/00 , A61K49/22
CPC分类号： A61M37/0092 , A61B6/032 , A61B8/481 , A61B17/320068 , A61K49/223 , A61M5/007 , A61M37/00 , A61N5/1001 , B01F5/0685 , B01F11/0071 , B01F13/0023 , B01F15/0225 , G01R33/5601
摘要： Medical apparatus and processes controllably generate medically useful micro or nano bubbles of medically desirable and controllably selectable size, size distribution, homogeneity and concentration (and/or other key bubble parameters) for patient infusion, and/or which may incorporate therapeutic or other agents for patient infusion and/or may be combined with therapeutic or other agents prior to infusion into patients. The bubble generation apparatus and processes controllably permit the adjustment and selection of key bubble parameters through bubble generation actuation and orientation techniques and through selection of bubble fluid compositions in order to facilitate medical research and/or to optimize treatment for imaging, therapy, sonoporation, inertial and non-inertial cavitation, and acoustic activation, among other medical uses. Disposable cartridges containing such bubbles are provided and may include means for patient infusion.
摘要翻译：医疗装置和过程可控制地产生医学上有用的微纳米气泡，其具有医学上期望和可控地选择的尺寸，尺寸分布，均匀性和浓度（和/或其他关键气泡参数）用于患者输注，和/或其可以结合治疗剂或其它药剂患者输注和/或可以在输入患者之前与治疗剂或其它试剂组合。气泡产生装置和过程可控地允许通过气泡产生致动和取向技术以及通过选择气泡流体组合物来调节和选择关键气泡参数，以便于医学研究和/或优化用于成像，治疗，声波，惯性的治疗和非惯性空化，以及声学激活等医疗用途。提供了包含这种气泡的一次性盒，并且可以包括用于患者输注的装置。

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