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1. 发明申请

US20120244614A1 METHOD FOR CULTURING MYCOPLASMA CONTAMINATION-FREE CELLS AND METHOD FOR REMOVING MYCOPLASMA CONTAMINATION OF CELLS 有权
标题翻译：用于培养MYCOPLASMA无污染细胞的方法和移除细胞的MYCOPLASMA污染的方法
公开(公告)号：US20120244614A1
公开(公告)日：2012-09-27
申请号：US13513743
申请日：2010-12-08
申请人： Jae-Jin Han
发明人： Jae-Jin Han
IPC分类号： C12N5/07
CPC分类号： C12N5/0602 , C12N5/0018 , C12N2500/76
摘要： Provided is a method for culturing cells, which prevents the possibility of mycoplasma contamination by culturing the cells using biomass extract obtained by culturing a strain with amphidinol productivity, preferably a strain such as Amphidinium klebsii, Amphididinium carterae, and the like belonging to Dinoflagellates, or using a fraction obtained from the extract; and a method for removing mycoplasma contamination of the cells by culturing the cells contaminated by mycoplasma using the amphidinol derivatives. In addition, provided is a method for removing mycoplasma contamination of the cells, including a combination of single cell-isolating enzyme solution treatment and cell aggregate removal.
摘要翻译：本发明提供一种培养细胞的方法，其通过利用通过培养具有阿奇霉素生产力的菌株获得的生物质提取物优选培养细胞来防止支原体污染的可能性，优选菌株如属于鞭毛藻的as螨属（Amphidinium klebsii），镰孢菌纲（Amphididinium carterae）等，或使用从提取物获得的级分; 以及通过使用二甲啶醇衍生物培养受支原体污染的细胞来去除细胞的支原体污染的方法。此外，提供了除去细胞的支原体污染的方法，包括单细胞分离酶溶液处理和细胞聚集体去除的组合。

2. 发明申请

US20060288139A1 Computer system and display apparatus 审中-公开
标题翻译：计算机系统及显示装置
公开(公告)号：US20060288139A1
公开(公告)日：2006-12-21
申请号：US11439945
申请日：2006-05-25
申请人： Jae-soon Lee , Jae-jin Han , Joon Lee , Hae-jin Hwang
发明人： Jae-soon Lee , Jae-jin Han , Joon Lee , Hae-jin Hwang
IPC分类号： G06F13/38
CPC分类号： G06F1/16 , G06F1/1601 , G06F1/181 , H01R9/032 , H01R27/00
摘要： A computer system includes a computer main body provided with a plurality of main body input-output ports; a monitor main body to display an image; a console stand having a console casing with an accommodating space inside and supporting the monitor main body, console input-output ports outside the console casing and connectable to an external device, an integrated port outside the console casing, and a control module controlling an interface between the integrated port and the console input-output port; and a main body/console cable having main body connectors respectively connected to the main body input-output ports, a console connector connected to the integrated port, an integrated cable electrically connecting the plurality of main body connectors and the console connector.
摘要翻译：计算机系统包括具有多个主体输入输出端口的计算机主体; 显示器主体，用于显示图像; 具有控制台壳体的控制台，其具有内部的容纳空间并且支撑监视器主体，控制台壳体外部的控制台输入输出端口并且可连接到外部设备，控制台壳体外部的集成端口以及控制接口的控制模块集成端口和控制台输入输出端口之间; 主体/控制台电缆，其主体连接器分别连接到主体输入输出端口，连接到集成端口的控制台连接器，电连接多个主体连接器和控制台连接器的集成电缆。

3. 发明申请

US20050222150A1 6-(4-substituted-anilino)pyrimidine derivates, method for preparation thereof and antiviral pharmaceutical composition comprising the same 失效
标题翻译： 6-（4-取代 - 苯胺基）嘧啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：US20050222150A1
公开(公告)日：2005-10-06
申请号：US10508306
申请日：2003-03-25
申请人： Jong-Woo Kim , Sang-Wook Lee , Geun-Hyung Lee , Jae-Jin Han , Sang-Jin Park , Eul-Yong Park , Joong-Chul Shin
发明人： Jong-Woo Kim , Sang-Wook Lee , Geun-Hyung Lee , Jae-Jin Han , Sang-Jin Park , Eul-Yong Park , Joong-Chul Shin
IPC分类号： C07D413/14 , A61K31/505 , A61K31/506 , A61P1/16 , A61P31/20 , C07D239/48 , C07D401/12 , A61K31/5377
CPC分类号： C07D239/48 , C07D401/12
摘要： The present invention relates to 6-(4-substituted-anilino)pyrimidine derivatives useful as an antiviral agent, and more particularly novel 6-(4-substituted-anilino)pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus; HCV), represented by the following formula I: in which R represents a C1-C4 straight or branched alkoxycarbonyl group, heterocycliccarbonyl group or carboxyalkyl group; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective ingredient. The 6-(4-substituted-anilino)pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的6-（4-取代 - 苯胺基）嘧啶衍生物，更特别地涉及对丙型肝炎病毒复制具有优异抑制作用的更特别新颖的6-（4-取代苯胺基）嘧啶衍生物。 HCV），其由下式I表示：其中R表示C 1 -C 4直链或支链烷氧基羰基，杂环羰基或羧基烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的6-（4-取代苯胺基）嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

4. 发明授权

US08815565B2 Method for culturing mycoplasma contamination-free cells and method for removing mycoplasma contamination of cells 有权
标题翻译：培养支原体无污染细胞的方法和细胞去除支原体污染的方法
公开(公告)号：US08815565B2
公开(公告)日：2014-08-26
申请号：US13513743
申请日：2010-11-24
申请人： Jae-Jin Han
发明人： Jae-Jin Han
IPC分类号： C12N1/00
CPC分类号： C12N5/0602 , C12N5/0018 , C12N2500/76
摘要： Provided is a method for culturing cells, which prevents the possibility of mycoplasma contamination by culturing the cells using biomass extract obtained by culturing a strain with amphidinol productivity, preferably a strain such as Amphidinium klebsii, Amphididinium carterae, and the like belonging to Dinoflagellates, or using a fraction obtained from the extract; and a method for removing mycoplasma contamination of the cells by culturing the cells contaminated by mycoplasma using the amphidinol derivatives. In addition, provided is a method for removing mycoplasma contamination of the cells, including a combination of single cell-isolating enzyme solution treatment and cell aggregate removal.
摘要翻译：本发明提供一种培养细胞的方法，其通过利用通过培养具有阿奇霉素生产力的菌株获得的生物质提取物优选培养细胞来防止支原体污染的可能性，优选菌株如属于鞭毛藻的as螨属（Amphidinium klebsii），镰孢菌纲（Amphididinium carterae）等，或使用从提取物获得的级分; 以及通过使用二甲啶醇衍生物培养受支原体污染的细胞来去除细胞的支原体污染的方法。此外，提供了除去细胞的支原体污染的方法，包括单细胞分离酶溶液处理和细胞聚集体去除的组合。

5. 发明授权

US08809034B2 Method for culturing mycoplasma contamination-free cells and method for removing mycoplasma contamination of cells 有权
公开(公告)号：US08809034B2
公开(公告)日：2014-08-19
申请号：US14090768
申请日：2013-11-26
申请人： Jae-Jin Han
发明人： Jae-Jin Han
IPC分类号： C12N1/00
CPC分类号： C12N5/0602 , C12N5/0018 , C12N2500/76
摘要： Provided is a method for culturing cells, which prevents the possibility of mycoplasma contamination by culturing the cells using biomass extract obtained by culturing a strain with amphidinol productivity, preferably a strain such as Amphidinium klebsii, Amphididinium carterae, and the like belonging to Dinoflagellates, or using a fraction obtained from the extract; and a method for removing mycoplasma contamination of the cells by culturing the cells contaminated by mycoplasma using the amphidinol derivatives. In addition, provided is a method for removing mycoplasma contamination of the cells, including a combination of single cell-isolating enzyme solution treatment and cell aggregate removal.

6. 发明授权

US07276501B2 6-(4-substituted-anilino)pyrimidine derivatives, method for preparation thereof and antiviral pharmaceutical composition comprising the same 失效
标题翻译： 6-（4-取代 - 苯胺基）嘧啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：US07276501B2
公开(公告)日：2007-10-02
申请号：US10508306
申请日：2003-03-25
申请人： Jong-Woo Kim , Sang-Wook Lee , Geun-Hyung Lee , Jae-Jin Han , Sang-Jin Park , Eul-Yong Park , Joong-Chul Shin
发明人： Jong-Woo Kim , Sang-Wook Lee , Geun-Hyung Lee , Jae-Jin Han , Sang-Jin Park , Eul-Yong Park , Joong-Chul Shin
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D239/48 , C07D401/12
摘要： The present invention relates to 6-(4-substituted-anilino)pyrimidine derivatives useful as an antiviral agent, and more particularly novel 6-(4-substituted-anilino)pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus; HCV), represented by the following formula I: in which R represents a C1-C4 straight or branched alkoxycarbonyl group, heterocycliccarbonyl group or carboxyalkyl group; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective ingredient. The 6-(4-substituted-anilino)pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的6-（4-取代 - 苯胺基）嘧啶衍生物，更特别地涉及对丙型肝炎病毒复制具有优异抑制作用的更特别新颖的6-（4-取代苯胺基）嘧啶衍生物。 HCV），其由下式I表示：其中R表示C 1 -C 4直链或支链烷氧基羰基，杂环羰基或羧基烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。根据本发明的6-（4-取代苯胺基）嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

7. 发明授权

US06306860B1 2,5-pyridinedicarboxylic acid derivatives 失效
标题翻译： 2,5-吡啶二羧酸衍生物
公开(公告)号：US06306860B1
公开(公告)日：2001-10-23
申请号：US09674844
申请日：2000-11-07
申请人： Sung Joon Yoon , Sang Wook Lee , Hyeong Su Sim , Yong Kyun Park , Wang Yong Yang , Jong Woo Kim , Jae Jin Han , Je In Yoon , Sang Jin Park , Hee Jeoung Park , Dong Hyuk Sin , Hwan Bong Chang
发明人： Sung Joon Yoon , Sang Wook Lee , Hyeong Su Sim , Yong Kyun Park , Wang Yong Yang , Jong Woo Kim , Jae Jin Han , Je In Yoon , Sang Jin Park , Hee Jeoung Park , Dong Hyuk Sin , Hwan Bong Chang
IPC分类号： C07D40114
CPC分类号： C07D213/82 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Anti-viral agents of formula (1) have been identified. Their preparation method is described. These 2,5-pyridinedicarboxylic acid derivatives or their pharmaceutically acceptable salts are useful in countering the proliferation of viruses such as hepatitis B virus and human immunodeficiency virus.
摘要翻译：已经鉴定了式（1）的抗病毒剂。描述了它们的制备方法。这些2,5-吡啶二羧酸衍生物或其药学上可接受的盐可用于对抗乙型肝炎病毒和人类免疫缺陷病毒等病毒的增殖。

8. 发明授权

US08871749B2 Bone-transplant or bone-filling composition comprising a dihydroxybenzoic acid derivative 有权
标题翻译：包含二羟基苯甲酸衍生物的骨移植物或骨填充组合物
公开(公告)号：US08871749B2
公开(公告)日：2014-10-28
申请号：US13643803
申请日：2011-04-25
申请人： Jae-Jin Han
发明人： Jae-Jin Han
IPC分类号： A61K31/60 , A61K31/235 , A61K31/618 , A61L27/50 , C07C69/84 , A61C8/02 , C07C65/03
CPC分类号： A61C8/0006 , A61L27/50 , A61L2430/02 , A61L2430/12 , C07C65/03 , C07C69/84
摘要： Provided is a bone-transplant or bone-filling composition, which comprises a dihydroxybenzoic acid derivative which has been newly demonstrated to increase the activity of osteoblasts and so induce bone formation.
摘要翻译：提供了一种骨移植或骨填充组合物，其包含已被新证实增加成骨细胞活性并因此诱导骨形成的二羟基苯甲酸衍生物。

9. 发明授权

US07244731B2 6-Methylpyridine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same 失效
标题翻译： 6-甲基吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：US07244731B2
公开(公告)日：2007-07-17
申请号：US10528461
申请日：2003-10-02
申请人： Jong-Woo Kim , Sang-Wook Lee , Geun-Hyung Lee , Jae-Jin Han , Sang-Jin Park , Eul-Yong Park , Joong-Chul Shin
发明人： Jong-Woo Kim , Sang-Wook Lee , Geun-Hyung Lee , Jae-Jin Han , Sang-Jin Park , Eul-Yong Park , Joong-Chul Shin
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： C07D213/80
摘要： The present invention relates to 6-methylpyridine derivatives useful as an antiviral agent. More particularly, the present invention relates to novel 6-methylpyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), or pharmaceutically acceptable salts thereof, to a method for preparing thereof, and to an antiviral pharmaceutical composition comprising the compound as an active ingredient. The 6-methylpyridine derivatives of the present invention have an excellent inhibitory effect on replication of hepatitis C virus and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C
摘要翻译：本发明涉及可用作抗病毒剂的6-甲基吡啶衍生物。更具体地说，本发明涉及对丙型肝炎病毒（HCV）的复制或其药学上可接受的盐对其制备方法具有优异抑制作用的新型6-甲基吡啶衍生物，以及含有该化合物的抗病毒药物组合物作为活性成分。本发明的6-甲基吡啶衍生物对丙型肝炎病毒的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防药物

10. 发明申请

US20060269609A1 6-Methylpyridine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same 失效
标题翻译： 6-甲基吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：US20060269609A1
公开(公告)日：2006-11-30
申请号：US10528461
申请日：2003-10-02
申请人： Jong-Woo Kim , Sang-Wook Lee , Geun-Hyung Lee , Jae-Jin Han , Sang-Jin Park , Eul-Yong Park , Joong-Chul Shin
发明人： Jong-Woo Kim , Sang-Wook Lee , Geun-Hyung Lee , Jae-Jin Han , Sang-Jin Park , Eul-Yong Park , Joong-Chul Shin
IPC分类号： A61K36/254 , A61K36/82 , A61K36/16 , A61K36/13
CPC分类号： C07D213/80
摘要： The present invention relates to 6-methylpyridine derivatives useful as an antiviral agent. More particularly, the present invention relates to novel 6-methylpyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), or pharmaceutically acceptable salts thereof, to a method for preparing thereof, and to an antiviral pharmaceutical composition comprising the compound as an active ingredient. The 6-methylpyridine derivatives of the present invention have an excellent inhibitory effect on replication of hepatitis C virus and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.
摘要翻译：本发明涉及可用作抗病毒剂的6-甲基吡啶衍生物。更具体地说，本发明涉及对丙型肝炎病毒（HCV）的复制或其药学上可接受的盐对其制备方法具有优异抑制作用的新型6-甲基吡啶衍生物，以及含有该化合物的抗病毒药物组合物作为活性成分。本发明的6-甲基吡啶衍生物对丙型肝炎病毒的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

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